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MKRLSPSAVAFLTFPVVYAVSILAGRATRLGGGEIALVWPAAAVATVWLLAARRFSRWQRVAHLSALALA TFVVNLFTHATPQLSAWFVLVNLALALVTVEIIHYRRDEVVLRDPTDLVRVIVAVTAGTVCAAALATMYL VPVTGAPAWETFGLFTARNGATALIGVAAWLRLRDVRWTRPRLSPAATVEIIVTGGVVGFVLVWIFWLST GIPLGFLVLLPAMWVALRYSTTVSTVFLLVAAAWIIYSTLSGRGAFIVPDMQLRALLAQAMVFSLTVLVL ALALFRDSRMRLIGQLEAARDRADQDSELLGAVLDSIHDSVVLADPDGRVVLQNARATDSGLVSDVVSAV HTPGLVDDMAASASHAPRDIVVSVEDSRILELATTPLSRQSQFTVMAFRDVTEERRNARELREARDLFAG VLEAASEQAIVGTDPSGCITVFNNGAERLLGWTEEEMLGRTPMDFHYPPEVRARAEELGIPEGFEVFVHN VTPDAAEIREWTFVRRDGGHVDVSLAVSLMTDERGTCVGYIGVATDITDQKAAERALAESEERFRLAFDT APVGMFMFDVTPDGTGRITRCNTTLADFLGRSTADVLGSSTTELGADESTSSTKGLTGLPTLRKGEPWGA EVAFRRADGATVWGAVSASLVAPPGADPYGICLVEDITSRKRAEADLQFLALHDPLTGLANRTLLMNRME QALADEGRHVPGRVGLLFLDLDGFKPVNDTWGHAAGDEVLKAVARRIENSIRPGDTAARLGGDEFAVLCP VIGENGELHGVAERIQTELSRPLTLIGGQSYDQLSASVGVAMSGCGRTAEELLHHADRLMYHAKRQGNGG LVGDHTPAGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3629 | - | - | 100% (850) | diguanylate cyclase with PAS/PAC sensor |
| M. vanbaalenii PYR-1 | Mvan_1918 | - | 1e-28 | 43.45% (168) | diguanylate cyclase/phosphodiesterase |
| M. vanbaalenii PYR-1 | Mvan_1152 | - | 5e-28 | 31.35% (303) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 1e-22 | 39.20% (176) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_2883 | - | 0.0 | 68.24% (847) | diguanylate cyclase with PAS/PAC sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 1e-22 | 39.20% (176) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01419 | - | 7e-29 | 27.99% (468) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_1839 | - | 4e-16 | 35.50% (169) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1410 | - | 2e-23 | 36.89% (206) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 2e-19 | 36.31% (179) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 3e-21 | 36.93% (176) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 MKRWAVNPWRRSGVPARVGWLLAGGYGTAALLVLLSSVRGWRGPYGTRPV
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 DDLVMFVCLAVAAMCAARAARAASGRRRYGWLALTTALLGWAVGEVIWAV
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 YDVRPEFEHAAHPAAAEMVLLLFPVGAMTSLVLLSQLSRHSPRRLLLDGL
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 IVATSLFVISWVFVVEAQLREHTGTQVATLAEVFNDIVLMTTAILTLSRA
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 RPGDRPSRSLLACGIATISVTDIAMVFYTGIGSYHTDDIGDLARVAGVGT
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 LALAGLASVYEQPAPGSPDEIEFRTRLWLPYLPLILAAAVGWGHAAGKAI
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 HEPMLAALGILVAAVLARQFVVLVDNQNLLSEVAREAFRDNLTGLANRAL
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 FVHRLEQAVARRHPDGTPIAVLCLDLDNFKAVNDALGHPAGDELLVRVAE
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 RLTAALGDSGTIARLGGDEFAAVIEASVDESQAAAHRILEAFTGAILIDG
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2883|M.gilvum_PYR-GCK --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
MAV_1410|M.avium_104 IPITVRPSIGFTVCTGASTCTVDQLLRHADLAMYAAKREGGQCIRSFMPD
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 ----------------------------MKRLSPSAVAFLTFPVVYAVSI
Mflv_2883|M.gilvum_PYR-GCK ----------------------------MRRLSTSAVVLLTFPPVFALSI
Mb1389c|M.bovis_AF2122/97 --------------------------MCNDTATPQLEELVTTVANQLMTV
Rv1354c|M.tuberculosis_H37Rv --------------------------MCNDTATPQLEELVTTVANQLMTV
MSMEG_2196|M.smegmatis_MC2_155 -------------------------------MSESLDVLVTSVATQLMAV
TH_0811|M.thermoresistible__bu -------------------------------VSTELDLLVTGVATKLMAA
MAV_1410|M.avium_104 LPLPYAFPPPPGSAAPTAVAAVAAGGNGAAPASPPQVATAATSSPSPHDA
MAB_1839|M.abscessus_ATCC_1997 ----------------------------------------MVTTYPGRNG
MLBr_01419|M.leprae_Br4923 ------------------------------MLETVRSVMVHSGECSAEST
Mvan_3629|M.vanbaalenii_PYR-1 LAGRATRLGGGEIALVWPAAAVATVWLLAARRFSRWQRVAHLSALALATF
Mflv_2883|M.gilvum_PYR-GCK VAGRATRLGGSEVALVWPAAAVAVMWLLAVHHCSLRQRAIHVTLLGILAY
Mb1389c|M.bovis_AF2122/97 DAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRD-----------------
Rv1354c|M.tuberculosis_H37Rv DAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRD-----------------
MSMEG_2196|M.smegmatis_MC2_155 EAATSVSVSQQVLAELVSFFDVDVSFLRHNDHR-----------------
TH_0811|M.thermoresistible__bu DAATARDVSRRVLADLVRAFELDFSFLRHNDHE-----------------
MAV_1410|M.avium_104 ARRPPRGIRAALGMLAIGVVAFSVSSVAHPDAGHGIFSATALYSALNAVA
MAB_1839|M.abscessus_ATCC_1997 FGSESNRCSTGAQVYGANNDILERVGLRR---------------------
MLBr_01419|M.leprae_Br4923 ADKEHRHHDLVAQRYQRLVDHSPNMTCVHESGR-----------------
Mvan_3629|M.vanbaalenii_PYR-1 VVNLFTHATPQLSA---WFVLVN----------------------LALAL
Mflv_2883|M.gilvum_PYR-GCK GMNVATGATVSLSA---WFVLVN----------------------VVLAV
Mb1389c|M.bovis_AF2122/97 -----RRATRLVAE---WPPRL-----------------------NIPDP
Rv1354c|M.tuberculosis_H37Rv -----RRATRLVAE---WPPRL-----------------------NIPDP
MSMEG_2196|M.smegmatis_MC2_155 -----AHATRLVAE---WPPRP-----------------------VDAAT
TH_0811|M.thermoresistible__bu -----IRASKLIAE---WPVRE-----------------------NVPDP
MAV_1410|M.avium_104 AGLIALRACRIPADRWAWALIAAGMACSAVGDVVYAVWVPDGRSPSVADP
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 ----------------------------------------------VTYL
Mvan_3629|M.vanbaalenii_PYR-1 VTVEIIHYRRDEVVLRDPTDLVRVIVAVTAGTVCAAALATMYLVPVTGAP
Mflv_2883|M.gilvum_PYR-GCK VTVGLLHYGRSDAVLRDPADLARLVVAVATGTMCAAVLATLYLTPVTGAP
Mb1389c|M.bovis_AF2122/97 DPLRLIYFADADPVFALCEHAKEPLVFRPE---PATEDYQRLIEEARGVP
Rv1354c|M.tuberculosis_H37Rv DPLRLIYFADADPVFALCEHAKEPLVFRPE---PATEDYQRLIEEARGVP
MSMEG_2196|M.smegmatis_MC2_155 DPIAVVHFADADPVFAMAEHLKEPAVFRPE---PLYDDYQRTIEAGRHIP
TH_0811|M.thermoresistible__bu DPIGVVHFEGADPVFALAEHAKEIHIFRPE---PATDEFQRLIEESSGVP
MAV_1410|M.avium_104 EYLAYYPFVYAGLLLLMRARLKRLPIAVQLDSVVCALTLAAVAAALTAGP
MAB_1839|M.abscessus_ATCC_1997 ------PVSRANAVFITAVGAAAILLAATG--------------------
MLBr_01419|M.leprae_Br4923 NPVGVKWMAAQSPEQIIGHPLIEFVHPDSMP-------------------
Mvan_3629|M.vanbaalenii_PYR-1 AWETFGLFTARNGA------------TALIGVAAWLRLRDVR--------
Mflv_2883|M.gilvum_PYR-GCK AWETFALFTARNGA------------SALVGVAVWLCLRDVP--------
Mb1389c|M.bovis_AF2122/97 VTSAAAVPLVSG--------------EITTGLLGFIKFGDRK--------
Rv1354c|M.tuberculosis_H37Rv VTSAAAVPLVSG--------------EITTGLLGFIKFGDRK--------
MSMEG_2196|M.smegmatis_MC2_155 ATSMACVPLLSG--------------DVTTGVLGFVKFGDRE--------
TH_0811|M.thermoresistible__bu ASTVAAVPLVSG--------------EITTGVLGFVKYGDRQ--------
MAV_1410|M.avium_104 LHQAAVHAPKTVWVGLAYPWCDLMLLALAAGMLPILGWRNEIRWALLVAG
MAB_1839|M.abscessus_ATCC_1997 -------------------------------------MSTIP--------
MLBr_01419|M.leprae_Br4923 --------------------------AMMSRIAPLREVGDAS--------
Mvan_3629|M.vanbaalenii_PYR-1 -----------------------------------------WTRP-----
Mflv_2883|M.gilvum_PYR-GCK -----------------------------------------WKRP-----
Mb1389c|M.bovis_AF2122/97 -----------------------------------------WHEA-----
Rv1354c|M.tuberculosis_H37Rv -----------------------------------------WHEA-----
MSMEG_2196|M.smegmatis_MC2_155 -----------------------------------------WLPA-----
TH_0811|M.thermoresistible__bu -----------------------------------------WHPD-----
MAV_1410|M.avium_104 LVLFAVADGAYLFQTAAGSYRVGSLLDVCWPASSVLIAMASWAPPPATAT
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 ----RLSPAATVEIIVTGGVVGFVLVWIFWLSTGIPLGFLVLLPAMWVAL
Mflv_2883|M.gilvum_PYR-GCK ----RVRPAMLVEGLVVGTIVVFVFAWSFWLNTGTPMTFVVLLPTTWVAL
Mb1389c|M.bovis_AF2122/97 ----ELN-------------------------------ALMTIATLFAQV
Rv1354c|M.tuberculosis_H37Rv ----ELN-------------------------------ALMTIATLFAQV
MSMEG_2196|M.smegmatis_MC2_155 ----ELN-------------------------------ALKAIASLFAQV
TH_0811|M.thermoresistible__bu ----ELN-------------------------------ALKAIASLFAQV
MAV_1410|M.avium_104 QARRRFSPYVTPVASTIVALGVIVLAHHSRSAATLAALSLVVGAGRFSLT
MAB_1839|M.abscessus_ATCC_1997 ---------------------------------------LLCISLSIPAF
MLBr_01419|M.leprae_Br4923 -------------------------------------QPSEAVLLRLDGT
Mvan_3629|M.vanbaalenii_PYR-1 RYSTTVSTVFLLVAAAWIIYSTLSGRGAFIVPDMQLRALLAQA-------
Mflv_2883|M.gilvum_PYR-GCK RYSTPVSTLFVIAAANWIVFATLSDRGPLLASDLQVRALLAQG-------
Mb1389c|M.bovis_AF2122/97 QARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGP-------
Rv1354c|M.tuberculosis_H37Rv QARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGP-------
MSMEG_2196|M.smegmatis_MC2_155 QARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLAPGQPGP-------
TH_0811|M.thermoresistible__bu QARVEAEERLRYLAEHDDLTGLHNRRALLAHLDARLAAGQPGP-------
MAV_1410|M.avium_104 FRDVSLLHSHDRHAMTDELTALPNRRQLVTALQGLPASASPGAGSMPSRA
MAB_1839|M.abscessus_ATCC_1997 LWGIRYARARAVTYGESVAYVLYCDVAILIGICVVTTTG-----------
MLBr_01419|M.leprae_Br4923 TLEVEAVSVLTVWEGKPAYQVIFRDLTTQKAAEETLRFQAALVN------
Mvan_3629|M.vanbaalenii_PYR-1 ---MVFSLTVLVLALALFRDSRMRLIGQLEAARDRADQDSELLGAVLDSI
Mflv_2883|M.gilvum_PYR-GCK ---MVFSLTVIVLALALYRDTRVRLIAELEASRDQADQDSELLGAVLDSI
Mb1389c|M.bovis_AF2122/97 ---VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARL
Rv1354c|M.tuberculosis_H37Rv ---VAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARL
MSMEG_2196|M.smegmatis_MC2_155 ---VAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLIARL
TH_0811|M.thermoresistible__bu ---VSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDLIARL
MAV_1410|M.avium_104 NPRRALLLLSLSDFHEITESIGRQFGDELLCHIANRLAGSVRRDDLLARV
MAB_1839|M.abscessus_ATCC_1997 -----VAFVKLAWLLAVSAYVSLVHGRVAVAMQS------------LVTT
MLBr_01419|M.leprae_Br4923 -----HVSDAIIATTSTGMVTSWNPAAEAIYRRSASDVLGMPIGEAVGAP
: :
Mvan_3629|M.vanbaalenii_PYR-1 HDSVVLADPDGRVVLQNARATDSGLVSDVVSAVHTPGLVDDMAASASHAP
Mflv_2883|M.gilvum_PYR-GCK HDGVILVDPADRVVLRNARADDSGLVDEVVAAARAVG-HGGADGPEPAVP
Mb1389c|M.bovis_AF2122/97 GGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG---------EVLT
Rv1354c|M.tuberculosis_H37Rv GGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGG---------EVLT
MSMEG_2196|M.smegmatis_MC2_155 GGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDG---------EMLT
TH_0811|M.thermoresistible__bu GGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDG---------EMLT
MAV_1410|M.avium_104 GDDQFAVLLADGANLTAASAQAGRLLEALSEPIALDP---------ITVQ
MAB_1839|M.abscessus_ATCC_1997 AGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAGL-------------
MLBr_01419|M.leprae_Br4923 LDPGAIITEGGVLSTTQYASDGMALAVRVSAAVMENG-------------
. : :
Mvan_3629|M.vanbaalenii_PYR-1 RDIVVSVEDSRILELATTPLSRQSQFTVMAFRDVTEERRNARELREARDL
Mflv_2883|M.gilvum_PYR-GCK HDVIVSVEDSRTLELTTTPLPRQPQFDVMAFRDVTEVRRNARELREARDL
Mb1389c|M.bovis_AF2122/97 RTVSIGVASGTPGQHTPSDLLRRADQAALAAK------------------
Rv1354c|M.tuberculosis_H37Rv RTVSIGVASGTPGQHTPSDLLRRADQAALAAK------------------
MSMEG_2196|M.smegmatis_MC2_155 RTVSIGIAQGIPGKDSTSDVLNRADHAVLTAK------------------
TH_0811|M.thermoresistible__bu RTASIGVAQGTPGRDTTSDLLRRADQAVLTAK------------------
MAV_1410|M.avium_104 VDGRIAIALCPDHCDHPRELLSRAETALAHAK------------------
MAB_1839|M.abscessus_ATCC_1997 -VIYVGKAQFSEHADGRDRLARHDVLTGLLNR------------------
MLBr_01419|M.leprae_Br4923 ----FVLVCSDYTALLRVERRFQTVVALLEEG------------------
. :
Mvan_3629|M.vanbaalenii_PYR-1 FAGVLEAASEQAIVGTDPSGCITVFNNGAERLLGWTEEEMLGRTPMDFHY
Mflv_2883|M.gilvum_PYR-GCK FAGVLQAASEQAIIGTDQDGLITVFNQGAERLLGWTAEEMIGRPVTDVHD
Mb1389c|M.bovis_AF2122/97 -----HAGGDSVAIFTADMSVSGELRNDIELHL----RRGIESDALRLVY
Rv1354c|M.tuberculosis_H37Rv -----HAGGDSVAIFTADMSVSGELRNDIELHL----RRGIESDALRLVY
MSMEG_2196|M.smegmatis_MC2_155 -----GSGGNRVAVFSDAMAMEIDFRNDIELHL----QSVIEGGALVLHY
TH_0811|M.thermoresistible__bu -----SAGGNQITVFTDDMSLEAEFRNDIELHL----QSVIQDEALLLHF
MAV_1410|M.avium_104 ------SARSKIAVYDSAFEAHRDNDTNLIEELR---TALFDTDELKLHY
MAB_1839|M.abscessus_ATCC_1997 --------RGLQEAYEATVGVPG---------------MHVTVVVVDLNL
MLBr_01419|M.leprae_Br4923 ------------VIVLDGDGYVESVNPAALRILGVSDRSALDDPVRRAAT
.
Mvan_3629|M.vanbaalenii_PYR-1 PPEVRARAEELGIPEGFEVFVHNVTPDAAEIREWTFVRRDGGHVDVSLAV
Mflv_2883|M.gilvum_PYR-GCK LAEMIVRADELGVPPGFEAFIANVTPDDAEIREWTYVRRDGSHAEVSLAI
Mb1389c|M.bovis_AF2122/97 LPEVDLRTGDIVG--------------TEALVRWQHPTRGLLAPGC----
Rv1354c|M.tuberculosis_H37Rv LPEVDLRTGDIVG--------------TEALVRWQHPTRGLLAPGC----
MSMEG_2196|M.smegmatis_MC2_155 LPEIDMRTGEVLA--------------AEALVRWEHPTRGLLSPDS----
TH_0811|M.thermoresistible__bu LPEVDMRTGEILA--------------TEALVRWHHPTRGLLAPDT----
MAV_1410|M.avium_104 QPKIDGRDGSIHS--------------VEAVLRWQHPTRGTLLPEE----
MAB_1839|M.abscessus_ATCC_1997 FKQINDTFGHHVG--------------DQVLQRTAHRLRSVVGPDA----
MLBr_01419|M.leprae_Br4923 LPMYDAQGRLLDHG-------------RGAVREFLRTGTPKTGFIVG---
: .
Mvan_3629|M.vanbaalenii_PYR-1 SLMTDERGTCVGYIGVATDITDQKAAERALAESEERFRLAFDTAPVGMFM
Mflv_2883|M.gilvum_PYR-GCK SQMSDADGCCVGYIGVATDITERKKAEHALAESEERFRSAFDTAPMGMFM
Mb1389c|M.bovis_AF2122/97 ------------FIPVAESIN----------LAGELDRWVLRRACNEFSE
Rv1354c|M.tuberculosis_H37Rv ------------FIPVAESIN----------LAGELDRWVLRRACNEFSE
MSMEG_2196|M.smegmatis_MC2_155 ------------FIGVAESIN----------LAGELGRWVLRTACAEFSR
TH_0811|M.thermoresistible__bu ------------FIGVAESVN----------LAGELGRWVMRTACGEFAK
MAV_1410|M.avium_104 ------------FLPVAERAG----------LMRKISNRTLSMALQQVRS
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01419|M.leprae_Br4923 --------------------------------------------------
Mvan_3629|M.vanbaalenii_PYR-1 FDVTPDGTGRITRCNTTLADFLGRSTADVLGSSTTELGADESTSSTKGLT
Mflv_2883|M.gilvum_PYR-GCK FTVTPEDAGRITRCNQALADFLGRSTSEVPGMSVTDLGTNENADGTEGLA
Mb1389c|M.bovis_AF2122/97 WQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDA---------
Rv1354c|M.tuberculosis_H37Rv WQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDA---------
MSMEG_2196|M.smegmatis_MC2_155 WRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPR---------
TH_0811|M.thermoresistible__bu WRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDG---------
MAV_1410|M.avium_104 WREE--GLRLTVAVNLSTTNLLDIELVGTVERLLANYDLPA---------
MAB_1839|M.abscessus_ATCC_1997 ----------------------------LLARLGGDE-------------
MLBr_01419|M.leprae_Br4923 ---------------IDRPSDGTRVWLSVNSRSLNPVDPED---------
Mvan_3629|M.vanbaalenii_PYR-1 GLPTLRKGEPWGAEVAFRRADGATVWGAVSASLVAPPGADPYGICLVEDI
Mflv_2883|M.gilvum_PYR-GCK RLLALTDGEPVSAEVRFRRWDGDTMWGAVSASVVAAAGADPYGICLVEDI
Mb1389c|M.bovis_AF2122/97 --------------------------SSVCLEITEN--------VVVQDL
Rv1354c|M.tuberculosis_H37Rv --------------------------SSVCLEITEN--------VVVQDL
MSMEG_2196|M.smegmatis_MC2_155 --------------------------GSVCLEITES--------VVVQDI
TH_0811|M.thermoresistible__bu --------------------------SSVCLEITES--------VVVQDI
MAV_1410|M.avium_104 --------------------------DALILEITES---------ALVDS
MAB_1839|M.abscessus_ATCC_1997 -------------------------FGIVVVGDAPP------------HI
MLBr_01419|M.leprae_Br4923 --------------------------ATLLISFT--------------DV
: . .
Mvan_3629|M.vanbaalenii_PYR-1 TSRKRAEADLQFLALHDPLTGLANRTLLMNRMEQALADEGRHVPGRVGLL
Mflv_2883|M.gilvum_PYR-GCK TSRKRAEAELQHLALHDPLTGLANRALLVDRVEQAIADIGRHAPACVGLL
Mb1389c|M.bovis_AF2122/97 HTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT-----------
Rv1354c|M.tuberculosis_H37Rv HTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT-----------
MSMEG_2196|M.smegmatis_MC2_155 ETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDT-----------
TH_0811|M.thermoresistible__bu KTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDT-----------
MAV_1410|M.avium_104 VRSRNTVTALQRLGIRISIDDYGTGWSSLARLQEVSVDE-----------
MAB_1839|M.abscessus_ATCC_1997 DYQRAVEEALNSASEDVPVSASVG--------------------------
MLBr_01419|M.leprae_Br4923 TAERQASQYLAHQAAHDTLTGLPNRTSILARIDEQRYCG-APDQLLTAVL
: . * . .:
Mvan_3629|M.vanbaalenii_PYR-1 FLDLDGFKPVNDTWGHAAGDEVLKAVARRIENSIRPGDTAARLGGDEFAV
Mflv_2883|M.gilvum_PYR-GCK YLDLDGFKPVNDTWGHAAGDEVLNAVARRIENSIRPGDTAARLGGDEFAV
Mb1389c|M.bovis_AF2122/97 -LKID--KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
Rv1354c|M.tuberculosis_H37Rv -LKID--KTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAAR
MSMEG_2196|M.smegmatis_MC2_155 -LKID--RSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAAL
TH_0811|M.thermoresistible__bu -LKID--KGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAAL
MAV_1410|M.avium_104 -LKLD--RIFVARLAHDARSVAIVRSTVALADNLGADLVAEGVENEDTLD
MAB_1839|M.abscessus_ATCC_1997 -----------------VAAAILPESDRTTIHTLGPIVTHLLVEADGAMY
MLBr_01419|M.leprae_Br4923 FIDLDNFKGINDSLGHDVGDVVLQTAAQRLRAGLRSRDVVGRFGGDEFVA
: : . . :
Mvan_3629|M.vanbaalenii_PYR-1 LCPVIGENGELHGVAERIQTELSRPLTLIGGQSYDQLSASVGVAMSGCGR
Mflv_2883|M.gilvum_PYR-GCK LCPVIKDSEALHGIAERIRREVRRPLRLRAGRTYDRLSASTGAATSGGNS
Mb1389c|M.bovis_AF2122/97 ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS----
Rv1354c|M.tuberculosis_H37Rv ILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS----
MSMEG_2196|M.smegmatis_MC2_155 TLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM-------
TH_0811|M.thermoresistible__bu TLLRHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP---------
MAV_1410|M.avium_104 ALRRYGCNITQGFVHTPPLPPDELRAWIASHAPDPSQSRG----------
MAB_1839|M.abscessus_ATCC_1997 GAKKAG--------------------------------------------
MLBr_01419|M.leprae_Br4923 LILGKITHTELSKVVDRMHAALSEPTYVADAVLHLRASIGVVAIKGDDPR
Mvan_3629|M.vanbaalenii_PYR-1 TAEELLHHADRLMYHAKRQGNGGLVGDHTPAGA--
Mflv_2883|M.gilvum_PYR-GCK NAESLIAHTDRLMYRAKRNGKDRVADDLVPVEG--
Mb1389c|M.bovis_AF2122/97 -----------------------------------
Rv1354c|M.tuberculosis_H37Rv -----------------------------------
MSMEG_2196|M.smegmatis_MC2_155 -----------------------------------
TH_0811|M.thermoresistible__bu -----------------------------------
MAV_1410|M.avium_104 -----------------------------------
MAB_1839|M.abscessus_ATCC_1997 -----------------------------------
MLBr_01419|M.leprae_Br4923 NIGQILRDADTAMYRAKLSGEGTSYYTDTFNQQPS