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MATPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAAC GSTAMIYLMHMAAAVTVAASPPPGLPDLLADMASGKQLGTLAFSEPGSRSHFWAPVSTASADGDGIAVRA DKSWVTSAGFADVYVVSVGSADGAAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAPMAVDIRIPDSYR LGEAGGGFGIMMQTVLPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTT LAAQKAYLEVAANSVSSPDDTTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDARAGS VMAPTADALYDFYGRAVTGLPLF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1679 | fadE16 | - | 100% (373) | POSSIBLE ACYL-CoA DEHYDROGENASE FADE16 |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 4e-25 | 26.06% (353) | acyl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 8e-25 | 25.29% (344) | acyl-CoA dehydrogenase FADE25 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1706 | fadE16 | 0.0 | 100.00% (373) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4743 | - | 1e-28 | 25.87% (344) | butyryl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 6e-26 | 25.87% (344) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 4e-29 | 26.45% (344) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1262 | fadE25 | 4e-27 | 25.29% (344) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_4243 | - | 3e-24 | 24.71% (344) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3982 | - | 3e-29 | 28.37% (349) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4417 | - | 3e-27 | 28.18% (362) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 7e-28 | 25.58% (344) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_5885 | - | 1e-148 | 70.13% (375) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1262|M.marinum_M ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MUL_2626|M.ulcerans_Agy99 ----------------------------MAGWAGNPSFDLFQLPEEHQEL
MAV_4243|M.avium_104 ----------------------------MAGWAGNPDFDLFQLPEEHQEL
Mflv_4743|M.gilvum_PYR-GCK MQAEKSVPRNSLPAATALKLPTSSKEMLMASWAGNPSFDLFQLPEEHQEL
MLBr_00737|M.leprae_Br4923 ----------------------------MVGWSGNPLFDLFKLPEEHNEL
MAB_3618c|M.abscessus_ATCC_199 -------------------------------MAGNPSFDLFKLGEEHDEL
MSMEG_3982|M.smegmatis_MC2_155 ------------------------------------------MNTELLDF
TH_4417|M.thermoresistible__bu -------------------------------------MDYLGLDDDERVI
Rv1679|M.tuberculosis_H37Rv ------------------------------------------------MA
Mb1706|M.bovis_AF2122/97 ------------------------------------------------MA
Mvan_5885|M.vanbaalenii_PYR-1 ------------------------------------------------MY
MMAR_1262|M.marinum_M RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNAVHVPEEYGGQ
MUL_2626|M.ulcerans_Agy99 RAAIRALAEKEIAPHAADVDENSRFPQEALDALNASGFNALHVPEEYGGQ
MAV_4243|M.avium_104 RAAIRALAEKEIAPHAADVDENSRFPQEALEALNAAGFNAVHVPEEYGGQ
Mflv_4743|M.gilvum_PYR-GCK RAAIRALAEKEIAPHAADVDENARFPQEALDALVANGFNAVHVPEEYGGQ
MLBr_00737|M.leprae_Br4923 RATIRALAEKEIAPHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQ
MAB_3618c|M.abscessus_ATCC_199 RAAIRGLAEKEIAPHAKDVDEKARFPQEALDALVASGFNAVHVPEEYDGQ
MSMEG_3982|M.smegmatis_MC2_155 RAMMQDLASTQVAPYARDVDEQERFPEEAWQALCAADLPGLAHPTELGGS
TH_4417|M.thermoresistible__bu AETAAAFAEKRLAPYALEWDATKHFPTDALREAAELGMAAIYCSEEVGGS
Rv1679|M.tuberculosis_H37Rv TPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGM
Mb1706|M.bovis_AF2122/97 TPGVVQEVVSVAAEHAERVDTDCAFPAEAVDALRKTGLLGLVLPREIGGM
Mvan_5885|M.vanbaalenii_PYR-1 STEALNHVISVAAASADQVDAEGAYPAAAVDALRGSGLLGLVVPEEAGGL
. . * * * :* * .: .: . * .*
MMAR_1262|M.marinum_M GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDDLKKQVLPS
MUL_2626|M.ulcerans_Agy99 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKKQVLPS
MAV_4243|M.avium_104 GADSVAACIVIEEVARVDTSASLIPAVNKLGTMGLILRGSDELKKQVLPS
Mflv_4743|M.gilvum_PYR-GCK GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSDELKQKVLPS
MLBr_00737|M.leprae_Br4923 GADSVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPS
MAB_3618c|M.abscessus_ATCC_199 GADSVAACIVIEEVARVCASSSLIPAVNKLGTMGLILNGSDELKKQVLPA
MSMEG_3982|M.smegmatis_MC2_155 DGDLAAQAIAVEELSAACASTAMVLLVNWAGTCTVIHQGSDELKKLVVPD
TH_4417|M.thermoresistible__bu GLRRLDAVRIFEHLSAADPTTAAFLSIHNMCAWMVDTYGTDEQRKTWVPR
Rv1679|M.tuberculosis_H37Rv GSGPVEFTEVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLP-DLLAD
Mb1706|M.bovis_AF2122/97 GSGPVEFTEVVAQLSAACGSTAMIYLMHMAAAVTVAASPPPGLP-DLLAD
Mvan_5885|M.vanbaalenii_PYR-1 GAGPQQFVDVVGGLAAACGSTAMVYLMHTAAAVTVAAAPPPGMP-EMLSA
. . :: . ::: . :: : : . :.
MMAR_1262|M.marinum_M LADGAAMASYALSEREAGSDAGAMRTRAK--ADGDDWILNGTKCWITNGG
MUL_2626|M.ulcerans_Agy99 LADGAAMASYALSEREAGSDAGAMRTRAK--ADGDDWILNGTKCWITNGG
MAV_4243|M.avium_104 IADGSAMASYALSEREAGSDAASMRTRAR--ADGDDWILNGAKCWITNGG
Mflv_4743|M.gilvum_PYR-GCK LAAGESMASYALSEREAGSDAASMRTRAK--ADGDDWILNGAKCWITNGG
MLBr_00737|M.leprae_Br4923 LAAEGAMASYALSEREAGSDAASMRTRAK--ADGDDWILNGFKCWITNGG
MAB_3618c|M.abscessus_ATCC_199 IASGEAMASYALSEREAGSDAASMRTRAK--ADGDDWIINGSKCWITNGG
MSMEG_3982|M.smegmatis_MC2_155 VSTGAVGAGWCLTEPTGGSDLSGIRTKAQ--RDGSDWVLNGQKRFISNAD
TH_4417|M.thermoresistible__bu LASMDAIASYCLTEPGAGSDAAALRTRAV--RDGDHFVLDGVKQFISGAG
Rv1679|M.tuberculosis_H37Rv MASGKQLGTLAFSEPGSRSHFWAPVSTA--SADGDGIAVRADKSWVTSAG
Mb1706|M.bovis_AF2122/97 MASGKQLGTLAFSEPGSRSHFWAPVSTA--SADGDGIAVRADKSWVTSAG
Mvan_5885|M.vanbaalenii_PYR-1 MASGNALGTLAFSEKGSRSHFWAPVSTAALSDDGDTVKLRADKSWVTSAG
:: . .::* . *. . : * **. : . * :::...
MMAR_1262|M.marinum_M KSSWYTVMAVTDPEKGANGISAFMVHKDDEGFVVGPKERKLGIKGSPTTE
MUL_2626|M.ulcerans_Agy99 KSSWYTVMAVTDPENGANGISAFVVHKDDEGFVVGPKERKLGIKGSPTTE
MAV_4243|M.avium_104 KSSWYTVMAVTDPDKGANGISSFMVHKDDEGFTVGPKEKKLGIKGSPTTE
Mflv_4743|M.gilvum_PYR-GCK KSDWYTVMAVNDPDKGANGISAFMVHVDDEGFSIGPKERKLGIKGSPTTE
MLBr_00737|M.leprae_Br4923 KSTWYTVMAVTDPDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTE
MAB_3618c|M.abscessus_ATCC_199 KSSWYTVMAVTDPEKKANGISAFMVHKDDEGFTVGPLEHKLGIKGSPTAE
MSMEG_3982|M.smegmatis_MC2_155 WGDWFAVLARSGEE---NEFGVFMVHKSDAGLSFGPPEKKMGLRGSPTAD
TH_4417|M.thermoresistible__bu ASDVYVVMARTGED-GPKGISTFIVEKGTPGLSFGADEQKMGWNAQPTAQ
Rv1679|M.tuberculosis_H37Rv FADVYVVSVGSADG-AAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAP
Mb1706|M.bovis_AF2122/97 FADVYVVSVGSADG-AAGDVDLYAVPADTPGLRVAGTFTGMGLRGNASAP
Mvan_5885|M.vanbaalenii_PYR-1 YADIYIVSAGSTSG-VAGEVDLYALPRSGEGLSVVAPFAGMGLRGNASSP
. : * . . .. : : . *: . :* ....::
MMAR_1262|M.marinum_M LYFENCRVPGDRMIGEP---GTGFKTALATLD-HTRPTIGAQAVGIAQGA
MUL_2626|M.ulcerans_Agy99 LYFENCRVPGDRMIGEP---GTGFKTALATLD-HTRPTIGAQAVGIAQGA
MAV_4243|M.avium_104 LYFENCRIPGDRIIGEP---GTGFKTALATLD-HTRPTIGAQAVGIAQGA
Mflv_4743|M.gilvum_PYR-GCK LYFENCRIPGDRIIGEP---GTGFKTALATLD-HTRPTIGAQAVGIAQGA
MLBr_00737|M.leprae_Br4923 LYFDKCRIPGDRIIGEP---GTGFKTALATLD-HTRPTIGAQAVGIAQGA
MAB_3618c|M.abscessus_ATCC_199 LYFENCRIPGDRIIGEP---GTGFKTALQTLD-HTRPTIGAQALGIAQGA
MSMEG_3982|M.smegmatis_MC2_155 VILEDCRIPGERVVGDP---TQGYKYIIDELN-GSRALIAAQALGLAKGA
TH_4417|M.thermoresistible__bu VILEGARVPAENMLGGPEGEGKGFSIAMNGLN-GGRLNIAACSLGGAQTA
Rv1679|M.tuberculosis_H37Rv MAVD-IRIPDSYRLGEA---GGGFGIMMQTVLPWFNLGNAAVSLGLATAA
Mb1706|M.bovis_AF2122/97 MAVD-IRIPDSYRLGEA---GGGFGIMMQTVLPWFNLGNAAVSLGLATAA
Mvan_5885|M.vanbaalenii_PYR-1 MTVD-ATIPVASRLGAQ---AAGFGLLMETVLPWFNLGNAAVSLGLAGSA
: .: :* :* *: : : . .* ::* * *
MMAR_1262|M.marinum_M LDAAIAYTKDR--KQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAAR
MUL_2626|M.ulcerans_Agy99 LDAAIAYTKDR--KQFGKSISDFQAVQFMLADMAMKVESARLMVYSAAAR
MAV_4243|M.avium_104 LDAAIAYTKER--KQFGRPVSDNQGVQFMLADMAMKVESARLMVYHAAAR
Mflv_4743|M.gilvum_PYR-GCK LDAAIEYTKDR--KQFGKSISDFQAVQFMLADMAMKVEAARLMVYSAAAR
MLBr_00737|M.leprae_Br4923 LDAAIVYTKDR--KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAAR
MAB_3618c|M.abscessus_ATCC_199 LDQAIAYTKDR--KQFGKSISDFQGVQFMLADMAMKVEAARLMVYTAAAR
MSMEG_3982|M.smegmatis_MC2_155 LRTAIEYTAER--RQFGSALSTFQMVRAMVADAAIRVESASALLYKAVDA
TH_4417|M.thermoresistible__bu YEKAASYVADR--QAFGGSLIDEPTIRFTLADMATALQTSRLMLWRAATA
Rv1679|M.tuberculosis_H37Rv TGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANS
Mb1706|M.bovis_AF2122/97 TGAAVKHVGTARLEHLGGSLAELPTIRAQIARMGTTLAAQKAYLEVAANS
Mvan_5885|M.vanbaalenii_PYR-1 YVATIGHVSGARLEHRDEALSALPTIRAQIAKMGTTLAAQRAYLRSAAAS
: :. . . .: :: :* . : : : *.
MMAR_1262|M.marinum_M AERGESNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMR
MUL_2626|M.ulcerans_Agy99 AERGESNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMR
MAV_4243|M.avium_104 AERGESHLGFISAASKCLASDVAMEVTTDAVQLFGGYGYTQDFPVERMMR
Mflv_4743|M.gilvum_PYR-GCK AERGEGNLGFISAASKCLASDVAMEVTTDAVQLFGGAGYTVDFPVERMMR
MLBr_00737|M.leprae_Br4923 AERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMR
MAB_3618c|M.abscessus_ATCC_199 AERGEKNLGFISSASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERMMR
MSMEG_3982|M.smegmatis_MC2_155 IENKDPRARSLVSMAKVLCSDNAMAVTTDAVQLLGGYGFTREYPVERMMR
TH_4417|M.thermoresistible__bu LDENHPDKVELCAMAKLHVTEACYEVADKALQLHGGYGYLNEYGLEKIVR
Rv1679|M.tuberculosis_H37Rv VSSPDDTTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFR
Mb1706|M.bovis_AF2122/97 VSSPDDTTLTHVLGVKASVNDAALTITESAMRVCGGAAFSKHLPIERAFR
Mvan_5885|M.vanbaalenii_PYR-1 VSAPDEETLNHVLGIKASANDAALTITESAMRVCGGAAFSKHLPIERNFR
. . * .: . :: .*::: ** .: . :*: .*
MMAR_1262|M.marinum_M DAKITQIYEGTNQIQRVVMSRALLR---------------
MUL_2626|M.ulcerans_Agy99 DAKITQIYEGTNQIQRVVMSRALLR---------------
MAV_4243|M.avium_104 DAKITQIYEGTNQIQRVVMSRALLR---------------
Mflv_4743|M.gilvum_PYR-GCK DAKITQIYEGTNQIQRVVMSRALLK---------------
MLBr_00737|M.leprae_Br4923 DAKITQIYEGTNQIQRVVMSRALLR---------------
MAB_3618c|M.abscessus_ATCC_199 DAKITQIYEGTNQIQRVVMSRALLTS--------------
MSMEG_3982|M.smegmatis_MC2_155 DAKVTQIYEGSNQIQRLVISKGLYKGEALS----------
TH_4417|M.thermoresistible__bu DLRVHRILEGTNEIMRVVIGRAVAGRARGAAESGRARASA
Rv1679|M.tuberculosis_H37Rv DARAGSVMAPTADALYDFYGRAVTGLPLF-----------
Mb1706|M.bovis_AF2122/97 DARAGSVMAPTADALYDFYGRAVTGLPLF-----------
Mvan_5885|M.vanbaalenii_PYR-1 DARAGAVMAPTADVLYDFYGKAVTGLPLF-----------
* : : : : . .:.: