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SESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPVDAAT DPIAVVHFADADPVFAMAEHLKEPAVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVK FGDREWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRALMAHLEARLAPGQPGPVAV MFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQ SVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAMAMEIDFRND IELHLQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLR TACAEFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRT TLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLV AEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2196 | - | - | 100% (615) | sensory box/response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 0.0 | 62.96% (602) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4377 | - | 0.0 | 74.59% (610) | diguanylate cyclase/phosphodiesterase with GAF sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 0.0 | 62.96% (602) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 0.0 | 64.91% (607) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_1839 | - | 5e-15 | 36.81% (182) | diguanylate cyclase/phosphodiesterase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 0.0 | 62.75% (612) | GGDEF domain-containing protein |
| M. thermoresistible (build 8) | TH_0811 | - | 0.0 | 71.45% (613) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 0.0 | 75.45% (607) | diguanylate cyclase/phosphodiesterase with GAF sensor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Rv1354c|M.tuberculosis_H37Rv MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSF
Mflv_4377|M.gilvum_PYR-GCK MSES-----LDLVVTSVATRLMGAGAATWAEASQQVLADLVEHFGVDVSF
Mvan_1967|M.vanbaalenii_PYR-1 MSDSDTLRSLDLVITSVATKLMAANAATSVEVSQRVLAELVDYLGVDVSF
MSMEG_2196|M.smegmatis_MC2_155 MSES-----LDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDVSF
TH_0811|M.thermoresistible__bu VSTE-----LDLLVTGVATKLMAADAATARDVSRRVLADLVRAFELDFSF
MLBr_01750|M.leprae_Br4923 MTRS-----LDELVTRVASKLMAATAATAVTISEGVLAILVEHFGVDVSF
MAV_3132|M.avium_104 MSGT-----LDHLVTAAAAELMAATAADAAQISERVLADLVSHFGVNFGF
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Rv1354c|M.tuberculosis_H37Rv LRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEP
Mflv_4377|M.gilvum_PYR-GCK LRRNDHTIRASVLVAEWPVRPGIPDPDPLAVVYFADADPVFALAEFQKEP
Mvan_1967|M.vanbaalenii_PYR-1 LRYNDHKIRASRLVAEWPVRPGVPDPDPLALVYFADADPVFAQSEHGKKP
MSMEG_2196|M.smegmatis_MC2_155 LRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVFAMAEHLKEP
TH_0811|M.thermoresistible__bu LRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVFALAEHAKEI
MLBr_01750|M.leprae_Br4923 LRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVFAMAEYLKEP
MAV_3132|M.avium_104 LRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADSVFARVETMKEP
MAB_1839|M.abscessus_ATCC_1997 ------------MVTTYPGRNGFGSES----NRCSTGAQVYGANNDILER
::. :* * . . *:. : :
Mb1389c|M.bovis_AF2122/97 LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Rv1354c|M.tuberculosis_H37Rv LVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDR
Mflv_4377|M.gilvum_PYR-GCK LVFRPDANTDEYQKTIEEGRQVPQVSMAAVPLLSGDVTTGVLGFVKFGDR
Mvan_1967|M.vanbaalenii_PYR-1 MVFRPEPATDDYQKRIEETRAVPATSMAAAPLVSGELTTGVLGFIKFGDR
MSMEG_2196|M.smegmatis_MC2_155 AVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGVLGFVKFGDR
TH_0811|M.thermoresistible__bu HIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGVLGFVKYGDR
MLBr_01750|M.leprae_Br4923 AVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGVLGFVKYGDR
MAV_3132|M.avium_104 DVLRPEPANADYQRNIEDGTGIPEVSLAAVPLLSGDVTTGTLGFVKFGDR
MAB_1839|M.abscessus_ATCC_1997 VGLR---------RPVSRANAVFITAVGAAAILLAATGMSTIPLLCIS--
:* : :. : : ....:: . . : :: .
Mb1389c|M.bovis_AF2122/97 KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Rv1354c|M.tuberculosis_H37Rv KWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQ
Mflv_4377|M.gilvum_PYR-GCK DWTGVELNALKAIASLFAQVQARVEAETQLRYLAEHDDLTGLNNRRALLS
Mvan_1967|M.vanbaalenii_PYR-1 EWTAEELNGLEAIASLFAQVQARVQAEEQLRYLAEHDDLTGLYNRRALLA
MSMEG_2196|M.smegmatis_MC2_155 EWLPAELNALKAIASLFAQVQARIEAEERLRYLADHDHLTGLYNRRALMA
TH_0811|M.thermoresistible__bu QWHPDELNALKAIASLFAQVQARVEAEERLRYLAEHDDLTGLHNRRALLA
MLBr_01750|M.leprae_Br4923 EWHDDELRALQAIATLFAQLQARIVAEEQLRYLAEHDDLTGLLNRRALIA
MAV_3132|M.avium_104 EWLSEELNALQAIAALFAQLQARVVAEEQIHYLAEHDELTGLLNRRALIA
MAB_1839|M.abscessus_ATCC_1997 ---------LSIPAFLWG-----------IRYARARAVTYGESVAYVLYC
* * *:. ::* : * .*
Mb1389c|M.bovis_AF2122/97 HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Rv1354c|M.tuberculosis_H37Rv HLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDA
Mflv_4377|M.gilvum_PYR-GCK HLDGRLAEGQPGPVSALFFDLDRLKAINDYLGHTAGDWFIRVLAERLREG
Mvan_1967|M.vanbaalenii_PYR-1 HLDERLAEGRPGPVSALFFDLDRLKAINDYLGHTAGDWFIRVLAERLRRG
MSMEG_2196|M.smegmatis_MC2_155 HLEARLAPGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRG
TH_0811|M.thermoresistible__bu HLDARLAAGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREG
MLBr_01750|M.leprae_Br4923 HLDERLADGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREA
MAV_3132|M.avium_104 HLDKRLAPGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREA
MAB_1839|M.abscessus_ATCC_1997 DVAILIGICVVTTTGVAFVKLAWLLAVSAYVSLVHG------------RV
.: :. .. :. : : .:. :. *
Mb1389c|M.bovis_AF2122/97 LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Rv1354c|M.tuberculosis_H37Rv LVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVL
Mflv_4377|M.gilvum_PYR-GCK ADPRALIARLGGDEFVVVPAGPMDGEAAESLAHQLQSTLKERVSIDGEML
Mvan_1967|M.vanbaalenii_PYR-1 ADCPNIIARLGGDEFVLVPTVPMDGAAAEALAHRLQSTLRERVSIDGEML
MSMEG_2196|M.smegmatis_MC2_155 DDAPKLIARLGGDEFVVVPDDPMSLDEATALAYRLQSVLRERVTVDGEML
TH_0811|M.thermoresistible__bu AGPDDLIARLGGDEFVVVPSGPVDADAALELANRLRSRLQQQVCVDGEML
MLBr_01750|M.leprae_Br4923 AESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQTRLQKQVVIDGEIL
MAV_3132|M.avium_104 TEIPSVIARFGGDEFGVVPAAPMDVEAAESFAHSLHERLHHPIAIDDEML
MAB_1839|M.abscessus_ATCC_1997 AVAMQSLVTTAGTVLAVVGAVSRDEYSAAALAAAVVTMLLANLFAG--LV
:. .* : :: . . * :* : * : . ::
Mb1389c|M.bovis_AF2122/97 TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Rv1354c|M.tuberculosis_H37Rv TRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVS
Mflv_4377|M.gilvum_PYR-GCK TRTVSIGVAVGIPGQDTTSDLLRRADQAVLTAKNSGGNRVTVFTEEMSLK
Mvan_1967|M.vanbaalenii_PYR-1 TRTVSIGVAQGIPGRDTTSDLLRRADQAVLTAKGSGGNEVVVFTDDMSMR
MSMEG_2196|M.smegmatis_MC2_155 TRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAMAME
TH_0811|M.thermoresistible__bu TRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDMSLE
MLBr_01750|M.leprae_Br4923 TRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGISAQ
MAV_3132|M.avium_104 SRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEMSTI
MAB_1839|M.abscessus_ATCC_1997 IYVGKAQFSEHADGRD------RLARHDVLTGLLNRRGLQEAYEATVGVP
. . .: * . . . : . :. . :.
Mb1389c|M.bovis_AF2122/97 GELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQHPT
Rv1354c|M.tuberculosis_H37Rv GELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQHPT
Mflv_4377|M.gilvum_PYR-GCK QEFNNDIELHLQSVIEN--GALLLHYLPEIDMRTGDILAMEALVRWQHPT
Mvan_1967|M.vanbaalenii_PYR-1 HEFNNDIELHLQSVIEN--GALLLHYLPEVDMRTGEILACEALVRWQHPT
MSMEG_2196|M.smegmatis_MC2_155 IDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWEHPT
TH_0811|M.thermoresistible__bu AEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWHHPT
MLBr_01750|M.leprae_Br4923 HTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQHPT
MAV_3132|M.avium_104 DTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQHPT
MAB_1839|M.abscessus_ATCC_1997 G-------MHVTVVVVD------LNLFKQINDTFGHHVGDQVLQRTAHRL
::: : * : :.: *. :. :.* * *
Mb1389c|M.bovis_AF2122/97 RGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRI
Rv1354c|M.tuberculosis_H37Rv RGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRI
Mflv_4377|M.gilvum_PYR-GCK RGLLSPESFIGVAESINLAGELGRWVMRSACTDFARWRALGIGKDAIMRI
Mvan_1967|M.vanbaalenii_PYR-1 RGLLSPESFIGVAESINLAGELGRWVMRSACADFAGWRARGIGTGTVMRI
MSMEG_2196|M.smegmatis_MC2_155 RGLLSPDSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRI
TH_0811|M.thermoresistible__bu RGLLAPDTFIGVAESVNLAGELGRWVMRTACGEFAKWRAEGIGLDAVLRI
MLBr_01750|M.leprae_Br4923 RGLLFPDSFIPVAESINLAGKLGRMVMHSACAEFSRWRSAGVGLDALLRI
MAV_3132|M.avium_104 LGLLMPDSFIQVAESINLGAKLGRLVMRSACAQFGQWRSRGVGQGTVLRI
MAB_1839|M.abscessus_ATCC_1997 RSVVGPDALLARLG----GDEFGIVVVGDAPPHIDYQR------AVEEAL
.:: * :: . ::. *: * .: : :
Mb1389c|M.bovis_AF2122/97 NVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATL
Rv1354c|M.tuberculosis_H37Rv NVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATL
Mflv_4377|M.gilvum_PYR-GCK NVSPVQLVTDGFVESVAGIVDEFGLEHGSVCLEITESVVVQDIETTRVTL
Mvan_1967|M.vanbaalenii_PYR-1 NVSPVQLVTDGFVESVAGIVDEFDLDEGSVCLEITESVVVQDIETTRVTL
MSMEG_2196|M.smegmatis_MC2_155 NVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTL
TH_0811|M.thermoresistible__bu NVSPVQLVTDGFVASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITL
MLBr_01750|M.leprae_Br4923 NVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTL
MAV_3132|M.avium_104 NVSPVQLVTAGIVDTVAATLDEFGLDPSTVCLEITESVVVQDIDATRQTL
MAB_1839|M.abscessus_ATCC_1997 NSASEDVPVSASVGVAAAILPES----------------------DRTTI
* :. :: . . * .* : : * *:
Mb1389c|M.bovis_AF2122/97 ARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDL
Rv1354c|M.tuberculosis_H37Rv ARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDL
Mflv_4377|M.gilvum_PYR-GCK NGLKKAGVLVAIDDFGTGYSALSHLKSLPVDTLKIDKSFVRELGSDPGDL
Mvan_1967|M.vanbaalenii_PYR-1 KGLKEAGVRIAIDDFGTGYSALSHLKSLPVDTLKIDKSFVRELGSDPGDL
MSMEG_2196|M.smegmatis_MC2_155 TGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDL
TH_0811|M.thermoresistible__bu EGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDLGNSPGDL
MLBr_01750|M.leprae_Br4923 AGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDL
MAV_3132|M.avium_104 FGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDSLKIDKGFVQSLDTNPGDL
MAB_1839|M.abscessus_ATCC_1997 HTLGPIVTHLLVEADGAMYGAKKAG-------------------------
* . : :: *: *.. .
Mb1389c|M.bovis_AF2122/97 VIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPG
Rv1354c|M.tuberculosis_H37Rv VIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPG
Mflv_4377|M.gilvum_PYR-GCK AIVRAIIALAEAFGLELVAEGVETDVGALTLLRHGCHRAQGFLLSRPIPT
Mvan_1967|M.vanbaalenii_PYR-1 AIVRAVIALAEAFGLELVAEGVETEAAAMTLLRHGCHRAQGFLLSRPIDG
MSMEG_2196|M.smegmatis_MC2_155 PIVRAVIALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILG
TH_0811|M.thermoresistible__bu AIVRAIIALAEAFGLQLVAEGVETEAAALTLLRHGCHRAQGFLLSRPIPS
MLBr_01750|M.leprae_Br4923 AIVRAIMALAKEFELEVVAEGVETAVAAQVLLELGCNRAQGFLLSRPVDG
MAV_3132|M.avium_104 AIVRSTLALADAFGLDVVAEGVETVAAAETLLSLGCHRAQGFLLSRPLDS
MAB_1839|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 EAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv EAMRHMLSARRLPPTCIPATDPALS-------
Mflv_4377|M.gilvum_PYR-GCK DAMETLLAQGRIPVSFSKG-------------
Mvan_1967|M.vanbaalenii_PYR-1 AAMKALLARGRVPVSFAKS-------------
MSMEG_2196|M.smegmatis_MC2_155 SEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu NEMRELLARGRIPMRFSATP------------
MLBr_01750|M.leprae_Br4923 AAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MAV_3132|M.avium_104 AGMEALLIKGAIPMRFSDGGAPE-NQHVV---
MAB_1839|M.abscessus_ATCC_1997 --------------------------------