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KSTIVTGPGSTEVIDITRPQCGPDDVLVRMRACGICGSDAFYITIGGIPPRQGHTPLGHEPAGEVVEVGA AVTGVDVGDHVVINPMAAPSGIIGNGGATGALADYLLIENAQRGKSLEVIPKHIPWEVAALNEPMAVARH GVNRCRPRPEHQVVVFGAGPIGLGATLAFKALGVRHVVVVDIVASRLAKALQIGADAVIDSSEEDVVARL IELHGEGEAMWPGKAGTDIYLDAAGAGAVVTTALAAAKAGAILGVVGVHKEPVPVDFAGIMSNEITIVGS MGYPEEIFQVTEDLVENWEKYALIVSHTIPFDKVHDALELADTPGGAGKVVVTFD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3479 | - | - | 100% (336) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0125 | - | 2e-25 | 28.45% (341) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4997 | - | 3e-22 | 24.79% (359) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 9e-17 | 27.88% (330) | alcohol dehydrogenase adh |
| M. tuberculosis H37Rv | Rv1895 | - | 1e-20 | 30.87% (298) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 5e-16 | 27.46% (284) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_4388 | - | 1e-23 | 29.18% (305) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_3529 | - | 1e-136 | 68.96% (335) | dehydrogenase |
| M. avium 104 | MAV_4173 | - | 1e-158 | 81.57% (331) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2914 | - | 2e-34 | 32.05% (337) | L-idonate 5-dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 2e-22 | 31.93% (285) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 2e-23 | 32.21% (298) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | 1e-28 | 29.03% (341) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3479|M.gilvum_PYR-GCK ------MKSTIVTGPGS-TEVIDITRPQCGPDDVLVRMRACGICGSDAFY
MAV_4173|M.avium_104 ----------MVTSPDR-AEVIDVERPGVGPRDVLVRMRACGICGSDAFY
MMAR_3529|M.marinum_M ------MRSAVVTTPGH-TDVIEAPDPQVGPKDVLVKIRACGICGTDSFY
MSMEG_2914|M.smegmatis_MC2_155 ------MKAVVVHGAND-LRVEELPDPAPGTGEVLVAMEWGGICGSDISY
Rv1895|M.tuberculosis_H37Rv ------MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH-
MUL_2962|M.ulcerans_Agy99 ------MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH-
TH_4349|M.thermoresistible__bu ------MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHL
Mvan_0788|M.vanbaalenii_PYR-1 ------MRAAVYYGPNK-LEVDDVAEPEPGPGTVKLKVGFNGICGTDLHE
MLBr_01784|M.leprae_Br4923 --MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTY
MAB_4388|M.abscessus_ATCC_1997 ----MKVTAALSASPAAPFTLQELELDEPRSDEVLVKIHATGLCHTDLTF
Mb1557|M.bovis_AF2122/97 MSDGAVVRALVLEAPRR-LVVRQYRLPRIGDDDALVRVEACGLCGTDHEQ
. : : * * :*
Mflv_3479|M.gilvum_PYR-GCK ITIG--GIPPR-------QGHTPLGHEPAGEVVEVGAAVTG---VDVGDH
MAV_4173|M.avium_104 ISIG--GVPPR-------QGHTPLGHEPAGEVVEVGAEVTG---LAVGDH
MMAR_3529|M.marinum_M ISIG--GLPPH-------RGRMPLGHEPAGEVVAVGSRVSG---LAVGDH
MSMEG_2914|M.smegmatis_MC2_155 WRHGSTGTAVL-------KHPMVLGHEVAGHIAGVGAGVTG---LREGDR
Rv1895|M.tuberculosis_H37Rv ---FYEGEYPF-------TEPVALGHEAVGTIVEAGPQVRT---VGVGDL
MUL_2962|M.ulcerans_Agy99 ---FYEGEYPL-------AEPVALGHEAVGTVVEKGPDVHT---VEVGDQ
TH_4349|M.thermoresistible__bu MHDFEPGMMPW-------QLPFTLGHENAGWVAAVGAGVGT---VTEGDA
Mvan_0788|M.vanbaalenii_PYR-1 YYAGPIFVPTEPHPLTGQQLPLTMGHEFSGTIAAVGDGVTG---WSEGDR
MLBr_01784|M.leprae_Br4923 RE---GGINDR--------YPFLLGHEAAGTVEVVGPGVTA---VEPGDF
MAB_4388|M.abscessus_ATCC_1997 KSQVP--------------IPAVLGHEGAGIVTAVGEAVSG---ISPGDH
Mb1557|M.bovis_AF2122/97 YTGELAG-----------GFAFVPGHETVGTIAAIGPRAEQRWGVSAGDR
*** * : * . **
Mflv_3479|M.gilvum_PYR-GCK VVINPMAAPSGIIGNGGATGALADY-------------------------
MAV_4173|M.avium_104 VVINPMAAPSGIIGNGGASGALADY-------------------------
MMAR_3529|M.marinum_M VVINPMAAPNGIIGNGGASGALADY-------------------------
MSMEG_2914|M.smegmatis_MC2_155 VTIHPATESGGYFGSAAFDPHTDGG-------------------------
Rv1895|M.tuberculosis_H37Rv VMVSSVAGCGVCPGCETHDPVMCFS------GPMIFGAG--VLGG-----
MUL_2962|M.ulcerans_Agy99 VMVSSVAGCGACAGCATRDPAMCVS------GPQIFGSG--ALGG-----
TH_4349|M.thermoresistible__bu VAVYGPWGCGTCERCMGGAENYCENPA---GAPVLSGGAGLGMDG-----
Mvan_0788|M.vanbaalenii_PYR-1 VAVEPIYKCGHCGPCRAGNYNVCQQIG---FHGLMSDGG-----------
MLBr_01784|M.leprae_Br4923 VILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPAL-----
MAB_4388|M.abscessus_ATCC_1997 VVLSYRS-CGGCRSCAAGERAYCSRSMRLNSAGVRADGSPTLSDNGTPVY
Mb1557|M.bovis_AF2122/97 VAVEVFQSCRQCANCRGGEYRRCVRHGLADMYGFIPVDREPGLWG-----
* :
Mflv_3479|M.gilvum_PYR-GCK --------LLIENAQRGKSLEVIPKHIPWEVAALNEPMAVARHGVNR--C
MAV_4173|M.avium_104 --------LLIENAVRGTSLEVIPDHIPWEVAALNEPMAVARHGVNR--C
MMAR_3529|M.marinum_M --------LLIEEAVRGVSLEVIPEHIPFEVAALNEPMAVARHAVNQ--C
MSMEG_2914|M.smegmatis_MC2_155 --------FCGLKVVRAEQIRRLPDAVDTVRGALAEPLAVAMHAVNR--A
Rv1895|M.tuberculosis_H37Rv ----AQADLLAVPAADFQVLKIPEGITTEQALLLTDNLATGWAAAQR--A
MUL_2962|M.ulcerans_Agy99 ----AQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGWAAARR--A
TH_4349|M.thermoresistible__bu ----GMAEYLLVPAER-LVVKLPESMTPVTAAALTDAGLTPYHAIRRSWP
Mvan_0788|M.vanbaalenii_PYR-1 --------MAEYTVVPTSMLHKLPDNVSLELGALVEPMSVAYHAATLG--
MLBr_01784|M.leprae_Br4923 ----GIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTA
MAB_4388|M.abscessus_ATCC_1997 GSFFGQSSFAQYALTGADNTVVVDPSIDLAVAAPLGCGFQTGAGAVLNVL
Mb1557|M.bovis_AF2122/97 -----GYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIP--
.
Mflv_3479|M.gilvum_PYR-GCK RPRPEHQVVVFGAGPIGLGATLAFKALGVRHVVVVDIVA---SRLAKALQ
MAV_4173|M.avium_104 QPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIP---GRLDKAVR
MMAR_3529|M.marinum_M KPKPSDKVLIFGAGPIGLGAVLAFKSAGAAHVAVVDLIP---SRLDKALQ
MSMEG_2914|M.smegmatis_MC2_155 GTVRGRDVLVNGAGPIGALVVAAAKYAGAASVVAADVVE---APLAIAKA
Rv1895|M.tuberculosis_H37Rv DISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVK---GRLQRAAT
MUL_2962|M.ulcerans_Agy99 DIPFGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQ---GRLQRAAE
TH_4349|M.thermoresistible__bu KLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRS---EALELARE
Mvan_0788|M.vanbaalenii_PYR-1 DVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSP---TRRAAIEV
MLBr_01784|M.leprae_Br4923 AVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDD---TKLEWART
MAB_4388|M.abscessus_ATCC_1997 SPEPDSRLVVFGAGGVGLAAVMAAKAQGVETIIAVDPVA---SRRAKATE
Mb1557|M.bovis_AF2122/97 ETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQ
: * * * : .
Mflv_3479|M.gilvum_PYR-GCK IGADAVIDSSEEDVVARLIELHGEGEAMWPGKAGTDIYLDAAGAG-AVVT
MAV_4173|M.avium_104 IGADAVVNSAEEDVAARLVELHGPGESMFPGKAGTDIYLDAAGAP-AVVS
MMAR_3529|M.marinum_M VGADAVINSAEEDLTRRLIDLHGPGQALFPGKAGTDIYLDAAGAP-AAVN
MSMEG_2914|M.smegmatis_MC2_155 MGADGVVNLAGGEQLP----------------SDVAVVFEASGAV-AALG
Rv1895|M.tuberculosis_H37Rv WGATPIPSP---AAETILAATRG---------RGADSVIDAVGTD-ASMS
MUL_2962|M.ulcerans_Agy99 WGATAVASP---AAEAIVAATSG---------RGADSVIDAVDTD-ASMT
TH_4349|M.thermoresistible__bu MGADHVVRSDEQAVEAIWELTGG---------RGADVLLDFVGAD-ATIE
Mvan_0788|M.vanbaalenii_PYR-1 LGARTLDPTSADVPAFIADHTRG---------DGADAVFDAAGVT-PAVS
MLBr_01784|M.leprae_Br4923 FGATHTVNALELEVVKTIQDLTSG--------FGVDVVIDTVGRP-ETWK
MAB_4388|M.abscessus_ATCC_1997 LGATQTVDPAMEDVAAMAR--------------GATHALDTTANA-GVIA
Mb1557|M.bovis_AF2122/97 FGADLAVDVAIDDPVAALTEQTG---------GLADVVVDVTAKAPAAFA
** . .:
Mflv_3479|M.gilvum_PYR-GCK -TALAAAKAGAILGVVG--VHKEPVPVDFAGIMSNEITIVGSMG---YPE
MAV_4173|M.avium_104 -TALAAAKKGATLGIVG--VHKEPVPVDLINVMSNEITIVGSMG---YPD
MMAR_3529|M.marinum_M -SALTNAKKGATIGIVA--VHKKPVEVDLVTVMSHEITLVGSIG---YPT
MSMEG_2914|M.smegmatis_MC2_155 GVLHAAARNGVVVQVGN--LPGQPTPASLGDLVSRELTWIGSFR---FVD
Rv1895|M.tuberculosis_H37Rv DALNAVRPGGTVSVVGV--HDLQPFPVPALTCLLRSITLRMTMA---PVQ
MUL_2962|M.ulcerans_Agy99 DALNAVRAGGTVSVVGV--HDLQPFPLPALTCLLRSITLRLTIA---PVQ
TH_4349|M.thermoresistible__bu LARAAARPLGDVTIVGI--AGGS----VPLSFFSQPYEVSIQTT---YWG
Mvan_0788|M.vanbaalenii_PYR-1 -TALACVGSRKPMISVA--IYEKPLETPLLNLVMNESRIQGSLC---YTG
MLBr_01784|M.leprae_Br4923 QAFYARDLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPE
MAB_4388|M.abscessus_ATCC_1997 TALGLLRQRGVLVLVGL---GAQPGPIDLNDLMLGGKVIRGCIEGDANPQ
Mb1557|M.bovis_AF2122/97 QAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG---VDA
.
Mflv_3479|M.gilvum_PYR-GCK EIFQVTEDLVEN-WEKYALIVSHTIPFDKVHDALELADTP-GGAGKVVVT
MAV_4173|M.avium_104 EIFEVTGDLVRN-WEKYALIVSHTIPFDRVGEALELARTP-GAADKVVVT
MMAR_3529|M.marinum_M EIFDVTKDIVAD-WQKYALIVDRTIAFDNVQDALAAAATP-GTADKIVVT
MSMEG_2914|M.smegmatis_MC2_155 EITDAVAALNDG-LDVTPLIT-HRYPIDHAAEAIAVAADRNTGSGKVLIQ
Rv1895|M.tuberculosis_H37Rv RTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSGEELRFCLR
MUL_2962|M.ulcerans_Agy99 RTWSELIPLLESGRLDVDGIFTTSLPLDEAAKGYSIAGSRSGNDVKVLLK
TH_4349|M.thermoresistible__bu -TRPELVELLDLAARGLVHVESTTYPLDDALQAYRDLRAGRVRGRAVIVP
Mvan_0788|M.vanbaalenii_PYR-1 ADFEAVIALMGQGKYDTTGWVTRIPIDDVVDEGFEALHAG--TKMKVLVD
MLBr_01784|M.leprae_Br4923 RDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-
MAB_4388|M.abscessus_ATCC_1997 EFIPELLQMHARGHFPIESLI-TTYPAADIEQAVADARSGAAIKPVLLW-
Mb1557|M.bovis_AF2122/97 TAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVPPIHGV
: . .
Mflv_3479|M.gilvum_PYR-GCK FD------------------------------------------
MAV_4173|M.avium_104 FC------------------------------------------
MMAR_3529|M.marinum_M FP------------------------------------------
MSMEG_2914|M.smegmatis_MC2_155 LNG-----------------------------------------
Rv1895|M.tuberculosis_H37Rv PDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 V-------------------------------------------
TH_4349|M.thermoresistible__bu --------------------------------------------
Mvan_0788|M.vanbaalenii_PYR-1 PNGA----------------------------------------
MLBr_01784|M.leprae_Br4923 --------------------------------------------
MAB_4388|M.abscessus_ATCC_1997 --------------------------------------------
Mb1557|M.bovis_AF2122/97 LTP-----------------------------------------