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VPRSLDLVVTSVATALMEATASTARSVSETVLAQLVEQFDVDASFLHHHDAAGPVPVAEWPRRTDAAGPM AALRSEDVESVLAQCERQRRPVVSSPDQADGWLRRWLQRDKAAGAPSVAAAPLVSGDATTGVLGFVKFGA RRWKPEEINTLEAVAALFAQLQARIAAEERLRYLAEHDDLTGVYNRRALVAHLTERLAAGNPGPVAVFYL DLDRLKPINDYLGHTAGDWFIRVFAQRIEECAGEQSMIARLGGDEFVVIPHQPMASEAAEAFARRLSTLL CDRLTIGGHVISRTVSIGLAVGTPGADNCTDLLRRADEAVLTAKRAGGNQTAVSTDDMSLKRAFRNDIEL HLQGDIESEGLLLHYLPEVDLWTGAVVGAEALVRWRHPIWGLLLPDSFIGVAESTNLGAELGGWVMRSAC ADFSRWRANGVGHGAMLRINVSPIQLISRGFVETVADTIGEFGIDAGSVCLEITERAVVHDTETTRKTLS ELKEVGVQIAIDDFGTGYAVLSHLKSLPVDMLKIDAGFVREVGTDAGDLAIVRAIIGLAEAFGLEVVAEG VETPAAALTLMQHGCHRAQGFLLSRPIPGEAMEALLSARWMPMPFLADREASSMGSI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1132 | - | - | 100% (617) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. avium 104 | MAV_3132 | - | 0.0 | 56.60% (606) | GGDEF domain-containing protein |
| M. avium 104 | MAV_1410 | - | 6e-53 | 31.11% (434) | cyclic diguanylate phosphodiesterase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 0.0 | 58.14% (602) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4377 | - | 0.0 | 62.07% (609) | diguanylate cyclase/phosphodiesterase with GAF sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 0.0 | 58.14% (602) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 0.0 | 57.02% (605) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_0124 | - | 6e-14 | 30.10% (206) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 0.0 | 61.05% (611) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 0.0 | 61.37% (611) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 0.0 | 63.26% (607) | diguanylate cyclase/phosphodiesterase with GAF sensor |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4377|M.gilvum_PYR-GCK -----MSES-----LDLVVTSVATRLMGAGAATWAEASQQVLADLVEHFG
Mvan_1967|M.vanbaalenii_PYR-1 -----MSDSDTLRSLDLVITSVATKLMAANAATSVEVSQRVLAELVDYLG
MSMEG_2196|M.smegmatis_MC2_155 -----MSES-----LDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFD
TH_0811|M.thermoresistible__bu -----VSTE-----LDLLVTGVATKLMAADAATARDVSRRVLADLVRAFE
MLBr_01750|M.leprae_Br4923 -----MTRS-----LDELVTRVASKLMAATAATAVTISEGVLAILVEHFG
Mb1389c|M.bovis_AF2122/97 -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
Rv1354c|M.tuberculosis_H37Rv -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
MAV_1132|M.avium_104 -----MPRS-----LDLVVTSVATALMEATASTARSVSETVLAQLVEQFD
MAB_0124|M.abscessus_ATCC_1997 MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
: :* . . : * * **. *:
Mflv_4377|M.gilvum_PYR-GCK VDVS----FLRRNDHTIRASVLVAEWPVRPGIPDPDPLAVVYFADADPVF
Mvan_1967|M.vanbaalenii_PYR-1 VDVS----FLRYNDHKIRASRLVAEWPVRPGVPDPDPLALVYFADADPVF
MSMEG_2196|M.smegmatis_MC2_155 VDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVF
TH_0811|M.thermoresistible__bu LDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVF
MLBr_01750|M.leprae_Br4923 VDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVF
Mb1389c|M.bovis_AF2122/97 VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
Rv1354c|M.tuberculosis_H37Rv VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
MAV_1132|M.avium_104 VDAS----FLHH--HDAAGPVPVAEWPRRTDAAG--PMAALRSEDVESVL
MAB_0124|M.abscessus_ATCC_1997 LGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWADISMVV
:. * * .: : . . *.
Mflv_4377|M.gilvum_PYR-GCK ALAEFQKEPLVFRPDANTDEYQKTIEEGRQVPQVSMAAVPLLSGDVTTGV
Mvan_1967|M.vanbaalenii_PYR-1 AQSEHGKKPMVFRPEPATDDYQKRIEETRAVPATSMAAAPLVSGELTTGV
MSMEG_2196|M.smegmatis_MC2_155 AMAEHLKEPAVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGV
TH_0811|M.thermoresistible__bu ALAEHAKEIHIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGV
MLBr_01750|M.leprae_Br4923 AMAEYLKEPAVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGV
Mb1389c|M.bovis_AF2122/97 ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
Rv1354c|M.tuberculosis_H37Rv ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
MAV_1132|M.avium_104 AQCERQRRPVVSSPDQADGWLRRWLQRDKAAGAPSVAAAPLVSGDATTGV
MAB_0124|M.abscessus_ATCC_1997 GACTLSAPASRLGALAHMGLIG--VFAAFLLGWRVLAVHCVFATVAIFGL
. . . : * :.: *:
Mflv_4377|M.gilvum_PYR-GCK LGF-VKFGDRDWTGVELN---ALKAIASLFAQVQARVEAETQ----LRYL
Mvan_1967|M.vanbaalenii_PYR-1 LGF-IKFGDREWTAEELN---GLEAIASLFAQVQARVQAEEQ----LRYL
MSMEG_2196|M.smegmatis_MC2_155 LGF-VKFGDREWLPAELN---ALKAIASLFAQVQARIEAEER----LRYL
TH_0811|M.thermoresistible__bu LGF-VKYGDRQWHPDELN---ALKAIASLFAQVQARVEAEER----LRYL
MLBr_01750|M.leprae_Br4923 LGF-VKYGDREWHDDELR---ALQAIATLFAQLQARIVAEEQ----LRYL
Mb1389c|M.bovis_AF2122/97 LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
Rv1354c|M.tuberculosis_H37Rv LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
MAV_1132|M.avium_104 LGF-VKFGARRWKPEEIN---TLEAVAALFAQLQARIAAEER----LRYL
MAB_0124|M.abscessus_ATCC_1997 MGWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLA
:*: :: * * : * ::. * :*. : . : :
Mflv_4377|M.gilvum_PYR-GCK AEHDDLTGLNNRRALLSHLDGRLAEGQPG-PVSALFFDLDRLKAINDYLG
Mvan_1967|M.vanbaalenii_PYR-1 AEHDDLTGLYNRRALLAHLDERLAEGRPG-PVSALFFDLDRLKAINDYLG
MSMEG_2196|M.smegmatis_MC2_155 ADHDHLTGLYNRRALMAHLEARLAPGQPG-PVAVMFFDLDRLKAINDYLG
TH_0811|M.thermoresistible__bu AEHDDLTGLHNRRALLAHLDARLAAGQPG-PVSALYFDLDRLKAVNDYLG
MLBr_01750|M.leprae_Br4923 AEHDDLTGLLNRRALIAHLDERLADGQRG-PVTLLFLGLDRLKAVNDYLG
Mb1389c|M.bovis_AF2122/97 ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
Rv1354c|M.tuberculosis_H37Rv ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
MAV_1132|M.avium_104 AEHDDLTGVYNRRALVAHLTERLAAGNPG-PVAVFYLDLDRLKPINDYLG
MAB_0124|M.abscessus_ATCC_1997 AHQDPLTGLLNRRGVQVALSSLLSGQRATRIVAVVLVDVDELKELNDRLG
*.:* ***: ***.: * *: . *: . ..:*.** :** **
Mflv_4377|M.gilvum_PYR-GCK HTAGDWFIRVLAERLREGADPRALIARLGGDEFVVVPAGPMDGEAAESLA
Mvan_1967|M.vanbaalenii_PYR-1 HTAGDWFIRVLAERLRRGADCPNIIARLGGDEFVLVPTVPMDGAAAEALA
MSMEG_2196|M.smegmatis_MC2_155 HTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALA
TH_0811|M.thermoresistible__bu HTVGDWFIRVLAERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELA
MLBr_01750|M.leprae_Br4923 HNAGDRLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFA
Mb1389c|M.bovis_AF2122/97 HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
Rv1354c|M.tuberculosis_H37Rv HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
MAV_1132|M.avium_104 HTAGDWFIRVFAQRIEECAGEQSMIARLGGDEFVVIPHQPMASEAAEAFA
MAB_0124|M.abscessus_ATCC_1997 HDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVG----FFDHADEAT
* .** * .* : : **:*****::: * :
Mflv_4377|M.gilvum_PYR-GCK HQLQSTLKERVSIDGEMLTRTVSIGVAVGIPGQDTTSDLLRRADQAVLTA
Mvan_1967|M.vanbaalenii_PYR-1 HRLQSTLRERVSIDGEMLTRTVSIGVAQGIPGRDTTSDLLRRADQAVLTA
MSMEG_2196|M.smegmatis_MC2_155 YRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTA
TH_0811|M.thermoresistible__bu NRLRSRLQQQVCVDGEMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTA
MLBr_01750|M.leprae_Br4923 HRLQTRLQKQVVIDGEILTRTVSIGVATGLPGRDTTSDLLRWADHAALSA
Mb1389c|M.bovis_AF2122/97 ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
Rv1354c|M.tuberculosis_H37Rv ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
MAV_1132|M.avium_104 RRLSTLLCDRLTIGGHVISRTVSIGLAVGTPGADNCTDLLRRADEAVLTA
MAB_0124|M.abscessus_ATCC_1997 GLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGA
: :. :. . : : . .: . .: . **. *
Mflv_4377|M.gilvum_PYR-GCK KNSGGNRVTVFTEEMSLKQEFNNDIELHLQSVIENGALLLHYLPEIDMRT
Mvan_1967|M.vanbaalenii_PYR-1 KGSGGNEVVVFTDDMSMRHEFNNDIELHLQSVIENGALLLHYLPEVDMRT
MSMEG_2196|M.smegmatis_MC2_155 KGSGGNRVAVFSDAMAMEIDFRNDIELHLQSVIEGGALVLHYLPEIDMRT
TH_0811|M.thermoresistible__bu KSAGGNQITVFTDDMSLEAEFRNDIELHLQSVIQDEALLLHFLPEVDMRT
MLBr_01750|M.leprae_Br4923 K-SDGSKVVVLDHGISAQHTLRTEVELHLAGMIDT-DLVLHYLPEVDMST
Mb1389c|M.bovis_AF2122/97 KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
Rv1354c|M.tuberculosis_H37Rv KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
MAV_1132|M.avium_104 KRAGGNQTAVSTDDMSLKRAFRNDIELHLQGDIESEGLLLHYLPEVDLWT
MAB_0124|M.abscessus_ATCC_1997 KIERRNGFHAVP--------------------------------------
* .
Mflv_4377|M.gilvum_PYR-GCK GDILAMEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACTDF
Mvan_1967|M.vanbaalenii_PYR-1 GEILACEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACADF
MSMEG_2196|M.smegmatis_MC2_155 GEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEF
TH_0811|M.thermoresistible__bu GEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACGEF
MLBr_01750|M.leprae_Br4923 GKVLGTEALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACAEF
Mb1389c|M.bovis_AF2122/97 GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
Rv1354c|M.tuberculosis_H37Rv GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
MAV_1132|M.avium_104 GAVVGAEALVRWRHPIWGLLLPDSFIGVAESTNLGAELGGWVMRSACADF
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4377|M.gilvum_PYR-GCK ARWRALGIGKDAIMRINVSPVQLVTDGFVESVAGIVDEFGLEHGSVCLEI
Mvan_1967|M.vanbaalenii_PYR-1 AGWRARGIGTGTVMRINVSPVQLVTDGFVESVAGIVDEFDLDEGSVCLEI
MSMEG_2196|M.smegmatis_MC2_155 SRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEI
TH_0811|M.thermoresistible__bu AKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEI
MLBr_01750|M.leprae_Br4923 SRWRSAGVGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEI
Mb1389c|M.bovis_AF2122/97 SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
Rv1354c|M.tuberculosis_H37Rv SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
MAV_1132|M.avium_104 SRWRANGVGHGAMLRINVSPIQLISRGFVETVADTIGEFGIDAGSVCLEI
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4377|M.gilvum_PYR-GCK TESVVVQDIETTRVTLNGLKKAGVLVAIDDFGTGYSALSHLKSLPVDTLK
Mvan_1967|M.vanbaalenii_PYR-1 TESVVVQDIETTRVTLKGLKEAGVRIAIDDFGTGYSALSHLKSLPVDTLK
MSMEG_2196|M.smegmatis_MC2_155 TESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLK
TH_0811|M.thermoresistible__bu TESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLK
MLBr_01750|M.leprae_Br4923 TENVVVQNIDATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIK
Mb1389c|M.bovis_AF2122/97 TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
Rv1354c|M.tuberculosis_H37Rv TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
MAV_1132|M.avium_104 TERAVVHDTETTRKTLSELKEVGVQIAIDDFGTGYAVLSHLKSLPVDMLK
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4377|M.gilvum_PYR-GCK IDKSFVRELGSDPGDLAIVRAIIALAEAFGLELVAEGVETDVGALTLLRH
Mvan_1967|M.vanbaalenii_PYR-1 IDKSFVRELGSDPGDLAIVRAVIALAEAFGLELVAEGVETEAAAMTLLRH
MSMEG_2196|M.smegmatis_MC2_155 IDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLLRH
TH_0811|M.thermoresistible__bu IDKGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLLRH
MLBr_01750|M.leprae_Br4923 IDKSFVAELGSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLLEL
Mb1389c|M.bovis_AF2122/97 IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
Rv1354c|M.tuberculosis_H37Rv IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
MAV_1132|M.avium_104 IDAGFVREVGTDAGDLAIVRAIIGLAEAFGLEVVAEGVETPAAALTLMQH
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4377|M.gilvum_PYR-GCK GCHRAQGFLLSRPIPTDAMETLLAQGRIPVSFSKG-------------
Mvan_1967|M.vanbaalenii_PYR-1 GCHRAQGFLLSRPIDGAAMKALLARGRVPVSFAKS-------------
MSMEG_2196|M.smegmatis_MC2_155 GCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu GCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP------------
MLBr_01750|M.leprae_Br4923 GCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
Mb1389c|M.bovis_AF2122/97 RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MAV_1132|M.avium_104 GCHRAQGFLLSRPIPGEAMEALLSARWMPMPFLADREASSMGSI----
MAB_0124|M.abscessus_ATCC_1997 ------------------------------------------------