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RAAVLRDGRMVYRDDVPEPIPETGQVLVGVRACGICGSDLHFAAHGAQVLQMSDRVAGGAAGMRVDLDHD IFMGHEFSAEILEAGPDTETHPPGTLVTSLPVLLSAKGVEPIVYSNTTIGGYAERMLLSAPLLLPIPNGL DVKHAALTEPMAVGLHAVNKSNITPAETALVLGCGPIGIAIIAALATRGVESIVASDFSPKRRQLATAMG AHRTLDPAQGSPFDSVKPAVVFEAVGVPGIIDDVLLRARPGTRLVVAGVCMQPDTVHPFFAIAKEINVQF VLAYTPEEFGDSLRALAEGDIDVAPLITGEVGLDGVGAAFDDLADPERHCKVLVTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0537 | - | - | 100% (337) | zinc-binding dehydrogenase |
| M. avium 104 | MAV_5236 | - | 5e-46 | 34.38% (352) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. avium 104 | MAV_4173 | - | 1e-24 | 27.65% (340) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3753 | - | 2e-75 | 42.90% (373) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0638 | - | 1e-30 | 27.37% (358) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3726 | - | 2e-75 | 42.90% (373) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 4e-10 | 21.68% (346) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0526c | - | 1e-125 | 64.43% (343) | hypothetical protein MAB_0526c |
| M. marinum M | MMAR_5116 | - | 1e-152 | 78.93% (337) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6108 | - | 1e-135 | 71.30% (338) | zinc-binding dehydrogenase |
| M. thermoresistible (build 8) | TH_4631 | - | 7e-17 | 27.72% (202) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_2962 | - | 2e-19 | 26.02% (342) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5762 | - | 3e-72 | 41.30% (368) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0537|M.avium_104 ----MRAAVLRDGRMVYRDDVPEPI-PETGQVLVGVRACGICGSDLHFAA
MMAR_5116|M.marinum_M ----MRASVLRNGHMTYRDDVAEPT-PGQGQVLVGVRACGICGSDLHFAA
MSMEG_6108|M.smegmatis_MC2_155 ----MRAAVLRQGRMVVRDDVAEPV-PGPGQVLVEVKACGICGSDLHFAQ
MAB_0526c|M.abscessus_ATCC_199 ----MRASVLRNGSMVYRDDVPSPT-PGEGQVLVKVSACGICGSDLHFAK
Mb3753|M.bovis_AF2122/97 ----MKAVTCTNAKLEVVD-RPSPA-PAKGQLLLDVLRCGICGSDLHARL
Rv3726|M.tuberculosis_H37Rv ----MKAVTCTNAKLEVVD-RPSPA-PAKGQLLLDVLRCGICGSDLHARL
Mvan_5762|M.vanbaalenii_PYR-1 ----MKAVSCVHGTLEVVD-LPSPR-PGEGQLVLDVLRCGICGSDLHAKD
Mflv_0638|M.gilvum_PYR-GCK ----MRAAIYHGREDVRIEELPDPS-PRAGEVVIEVARAGICGTDLHEYI
TH_4631|M.thermoresistible__bu ----------------------------------------VNGXXXEETR
MUL_2962|M.ulcerans_Agy99 ----MRTVVIDGPGSIRVDNRPDPALPGSDGVIVVVSAAGICGSDLHFYE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
:
MAV_0537|M.avium_104 HGAQVLQMSDRVAGGAAGMR-VDLDHDIFMGHEFSAEILEAGPDT-ETHP
MMAR_5116|M.marinum_M HGPEVLAMSSRLSHGDGYTN-TDLSRDVFMGHEFCAEVIEAGPDT-DTYP
MSMEG_6108|M.smegmatis_MC2_155 HGEDLLASTAQLEGVANQNDDVDLSRDIFMGHEFSAEILEAGPST-DTYA
MAB_0526c|M.abscessus_ATCC_199 HGARAIELSKQMVGMPSLTDGVDLSTDVFMGHEFAAEVIEAGPRT-QAPA
Mb3753|M.bovis_AF2122/97 HCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPR
Rv3726|M.tuberculosis_H37Rv HCDELADVMAESG----YHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPR
Mvan_5762|M.vanbaalenii_PYR-1 HADELTEVMAEGG----YHDFVRSDTPVVMGHEFCGVVADRGRKVGKEFK
Mflv_0638|M.gilvum_PYR-GCK AGP------------------MHAAPGVVIGHEYSGTVVGVGSGV-REFT
TH_4631|M.thermoresistible__bu RGR----------------------------YNLCPHMRFYGTPP-----
MUL_2962|M.ulcerans_Agy99 GEYP-------------------LAEPVALGHEAVGTVVEKGPDV-HTVE
MLBr_01784|M.leprae_Br4923 GGIN-------------------DRYPFLLGHEAAGTVEVVGPGV-TAVE
:: : *
MAV_0537|M.avium_104 PGTLVTSLPVLL------SAKGVEPIVYSN------------------TT
MMAR_5116|M.marinum_M AGTLVTSIPVLL------SAKGVEPIFSSN------------------DT
MSMEG_6108|M.smegmatis_MC2_155 PGTLVTSVPVLI------SPQGMDMIVYSN------------------TT
MAB_0526c|M.abscessus_ATCC_199 SGTAVTSIPILL------SAKGLEPIVYSN------------------TT
Mb3753|M.bovis_AF2122/97 RGTPVVAMPLLRR-----GNKEVHGIGLST------------------MA
Rv3726|M.tuberculosis_H37Rv RGTPVVAMPLLRR-----GNKEVHGIGLST------------------MA
Mvan_5762|M.vanbaalenii_PYR-1 PGSTVVAFPLMR------AHGGVHLTGLSP------------------LA
Mflv_0638|M.gilvum_PYR-GCK EGDRVCGVGVFGCGECGFCKQGAEALCGAVG-----------FIG--FAV
TH_4631|M.thermoresistible__bu -------------------------------------------------V
MUL_2962|M.ulcerans_Agy99 VGDQVMVSSVAGCGACAGCATRDPAMCVSGP-----------QIFGSGAL
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG
MAV_0537|M.avium_104 IGGYAERMLLSAP--LLLPIPNGLDVKHAALTEP-MAVGL-HAVNKSNIT
MMAR_5116|M.marinum_M IGGYAERMLLSAP--LLLPVPNGLDFRHAALTEP-MAVGL-HAVNKAGVD
MSMEG_6108|M.smegmatis_MC2_155 LGGYAERMLLSAP--LLLPVPNGLDAGPAALTEP-MAVGL-HAVNTSRIE
MAB_0526c|M.abscessus_ATCC_199 LGGYAEQMLLSAP--LLLPIPNGLDPRHAALTEP-MAVGL-HAVNKSAIQ
Mb3753|M.bovis_AF2122/97 PGAYAERLVVEQS--LTFPVPNGLAPEIAALTEP-MAVGW-HAVRRGEVG
Rv3726|M.tuberculosis_H37Rv PGAYAERLVVEQS--LTFPVPNGLAPEIAALTEP-MAVGW-HAVRRGEVG
Mvan_5762|M.vanbaalenii_PYR-1 PGGYAEQVVAEAA--LTFVVPNGLDPATAALTEP-MAVAY-HAVRRSDVT
Mflv_0638|M.gilvum_PYR-GCK NGALARYASLPTK--ALFRIPDEISLAEAAVVEP-IASAY-HAVRRSGLA
TH_4631|M.thermoresistible__bu DGALCEYVTIGAA--FAHPVPAEMTDNAAALCEP-LSVAI-ATVDKAAVA
MUL_2962|M.ulcerans_Agy99 GGAQADLLAVPATDFQVLKIPAAITTEQALLLTDNLATGW-AAARRADIP
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSG--QCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVS
*. . : * : : . : . :
MAV_0537|M.avium_104 PAETALVLGCGPIGIAIIAALATRGVESIVASDFSPKRRQLATAMGAHRT
MMAR_5116|M.marinum_M VGDTALVLGCGPIGIAIIAALRMRGVETIVASDFSQKRRELASIMGAHQT
MSMEG_6108|M.smegmatis_MC2_155 RNETALVIGCGPVGIAVIAALKLLGVEDIVASDFSPTRRRLAAAMGAHVT
MAB_0526c|M.abscessus_ATCC_199 PGTGAIVIGCGPVGIAVIAALHNLGIEPIVASDYSSARRDLAQRMGAHQV
Mb3753|M.bovis_AF2122/97 KGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSV
Rv3726|M.tuberculosis_H37Rv KGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSV
Mvan_5762|M.vanbaalenii_PYR-1 TKDVAIVLGCGPVGLAVICHLKALGVRTIVASDFSPGRRALAARCGADVV
Mflv_0638|M.gilvum_PYR-GCK AGGTVFIAGAGPIGLALVQFSLAQGATQVIVSEVSATRRVAAHRVGATRV
TH_4631|M.thermoresistible__bu GGSRVLIAGAGPIGLMTAQVARAYGATDIVVTDLDPHRRRLAHRFGATTT
MUL_2962|M.ulcerans_Agy99 FGATVAVIGLGAVGLCAVRSALAQGAATVFAVDRVQGRLQRAAEWGATAV
MLBr_01784|M.leprae_Br4923 RDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHT
. : * * :* * :.. : : * ** .
MAV_0537|M.avium_104 LDPAQGSPFDSVK-------------------------------------
MMAR_5116|M.marinum_M VDPAVSSPFEHVK-------------------------------------
MSMEG_6108|M.smegmatis_MC2_155 LDPAQDSPFHQCR-------------------------------------
MAB_0526c|M.abscessus_ATCC_199 VDPKIEPTFHAWSR------------------------------------
Mb3753|M.bovis_AF2122/97 VDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVESLQRLRLPWWHLW
Rv3726|M.tuberculosis_H37Rv VDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLW
Mvan_5762|M.vanbaalenii_PYR-1 VDPAVDSPYEAVPAKQRG---LTELPALYELGVGSMEKLRKIPG-WSHVY
Mflv_0638|M.gilvum_PYR-GCK IDPLAEDAVEVVRTLTNG--------------------------------
TH_4631|M.thermoresistible__bu LDPQTDDVTGLRVD------------------------------------
MUL_2962|M.ulcerans_Agy99 ASPAAEAIVAATSG------------------------------------
MLBr_01784|M.leprae_Br4923 VNALELEVVKTIQDLTSG--------------------------------
..
MAV_0537|M.avium_104 ------------PAVVFEAVGVPGIIDDVLLRARPGTRLVVAGVC----M
MMAR_5116|M.marinum_M ------------ATVVFEAVGVPGMIDEVILRARPGTRLIVAGVC----M
MSMEG_6108|M.smegmatis_MC2_155 ------------PAVVFEAVGAPGIIDDILRRCPAGTRVVVAGVC----M
MAB_0526c|M.abscessus_ATCC_199 --------IGAGAPVIFEAVGVPGILNEVLRDAPRSARVVVVGVC----M
Mb3753|M.bovis_AF2122/97 RAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC----M
Rv3726|M.tuberculosis_H37Rv RAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVC----M
Mvan_5762|M.vanbaalenii_PYR-1 RVADRLGGTAPKRPVIFECVGVPGMIDGIIGAAPLASRVVVVGVC----M
Mflv_0638|M.gilvum_PYR-GCK ----------NGVDISFDAAGVQPALDAALGVLRPRGRLMVVAIW----E
TH_4631|M.thermoresistible__bu --------------AFIDASGAPAAVMSGLAAVRPAGRAVLVGMG----A
MUL_2962|M.ulcerans_Agy99 ----------RGADSVIDAVDTDASMTDALNAVRAGGTVSVVGVHD---L
MLBr_01784|M.leprae_Br4923 ----------FGVDVVIDTVGRPETWKQAFYARDLAGTVVLVGVPTPDMR
:: . : :..:
MAV_0537|M.avium_104 QPDTVHPFFAIAKEINVQFVLAYTPE-EFGDSLRALAEGDIDVAPLITGE
MMAR_5116|M.marinum_M QPDTVHPFFAITKEINVQFVLAYDPE-EFATSLRALAEGLIDVSPLITGE
MSMEG_6108|M.smegmatis_MC2_155 QPDTVHPLYAAVKQISVSFVFGYDPA-EFASSLRAIAEGDIDVRPMITGS
MAB_0526c|M.abscessus_ATCC_199 EPDAITPYFGIAKEVAVQFVLAYEPA-EFSETLRRIAHGEIDVAPLVTGE
Mb3753|M.bovis_AF2122/97 GSDHIRPAMAINKEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGT
Rv3726|M.tuberculosis_H37Rv GSDHIRPAMAINKEINLRFVLGYTPL-EFRDTLHMLADGKVNAAPLITGT
Mvan_5762|M.vanbaalenii_PYR-1 GDDKLRPAMAIGKEIDLRFVFGYTPL-EFRDTLHMLADGKLDASALVTGT
Mflv_0638|M.gilvum_PYR-GCK APAGIDINRSVMREANIGFSFCYEAQRQVPAILDLLATGAINLGELITDE
TH_4631|M.thermoresistible__bu ETMELPVQTIQNRELILTGVFRYANT--WPAAIALIRTGRVDVDALITGR
MUL_2962|M.ulcerans_Agy99 QPFPLPALTCLLRSITLRLTIAPVQR-TWSELIPLLESGRLDVDGIFTTS
MLBr_01784|M.leprae_Br4923 LDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGKFVSER
: . : * : :.:
MAV_0537|M.avium_104 VGLDGVGAA-FDDLAD-PERHCKVLVTP-------------
MMAR_5116|M.marinum_M VDLVGVGAA-FDDLAD-PERHCKVLVTP-------------
MSMEG_6108|M.smegmatis_MC2_155 VPLDGMADA-FDELAT-PDAHCKILVTP-------------
MAB_0526c|M.abscessus_ATCC_199 VGLEDVGSA-FADLGD-PERHCKILVVP-------------
Mb3753|M.bovis_AF2122/97 VGLPGVAAA-FDALGD-PEAHAKIMIDPKSNAASPQPFRVE
Rv3726|M.tuberculosis_H37Rv VGLPGVAAA-FDALGD-PEAHAKIMIDPKSNAASPQPFRVE
Mvan_5762|M.vanbaalenii_PYR-1 VGLGGVAAA-FDALGD-PETHAKILIDPAGTAVTP------
Mflv_0638|M.gilvum_PYR-GCK IPLDAVVSQGLEELRVNRDAHVKILIDPSA-----------
TH_4631|M.thermoresistible__bu YPLEKTAEA-LESDRIPGNIKSVVEVGTS------------
MUL_2962|M.ulcerans_Agy99 LPLDEAAKG-YSIAGSRSGNDVKVLLKV-------------
MLBr_01784|M.leprae_Br4923 IGLGDVEEA-FHKIHGGKVLRSVVML---------------
* : :