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RASVLRNGSMVYRDDVPSPTPGEGQVLVKVSACGICGSDLHFAKHGARAIELSKQMVGMPSLTDGVDLST DVFMGHEFAAEVIEAGPRTQAPASGTAVTSIPILLSAKGLEPIVYSNTTLGGYAEQMLLSAPLLLPIPNG LDPRHAALTEPMAVGLHAVNKSAIQPGTGAIVIGCGPVGIAVIAALHNLGIEPIVASDYSSARRDLAQRM GAHQVVDPKIEPTFHAWSRIGAGAPVIFEAVGVPGILNEVLRDAPRSARVVVVGVCMEPDAITPYFGIAK EVAVQFVLAYEPAEFSETLRRIAHGEIDVAPLVTGEVGLEDVGSAFADLGDPERHCKILVVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0526c | - | - | 100% (343) | hypothetical protein MAB_0526c |
| M. abscessus ATCC 19977 | MAB_0983c | - | 6e-14 | 24.10% (361) | zinc-containing alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1869c | - | 1e-11 | 24.24% (330) | zinc-dependent alcohol dehydrogenase AdhE2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 7e-72 | 41.71% (374) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0638 | - | 1e-28 | 25.91% (359) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3726 | - | 7e-72 | 41.71% (374) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-12 | 23.08% (351) | putative alcohol dehydrogenase (Zn dependent) |
| M. marinum M | MMAR_5116 | - | 1e-123 | 63.85% (343) | dehydrogenase |
| M. avium 104 | MAV_0537 | - | 1e-125 | 64.43% (343) | zinc-binding dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6108 | - | 1e-116 | 59.77% (343) | zinc-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_4349 | - | 2e-17 | 27.02% (359) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 2e-21 | 26.57% (350) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5762 | - | 6e-73 | 43.09% (369) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_4349|M.thermoresistible__bu ----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHLMH
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLH---
MMAR_5116|M.marinum_M ----MRASVLRN-GHMTYRDDVAEPTPGQGQVLVGVRACGICGSDLH-FA
MAV_0537|M.avium_104 ----MRAAVLRD-GRMVYRDDVPEPIPETGQVLVGVRACGICGSDLH-FA
MSMEG_6108|M.smegmatis_MC2_155 ----MRAAVLRQ-GRMVVRDDVAEPVPGPGQVLVEVKACGICGSDLH-FA
MAB_0526c|M.abscessus_ATCC_199 ----MRASVLRN-GSMVYRDDVPSPTPGEGQVLVKVSACGICGSDLH-FA
Mb3753|M.bovis_AF2122/97 ----MKAVTCTN-AKLEVVD-RPSPAPAKGQLLLDVLRCGICGSDLH-AR
Rv3726|M.tuberculosis_H37Rv ----MKAVTCTN-AKLEVVD-RPSPAPAKGQLLLDVLRCGICGSDLH-AR
Mvan_5762|M.vanbaalenii_PYR-1 ----MKAVSCVH-GTLEVVD-LPSPRPGEGQLVLDVLRCGICGSDLH-AK
Mflv_0638|M.gilvum_PYR-GCK ----MRAAIYHG-REDVRIEELPDPSPRAGEVVIEVARAGICGTDLH---
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLT---
:: . * . :: : .* * :**
TH_4349|M.thermoresistible__bu DFEPGMMPWQLPFTLGHENAGWVAAVGAGVGTVTEGDAVAVYGPWGCGTC
MUL_2962|M.ulcerans_Agy99 -FYEGEYPLAEPVALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGAC
MMAR_5116|M.marinum_M AHGPEVLAMSSRLSHGDGYTN-TDLSRDVFMGHEFCAEVIEAGPDT-DTY
MAV_0537|M.avium_104 AHGAQVLQMSDRVAGGAAGMR-VDLDHDIFMGHEFSAEILEAGPDT-ETH
MSMEG_6108|M.smegmatis_MC2_155 QHGEDLLASTAQLEGVANQNDDVDLSRDIFMGHEFSAEILEAGPST-DTY
MAB_0526c|M.abscessus_ATCC_199 KHGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRT-QAP
Mb3753|M.bovis_AF2122/97 LHCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP
Rv3726|M.tuberculosis_H37Rv LHCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTP
Mvan_5762|M.vanbaalenii_PYR-1 DHADELTEVMAEGG----YHDFVRSDTPVVMGHEFCGVVADRGRKVGKEF
Mflv_0638|M.gilvum_PYR-GCK EYIAGPMHAAPGVVIGHEYSGTVVGVGSGVREFTEGDRVCGVGVFGCGEC
MLBr_01784|M.leprae_Br4923 -YREGGINDRYPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAVCGQC
. . :
TH_4349|M.thermoresistible__bu ERCMGGAENYCENPAGAPVLSGGAG------LGMDGGMAEYLLVPAER-L
MUL_2962|M.ulcerans_Agy99 AGCATRDPAMCVS--GPQIFGSGA---------LGGAQADLLAVPATDFQ
MMAR_5116|M.marinum_M PAGTLVTSIPVLL-SAKGVEPIFSS------NDTIGGYAERMLLSAPL--
MAV_0537|M.avium_104 PPGTLVTSLPVLL-SAKGVEPIVYS------NTTIGGYAERMLLSAPL--
MSMEG_6108|M.smegmatis_MC2_155 APGTLVTSVPVLI-SPQGMDMIVYS------NTTLGGYAERMLLSAPL--
MAB_0526c|M.abscessus_ATCC_199 ASGTAVTSIPILL-SAKGLEPIVYS------NTTLGGYAEQMLLSAPL--
Mb3753|M.bovis_AF2122/97 RRGTPVVAMPLLRRGNKEVHGIGLS------TMAPGAYAERLVVEQSL--
Rv3726|M.tuberculosis_H37Rv RRGTPVVAMPLLRRGNKEVHGIGLS------TMAPGAYAERLVVEQSL--
Mvan_5762|M.vanbaalenii_PYR-1 KPGSTVVAFPLMR-AHGGVHLTGLS------PLAPGGYAEQVVAEAAL--
Mflv_0638|M.gilvum_PYR-GCK GFCKQGAEALCGA-------VGFIG------FAVNGALARYASLPTKA--
MLBr_01784|M.leprae_Br4923 RACKRGRPSYCFDTFNAQQKMTLIDGTELTPALGIGAFADKTLVHSGQ--
*. *
TH_4349|M.thermoresistible__bu VVKLPESMTPVTAAALTDAGLTPYHAIRRSWPKLTPTSTAVVIGVGGLGH
MUL_2962|M.ulcerans_Agy99 VLKIPAAITTEQALLLTDNLATGWAAARR--ADIPFGATVAVIGLGAVGL
MMAR_5116|M.marinum_M LLPVPNGLDFR-HAALTEPMAVGLHAVNK--AGVDVGDTALVLGCGPIGI
MAV_0537|M.avium_104 LLPIPNGLDVK-HAALTEPMAVGLHAVNK--SNITPAETALVLGCGPIGI
MSMEG_6108|M.smegmatis_MC2_155 LLPVPNGLDAG-PAALTEPMAVGLHAVNT--SRIERNETALVIGCGPVGI
MAB_0526c|M.abscessus_ATCC_199 LLPIPNGLDPR-HAALTEPMAVGLHAVNK--SAIQPGTGAIVIGCGPVGI
Mb3753|M.bovis_AF2122/97 TFPVPNGLAPE-IAALTEPMAVGWHAVRR--GEVGKGDVAIVIGCGPIGL
Rv3726|M.tuberculosis_H37Rv TFPVPNGLAPE-IAALTEPMAVGWHAVRR--GEVGKGDVAIVIGCGPIGL
Mvan_5762|M.vanbaalenii_PYR-1 TFVVPNGLDPA-TAALTEPMAVAYHAVRR--SDVTTKDVAIVLGCGPVGL
Mflv_0638|M.gilvum_PYR-GCK LFRIPDEISLA-EAAVVEPIASAYHAVRR--SGLAAGGTVFIAGAGPIGL
MLBr_01784|M.leprae_Br4923 CTKVDPAADPAVAGLLGCGVMAGLGAAIN-TAAVSRDDTVAVIGCGGVGD
: : * : . : * * :*
TH_4349|M.thermoresistible__bu VAVQLVKATTAARLIAVDNRSEALELAREMGADHVVRSDEQAVEAIWELT
MUL_2962|M.ulcerans_Agy99 CAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAVASP---AAEAIVAAT
MMAR_5116|M.marinum_M AIIAALRMRGVETIVASDFSQKRRELASIMGAHQTVDP---AVSSPFEHV
MAV_0537|M.avium_104 AIIAALATRGVESIVASDFSPKRRQLATAMGAHRTLDP---AQGSPFDSV
MSMEG_6108|M.smegmatis_MC2_155 AVIAALKLLGVEDIVASDFSPTRRRLAAAMGAHVTLDP---AQDSPFHQC
MAB_0526c|M.abscessus_ATCC_199 AVIAALHNLGIEPIVASDYSSARRDLAQRMGAHQVVDP---KIEPTFHAW
Mb3753|M.bovis_AF2122/97 AVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDP---VQDSPYAVA
Rv3726|M.tuberculosis_H37Rv AVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDP---VQDSPYAVA
Mvan_5762|M.vanbaalenii_PYR-1 AVICHLKALGVRTIVASDFSPGRRALAARCGADVVVDP---AVDSPYEAV
Mflv_0638|M.gilvum_PYR-GCK ALVQFSLAQGATQVIVSEVSATRRVAAHRVGATRVIDP---LAEDAVEVV
MLBr_01784|M.leprae_Br4923 AAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALELEVVKTIQDL
: :.. : * ** . .
TH_4349|M.thermoresistible__bu GG----------------------------------------------RG
MUL_2962|M.ulcerans_Agy99 SG----------------------------------------------RG
MMAR_5116|M.marinum_M K-------------------------------------------------
MAV_0537|M.avium_104 K-------------------------------------------------
MSMEG_6108|M.smegmatis_MC2_155 R-------------------------------------------------
MAB_0526c|M.abscessus_ATCC_199 SR--------------------------------------------IGAG
Mb3753|M.bovis_AF2122/97 AGLGQGNRHLQSILDAFDLAVGTVESLQRLRLPWWHLWRAAEAAGAATPK
Rv3726|M.tuberculosis_H37Rv AGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPK
Mvan_5762|M.vanbaalenii_PYR-1 PAKQRG---LTELPALYELGVGSMEKLRKIPG-WSHVYRVADRLGGTAPK
Mflv_0638|M.gilvum_PYR-GCK RTLTNG------------------------------------------NG
MLBr_01784|M.leprae_Br4923 TSG---------------------------------------------FG
TH_4349|M.thermoresistible__bu ADVLLDFVGADATIELARAAARPLGDVTIVGIAGGS-------VPLSFFS
MUL_2962|M.ulcerans_Agy99 ADSVIDAVDTDASMTDALNAVRAGGTVSVVGVHDLQPF---PLPALTCLL
MMAR_5116|M.marinum_M ATVVFEAVGVPGMIDEVILRARPGTRLIVAGVCMQPD----TVHPFFAIT
MAV_0537|M.avium_104 PAVVFEAVGVPGIIDDVLLRARPGTRLVVAGVCMQPD----TVHPFFAIA
MSMEG_6108|M.smegmatis_MC2_155 PAVVFEAVGAPGIIDDILRRCPAGTRVVVAGVCMQPD----TVHPLYAAV
MAB_0526c|M.abscessus_ATCC_199 APVIFEAVGVPGILNEVLRDAPRSARVVVVGVCMEPD----AITPYFGIA
Mb3753|M.bovis_AF2122/97 RPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSD----HIRPAMAIN
Rv3726|M.tuberculosis_H37Rv RPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSD----HIRPAMAIN
Mvan_5762|M.vanbaalenii_PYR-1 RPVIFECVGVPGMIDGIIGAAPLASRVVVVGVCMGDD----KLRPAMAIG
Mflv_0638|M.gilvum_PYR-GCK VDISFDAAGVQPALDAALGVLRPRGRLMVVAIWEAPA----GIDINRSVM
MLBr_01784|M.leprae_Br4923 VDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHG
:: .. : :..:
TH_4349|M.thermoresistible__bu QPYEVSIQTTYWG--TRPELVELLDLAARGLVHVESTTYPLDDAL-QAYR
MUL_2962|M.ulcerans_Agy99 RSITLRLTIAPVQR-TWSELIPLLESGRLDVDGIFTTSLPLDEAA-KGYS
MMAR_5116|M.marinum_M KEINVQFVLAYDPE-EFATSLRALAEGLIDVSPLITGEVDLVGVG-AAFD
MAV_0537|M.avium_104 KEINVQFVLAYTPE-EFGDSLRALAEGDIDVAPLITGEVGLDGVG-AAFD
MSMEG_6108|M.smegmatis_MC2_155 KQISVSFVFGYDPA-EFASSLRAIAEGDIDVRPMITGSVPLDGMA-DAFD
MAB_0526c|M.abscessus_ATCC_199 KEVAVQFVLAYEPA-EFSETLRRIAHGEIDVAPLVTGEVGLEDVG-SAFA
Mb3753|M.bovis_AF2122/97 KEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGTVGLPGVA-AAFD
Rv3726|M.tuberculosis_H37Rv KEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGTVGLPGVA-AAFD
Mvan_5762|M.vanbaalenii_PYR-1 KEIDLRFVFGYTPL-EFRDTLHMLADGKLDASALVTGTVGLGGVA-AAFD
Mflv_0638|M.gilvum_PYR-GCK REANIGFSFCYEAQRQVPAILDLLATGAINLGELITDEIPLDAVVSQGLE
MLBr_01784|M.leprae_Br4923 GSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVE-EAFH
: . . : * .
TH_4349|M.thermoresistible__bu DLRA-GRVRGRAVIVP-------------
MUL_2962|M.ulcerans_Agy99 IAGS-RSGNDVKVLLKV------------
MMAR_5116|M.marinum_M DLAD-PERHCKVLVTP-------------
MAV_0537|M.avium_104 DLAD-PERHCKVLVTP-------------
MSMEG_6108|M.smegmatis_MC2_155 ELAT-PDAHCKILVTP-------------
MAB_0526c|M.abscessus_ATCC_199 DLGD-PERHCKILVVP-------------
Mb3753|M.bovis_AF2122/97 ALGD-PEAHAKIMIDPKSNAASPQPFRVE
Rv3726|M.tuberculosis_H37Rv ALGD-PEAHAKIMIDPKSNAASPQPFRVE
Mvan_5762|M.vanbaalenii_PYR-1 ALGD-PETHAKILIDPAGTAVTP------
Mflv_0638|M.gilvum_PYR-GCK ELRVNRDAHVKILIDPSA-----------
MLBr_01784|M.leprae_Br4923 KIHGGKVLRSVVML---------------
. ::