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VKAVVVHGANDLRVEELPDPAPGTGEVLVAMEWGGICGSDISYWRHGSTGTAVLKHPMVLGHEVAGHIAG VGAGVTGLREGDRVTIHPATESGGYFGSAAFDPHTDGGFCGLKVVRAEQIRRLPDAVDTVRGALAEPLAV AMHAVNRAGTVRGRDVLVNGAGPIGALVVAAAKYAGAASVVAADVVEAPLAIAKAMGADGVVNLAGGEQL PSDVAVVFEASGAVAALGGVLHAAARNGVVVQVGNLPGQPTPASLGDLVSRELTWIGSFRFVDEITDAVA ALNDGLDVTPLITHRYPIDHAAEAIAVAADRNTGSGKVLIQLNG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2914 | - | - | 100% (324) | L-idonate 5-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3605 | - | 1e-43 | 34.15% (325) | sorbitol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3603 | - | 9e-36 | 33.33% (351) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 3e-18 | 31.51% (219) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3479 | - | 1e-34 | 32.05% (337) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 4e-24 | 30.15% (335) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-14 | 27.34% (267) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 1e-28 | 27.84% (334) | hypothetical protein MAB_0526c |
| M. marinum M | MMAR_3529 | - | 6e-33 | 32.12% (330) | dehydrogenase |
| M. avium 104 | MAV_4173 | - | 1e-33 | 33.02% (321) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_4631 | - | 1e-20 | 31.22% (221) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 7e-27 | 29.57% (345) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0490 | - | 2e-33 | 30.17% (348) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3479|M.gilvum_PYR-GCK -----MKSTIVTGPGSTEVIDITRPQC-GPDDVLVRMRACGICGSDAFYI
MAV_4173|M.avium_104 ---------MVTSPDRAEVIDVERPGV-GPRDVLVRMRACGICGSDAFYI
MMAR_3529|M.marinum_M -----MRSAVVTTPGHTDVIEAPDPQV-GPKDVLVKIRACGICGTDSFYI
MSMEG_2914|M.smegmatis_MC2_155 -----MKAVVVHGANDLRVEELPDPAP-GTGEVLVAMEWGGICGSDISYW
Mb3753|M.bovis_AF2122/97 -----MKAVTCTNAKLEVVD-RPSPAP-AKGQLLLDVLRCGICGSDLHAR
MAB_0526c|M.abscessus_ATCC_199 -----MRASVLRNGSMVYRDDVPSPTP-GEGQVLVKVSACGICGSDLHFA
Rv1895|M.tuberculosis_H37Rv -----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLHFY
MUL_2962|M.ulcerans_Agy99 -----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLHFY
Mvan_0490|M.vanbaalenii_PYR-1 -----MEAIVLNGTNDVGLTSVPDPAP-QDGEVIIEVAATGLCGTDLHEY
TH_4631|M.thermoresistible__bu ----VNGXXXEETRRGR---------------------------------
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDP-GPGEAVVDVTACGVCHTDLTYR
Mflv_3479|M.gilvum_PYR-GCK TIG-----------------GIPPRQGHTPLGHEPAGEVVEVG-------
MAV_4173|M.avium_104 SIG-----------------GVPPRQGHTPLGHEPAGEVVEVG-------
MMAR_3529|M.marinum_M SIG-----------------GLPPHRGRMPLGHEPAGEVVAVG-------
MSMEG_2914|M.smegmatis_MC2_155 RHGS---------------TGTAVLKHPMVLGHEVAGHIAGVG-------
Mb3753|M.bovis_AF2122/97 LHCD---ELADVMAES-GYHAFMRSNQQVVFGHEFCGEVVDYG-------
MAB_0526c|M.abscessus_ATCC_199 KHGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAG-------
Rv1895|M.tuberculosis_H37Rv EGEY-------------------PFTEPVALGHEAVGTIVEAGPQVRTVG
MUL_2962|M.ulcerans_Agy99 EGEY-------------------PLAEPVALGHEAVGTVVEKGPDVHTVE
Mvan_0490|M.vanbaalenii_PYR-1 VAGP------------------TFSQPPVVLGHEVSGRIVEVGAGVDQSR
TH_4631|M.thermoresistible__bu --------------------------------YNLCPHMRFYG-------
MLBr_01784|M.leprae_Br4923 EGGIN-------------------DRYPFLLGHEAAGTVEVVGPGVTAVE
:: : *
Mflv_3479|M.gilvum_PYR-GCK ---------------AAVTGVDV-GDHVVINPMAAP-SGIIGNGGATGAL
MAV_4173|M.avium_104 ---------------AEVTGLAV-GDHVVINPMAAP-SGIIGNGGASGAL
MMAR_3529|M.marinum_M ---------------SRVSGLAV-GDHVVINPMAAP-NGIIGNGGASGAL
MSMEG_2914|M.smegmatis_MC2_155 ---------------AGVTGLRE-GDRVTIHPATES-GGYFGSAAFDPHT
Mb3753|M.bovis_AF2122/97 ---------------PGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMA
MAB_0526c|M.abscessus_ATCC_199 ---------------PRT-QAPASGTAVTSIPILLS-AKGLEPIVYSNTT
Rv1895|M.tuberculosis_H37Rv VGDLVMV--------SSVAGCGVCPGCETHDPVMCFSGPMIFGAGVLGGA
MUL_2962|M.ulcerans_Agy99 VGDQVMV--------SSVAGCGACAGCATRDPAMCVSGPQIFGSGALGGA
Mvan_0490|M.vanbaalenii_PYR-1 IGQG-----------AAVIPMDFCGSCHYCHRSLYHLCQRPGWIGFT--R
TH_4631|M.thermoresistible__bu ----------------------------------------------TPPV
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG
Mflv_3479|M.gilvum_PYR-GCK ADYLLIENAQRGKSLEVIPKHIPWEVAALNEP--MAVARHGVNRCRPRPE
MAV_4173|M.avium_104 ADYLLIENAVRGTSLEVIPDHIPWEVAALNEP--MAVARHGVNRCQPRPT
MMAR_3529|M.marinum_M ADYLLIEEAVRGVSLEVIPEHIPFEVAALNEP--MAVARHAVNQCKPKPS
MSMEG_2914|M.smegmatis_MC2_155 DGGFCGLKVVRAEQIRRLPDAVDTVRGALAEP--LAVAMHAVNRAGTVRG
Mb3753|M.bovis_AF2122/97 PGAYAERLVVEQSLTFPVPNGLAPEIAALTEP--MAVGWHAVRRGEVGKG
MAB_0526c|M.abscessus_ATCC_199 LGGYAEQMLLSAPLLLPIPNGLDPRHAALTEP--MAVGLHAVNKSAIQPG
Rv1895|M.tuberculosis_H37Rv QADLLAVPAADFQVLKIPEGITTEQALLLTDN--LATGWAAAQRADISFG
MUL_2962|M.ulcerans_Agy99 QADLLAVPATDFQVLKIPAAITTEQALLLTDN--LATGWAAARRADIPFG
Mvan_0490|M.vanbaalenii_PYR-1 NGGLANYVAVPSRLAVRVPDVVDLEEAALTEP--TAVAFHAVRRAELLLG
TH_4631|M.thermoresistible__bu DGALCEYVTIGAAFAHPVPAEMTDNAAALCEP--LSVAIATVDKAAVAGG
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
* :
Mflv_3479|M.gilvum_PYR-GCK HQVVVFGAGPIGLGATLAFKALGVRHVVVVDIVASRLAKALQIGADAVID
MAV_4173|M.avium_104 DKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIPGRLDKAVRIGADAVVN
MMAR_3529|M.marinum_M DKVLIFGAGPIGLGAVLAFKSAGAAHVAVVDLIPSRLDKALQVGADAVIN
MSMEG_2914|M.smegmatis_MC2_155 RDVLVNGAGPIGALVVAAAKYAGAASVVAADVVEAPLAIAKAMGADGVVN
Mb3753|M.bovis_AF2122/97 DVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVD
MAB_0526c|M.abscessus_ATCC_199 TGAIVIGCGPVGIAVIAALHNLGIEPIVASDYSSARRDLAQRMGAHQVVD
Rv1895|M.tuberculosis_H37Rv SAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVKGRLQRAATWGATPIPS
MUL_2962|M.ulcerans_Agy99 ATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAVAS
Mvan_0490|M.vanbaalenii_PYR-1 ETVMVLGAGALGLTVIQCARAAGAARIFVTEPSGVRASLARDLGATLVLD
TH_4631|M.thermoresistible__bu SRVLIAGAGPIGLMTAQVARAYGATDIVVTDLDPHRRRLAHRFGATTTLD
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVN
. : * * :* . * : . : * ** .
Mflv_3479|M.gilvum_PYR-GCK SSEEDVVARLIELHGE----------------------------------
MAV_4173|M.avium_104 SAEEDVAARLVELHGP----------------------------------
MMAR_3529|M.marinum_M SAEEDLTRRLIDLHGP----------------------------------
MSMEG_2914|M.smegmatis_MC2_155 LAGGEQLP------------------------------------------
Mb3753|M.bovis_AF2122/97 PVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLPWWHLWRA
MAB_0526c|M.abscessus_ATCC_199 PKIEPTFHAWSRIGAG----------------------------------
Rv1895|M.tuberculosis_H37Rv PAAETILAATRG--------------------------------------
MUL_2962|M.ulcerans_Agy99 PAAEAIVAATSG--------------------------------------
Mvan_0490|M.vanbaalenii_PYR-1 PHDPGTTACILEETRG----------------------------------
TH_4631|M.thermoresistible__bu PQTDDVTG------------------------------------------
MLBr_01784|M.leprae_Br4923 ALELEVVKTIQDLTSG----------------------------------
Mflv_3479|M.gilvum_PYR-GCK GEAMWPGKAGTDIYLDAAGAGAVVT-TALAAAKAGAILGVVGVH-KEPVP
MAV_4173|M.avium_104 GESMFPGKAGTDIYLDAAGAPAVVS-TALAAAKKGATLGIVGVH-KEPVP
MMAR_3529|M.marinum_M GQALFPGKAGTDIYLDAAGAPAAVN-SALTNAKKGATIGIVAVH-KKPVE
MSMEG_2914|M.smegmatis_MC2_155 --------SDVAVVFEASGAVAALGGVLHAAARNGVVVQVGNLP-GQPTP
Mb3753|M.bovis_AF2122/97 AEAAGAATPKRPVIFECVGVPGIID-GIIASAPLFSRVVVVGVC-MGSDH
MAB_0526c|M.abscessus_ATCC_199 ----------APVIFEAVGVPGILN-EVLRDAPRSARVVVVGVC-MEPDA
Rv1895|M.tuberculosis_H37Rv --------RGADSVIDAVGTDASMS-DALNAVRPGGTVSVVGVHDLQPFP
MUL_2962|M.ulcerans_Agy99 --------RGADSVIDAVDTDASMT-DALNAVRAGGTVSVVGVHDLQPFP
Mvan_0490|M.vanbaalenii_PYR-1 --------VGVDVVFHVAGSAEAFTQGLDCLRKQGRFMEMSSWA--GAAS
TH_4631|M.thermoresistible__bu --------LRVDAFIDASGAPAAVMSGLAAVRPAG-RAVLVGMG-AETME
MLBr_01784|M.leprae_Br4923 --------FGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLD
:. . :
Mflv_3479|M.gilvum_PYR-GCK VDFAGIMSNEITIVGSMGYP----EEIFQVTEDLVENWEKYALIVSHTIP
MAV_4173|M.avium_104 VDLINVMSNEITIVGSMGYP----DEIFEVTGDLVRNWEKYALIVSHTIP
MMAR_3529|M.marinum_M VDLVTVMSHEITLVGSIGYP----TEIFDVTKDIVADWQKYALIVDRTIA
MSMEG_2914|M.smegmatis_MC2_155 ASLGDLVSRELTWIGSFRFV----DEITDAVAALNDGLDVTPLIT-HRYP
Mb3753|M.bovis_AF2122/97 IRPAMAINKEINLRFVLGYTP---LEFRDTLHMLADGKVNAAPLITGTVG
MAB_0526c|M.abscessus_ATCC_199 ITPYFGIAKEVAVQFVLAYEP---AEFSETLRRIAHGEIDVAPLVTGEVG
Rv1895|M.tuberculosis_H37Rv VPALTCLLRSITLRMTMAPVQ---RTWPELIPLLQSGRLDVDGIFTTTLP
MUL_2962|M.ulcerans_Agy99 LPALTCLLRSITLRLTIAPVQ---RTWSELIPLLESGRLDVDGIFTTSLP
Mvan_0490|M.vanbaalenii_PYR-1 LDVNRHLLKEIQLRMVFGYDMF--DDFPAVLALIADGKLALAPQITARVP
TH_4631|M.thermoresistible__bu LPVQTIQNRELILTGVFRYAN----TWPAAIALIRTGRVDVDALITGRYP
MLBr_01784|M.leprae_Br4923 MPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIG
. .
Mflv_3479|M.gilvum_PYR-GCK FD-KVHDALELADTP-GGAGKVVVTFD-----------------------
MAV_4173|M.avium_104 FD-RVGEALELARTP-GAADKVVVTFC-----------------------
MMAR_3529|M.marinum_M FD-NVQDALAAAATP-GTADKIVVTFP-----------------------
MSMEG_2914|M.smegmatis_MC2_155 ID-HAAEAIAVAADRNTGSGKVLIQLNG----------------------
Mb3753|M.bovis_AF2122/97 LP-GVAAAFDALGDP-EAHAKIMIDPKSNAASPQPFRVE-----------
MAB_0526c|M.abscessus_ATCC_199 LE-DVGSAFADLGDP-ERHCKILVVP------------------------
Rv1895|M.tuberculosis_H37Rv LD-EAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSV
MUL_2962|M.ulcerans_Agy99 LD-EAAKGYSIAGSRSGNDVKVLLKV------------------------
Mvan_0490|M.vanbaalenii_PYR-1 LDRAVKEGLGGLLEGREGLVKVLVKP------------------------
TH_4631|M.thermoresistible__bu LE-KTAEALESDRIPGNIKSVVEVGTS-----------------------
MLBr_01784|M.leprae_Br4923 LG-DVEEAFHKIHGGKVLRSVVML--------------------------
: . . . :
Mflv_3479|M.gilvum_PYR-GCK -------------------
MAV_4173|M.avium_104 -------------------
MMAR_3529|M.marinum_M -------------------
MSMEG_2914|M.smegmatis_MC2_155 -------------------
Mb3753|M.bovis_AF2122/97 -------------------
MAB_0526c|M.abscessus_ATCC_199 -------------------
Rv1895|M.tuberculosis_H37Rv ADLQLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 -------------------
Mvan_0490|M.vanbaalenii_PYR-1 -------------------
TH_4631|M.thermoresistible__bu -------------------
MLBr_01784|M.leprae_Br4923 -------------------