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RRTDSGTTEFHNVAVRPDEVLGKPNAILEAFLASGRGSLFGPIVQLVFSSVYLGIARGALETAREYTRTQ ARPWTPAGVTQAVEDPYTIRSYGEFGIQLQAADAAAREAAQLLQAAWDKGDALTSQERGELMVQISGVKA IATQAALDVTSRIFEVIGARGTHPKYGFDRFWRNIRTHTLHDPVSYKIAEVGNYVLNQRYPIPGFTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3806 | - | - | 100% (208) | dibenzothiophene desulfurization enzyme C |
| M. avium 104 | MAV_3422 | - | 7e-20 | 33.83% (201) | acyl-CoA dehydrogenase domain-containing protein |
| M. avium 104 | MAV_4243 | - | 3e-05 | 24.59% (183) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 2e-05 | 25.68% (183) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_3829 | - | 6e-06 | 30.22% (139) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 2e-05 | 25.68% (183) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-05 | 26.78% (183) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4123 | - | 3e-34 | 38.65% (207) | monooxygenase |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3668 | - | 2e-28 | 33.33% (204) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3393 | - | 1e-21 | 32.34% (201) | PUTATIVE Acyl-CoA dehydrogenase, type 2, C-terminal domain |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 4e-27 | 31.40% (207) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3806|M.avium_104 --------------------------------------------------
MAB_4123|M.abscessus_ATCC_1997 ------MTTATTSPVHAYQGVSDTEFSEWEQVAARVAGELSATALTRDRA
MSMEG_3668|M.smegmatis_MC2_155 MTVTVPATGSHSPNHLPTDVGVLHTAQEALAAADALATEFAADSAERELH
Mvan_3173|M.vanbaalenii_PYR-1 -------MATDITDRIPDTL--LRTPADALAAAEEVAEAIAAGSAERERA
TH_3393|M.thermoresistible__bu -----------VTEPLTMAR--IVDTAEALAVAARLSGSFAAEASTRDAE
Mb3302c|M.bovis_AF2122/97 ------MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK
Rv3274c|M.tuberculosis_H37Rv ------MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEK
MLBr_00737|M.leprae_Br4923 ------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQR
Mflv_3829|M.gilvum_PYR-GCK --------------MTFSLELSSDLLDVQKWVHEFAADVVRPAAAEWDER
MAV_3806|M.avium_104 --------------------------------------------------
MAB_4123|M.abscessus_ATCC_1997 NQNPIAEIELLRRYGLLSFATAREFGGAGGSLVQALQLGRIIAAADGSIG
MSMEG_3668|M.smegmatis_MC2_155 GKSLLPQLRRVAESGLLGIVVPAAHGGPGLPASTKVEVVRRLSRGDGALG
Mvan_3173|M.vanbaalenii_PYR-1 GAVLTPQLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAVG
TH_3393|M.thermoresistible__bu RLLPYEQVCELKRSGLLTLSVPAEHGGLDVPATVLAEVFRLLAHGDPSVA
Mb3302c|M.bovis_AF2122/97 ARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASAS
Rv3274c|M.tuberculosis_H37Rv ARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASAS
MLBr_00737|M.leprae_Br4923 ARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASAS
Mflv_3829|M.gilvum_PYR-GCK EETPWPIIREAAKVGLYSMEFFAEQAAE-PSGLGMIVAFEEMFWGDAGIA
MAV_3806|M.avium_104 --------------------------------------------------
MAB_4123|M.abscessus_ATCC_1997 QLLVYHYSNGVWTYILGSPTQREYISRGVGGHG-----WFQGS-------
MSMEG_3668|M.smegmatis_MC2_155 QLLLSHFVIGEAISGLGEAAPAPRIYADTLAGA-----QLGNATAERGTA
Mvan_3173|M.vanbaalenii_PYR-1 QLLLSHFVVAQAISGLGHTQPAPRIYADLLAGA-----QLGNASAERGTA
TH_3393|M.thermoresistible__bu QIPHSHFTFLEVLRLQGTERQRGFFYGLVLEGA-----LFANAQSERG-P
Mb3302c|M.bovis_AF2122/97 LIPAVNKLGTMGLILRGSEELKKQVLPALAAEG---AMASYALSEREAGS
Rv3274c|M.tuberculosis_H37Rv LIPAVNKLGTMGLILRGSEELKKQVLPALAAEG---AMASYALSEREAGS
MLBr_00737|M.leprae_Br4923 LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEG---AMASYALSEREAGS
Mflv_3829|M.gilvum_PYR-GCK LAILGTGLAAASVAANGTPEQVGEWVPQMFGSVDDPKVAAFCSSEPNAGS
MAV_3806|M.avium_104 --------------------------------------------------
MAB_4123|M.abscessus_ATCC_1997 VSNPRDPGITVTRTEEGYRVNGKRTFATGVAVADLITVLLYEAEP-----
MSMEG_3668|M.smegmatis_MC2_155 TALDRRTSVTQRP-DGKWVLNGTKYYATGALGAAWIAVAAVIAG------
Mvan_3173|M.vanbaalenii_PYR-1 HALDRRTTVTRR--DGHWVLNGTKYYATGTLGATWIAVAARIEG------
TH_3393|M.thermoresistible__bu HPIDVDTTVLLRRGAGDYLLTGRKFYSTGALFADWIVVRASVPADAADAP
Mb3302c|M.bovis_AF2122/97 DAASMRTRAKADG--DHWILNGAKCWITNGGKSTWYTVMAVTDPD-----
Rv3274c|M.tuberculosis_H37Rv DAASMRTRAKADG--DHWILNGAKCWITNGGKSTWYTVMAVTDPD-----
MLBr_00737|M.leprae_Br4923 DAASMRTRAKADG--DDWILNGFKCWITNGGKSTWYTVMAVTDPD-----
Mflv_3829|M.gilvum_PYR-GCK DVGSILTRARYDEATDEWVLNGTKTWATNGGIANVHVVVASVYPE-----
MAV_3806|M.avium_104 -----------------------------MRRTDSGTTEFHNVAVRPDEV
MAB_4123|M.abscessus_ATCC_1997 -------INAIIPSERDGLRFNDDWDNLGQRLTASGSVEFDNVLLRHDEV
MSMEG_3668|M.smegmatis_MC2_155 RED-ETATVFVRPEQDGVTLDLDKWSAFGQRGTASGEVRLTDVVVDADLV
Mvan_3173|M.vanbaalenii_PYR-1 RENGDTATAFVRPDQEGVTLDLESWSAFGQRGTASGEVRLNNVVVDDDLL
TH_3393|M.thermoresistible__bu TAATPKAVAFVPRHAPGLTV-IDDWDGMGQRTTASGSVTLDEVRVPADHV
Mb3302c|M.bovis_AF2122/97 -RGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRI
Rv3274c|M.tuberculosis_H37Rv -RGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRI
MLBr_00737|M.leprae_Br4923 -KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
Mflv_3829|M.gilvum_PYR-GCK -LGTRGQVSFIIPPGTKGLSQGQKFLKHGIRASHTAEVVLDDVRIPGRMI
: : : : . : :
MAV_3806|M.avium_104 LG--KPNAILEAFLASG-RGSLFGPIVQLVFSSVYLGIARGALETAREYT
MAB_4123|M.abscessus_ATCC_1997 LTGLDEYSGLDGSRER--RDGLRALFSQLIFVHLYLGIAEGALAAGVAYI
MSMEG_3668|M.smegmatis_MC2_155 IEEGAAPDPVDA------PPTVLGAYDQALHAAIDIGIARAALEDGAHFV
Mvan_3173|M.vanbaalenii_PYR-1 IDEGPPPDPITA------DPSVLGAFDQALHAAIDIGIARAALEDGAVFV
TH_3393|M.thermoresistible__bu V----PFTPIFR------RPTVYGARAQLWHAALDVGIATAALEEG---V
Mb3302c|M.bovis_AF2122/97 IGEPG--------------TGFKTALATLDHTRPTIGAQAVGIAQG---A
Rv3274c|M.tuberculosis_H37Rv IGEPG--------------TGFKTALATLDHTRPTIGAQAVGIAQG---A
MLBr_00737|M.leprae_Br4923 IGEPG--------------TGFKTALATLDHTRPTIGAQAVGIAQG---A
Mflv_3829|M.gilvum_PYR-GCK VGGKERFDARIAKVREGKKAAGQAAMATFERTRPTVGAMAVGVARA---A
: :* .: .
MAV_3806|M.avium_104 RTQARPWTPAGVT---QAVEDPYTIRSYGEFGIQLQAADAAAREAAQLLQ
MAB_4123|M.abscessus_ATCC_1997 RDKGRPWPEAHST---DVTEDPYHQQLLGRLSAGIAAGVALADSATKEFE
MSMEG_3668|M.smegmatis_MC2_155 RTTSRPWKEAVLAGVTSAAEEPHVVRRFGELTARLYALEALLARGTAIID
Mvan_3173|M.vanbaalenii_PYR-1 RTRSRPWKEALDAGIERADQEPHVVRRFGELTARLYALEALLARGTALID
TH_3393|M.thermoresistible__bu RLAAR-ARPHFESGAPVATDDPTLIQSAGEVAVTVRAAQALLGEAARAVD
Mb3302c|M.bovis_AF2122/97 LDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAE
Rv3274c|M.tuberculosis_H37Rv LDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAE
MLBr_00737|M.leprae_Br4923 LDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAE
Mflv_3829|M.gilvum_PYR-GCK FEYARDYACEREQFGRKIGEFQGVAFKLADMKARIDAARLLVYRAGWMAR
. . . : * .
MAV_3806|M.avium_104 AAWDKGDALTSQERGELMVQISGVKAIATQAALDVTSRIFEVIGARGTHP
MAB_4123|M.abscessus_ATCC_1997 QALAFGEAPTEAQWGALAIRVDQAKSVATEISLDVTHNIYQATGARSTAN
MSMEG_3668|M.smegmatis_MC2_155 AGQS-EAELSRDTAAEASLTVAAAKALAQEYAVEIASGIFELTGASGTDS
Mvan_3173|M.vanbaalenii_PYR-1 EAYA-APEVTRDAAAQASLTVAAAKALAQQDAVEIAGAIFELTGTSGTDG
TH_3393|M.thermoresistible__bu AAT---ADLTEDTAAAASIAVATAKVAAERAALRASTALFELGGTRSATV
Mb3302c|M.bovis_AF2122/97 RGEP-----------DLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTT
Rv3274c|M.tuberculosis_H37Rv RGEP-----------DLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTT
MLBr_00737|M.leprae_Br4923 RGEP-----------DLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTS
Mflv_3829|M.gilvum_PYR-GCK NGKA-----------FESAEGSMAKLVASETAVYVTDEAIQILGGNGYTR
. * * :: : : * .
MAV_3806|M.avium_104 KYGFDRFWRNIRTHTLHDPVSYKIAEVGNYVLNQRYPIP----GFTS---
MAB_4123|M.abscessus_ATCC_1997 SVGLDIYWRNARTHTTHDPLPYRQREIGRHLLTDQWPSPRSLNGLGRLAE
MSMEG_3668|M.smegmatis_MC2_155 AVNLDRHWRNVRTHSLHDPARWKYVHLGNHTLHGTRPPRLGLVL------
Mvan_3173|M.vanbaalenii_PYR-1 AVNLDRHWRNVRVHSLHDPARWKYVHLGNHTLHDTRPPRLGLIL------
TH_3393|M.thermoresistible__bu SANLSRFWRDARTHTLHDPTRWKLHHIGRYLLSGTRPPRHGQL-------
Mb3302c|M.bovis_AF2122/97 DFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----------------
Rv3274c|M.tuberculosis_H37Rv DFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----------------
MLBr_00737|M.leprae_Br4923 DFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----------------
Mflv_3829|M.gilvum_PYR-GCK EYPVERMHRDAKIFTIFEGTSEIQRLVMARAITGLPIR------------
.. *: : .: : :
MAV_3806|M.avium_104 -------
MAB_4123|M.abscessus_ATCC_1997 TTQGKKP
MSMEG_3668|M.smegmatis_MC2_155 -------
Mvan_3173|M.vanbaalenii_PYR-1 -------
TH_3393|M.thermoresistible__bu -------
Mb3302c|M.bovis_AF2122/97 -------
Rv3274c|M.tuberculosis_H37Rv -------
MLBr_00737|M.leprae_Br4923 -------
Mflv_3829|M.gilvum_PYR-GCK -------