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LLAVSAVGGPESRCVMATLLQLKAFLAVVDQGGFTAASRSLGMSQPAVSRAVAGLERELGSPLLIRHRDR ILLNAPGKRALAHARSAVRHLDQMRAEVSAAAKLRGTLRIASLPYTTELLIAPQLQKFSERHPSVEIRVL EGGEPEIRDWLDLGAADAGVISLPATGLSAAFLAAQDMVAVLPSEHRLAAFSEVHYADLAKEPFIRSTGG CAHVFMAVADQVGVEFDVAFEAHGLMAVLEIVTAGLGVSIVPVAAVARPRAGIAVKRLVPKTTRNLAVAV SASAGSAARAFLEQIAALDGSERAGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4979 | - | - | 100% (307) | transcriptional regulator, LysR family protein, putative |
| M. avium 104 | MAV_2838 | - | 7e-28 | 32.01% (278) | hydrogen peroxide-inducible genes activator |
| M. avium 104 | MAV_1538 | - | 2e-23 | 31.33% (249) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 5e-11 | 28.25% (269) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 4e-25 | 31.65% (297) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 5e-11 | 28.25% (269) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-26 | 29.69% (293) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 5e-26 | 31.60% (288) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 2e-25 | 30.13% (302) | hydrogen peroxide-inducible genes activator, OxyR |
| M. smegmatis MC2 155 | MSMEG_6677 | - | 9e-91 | 60.21% (284) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-11 | 27.07% (266) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-24 | 29.80% (302) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 4e-22 | 30.71% (280) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4979|M.avium_104 MLLAVSAVGGPESRCVMATLLQLKAFLAVVDQGGFTAASRSLGMSQPAVS
MSMEG_6677|M.smegmatis_MC2_155 ----------------MSTLLQLRAFVAVVETGSFTSASRELGLSQPAVS
Mflv_3565|M.gilvum_PYR-GCK -----------------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVS
Mvan_3362|M.vanbaalenii_PYR-1 -----------------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVS
MAB_2238|M.abscessus_ATCC_1997 -----------------MEIHQLRYLLAVADTSSFTKAAAALHVAQPGVS
MMAR_2756|M.marinum_M --MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLS
MUL_2998|M.ulcerans_Agy99 -------MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLS
MLBr_02041|M.leprae_Br4923 ----------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLS
Mb2303c|M.bovis_AF2122/97 ----------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVS
Rv2282c|M.tuberculosis_H37Rv ----------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVS
TH_3504|M.thermoresistible__bu ------------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALS
: : ::*:.: : *: : * :*
MAV_4979|M.avium_104 RAVAGLERELGSPLLIRHRDRILLNAPGKRALAHARSAVRHLDQMRAEVS
MSMEG_6677|M.smegmatis_MC2_155 RAVAALEKELALPLLVRERGGVSLTEAGELALGHAREAVSHLTAMRKDVA
Mflv_3565|M.gilvum_PYR-GCK AQIRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVD
Mvan_3362|M.vanbaalenii_PYR-1 AQIRRLERQVGQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVD
MAB_2238|M.abscessus_ATCC_1997 AQIRLLERELGQDLFDRSGRQVRLTDAGKAVIPYARAALAAVDGVREAAD
MMAR_2756|M.marinum_M QALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAA
MUL_2998|M.ulcerans_Agy99 QALAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAA
MLBr_02041|M.leprae_Br4923 QALAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAA
Mb2303c|M.bovis_AF2122/97 RRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLG
Rv2282c|M.tuberculosis_H37Rv RRLASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLG
TH_3504|M.thermoresistible__bu SAVRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVR
: :* : * * :. * . :
MAV_4979|M.avium_104 AAA-KLRGTLRIASLPYTTELLIAPQLQKFSERHP-----SVEIRVLEGG
MSMEG_6677|M.smegmatis_MC2_155 ALAGSLTGTLTLASLPSVTGTLVAPHVREFRERHP-----AVAVRLLEGS
Mflv_3565|M.gilvum_PYR-GCK DVAGLLRGSVAIGTVT-LHPMNVAHLIAEFHADHP-----DVEITLGTAT
Mvan_3362|M.vanbaalenii_PYR-1 DVANLVRGAVAIGTVT-LHPVDVARLMADFHAEHP-----GVEITLGTDT
MAB_2238|M.abscessus_ATCC_1997 EIGGLIRGHIAFGTVT-SHGADLSSLLSAFHRDHP-----AISITLTEAG
MMAR_2756|M.marinum_M GEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP-----TLTVRVIEDQ
MUL_2998|M.ulcerans_Agy99 GEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP-----TLTVRVIEDQ
MLBr_02041|M.leprae_Br4923 GESDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP-----TLTLRVVEDQ
Mb2303c|M.bovis_AF2122/97 SLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATN
Rv2282c|M.tuberculosis_H37Rv SLRTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATN
TH_3504|M.thermoresistible__bu QTEAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP-----STSFTLRQLY
. : . :
MAV_4979|M.avium_104 EPEIRDWLDLGAADAGVISLPATG----LSAAFLAAQDMVAVLPSEHRLA
MSMEG_6677|M.smegmatis_MC2_155 EEEVRDWLDRGAAEAGVVSLPVKG----LESAVLGDQDMIAVVPADSRLA
Mflv_3565|M.gilvum_PYR-GCK SDVLIAELGDGRLDLAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLA
Mvan_3362|M.vanbaalenii_PYR-1 SDVLLAKLEDGRLDAAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLA
MAB_2238|M.abscessus_ATCC_1997 CEELVAGLREGRLDGAIVALGAQR-LAGLGLQVIDDQPLVAAVAADDLLA
MMAR_2756|M.marinum_M TERLLTALREGSLDTALIALPADY--GGLTEIPIYEEDFVLALPPGHPMA
MUL_2998|M.ulcerans_Agy99 TERLLTALREGSLDTALIALPADY--GGLTEIPIYEEDFVLALPPGHPMA
MLBr_02041|M.leprae_Br4923 TEHLLTALREGALDAAMIALPVET--AGIAEIPIYDEDFVLALPPGHPLS
Mb2303c|M.bovis_AF2122/97 SEHAIAAVRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWA
Rv2282c|M.tuberculosis_H37Rv SEHAIAAVRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWA
TH_3504|M.thermoresistible__bu PDALTDAVFDGTVQLGLRRGVVPT--PELATAVIGYHRVRVAFVDSHPLA
: * : .. : : . . .. :
MAV_4979|M.avium_104 AF-SEVHYADLA--KEPFIRSTG--GCAHVFMAVADQVG---VEFDVA-F
MSMEG_6677|M.smegmatis_MC2_155 GW-DVVDYVELA--KEPFVRSTG--GCAEAFTPVAQSIG---VDFDVA-F
Mflv_3565|M.gilvum_PYR-GCK HR-RSLSLEQLS--RHPLISLPAGTGLRTRLDTACAAAG---LRPRIA-F
Mvan_3362|M.vanbaalenii_PYR-1 RR-KSLSLKQLC--EYPVISLPAGTGLRSRLDDACAAAG---LRPRIA-F
MAB_2238|M.abscessus_ATCC_1997 TR-RTITLQRLC--EHTLICLPTGSGVRSILESECRSLG---LSPNVA-F
MMAR_2756|M.marinum_M DR-HGVPVAALS--ELPLLLLDEGHCLRDQALDVCQNAG---VRAELADT
MUL_2998|M.ulcerans_Agy99 DR-HGVPVAALS--ELPLLLLDEGHCLRDQALDVCQNAG---VRAEHADT
MLBr_02041|M.leprae_Br4923 GK-RRVPTTALA--QLPLLLLDEGHCLRDQTLDICRKSG---VQAELANT
Mb2303c|M.bovis_AF2122/97 RRSRVVSARELA--QTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVL
Rv2282c|M.tuberculosis_H37Rv RRSRVVSARELA--QTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVL
TH_3504|M.thermoresistible__bu AR-ESVDITELAREQVALWAPPGTSYYSDFLMGACRRAG---FEPDYVVS
: *. . .. .
MAV_4979|M.avium_104 EAHGLMAVLEIVTAGLGVSIVPVAAVARPRAG---IAVKRLVPKTTRNLA
MSMEG_6677|M.smegmatis_MC2_155 EARGLSAVLEIVRAGLGVSILPSAGLPDLPDG---VVIRPLTPTTVRNLG
Mflv_3565|M.gilvum_PYR-GCK EATSPAELAELARHGLGVAILPQS-MARGGSG---LHALRLAPELRGRLV
Mvan_3362|M.vanbaalenii_PYR-1 EATSPLELADLARHGLGVAILPRS-MARGSAG---LHPLRLSPELRGRLV
MAB_2238|M.abscessus_ATCC_1997 EASSPRALVSLVEQGLGIAVVPAP-YVRNRAG---VLALDIRPALRGRLA
MMAR_2756|M.marinum_M RAASLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIG
MUL_2998|M.ulcerans_Agy99 RADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIG
MLBr_02041|M.leprae_Br4923 RAASLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIG
Mb2303c|M.bovis_AF2122/97 ELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLR
Rv2282c|M.tuberculosis_H37Rv ELSSAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLR
TH_3504|M.thermoresistible__bu RVQGAATVAAPLTTG-GIAFVTAAAGPTMNGR---VQVVDLTPPLLVPVQ
. . * * : :. :
MAV_4979|M.avium_104 VAVSASA--GSAARAFLEQIAALDGSERAGA-------
MSMEG_6677|M.smegmatis_MC2_155 VAVSASA--SAPARAFLQQIVELGL-------------
Mflv_3565|M.gilvum_PYR-GCK WAWRADG-ANPAARVLGERARAMAVSPGSGAPAVVPGA
Mvan_3362|M.vanbaalenii_PYR-1 WAWRTDI-SGPAARLLNARARAMIAATG--TPAVIPGA
MAB_2238|M.abscessus_ATCC_1997 LAWRLDGPVGPAARAFLERARAVL--------------
MMAR_2756|M.marinum_M LVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN----
MUL_2998|M.ulcerans_Agy99 LVYRASSGRDEAYRQLAAIMGESISNEQQVRLVN----
MLBr_02041|M.leprae_Br4923 LAFRSASGRSASYRQIAKIIGELISTEHHVRLVA----
Mb2303c|M.bovis_AF2122/97 AIWVGGR--TPPAGAIRDLLSHITSRST----------
Rv2282c|M.tuberculosis_H37Rv AIWVGGR--TPPAGAIRDLLSHITSRST----------
TH_3504|M.thermoresistible__bu ALWQRHTLSAIRDRILEGLG------------------
: