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LDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGPSSITMAAAVA PYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHY AEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLP STLQSLATTATATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALL GPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPGTGAAP ALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVASTTTIIVIPAD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | - | 100% (409) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1801 | PPE29 | e-110 | 54.39% (421) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 6e-92 | 49.63% (407) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 0.0 | 99.76% (409) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-31 | 38.46% (221) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-47 | 32.83% (399) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 1e-30 | 31.29% (425) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 1e-132 | 60.19% (422) | PPE family protein, PPE32 |
| M. avium 104 | MAV_2906 | - | 1e-137 | 62.05% (419) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 7e-34 | 30.94% (417) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-33 | 32.46% (382) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-132 | 59.95% (422) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-32 | 31.00% (400) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2254c|M.abscessus_ATCC_199 ----------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
*:.** :* : *.*...: :*. * *. *
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2254c|M.abscessus_ATCC_199 YSMAATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* : : * .: *: * . . .
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2254c|M.abscessus_ATCC_199 ALHETSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
. :* .: :* : . : *:: *: :*::* *: .** *
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQ-----------TTN
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQ-----------TTN
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAGTAAAAS-ALTPFTEPPQ-----------TTN
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAAS-ALTPFTEPPQ-----------TTN
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAA-ELTPFTEPPR-----------TTE
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_2254c|M.abscessus_ATCC_199 ADYVRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPGS-ELSRMAA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*.* .** * *::* * . * .*
Rv1808|M.tuberculosis_H37Rv PSATAAQSAVVAQAAGAAASSDITAQLS-------------------QLI
Mb1837|M.bovis_AF2122/97 PSATAAQSAVVAQAAGAAASSDITAQLS-------------------QLI
MMAR_2684|M.marinum_M PVAGAAQSAAVAQASSTAASSDVVSQLA-------------------GLI
MUL_3072|M.ulcerans_Agy99 PVAGAAQSAAVAQASSTAASSDVVSQLA-------------------GLI
MAV_2906|M.avium_104 SSAAARQSAAVAQS----AASDLPAQLS-------------------TLI
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG-------------------MEA
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_2254c|M.abscessus_ATCC_199 DMSGFAAQAQATESGSALDSSNSVIDQL--------------LNFFRDPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
. :: . :
Rv1808|M.tuberculosis_H37Rv SLLPSTLQSLATTATATSAS------------------------------
Mb1837|M.bovis_AF2122/97 SLLPSTLQSLATTATATSAS------------------------------
MMAR_2684|M.marinum_M TSVPNALQTLATTSAAPTAASI----------------------------
MUL_3072|M.ulcerans_Agy99 TSVPNALQTLATTSAAPTAASI----------------------------
MAV_2906|M.avium_104 DVTPTMLQGLATTPSAAAAT------------------------------
MLBr_01182|M.leprae_Br4923 TVVPQVDQQVNVDVATPQTAVP----------------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_2254c|M.abscessus_ATCC_199 GTLRQIIEDFIRNPGAALATWLPFLLVLASMT---YVLFAQVFWLFWAAL
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
. :
Rv1808|M.tuberculosis_H37Rv -----------------------------------AGWDTVLQSITTILA
Mb1837|M.bovis_AF2122/97 -----------------------------------AGWDTVLQSITTILA
MMAR_2684|M.marinum_M ----------------------------LPEVSLPPWLATNLANWNTIMA
MUL_3072|M.ulcerans_Agy99 ----------------------------LPEVSLPPWLATNLANWNTIMA
MAV_2906|M.avium_104 -----------------------------PAASIIEAIYPITAALRPFFA
MLBr_01182|M.leprae_Br4923 -------------------------------DSSSAAAPQLWGGFAQHLS
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_2254c|M.abscessus_ATCC_199 LSAPLWLP--LLILAAWQYLQPPAVDAAPADEIRPELGSTVNGQREHIEP
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Rv1808|M.tuberculosis_H37Rv NLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG-PKAAAG---
Mb1837|M.bovis_AF2122/97 NLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLG-PKAAAG---
MMAR_2684|M.marinum_M TLTGPFSLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS-PKAITG---
MUL_3072|M.ulcerans_Agy99 TLTGPFSLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS-PKAITG---
MAV_2906|M.avium_104 AVTGAYSPIGAIILPGGWWLLSLQALGLAQNAPGVAELLGGGKAIAG---
MLBr_01182|M.leprae_Br4923 PINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAP----TTTKAAES---
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_2254c|M.abscessus_ATCC_199 LPAIALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPDEPP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. . . . .
Rv1808|M.tuberculosis_H37Rv -------ALSPLAPLR--GGYIGDITPLGGGATGGIARAIYVGSLSVPQG
Mb1837|M.bovis_AF2122/97 -------ALSPLAPLR--GGYIADITPLGGGATGGIARAIYVGSLSVPQG
MMAR_2684|M.marinum_M -------TLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQG
MUL_3072|M.ulcerans_Agy99 -------TLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQG
MAV_2906|M.avium_104 -------GLSPLAPLR--GGYVSAVTPDAGGVAGSMGRSTLVGSLSVPPG
MLBr_01182|M.leprae_Br4923 -------AFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQT
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_2254c|M.abscessus_ATCC_199 AIQFGPTLNEGNKAQAPASGISAAAA-AAASARSRARRKRGARVKDPAPQ
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
: .
Rv1808|M.tuberculosis_H37Rv WAEAAPVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGT
Mb1837|M.bovis_AF2122/97 WAEAAPVMRAVASVLPG-TGAAPALAAEAPGALFGEMALSSLAGRALAGT
MMAR_2684|M.marinum_M WTQAAPAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGAS
MUL_3072|M.ulcerans_Agy99 WTQAAPAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGAS
MAV_2906|M.avium_104 WTTAAPVLRTVASVLPAASSATAAAMPASGGAVFGEMAAASLAGRALAGA
MLBr_01182|M.leprae_Br4923 WTTASQPVTAATRALSP-----------ARVAVATESESAPLLGGGLPMA
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQAGGL
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQAGGL
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGL
MAB_2254c|M.abscessus_ATCC_199 YMDMNVTVDADYGEPPGSAQR-QSTASARGAGHLGLAGTSPKTTATAAGL
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHG--HRHEHQQPASMSAATAPSAAGI
.
Rv1808|M.tuberculosis_H37Rv AVRSGAG--AARVAGGSVTEDVASTTTIIVIPAD----------------
Mb1837|M.bovis_AF2122/97 AVRSGAG--AARVAGGSVTEDVASTTTIIVIPAD----------------
MMAR_2684|M.marinum_M TFGSSSGGAVANSLGGVVAEADPAAATIIVIPALDE--------------
MUL_3072|M.ulcerans_Agy99 TFGSSSGGAVANSLGGVVAEADPAAATIIVIPALDE--------------
MAV_2906|M.avium_104 GVRTVGNG-TTGAATAAAADGAATTATIIVVPAD----------------
MLBr_01182|M.leprae_Br4923 PMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-----------------
Mflv_0325|M.gilvum_PYR-GCK TTLA-----GDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 TTLP-----GDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 TTLT-----GDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_2254c|M.abscessus_ATCC_199 VARGSAGSDTDVPETARIVPMIPTTWSTDSDEAID---------------
TH_3113|M.thermoresistible__bu RVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------
.
Rv1808|M.tuberculosis_H37Rv -
Mb1837|M.bovis_AF2122/97 -
MMAR_2684|M.marinum_M -
MUL_3072|M.ulcerans_Agy99 -
MAV_2906|M.avium_104 -
MLBr_01182|M.leprae_Br4923 -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MSMEG_0619|M.smegmatis_MC2_155 R
MAB_2254c|M.abscessus_ATCC_199 -
TH_3113|M.thermoresistible__bu -