For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VLMRFADLIEAHAEDFARTAALDNGTPVGTSALLVPVAVEWTRYYAGWADKISSEVTASLRADGEFSYTL AQPWGVIGAIITWNGPLISLAMKVPAALAAGNTVVIKPSELTPFTAGLFADLAAEAGIPDGVINVVPGGA EAGAALVAHPLVKKISFTGGPDTARKILHTCADLIKPAVMELGGKSGNIVFADADLDTACGIGTMMSVAI LSGQGCAFPTRMLVERSVYDEVIERVRTIAGFVKVGNPFEADTVSGPVVNEQALVRITGMIERASRDGAR LVTGGGRLGGELAGGYYLEPTVFADVDPQSELAQNEVFGPVLSIIPFDDEAQAIEITNGTPYGLSGYVFT NDLRRAHRVAEELETGEVLINGAANLGATRPFGGIGISGMGKEGGRQGLEEFLHIKTVSMA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1922 | - | - | 100% (411) | aldehyde dehydrogenase |
| M. avium 104 | MAV_3553 | - | 5e-96 | 44.77% (411) | aldehyde dehydrogenase |
| M. avium 104 | MAV_2765 | - | 2e-91 | 41.49% (417) | P-cumic aldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0467 | - | 3e-65 | 36.06% (416) | aldehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1907 | - | 6e-90 | 43.77% (409) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 4e-77 | 41.42% (367) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 7e-50 | 32.11% (408) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 3e-75 | 39.42% (416) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 2e-75 | 38.90% (419) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5815 | - | 6e-89 | 42.79% (416) | betaine aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2957 | - | 0.0 | 75.43% (411) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 1e-73 | 38.19% (419) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0240 | - | 2e-79 | 39.90% (411) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1922|M.avium_104 --------------------------------------------------
TH_2957|M.thermoresistible__bu ----------MTSTLERPEVTLRIGGEKRRTASGGTFDHINPCTGAPDAA
Mflv_1907|M.gilvum_PYR-GCK -----------MVADPVTPIGLLIGTDRLTRTSLAPHPHIYPATGAPNAT
MSMEG_5815|M.smegmatis_MC2_155 ---------MTSVVLPGDPIGSLIGDRRVTASSGGLHAHVYPATGLPNAT
Mb0467|M.bovis_AF2122/97 MTVFSRPGSAGALMSYESRYQNFIGGQWVAPVHGRYFENPTPVTGQPFCE
MMAR_0472|M.marinum_M ------------MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGK
MUL_1122|M.ulcerans_Agy99 ------------MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGK
Rv0223c|M.tuberculosis_H37Rv -----------MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGK
MAB_4484|M.abscessus_ATCC_1997 ---------------MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQ
Mvan_0240|M.vanbaalenii_PYR-1 --------MTQSTTFRTEWDKLFIGGKWVEPATSDVIEVHSPATGELVGK
MLBr_02573|M.leprae_Br4923 ----------------------------------MSIATINPATGETVKT
MAV_1922|M.avium_104 -----------------------------------MLMRFADLIEAHAED
TH_2957|M.thermoresistible__bu IPLAGPAEIDDAVKAAHDAFH--SWRQTNPAERRRLLFRLAELIEQHTDD
Mflv_1907|M.gilvum_PYR-GCK VALAGADEVGMAVSAAREAQR--EWITLGVDQRRDKLIDLADVVREHLGE
MSMEG_5815|M.smegmatis_MC2_155 VALAGAAEVDAAVSAAWEAHR--EWVAHPADRRRDMLVGLADVVHEHLDE
Mb0467|M.bovis_AF2122/97 VPRSDAADIDKALDAAHAAAP--GWGKTAPAERAAILNMIADRIDKNAAA
MMAR_0472|M.marinum_M VPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDH
MUL_1122|M.ulcerans_Agy99 VPLAAAADVDAAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDH
Rv0223c|M.tuberculosis_H37Rv VPMAAAADVDAAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDL
MAB_4484|M.abscessus_ATCC_1997 CPLASPADVDAAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDE
Mvan_0240|M.vanbaalenii_PYR-1 VPLASAADVDAACAAAREAFDNGPWPHMSPAERGEILGRAVKIMEERADE
MLBr_02573|M.leprae_Br4923 FTPTTQDEVEDAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQ
. : .
MAV_1922|M.avium_104 FARTAALDNGTPVGT-SALLVPVAVEWTRYYAGWADKISSEVTASLRADG
TH_2957|M.thermoresistible__bu FVRLGTFDNGTPVGL-VAGLVAMSAEWTRYYAGWADKITSEVSGTYGTTG
Mflv_1907|M.gilvum_PYR-GCK LAELNTLDYGVPIS--YAGNAVMLDQFLRHFAGYVDKPHGSSTPVSGSS-
MSMEG_5815|M.smegmatis_MC2_155 LAGLNVHDYAVPIS--NAGTALLLERFLRHFAGYADKPHGTSSPVSGSF-
Mb0467|M.bovis_AF2122/97 LAVAEVWDNGKPVREALAADIPLAVDHFRYFAAAIRAQEGALSQIDEDT-
MMAR_0472|M.marinum_M FAKLLADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSY-
MUL_1122|M.ulcerans_Agy99 FAKLFADETGQPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSY-
Rv0223c|M.tuberculosis_H37Rv FTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSY-
MAB_4484|M.abscessus_ATCC_1997 ICKAIADETGAPPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAY-
Mvan_0240|M.vanbaalenii_PYR-1 LKFLLAAETGQPPTIVDMMQYGAAMSSFQFYAG-AADKFTWQDIRDGVY-
MLBr_02573|M.leprae_Br4923 SAALMTLEMGKTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGA
. : . . .
MAV_1922|M.avium_104 EFSYTLAQPWGVIGAIITWNGPLISLAMKVPAALAAGNTVVIKPSELTPF
TH_2957|M.thermoresistible__bu EFSYTLSQPYGVIGVIITWNGPLISLAMKVPAALAAGNTVVVKPSELTPF
Mflv_1907|M.gilvum_PYR-GCK DVNLIEREPFGAVGVIAPWNGSLVVAASCVAPALAAGNAVVFKPSELAPL
MSMEG_5815|M.smegmatis_MC2_155 DVNIIEREPYGVVGVIAPWNGALAVAASCVAPALAAGNAVVFKPSELAPL
Mb0467|M.bovis_AF2122/97 -VAYHFHEPLGVVGQIIPWNFPILMAAWKLAPALAAGNTAVLKPAEQTPA
MMAR_0472|M.marinum_M GQTIVHREPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPL
MUL_1122|M.ulcerans_Agy99 GQTIVHREPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAETPL
Rv0223c|M.tuberculosis_H37Rv GQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPL
MAB_4484|M.abscessus_ATCC_1997 GQTLVTREPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPL
Mvan_0240|M.vanbaalenii_PYR-1 GQTLVVREPVGVVGAVTAWNVPFFLAANKLGPALLAGCTVVLKPAAETPL
MLBr_02573|M.leprae_Br4923 SKALARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQ
:* *.: : .** .: .* ** . :.* : .*
MAV_1922|M.avium_104 TAGLFADLAAEAGIPDGVINVVP-GGAEAGAALVAHPLVKKISFTGGPDT
TH_2957|M.thermoresistible__bu SATLFADLAAEAGIPDGVINVVP-GTGDAGAALVAHPLVKKVTFTGGPDT
Mflv_1907|M.gilvum_PYR-GCK AALRFGELCLEAGLPPGLVNILP-AAAEGGDALVRHAGIAKIHFTGGGHT
MSMEG_5815|M.smegmatis_MC2_155 AALRFGELCLVAGLPPGLVNILP-AASDGGDALVRHPGIRKIHFTGGGTT
Mb0467|M.bovis_AF2122/97 SVLYLMSLIGDL-LPPGVVNVVNGFGAEAGKPLASSDRIAKVAFTGETTT
MMAR_0472|M.marinum_M TANALAEVFAEAGLPEGVLSVVP-GGVETGQALTSNPGVDLFTFTGSSAV
MUL_1122|M.ulcerans_Agy99 TANALAEVFAEAGLPEGVLSVVP-GGVETGQALTSNPGVDLFTFTGSSAV
Rv0223c|M.tuberculosis_H37Rv TANALAEVFAEVGLPEGVLSVVP-GGIETGQALTSNPDIDMFTFTGSSAV
MAB_4484|M.abscessus_ATCC_1997 SSFILAEVFAEAGVPEGVLSVVP-GGAETGRALTNNPDVDVFSFTGSTAV
Mvan_0240|M.vanbaalenii_PYR-1 SVFAMAEMFVEAGLPEGVLSIVP-GGPETGQALTANPNLDKYTFTGSSGV
MLBr_02573|M.leprae_Br4923 CALYLADVIARGGFPEDCFQTLL-ISANGVEAILRDPRVAAATLTGSEPA
: .: .* . .. : : .: : :** .
MAV_1922|M.avium_104 ARKILHTCADLIKPAVMELGGKSGNIVFADADLDTACGIGTMMS----VA
TH_2957|M.thermoresistible__bu ARKILQSCAEHIKPSVMELGGKSGNIIFEDANLDTACSVGTLMS----VG
Mflv_1907|M.gilvum_PYR-GCK ARAILRAAADNLTPVVTELGGKSANIIFDDADLDIAAVRSAHQG----PL
MSMEG_5815|M.smegmatis_MC2_155 ARAVLRAATDNLTPVVTELGGKSANIIFPDADLGRAAALAAHQG----PL
Mb0467|M.bovis_AF2122/97 GRLIMQYASHNLIPVTLELGGKSPNIFFADVLAAHDDFCDKALEGFTMFA
MMAR_0472|M.marinum_M GKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSG-----I
MUL_1122|M.ulcerans_Agy99 GKEIGRRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSG-----I
Rv0223c|M.tuberculosis_H37Rv GREVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSG-----V
MAB_4484|M.abscessus_ATCC_1997 GKEIAEIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSG-----L
Mvan_0240|M.vanbaalenii_PYR-1 GKEIAKIAADKLKPCTLELGGKSAAIILEDADLDSTLPMLVFSG-----L
MLBr_02573|M.leprae_Br4923 GQAVGAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGR-----V
.: : . . : . ****.. *.: ..
MAV_1922|M.avium_104 ILSGQGCAFPTRMLVERSVYDEVIERVRTIAGFVKVGNPFEADTVSGPVV
TH_2957|M.thermoresistible__bu MMSGQGCAFPTRMIVARPLYDEVLTRVSALAPMVKVGDPLEPDTVAGPVV
Mflv_1907|M.gilvum_PYR-GCK MQSGQSCACASRILVHEAVYEAFTERFIDVVESARIGDPLDPATVFGPVI
MSMEG_5815|M.smegmatis_MC2_155 MQSGQSCACASRILVHESVYDAFTEQFLAVIGAARVGDPFDPEVNFGPVI
Mb0467|M.bovis_AF2122/97 LNQGEVCTCPSRSLIQADIYDEFLELAAIRTKAVRQGDPLDTETMLGSQA
MMAR_0472|M.marinum_M MNTGQACVGQTRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLI
MUL_1122|M.ulcerans_Agy99 MNTGQACVGQTRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLI
Rv0223c|M.tuberculosis_H37Rv MNAGQGCVNQTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLI
MAB_4484|M.abscessus_ATCC_1997 MNAGQGCVNQTRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLI
Mvan_0240|M.vanbaalenii_PYR-1 MNSGQACVGQTRILAPRSRYDEVVEKLAAAAAGMAPGLPDNPAAMIGPLI
MLBr_02573|M.leprae_Br4923 QNNGQSCIAAKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLA
*: * .* : *: . * * :. . *.
MAV_1922|M.avium_104 NEQALVRITGMIERASRDGAR-LVTGGGRLG-GELAGGYYLEPTVFADVD
TH_2957|M.thermoresistible__bu NEAALQRILGMIERAKQDGAR-LLTGGERLG-GDLADEYFVAPTVFADVD
Mflv_1907|M.gilvum_PYR-GCK SAAALDRIVGVVGEAVDSGSGDLLAGGRRLTEDSLAAGYYLEPTVLGNVD
MSMEG_5815|M.smegmatis_MC2_155 SAGSLDRLLNVVHRAVEERAGELLVGGERLVDGALAGGFYMQPTVFGGVD
Mb0467|M.bovis_AF2122/97 SNDQLEKVLSYIEIGKQEGAVIIAGGERAELGGDLSGGYYMQPTIFTGTN
MMAR_0472|M.marinum_M SEKQRARVEGYIAKGIEEGARLVSGGGRPEG---LDNGFFVQPTVFADVD
MUL_1122|M.ulcerans_Agy99 SEKQRARVEGYIAKGIEEGARLVSGGGRPES---LDNGFFVQPTVFADVD
Rv0223c|M.tuberculosis_H37Rv SEKQRTRVEGYIAKGIEEGARLVCGGGRPEG---LDNGFFIQPTVFADVD
MAB_4484|M.abscessus_ATCC_1997 TEKQRTRVEGYIAKGIAEGARLAYGGKRPEG---LDGGYFVQPTIFADVD
Mvan_0240|M.vanbaalenii_PYR-1 SEKQRDRVEGYIKKGIEEGARVVTGGGRPEG---LDSGWYVQPTVFADVD
MLBr_02573|M.leprae_Br4923 TESGRAQVEQQVDAAAAAGAVIRCGGKRPDR-----PGWFYPPTVITDIT
. :: : . : * :: **:: .
MAV_1922|M.avium_104 PQSELAQNEVFGPVLSIIPFDDEAQAIEITNGTPYGLSGYVFTNDLRRAH
TH_2957|M.thermoresistible__bu PYSELAQKEVFGPVLSIIPFDTEEQAVEIANSTPYGLSGYVFTNDLKRAH
Mflv_1907|M.gilvum_PYR-GCK NTSPLAQTETFGPVVSLIPFADDDGAVRIANDTPYGLNAFVHTRDLTRAH
MSMEG_5815|M.smegmatis_MC2_155 NRSRLAQVETFGPVVSLIRFVDDDEAVRLANDTPYGLNAFVHTADLTRAH
Mb0467|M.bovis_AF2122/97 N-MRIFKEEIFGPVVAVTSFTDYDDAIGIANDTLYGLGAGVWSRDGNTAY
MMAR_0472|M.marinum_M NKMTIAQEEIFGPVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGI
MUL_1122|M.ulcerans_Agy99 NKMTIAQEEIFGPVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGI
Rv0223c|M.tuberculosis_H37Rv NKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGI
MAB_4484|M.abscessus_ATCC_1997 NSMTIAQEEIFGPVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGL
Mvan_0240|M.vanbaalenii_PYR-1 NSMTIAQEEIFGPVLAVIPYEDEDDAVRIANDSVYGLAGSVYTTDNDRAL
MLBr_02573|M.leprae_Br4923 KDMALYTDEVFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQR
: * **** : *: ::* : :** . . : :
MAV_1922|M.avium_104 RVAEELETGEVLINGAANLGATRPFGGIGISGMGKEGGRQGLEEFLHIKT
TH_2957|M.thermoresistible__bu RVAEQLETGEVLINGAAPLTVHRPFGGFGISGIGKEGGREGLAEFLRTKS
Mflv_1907|M.gilvum_PYR-GCK TVARRLQSGSVWINQGSRISPQGPYGGYKQSGSGRTGGLEGLREFQQVKN
MSMEG_5815|M.smegmatis_MC2_155 TVSRQLEAGSVWVNQFSQISPQGPYGGYKQSGSGRTGGLDGLHEFQQIKN
Mb0467|M.bovis_AF2122/97 RAGRDIQAGRVWVNCYHLYPAHAAFGGYKQSGIGREGHQMMLQHYQHTKN
MMAR_0472|M.marinum_M EISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKS
MUL_1122|M.ulcerans_Agy99 EISEKIRTGTYAIN-WYAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKS
Rv0223c|M.tuberculosis_H37Rv KISQQIRTGTYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKS
MAB_4484|M.abscessus_ATCC_1997 EVAAQIRTGTYGIN-WYAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKS
Mvan_0240|M.vanbaalenii_PYR-1 KIARRIRTGTYAVN-MYAFDPCAPFGGFKNSGIGRENGWEGIEAYCEPKS
MLBr_02573|M.leprae_Br4923 HFIDNIVAGQVFINGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKT
: :* :* .:** ** *: : : . *.
MAV_1922|M.avium_104 VSMA---------
TH_2957|M.thermoresistible__bu VSIA---------
Mflv_1907|M.gilvum_PYR-GCK IRIGIG-------
MSMEG_5815|M.smegmatis_MC2_155 IRIGMG-------
Mb0467|M.bovis_AF2122/97 LLVSYSDKALGFF
MMAR_0472|M.marinum_M VLMPMGYTLES--
MUL_1122|M.ulcerans_Agy99 VLMPMGYTLES--
Rv0223c|M.tuberculosis_H37Rv VLLPMGYTVA---
MAB_4484|M.abscessus_ATCC_1997 VLLPMGYTLESI-
Mvan_0240|M.vanbaalenii_PYR-1 ILLPFGYTPAT--
MLBr_02573|M.leprae_Br4923 VWIA---------
: :