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DFAVLPPEVNSARMYAGPGSGPMLAAAMAWDELAATLHSTADSYQAEITALTSGPWVGPSAAAMIAAITP YLTWMRTTGAQAEETANNARAAAFAYETAFAETVPPPVVTANRTLLAQLVATNILGQNTPAIATTEAEYA EMWARDAAAMYGYAGAAAAATRLTPFTQPDPTTNSGADQSQAVSKAAATAAGSTRNTVTQQPFSAVPNML NNLAVSPNALGDPSVTDLLGLESDLIAIFLDAPASVVGMGVDAPSATIALPFDIAGALTGFHTDDIVSGW AGVQPWPGTGAVPPSPFPVITNPAGGFGTLASAGLGQAKTVGTLSVPPTWTAAAPAIRPAALALPATTVT AAAETAATAAPAGTGSLFGEMAAAGLAGRAMAGTTGLGRERARAEAAKAPREPGQEPGKAPKQEPAAPAV SAGGPITSIAAELRELASLRDAGILTQQEFEEQKKRLLPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2746 | - | - | 100% (461) | PPE family protein |
| M. avium 104 | MAV_2006 | - | 1e-85 | 45.47% (464) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 6e-85 | 46.27% (415) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1829 | PPE29 | 1e-86 | 47.09% (412) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-31 | 32.58% (396) | PPE protein |
| M. tuberculosis H37Rv | Rv1801 | PPE29 | 2e-86 | 47.09% (412) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-43 | 32.86% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 8e-36 | 31.89% (417) | PPE family protein |
| M. marinum M | MMAR_2928 | - | 1e-140 | 57.85% (465) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-34 | 29.58% (453) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 9e-34 | 31.06% (454) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 4e-81 | 45.19% (405) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-35 | 29.86% (489) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MAV_2746|M.avium_104 -------------MDFAVLPPEVNSARMYAGPGSGPMLAAAMAWDELAAT
MMAR_2928|M.marinum_M -------------MDFALLPPEINSARMYAGPGSGPMLAAAAAWDGLAAE
Mb1829|M.bovis_AF2122/97 -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
Rv1801|M.tuberculosis_H37Rv -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : ***...: :*. * *.
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MAV_2746|M.avium_104 LHSTADSYQAEITALTSGPWVGPSAAAMIAAITPYLTWMRTTGAQAEETA
MMAR_2928|M.marinum_M LHSTASSYQLVVAGLTTGPWVGPSSVSMAAAAASYVAWTRITGTQAEQAA
Mb1829|M.bovis_AF2122/97 LHATAAGYASELSALTGA-WSGPSSTSMASAAAPYVAWMSATAVHAELAG
Rv1801|M.tuberculosis_H37Rv LHATAAGYASELSALTGA-WSGPSSTSMASAAAPYVAWMSATAVHAELAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
: * : : * .: .* * . . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MAV_2746|M.avium_104 NNARAAAFAYETAFAETVPPPVVTANRTLLAQLVATNILGQNTPAIATTE
MMAR_2928|M.marinum_M SQAAAAVAAYEAAFAETVPPPEVAANRALLMMLVATNLFGQNTPAIASTE
Mb1829|M.bovis_AF2122/97 AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
Rv1801|M.tuberculosis_H37Rv AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: * *: :* : . : *:: *: :*::* *: .* *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MAV_2746|M.avium_104 AEYAEMWARDAAAMYGYAGAAAAATRLTPFTQPDPTTNSG--ADQSQAVS
MMAR_2928|M.marinum_M AQYAEMWAQDSAAMYGYAGSSASATQLTPFDSPPSDTAPSGLATQAAAVA
Mb1829|M.bovis_AF2122/97 AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
Rv1801|M.tuberculosis_H37Rv AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* .** : :::* * * : .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MAV_2746|M.avium_104 KAAATAAGSTRNTVTQQP--FSAVPNMLNNLAVSPNALGDP---------
MMAR_2928|M.marinum_M QVAETSAGNVQSTVARTPQALAAVPNTLNSLAA-PAALPTL---------
Mb1829|M.bovis_AF2122/97 QTAATAAG--GNLQSAFPQLLSAVPRALQGLALPTASQSAS---------
Rv1801|M.tuberculosis_H37Rv QTAATAAG--GNLQSAFPQLLSAVPRALQGLALPTASQSAS---------
MUL_3072|M.ulcerans_Agy99 QASSTAAS--SDVVSQLAGLITSVPNALQTLATTSAAPTAASILPEV---
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVN--------
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MAV_2746|M.avium_104 -----------------------SVTDLLGLESDLIAIFLDAPASVVGMG
MMAR_2928|M.marinum_M -----------------------TPLELLDLLADLSGLFIDPEIGAAGLG
Mb1829|M.bovis_AF2122/97 -----------------------ATPQWVTDLGNLSTFLGGAVTGPYTFP
Rv1801|M.tuberculosis_H37Rv -----------------------ATPQWVTDLGNLSTFLGGAVTGPYTFP
MUL_3072|M.ulcerans_Agy99 ----------------------SLPPWLATNLANWNTIMA-TLTGPFSLQ
MLBr_01182|M.leprae_Br4923 ----------------------VDVATPQTAVPDSSSAAAPQLWGGFAQH
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MAV_2746|M.avium_104 VDAPSATIALPFDIAGALTGFHTD--DIVSGWAGVQPWPGTGAVPPSP--
MMAR_2928|M.marinum_M VDSFVGITALPYDIVGYLIGVHTD--DIVSGWAGLETWPGLASVPPTP--
Mb1829|M.bovis_AF2122/97 GVLPPSGVPYLLGIQSVLVTQNGQ--GVSALLGKIGGKPITGALAPLA-E
Rv1801|M.tuberculosis_H37Rv GVLPPSGVPYLLGIQSVLVTQNGQ--GVSALLGKIGGKPITGALAPLA-E
MUL_3072|M.ulcerans_Agy99 GISSIPGGPFLSFGQVYAYVQNAQ--GLNAFY---SPKAITGTLAPLVPE
MLBr_01182|M.leprae_Br4923 LSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAM
.
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQS--APSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPG
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSP--APTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPG
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP------RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVA
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAA--SAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-
TH_3113|M.thermoresistible__bu ASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSV
MAV_2746|M.avium_104 ---FPVITN--PAGGFGTLASAGLGQAKTVGTLSVPPTWTAAAPAIRPAA
MMAR_2928|M.marinum_M ---FPAAIT--NLG--GSAISAGLGEANSISGLSVPSAWTVSAPAIRTLA
Mb1829|M.bovis_AF2122/97 FALHTPILG--SEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPA
Rv1801|M.tuberculosis_H37Rv FALHTPILG--SEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPA
MUL_3072|M.ulcerans_Agy99 ISPGGVGLT--SASVSN-SVSGTMGRAALVGSMSVPQGWTQAAPAMR-LV
MLBr_01182|M.leprae_Br4923 GSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAAT
. ..
Mflv_0325|M.gilvum_PYR-GCK APAAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAA
Mvan_0415|M.vanbaalenii_PYR-1 APAAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAA
MSMEG_0619|M.smegmatis_MC2_155 APAPAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAA
MAB_0809c|M.abscessus_ATCC_199 PPVGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAE
TH_3113|M.thermoresistible__bu PPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAA
MAV_2746|M.avium_104 LALPATTVTAAAETAATA-----APAGTGSLFGEMAAAGLAGRAMAGTTG
MMAR_2928|M.marinum_M LELPGTSVAAAAEASS------------GGLLGQMALASVAGRAIAGTGG
Mb1829|M.bovis_AF2122/97 AALQATRLAAAPIAATD---------GAGALLGGMALSGLAGRAAAGST-
Rv1801|M.tuberculosis_H37Rv AALQATRLAAAPIAATD---------GAGALLGGMALSGLAGRAAAGST-
MUL_3072|M.ulcerans_Agy99 SSVLSTNLAAAPTAGLP---------GEAGVFGQMALSSLAGRAMGAST-
MLBr_01182|M.leprae_Br4923 RALSPARVAVATESESAP-----------LLGGGLPMAPMVPGGGSGTGG
. : ..
Mflv_0325|M.gilvum_PYR-GCK SAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRG
Mvan_0415|M.vanbaalenii_PYR-1 SAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERG
MSMEG_0619|M.smegmatis_MC2_155 SLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERG
MAB_0809c|M.abscessus_ATCC_199 TAAARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRG
TH_3113|M.thermoresistible__bu AAARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAG
MAV_2746|M.avium_104 LGRERARAEAAKAPREPGQEPGKAPKQE-PAAPAVSAGGPITSIAAELRE
MMAR_2928|M.marinum_M LGR----------PDRPG---GATTRDQ-TAPQTGAPTGPITSIAAELRE
Mb1829|M.bovis_AF2122/97 -----------------------------GHPIGSAAAPAVGAAAAAVED
Rv1801|M.tuberculosis_H37Rv -----------------------------GHPIGSAAAPAVGAAAAAVED
MUL_3072|M.ulcerans_Agy99 ----------------------------FGSSSGGAVANSLGGVVAEADP
MLBr_01182|M.leprae_Br4923 -------------------------------VNTALRLQPRAFVMPRNPA
.
Mflv_0325|M.gilvum_PYR-GCK AGPMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDR
Mvan_0415|M.vanbaalenii_PYR-1 AGPMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD-
MSMEG_0619|M.smegmatis_MC2_155 SDAMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP
MAB_0809c|M.abscessus_ATCC_199 AGTMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP------
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-----
MAV_2746|M.avium_104 LASLRDAGILTQQEFEEQKKRLLPS-------------------------
MMAR_2928|M.marinum_M LAALRDSGILTEEEFTEQKQRLLPH-------------------------
Mb1829|M.bovis_AF2122/97 LATE--ANIFVIPAMDD---------------------------------
Rv1801|M.tuberculosis_H37Rv LATE--ANIFVIPAMDD---------------------------------
MUL_3072|M.ulcerans_Agy99 AA----ATIIVIPALDE---------------------------------
MLBr_01182|M.leprae_Br4923 AG------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK HTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -----ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ------SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ------EHGRQD-----
TH_3113|M.thermoresistible__bu -----------------
MAV_2746|M.avium_104 -----------------
MMAR_2928|M.marinum_M -----------------
Mb1829|M.bovis_AF2122/97 -----------------
Rv1801|M.tuberculosis_H37Rv -----------------
MUL_3072|M.ulcerans_Agy99 -----------------
MLBr_01182|M.leprae_Br4923 -----------------