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TSAEVAEVSEQDFGEILAQTRQFVRTAVVPREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGGLGLNL MQDVELAMELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFALTEPGAGSNPAG LRTKAVADGDNWVISGQKRFITNAPVANLFVVFARTRPADDQGPGIAVFLVPADAAGVQIGAKDAKMGQE GAWTADVSFDDVRVGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVSYASTATQGGTP IGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGEDRRVAPSAAKLYCTEMAGRVADLAVQVHGGSGYM RGVPVERIYRDVRLLRLYEGTSEIQRLIIGSNLVKAAQRATTTKER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1571 | - | - | 100% (397) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1575 | - | 9e-58 | 35.98% (378) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_4958 | - | 1e-56 | 35.22% (372) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0221c | fadE3 | 3e-58 | 35.98% (378) | acyl-CoA dehydrogenase FADE3 |
| M. gilvum PYR-GCK | Mflv_4370 | - | 0.0 | 81.91% (387) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 2e-54 | 34.04% (376) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-54 | 34.04% (376) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1188c | - | 2e-55 | 36.70% (376) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4034 | fadE | 0.0 | 85.64% (383) | acyl-CoA dehydrogenase FadE |
| M. smegmatis MC2 155 | MSMEG_2205 | - | 0.0 | 83.33% (384) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 0.0 | 84.36% (390) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 1e-56 | 34.75% (377) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_1974 | - | 0.0 | 83.46% (387) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0221c|M.bovis_AF2122/97 -MRN-------------------------ELNDDEAMLVATVRAFIDRDV
MUL_4024|M.ulcerans_Agy99 MMNND--------------------SPDSQLDEDEAMLVATVRAFIDRDV
MAV_1571|M.avium_104 -MTSA--------------------EVAEVSEQDFGEILAQTRQFVRTAV
MMAR_4034|M.marinum_M -MT-----------------------APQVSDEDFAQILAQTRHFVRSVV
MSMEG_2205|M.smegmatis_MC2_155 -MTGTVTDG---------------QSAAEVGDEDFEEILAQARSFIRNAV
TH_3736|M.thermoresistible__bu -MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAV
Mflv_4370|M.gilvum_PYR-GCK -MASPPANAAEAG-----------IPSAEVNDEDFQAILAATREFVRTAV
Mvan_1974|M.vanbaalenii_PYR-1 ------------------------MSTAEVGDEDFRQILAQTRQFVRTAV
Rv3274c|M.tuberculosis_H37Rv ----------------MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEI
MLBr_00737|M.leprae_Br4923 ----------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEI
MAB_1188c|M.abscessus_ATCC_199 ---------------------------MFNLTEEQREIWNTAREFADIHI
:: : * : :
Mb0221c|M.bovis_AF2122/97 KPTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYGGSPVSMPCYVQVTQ
MUL_4024|M.ulcerans_Agy99 RPSVREVEHANTYPQAWIEQMKRIGIYGLAIGEAYGGSPVSMPCYVQVTQ
MAV_1571|M.avium_104 VPREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGGLGLNLMQDVELAM
MMAR_4034|M.marinum_M LPREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGGLGLNLVQDVELAM
MSMEG_2205|M.smegmatis_MC2_155 VPRENEILATDKVPDDIREQAKNMGLFGYAIPQQWGGLGLNLAQDVELAM
TH_3736|M.thermoresistible__bu VPRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGGLGLDLAQDVELAM
Mflv_4370|M.gilvum_PYR-GCK VPREQEILSTDQVPDDLREQTKSMGLFGYAIPQEWGGLGLNLAQDVELAM
Mvan_1974|M.vanbaalenii_PYR-1 VPREQEILTTDRVPDELREQAKSMGLFGYAIPQEWGGLGLDLTQDVELAM
Rv3274c|M.tuberculosis_H37Rv APHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIE
MLBr_00737|M.leprae_Br4923 APHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIE
MAB_1188c|M.abscessus_ATCC_199 APHALDWDRDKYFPVEIFPKAAALGMGGIYVNPDVGGSGLTRLDASLIFE
* : * *: . : ** :
Mb0221c|M.bovis_AF2122/97 ELARGWMSLAGAMGG-HTVVAKLLTLFGTEEQRRTYLPPMASGELRATMA
MUL_4024|M.ulcerans_Agy99 ELARGWMSLAGAMGG-HTVVAKLLMLFGTDEQKSTYLPAMATGELRATMA
MAV_1571|M.avium_104 ELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
MMAR_4034|M.marinum_M ELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MSMEG_2205|M.smegmatis_MC2_155 EFGYTSLALRSMFGTNNGIAGQVLVGFGTDEQKQQWLEGIASGEVVASFA
TH_3736|M.thermoresistible__bu ELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVASFA
Mflv_4370|M.gilvum_PYR-GCK ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1 ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKSTWLERIASGEVVASFA
Rv3274c|M.tuberculosis_H37Rv EVARVDASAS-LIPAVNKLGTMGLILRGSEELKKQVLPALAAEGAMASYA
MLBr_00737|M.leprae_Br4923 EVARVDASAS-LIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYA
MAB_1188c|M.abscessus_ATCC_199 AMATGCSAVS-AFISIHNMAAWMIDEFGDEEQRRRWLPSMCTMETIGAYC
.. : : : : : * : : * :.: .: .
Mb0221c|M.bovis_AF2122/97 LTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWISNARRSGLFAVLC
MUL_4024|M.ulcerans_Agy99 LTEPGGGSDLQNMSTTAMADGPDQ---LLITGAKTWISNARRSGLIALLC
MAV_1571|M.avium_104 LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPVANLFVVFA
MMAR_4034|M.marinum_M LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPVADLFVVFA
MSMEG_2205|M.smegmatis_MC2_155 LTEPGAGSNPAGLRTKAVRDGS----DWVINGQKRFITNAPTAGLFVVFA
TH_3736|M.thermoresistible__bu LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPVADLFVVFA
Mflv_4370|M.gilvum_PYR-GCK LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPNADLFVTFA
Mvan_1974|M.vanbaalenii_PYR-1 LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPNANLFVTFA
Rv3274c|M.tuberculosis_H37Rv LSEREAGSDAASMRTRAKADGD----HWILNGAKCWITNGGKSTWYTVMA
MLBr_00737|M.leprae_Br4923 LSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMA
MAB_1188c|M.abscessus_ATCC_199 LTEPECGSDAAALRTSAIRQGD----EYVLNGVKQFISGAGAADLYVVMA
*:* **. : : * :* ::.* * :*:.. : . :.
Mb0221c|M.bovis_AF2122/97 KTDPNATPRHQGMSIVLVEPG-PGLTVSRDLPKLGYKGVESCELSFDNLR
MUL_4024|M.ulcerans_Agy99 KTDPHATPRHHGISIVLVEPG-PGLNISADLPKLGYKGVEACELSFDNYR
MAV_1571|M.avium_104 RTRP-ADDQGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSFDDVR
MMAR_4034|M.marinum_M RTRP-ASDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSFTDVR
MSMEG_2205|M.smegmatis_MC2_155 RTRP-ADADGAGIAVFLVPADTPGVEVGPKDAKMGQEGAWTADVNFTDVR
TH_3736|M.thermoresistible__bu RSRP-ADERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTFTDVR
Mflv_4370|M.gilvum_PYR-GCK RSRP-ADDKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNFTDVE
Mvan_1974|M.vanbaalenii_PYR-1 RSRP-ADDKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNFTDVR
Rv3274c|M.tuberculosis_H37Rv VTDP--DRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCR
MLBr_00737|M.leprae_Br4923 VTDP--DKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCR
MAB_1188c|M.abscessus_ATCC_199 RTG---GPGPRGISTIVVPKGTPGLSFGAPERKMGWHAQPTAQVVFEDVR
: *:: .:* *. .. *:* .. : :: * . .
Mb0221c|M.bovis_AF2122/97 VPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLAYAQQ
MUL_4024|M.ulcerans_Agy99 APTSAILGGQPGQGFSQMMKGLETGRIQVAARALGVASAALDDALAYAQQ
MAV_1571|M.avium_104 VGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVSYAST
MMAR_4034|M.marinum_M VDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVAYAST
MSMEG_2205|M.smegmatis_MC2_155 VPAAALVGGSEDVGYRAAMTSLARGRVHIAALAVGTAQRALDESVAYAAT
TH_3736|M.thermoresistible__bu VPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVAYAAS
Mflv_4370|M.gilvum_PYR-GCK VPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVAYAAT
Mvan_1974|M.vanbaalenii_PYR-1 VPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVTYAAT
Rv3274c|M.tuberculosis_H37Rv IPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKD
MLBr_00737|M.leprae_Br4923 IPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKD
MAB_1188c|M.abscessus_ATCC_199 VPVANRIG-EEGIGFTIAMRGLNGGRLNIASCSLGGARSALEKVIEYLRT
:* . *: : * * :.: ::* * **: : *
Mb0221c|M.bovis_AF2122/97 RESFGRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQ-RCDMEA
MUL_4024|M.ulcerans_Agy99 RHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYDSGQ-RCDMEA
MAV_1571|M.avium_104 ATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGE-DRRVAP
MMAR_4034|M.marinum_M ATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGA-DRRIAP
MSMEG_2205|M.smegmatis_MC2_155 ATQGGQPIGNFQLVQAMIADQQTGVMAGRALVRDAAQKWVTGE-DRRIAP
TH_3736|M.thermoresistible__bu ATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGE-DRRVAP
Mflv_4370|M.gilvum_PYR-GCK ATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQ-DRRIAP
Mvan_1974|M.vanbaalenii_PYR-1 ATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGE-DRRIAP
Rv3274c|M.tuberculosis_H37Rv RKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFIS
MLBr_00737|M.leprae_Br4923 RKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS
MAB_1188c|M.abscessus_ATCC_199 RKAFGEELIKFQALQFRLADMATELEAARTMVWRAAAAVTEGDPRAAELC
* : .* : :** : *.* :. :* *
Mb0221c|M.bovis_AF2122/97 GMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILGEGTN
MUL_4024|M.ulcerans_Agy99 GMAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVGEGTN
MAV_1571|M.avium_104 SAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLRLYEGTS
MMAR_4034|M.marinum_M SAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLRLYEGTS
MSMEG_2205|M.smegmatis_MC2_155 SAAKLYCTEMAGTVADLAVQIHGGTGYMREVPVERIYREVRLLRLYEGTS
TH_3736|M.thermoresistible__bu SAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLRLYEGTS
Mflv_4370|M.gilvum_PYR-GCK SAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLYEGTS
Mvan_1974|M.vanbaalenii_PYR-1 SAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLYEGTS
Rv3274c|M.tuberculosis_H37Rv AASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTN
MLBr_00737|M.leprae_Br4923 AASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTN
MAB_1188c|M.abscessus_ATCC_199 AMAKRIATDVGFTVANEALQLHGGYGYLAEYGIEKIVRDLRVHQILEGTN
. :* .:: . :: *:::.** ** :*: *: : : ***.
Mb0221c|M.bovis_AF2122/97 EIQRNVIAGQLVARGGI-------
MUL_4024|M.ulcerans_Agy99 EIQRNVIARQLIARGGI-------
MAV_1571|M.avium_104 EIQRLIIGSNLVKAAQRATTTKER
MMAR_4034|M.marinum_M EIQQLIIGSNLIKAANR-------
MSMEG_2205|M.smegmatis_MC2_155 EIQRLIIGGGLVKAAQRQL-----
TH_3736|M.thermoresistible__bu EIQRLIIGGGLVKAAQRQTN----
Mflv_4370|M.gilvum_PYR-GCK EIQKLIIGGGLVKGAKGK------
Mvan_1974|M.vanbaalenii_PYR-1 EIQRLIIGGGLVKGAKAR------
Rv3274c|M.tuberculosis_H37Rv QIQRVVMSRALLR-----------
MLBr_00737|M.leprae_Br4923 QIQRVVMSRALLR-----------
MAB_1188c|M.abscessus_ATCC_199 EIMRVIVSRKLIEQGLPA------
:* : ::. *: