For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRAAVYYGPNKLEVDDVAEPEPGPGTVKLKVGFNGICGTDLHEYYAGPIFVPTEPHPLTGQQLPLTMGHE FSGTIAAVGDGVTGWSEGDRVAVEPIYKCGHCGPCRAGNYNVCQQIGFHGLMSDGGMAEYTVVPTSMLHK LPDNVSLELGALVEPMSVAYHAATLGDVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSPTRRAA IEVLGARTLDPTSADVPAFIADHTRGDGADAVFDAAGVTPAVSTALACVGSRKPMISVAIYEKPLETPLL NLVMNESRIQGSLCYTGADFEAVIALMGQGKYDTTGWVTRIPIDDVVDEGFEALHAGTKMKVLVDPNGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0788 | - | - | 100% (349) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0527 | - | 5e-64 | 38.35% (352) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0490 | - | 4e-53 | 36.47% (351) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 1e-23 | 28.91% (339) | alcohol dehydrogenase adh |
| M. gilvum PYR-GCK | Mflv_0125 | - | 0.0 | 92.84% (349) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 2e-26 | 27.45% (357) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 3e-21 | 26.20% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2084 | - | 7e-32 | 30.21% (374) | zinc-type alcohol dehydrogenase AdhD |
| M. marinum M | MMAR_0343 | - | 7e-37 | 32.77% (354) | zinc-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_4173 | - | 1e-31 | 31.70% (306) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_5021 | - | 1e-174 | 83.53% (346) | alcohol dehydrogenase, zinc-containing |
| M. thermoresistible (build 8) | TH_4349 | - | 9e-27 | 28.99% (345) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_4777 | - | 2e-36 | 32.49% (354) | zinc-dependent alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0788|M.vanbaalenii_PYR-1 -----MRAAVYYGPNK-LEVDDVAEPEPGPGTVKLKVGFNGICGTDLHEY
Mflv_0125|M.gilvum_PYR-GCK -----MRAAVYYGPNK-LEVDDVPEPEARPGTVKLKVGFNGICGTDLHEY
MSMEG_5021|M.smegmatis_MC2_155 -----MKAAVYHGPNK-LEIADLPEPQPGPGTVKVKVGFNGICGTDLHEY
MMAR_0343|M.marinum_M -MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLS--
MUL_4777|M.ulcerans_Agy99 -MAATMRAERFYADSKTVVLEDVPIPEPGPGEVLVKVAYCGICHSDLS--
Rv1895|M.tuberculosis_H37Rv -----MRAVVIDGAGSVRVNTQPDPALPGPDGVVVAVTAAGICGSDLH--
TH_4349|M.thermoresistible__bu -----MKALRLMDWKSEPELVEVPDPTPGPGQVLVKIGGAGACHSDLHLM
MLBr_01784|M.leprae_Br4923 -MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLT--
MAB_2084|M.abscessus_ATCC_1997 ---MKTRAAVLWGLEQKWEVEEVDLDPPGPGEVLVRLAATGLCHSDEH--
Mb1557|M.bovis_AF2122/97 MSDGAVVRALVLEAPRRLVVRQYRLPRIGDDDALVRVEACGLCGTDHE--
MAV_4173|M.avium_104 ----------MVTSPDRAEVIDVERPGVGPRDVLVRMRACGICGSDAFY-
: . : : * * :*
Mvan_0788|M.vanbaalenii_PYR-1 YAGPIFVPTEPHPLTGQQLPLTMG-HEFSGTIAAVGDGVTG---WSEGDR
Mflv_0125|M.gilvum_PYR-GCK YAGPIFVPTAPHPLTGAQLPLTMG-HEFSGTITAVGDGVTG---WQEGDR
MSMEG_5021|M.smegmatis_MC2_155 YAGPIFVPTEPHPLTGQVMPLTMG-HEFAGTITDVGAGVTG---FAPGDR
MMAR_0343|M.marinum_M ---------LINGTFPTQAPVVTQGHEASGTIAKLGPEVDG---WSEGDR
MUL_4777|M.ulcerans_Agy99 ---------LINGTFPTQAPVVTQGHEASGTIVKLGPEVDG---WSEGDR
Rv1895|M.tuberculosis_H37Rv ---------FYEGEYPFTEPVALG-HEAVGTIVEAGPQVRT---VGVGDL
TH_4349|M.thermoresistible__bu HD-------FEPGMMPWQLPFTLG-HENAGWVAAVGAGVGT---VTEGDA
MLBr_01784|M.leprae_Br4923 ---------YREGGINDRYPFLLG-HEAAGTVEVVGPGVTA---VEPGDF
MAB_2084|M.abscessus_ATCC_1997 ---------LVTGDLPIPLPVVGG-HEGAGTVVECGEGVED---LSEGDS
Mb1557|M.bovis_AF2122/97 ---------QYTGELAGGFAFVPG-HETVGTIAAIGPRAEQRWGVSAGDR
MAV_4173|M.avium_104 ---------ISIGGVPPRQGHTPLGHEPAGEVVEVGAEVTG---LAVGDH
** * : * . **
Mvan_0788|M.vanbaalenii_PYR-1 VAVEPIYKCGHCGPCRAGNYNVCQQ--------------------IGFHG
Mflv_0125|M.gilvum_PYR-GCK VAVEPIYKCDQCGPCRAGNYNVCQQ--------------------IGFHG
MSMEG_5021|M.smegmatis_MC2_155 VAIEPIYRCGHCAPCRAGNYNVCQQ--------------------IGFHG
MMAR_0343|M.marinum_M VVVAAGRPCQSCPNCRRGDTVNCLR--------------------IQLMA
MUL_4777|M.ulcerans_Agy99 VVVAAGRPCQSCPNCRRGDTVNCLR--------------------IQLMA
Rv1895|M.tuberculosis_H37Rv VMVSSVAGCGVCPGCETHDPVMCFS----------------GPMIFGAG-
TH_4349|M.thermoresistible__bu VAVYGPWGCGTCERCMGGAENYCENPA-------------GAPVLSGGAG
MLBr_01784|M.leprae_Br4923 VILNWRAVCGQCRACKRGRPSYCFDTFNAQQ-------KMTLIDGTELTP
MAB_2084|M.abscessus_ATCC_1997 VILTFLPSCGRCSYCARGMGNLCELGAALMMGPQIDGTYRFHARGEDVGQ
Mb1557|M.bovis_AF2122/97 VAVEVFQSCRQCANCRGGEYRRCVRHG----------LADMYGFIPVDRE
MAV_4173|M.avium_104 VVINPMAAPSGIIGNGGAS-------------------------------
* :
Mvan_0788|M.vanbaalenii_PYR-1 LMSDGGMAEYTVVPTSMLH----KLPDNVSLELGALVEPMSVAY-HAATL
Mflv_0125|M.gilvum_PYR-GCK LMSDGGMAEYTVVPTGMLH----RLPDTVSLELGALVEPMSVAY-HAATL
MSMEG_5021|M.smegmatis_MC2_155 LMCDGGMAEYTVVPVDMLH----KLPDNVSLQLGALVEPMSVAY-HAATL
MMAR_0343|M.marinum_M FAYDGAWAEYTVAQAAGLT----RVPDNVSLDQAAILADAVSTP-FGAVV
MUL_4777|M.ulcerans_Agy99 FAYDGAWAEYTVAQAAGLT----RVPDNVSLDQAAILADAVSTP-FGAVV
Rv1895|M.tuberculosis_H37Rv -VLGGAQADLLAVPAADFQV--LKIPEGITTEQALLLTDNLATG-WAAAQ
TH_4349|M.thermoresistible__bu LGMDGGMAEYLLVP-AERLV--VKLPESMTPVTAAALTDAGLTP-YHAIR
MLBr_01784|M.leprae_Br4923 ALGIGAFADKTLVHSGQCT----KVDPAADPAVAGLLGCGVMAG-LGAAI
MAB_2084|M.abscessus_ATCC_1997 MCLLGTFSEYTVVPQASVV----KIDGGIPLDRAALIGCGVTTG-YGSAV
Mb1557|M.bovis_AF2122/97 PGLWGGYAEYQYLAPDSMVL---RVAGDLSPEVATLFNPLGAGIRWGVTI
MAV_4173|M.avium_104 ----GALADYLLIENAVRGTSLEVIPDHIPWEVAALNEPMAVAR--HGVN
* :: : .
Mvan_0788|M.vanbaalenii_PYR-1 G---DVSPGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSP---TRRA
Mflv_0125|M.gilvum_PYR-GCK G---EVSAGDTAMVFGAGPIGIGLWFALRGKGLDDVFVVEPSP---TRRT
MSMEG_5021|M.smegmatis_MC2_155 G---DVGAGDTAVVFGAGPIGIGLWFALRGKGLESVYVAEPSP---TRRA
MMAR_0343|M.marinum_M R-TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINP---VVLD
MUL_4777|M.ulcerans_Agy99 R-TGKVAVGESVGVWGVGGVGTHIVQLARLVGAVPVIALDINP---VVLD
Rv1895|M.tuberculosis_H37Rv R--ADISFGSAVAVIGLGAVGLCALRSAFIHGAATVFAVDRVK---GRLQ
TH_4349|M.thermoresistible__bu RSWPKLTPTSTAVVIGVGGLGHVAVQLVKATTAARLIAVDNRS---EALE
MLBr_01784|M.leprae_Br4923 N-TAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDD---TKLE
MAB_2084|M.abscessus_ATCC_1997 R-TGEVRAGDTVVVVGAGGIGMNAIQGARIAGALAIVAVDPVN---FKRE
Mb1557|M.bovis_AF2122/97 P---ETKPGDVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLA
MAV_4173|M.avium_104 R--CQPRPTDKVVVFGAGPIGLGATLAFKSLGVQHIVVIDLIP---GRLD
. . * * * * : .
Mvan_0788|M.vanbaalenii_PYR-1 AIEVLGAR-TLDPTSADVPAFIADHTRGD--------GADAVFDAAGVTP
Mflv_0125|M.gilvum_PYR-GCK AIEALGAR-TLDPTADDVPAFIADHTGGD--------GADAVFDAAGVTP
MSMEG_5021|M.smegmatis_MC2_155 AIEALGAQ-TLDPTQVDVPAFIADVTGGR--------GADAAFDAAGVAP
MMAR_0343|M.marinum_M RALELGADYAFDSRDDQLHDKLAEITGGR--------MLDVAFDAVGLKA
MUL_4777|M.ulcerans_Agy99 RALELGADYAFDSRDDQLHDKLAEITGGR--------MLDVAFDAVGLKA
Rv1895|M.tuberculosis_H37Rv RAATWGATPIPSP----AAETILAATRGR--------GADSVIDAVGTDA
TH_4349|M.thermoresistible__bu LAREMGADHVVRSDE-QAVEAIWELTGGR--------GADVLLDFVGADA
MLBr_01784|M.leprae_Br4923 WARTFGATHTVNALELEVVKTIQDLTSGF--------GVDVVIDTVGRPE
MAB_2084|M.abscessus_ATCC_1997 QASGFGATHTAASMD-EAWSLVSDMTRGK--------LADVCILTTDVAE
Mb1557|M.bovis_AF2122/97 LAAQFGADLAVDVAIDDPVAALTEQTGG---------LADVVVDVTAKAP
MAV_4173|M.avium_104 KAVRIGADAVVNSAEEDVAARLVELHGPGESMFPGKAGTDIYLDAAGAPA
** : * . .
Mvan_0788|M.vanbaalenii_PYR-1 --AVSTALACVGSRKPMISVAIYEKP---LETPLLNLVMNESRIQG---S
Mflv_0125|M.gilvum_PYR-GCK --AVATALGCVGSRKPMISVAIYEKP---LETPLLNLVMNESRIQG---S
MSMEG_5021|M.smegmatis_MC2_155 --AIEAATASVGSRRPTISVAIYEKP---LTTPLLNLVMNESRIQG---S
MMAR_0343|M.marinum_M --TFEQALGSLTAGGRLVGVGMSAESP--TVGPTSMFGLTHKQVLG---H
MUL_4777|M.ulcerans_Agy99 --TFEQALGSLTAGGRLVGVGTSAESP--TVGPTSMFGLTHKQVLG---H
Rv1895|M.tuberculosis_H37Rv --SMSDALNAVRPGGTVSVVGVHDLQP--FPVPALTCLLRSITLRM---T
TH_4349|M.thermoresistible__bu --TIELARAAARPLGDVTIVGIAGGS------VPLSFFSQPYEVSI---Q
MLBr_01784|M.leprae_Br4923 --TWKQAFYARDLAGTVVLVGVPTPDMR-LDMPLLDFFSHGGSLKSSWYG
MAB_2084|M.abscessus_ATCC_1997 GSYTAEALALVGKRGRVVVTAIGHPDESSISGSLLEMTLYEKQIRGALYG
Mb1557|M.bovis_AF2122/97 -AAFAQAIALARPAGTVVVAGTRGVGSGAPGFSPDVVVFKELRVLG---A
MAV_4173|M.avium_104 --VVSTALAAAKKGATLGIVGVHKEP---VPVDLINVMSNEITIVG---S
* .. :
Mvan_0788|M.vanbaalenii_PYR-1 LCYTGADFEAVIALMGQGKYDTTGWVTRIPIDDVVDEGFEALHAG----T
Mflv_0125|M.gilvum_PYR-GCK LCYTGADFESVIALMADGRYDTTGWVTRIPIDDVVDEGFEALHAG----T
MSMEG_5021|M.smegmatis_MC2_155 LCYTSADFEAVIALMADGVYDTTGWVTTIGIDDVIDEGFEALHAG----R
MMAR_0343|M.marinum_M LGYQNVDIETLAKLVSLGRLDLSRSISEIVPLEDLPLGIEKLERQDG--N
MUL_4777|M.ulcerans_Agy99 LGYQNVDIETLAKLVSLGRLDLSRSISEIVPLEDLSLGIEKLERQDG--N
Rv1895|M.tuberculosis_H37Rv MAPVQRTWPELIPLLQSGRLDVDGIFTTTLPLDEAAKGYATARARSG--E
TH_4349|M.thermoresistible__bu TTYWG-TRPELVELLDLAARGLVHVESTTYPLDDALQAYRDLRAG-----
MLBr_01784|M.leprae_Br4923 DCLPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGG----K
MAB_2084|M.abscessus_ATCC_1997 SSNAPHDIPRLVELYSAGLLKLDELVTREYSLDQINEGYQDMRSG----R
Mb1557|M.bovis_AF2122/97 LGVDATAYRAALDLLVSGRYPFASLPRRCVRLEGAEDLLATMAGERDGVP
MAV_4173|M.avium_104 MGYPDEIFEVTGDLVRN-WEKYALIVSHTIPFDRVGEALELARTPG---A
*
Mvan_0788|M.vanbaalenii_PYR-1 KMKVLVDPNGA---------------------------------------
Mflv_0125|M.gilvum_PYR-GCK KMKVLVDPNGAQ--------------------------------------
MSMEG_5021|M.smegmatis_MC2_155 KMKVLIDPAI----------------------------------------
MMAR_0343|M.marinum_M PIRILVQP------------------------------------------
MUL_4777|M.ulcerans_Agy99 PIRILVQP------------------------------------------
Rv1895|M.tuberculosis_H37Rv ELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADLQLEGAADGVDGPSML
TH_4349|M.thermoresistible__bu ------RVRGRAVIVP----------------------------------
MLBr_01784|M.leprae_Br4923 VLRSVVML------------------------------------------
MAB_2084|M.abscessus_ATCC_1997 NIRGLVRF------------------------------------------
Mb1557|M.bovis_AF2122/97 PIHGVLTP------------------------------------------
MAV_4173|M.avium_104 ADKVVVTFC-----------------------------------------
Mvan_0788|M.vanbaalenii_PYR-1 -
Mflv_0125|M.gilvum_PYR-GCK -
MSMEG_5021|M.smegmatis_MC2_155 -
MMAR_0343|M.marinum_M -
MUL_4777|M.ulcerans_Agy99 -
Rv1895|M.tuberculosis_H37Rv N
TH_4349|M.thermoresistible__bu -
MLBr_01784|M.leprae_Br4923 -
MAB_2084|M.abscessus_ATCC_1997 -
Mb1557|M.bovis_AF2122/97 -
MAV_4173|M.avium_104 -