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MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVELHATAAGYASELSALTGAWSGPSSTSMASAAAP YVAWMSATAVHAELAGAQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTEAQYM EMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVAQTAATAAGGNLQSAFPQLLSAVPR ALQGLALPTASQSASATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSGVPYLLGIQSVLVTQNGQGVSA LLGKIGGKPITGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAAL QATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHPIGSAAAPAVGAAAAAVEDLATEANIFVIPA MDD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1801 | PPE29 | - | 100% (423) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | e-110 | 54.39% (421) | PPE family protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 5e-91 | 50.86% (407) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1829 | PPE29 | 0.0 | 100.00% (423) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-28 | 37.04% (189) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 6e-49 | 34.08% (402) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 3e-31 | 29.21% (428) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 1e-108 | 52.05% (438) | PPE family protein, PPE32 |
| M. avium 104 | MAV_2910 | - | 1e-103 | 51.52% (427) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-34 | 32.17% (429) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 9e-35 | 33.41% (425) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-107 | 51.83% (438) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-32 | 31.46% (426) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Rv1801|M.tuberculosis_H37Rv -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
Mb1829|M.bovis_AF2122/97 -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_2910|M.avium_104 ------------MLDFGAYPPEYNSGRMYVGAGSGPLLAAAAAWDELAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : *.*...: :*. * *: :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Rv1801|M.tuberculosis_H37Rv LHATAAGYASELSALT-GAWSGPSSTSMASAAAPYVAWMSATAVHAELAG
Mb1829|M.bovis_AF2122/97 LHATAAGYASELSALT-GAWSGPSSTSMASAAAPYVAWMSATAVHAELAG
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_2910|M.avium_104 LQSVGASYGSTVETLTTGPWTGPSSIAMAAAAAPYVAWLQATGAQAEQAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
: . : .: * .: . ** *: .. . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Rv1801|M.tuberculosis_H37Rv AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
Mb1829|M.bovis_AF2122/97 AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_2910|M.avium_104 AQAKLAAAAYETAFAATVPPPVIAANRALLATLVATNILGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
. : *: :* : . : *: *: :*::* *: .* *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSRMSA
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Rv1801|M.tuberculosis_H37Rv AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
Mb1829|M.bovis_AF2122/97 AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVA
MAV_2910|M.avium_104 AHYMEMWAQDAAAMYAYAASSASAAQLTPFTEPPRTTNESAGPLQSAAVA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*.* .** * *::* * . * : ..
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0047|M.abscessus_ATCC_1997 DMMSMAAQPQAAESGSALDSSNNIMDQL--------------MRFMTNPL
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FADALPDGLL
Rv1801|M.tuberculosis_H37Rv QTAATAAGGNLQSAFPQLLSA------------------------VPRAL
Mb1829|M.bovis_AF2122/97 QTAATAAGGNLQSAFPQLLSA------------------------VPRAL
MMAR_2684|M.marinum_M QASSTAASSDVVSQLAGLITS------------------------VPNAL
MUL_3072|M.ulcerans_Agy99 QASSTAASSDVVSQLAGLITS------------------------VPNAL
MAV_2910|M.avium_104 QSAAQSGS-NTAAHLSQLSAT------------------------AQPAA
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALD---------------------QAVNEGM
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_0047|M.abscessus_ATCC_1997 GTLQDMIEDFMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFWGVLLSAPA
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
Rv1801|M.tuberculosis_H37Rv QGLALPTASQSASATPQWVTD-------LGNLS------TFLGGAVTGPY
Mb1829|M.bovis_AF2122/97 QGLALPTASQSASATPQWVTD-------LGNLS------TFLGGAVTGPY
MMAR_2684|M.marinum_M QTLATTSAAPTAASILPEVSLPPWLATNLANWN------TIMA-TLTGPF
MUL_3072|M.ulcerans_Agy99 QTLATTSAAPTAASILPEVSLPPWLATNLANWN------TIMA-TLTGPF
MAV_2910|M.avium_104 QAAGNAASTTAASTQLTTPSF-------ITNWN------EFWS-VVTGVY
MLBr_01182|M.leprae_Br4923 EATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ------LWGGFAQHLSP
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_0047|M.abscessus_ATCC_1997 WLPIVLGLALSALVPPAG-----IEEPGQEDEPGREPTRIE---RRSPQQ
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Rv1801|M.tuberculosis_H37Rv TFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKI---------GGKPI
Mb1829|M.bovis_AF2122/97 TFPGVLPPSGVPYLLGIQSVLVTQNGQGVSALLGKI---------GGKPI
MMAR_2684|M.marinum_M SLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS------------PKAI
MUL_3072|M.ulcerans_Agy99 SLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYS------------PKAI
MAV_2910|M.avium_104 SPQSWTTIPGGPFLSFGQAYAWGQNGQGAAAYLAG-----------PKAI
MLBr_01182|M.leprae_Br4923 INDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTT----------TKAA
:
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAG-SPPAPGAPAAAAATFVPYVVAGRD
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATG-TAPAPGAPAAATASFVPYAVAGRD
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAP-AGTTVAAPAPAAATFVPYAVANRD
MAB_0047|M.abscessus_ATCC_1997 DLQLAHVPSGSPTPGGSTTTTVTSGGSAPPAPAPATATPAYMVYAVQEDP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSP
Rv1801|M.tuberculosis_H37Rv TGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAA
Mb1829|M.bovis_AF2122/97 TGALAPLAEFALHTPILGSEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAA
MMAR_2684|M.marinum_M TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
MUL_3072|M.ulcerans_Agy99 TGTLAPLVPEISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAA
MAV_2910|M.avium_104 SGALAPLASGGNAVKPMLSSAVGAGQVSGSMGKAALVGSMSVPQGWTEAA
MLBr_01182|M.leprae_Br4923 ESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTAS
.
Mflv_0325|M.gilvum_PYR-GCK PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGR
Mvan_0415|M.vanbaalenii_PYR-1 PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGR
MSMEG_0619|M.smegmatis_MC2_155 PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEER
MAB_0047|M.abscessus_ATCC_1997 PAARFGPTLNEGSGAKAPAAGISAAA---AAAASARSRARRKRAARIKDP
TH_3113|M.thermoresistible__bu PPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEP
Rv1801|M.tuberculosis_H37Rv PEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHP
Mb1829|M.bovis_AF2122/97 PEIPSPAAALQATRLAAAPIAATDGAGALLGGMALSGLAGRAAAGSTGHP
MMAR_2684|M.marinum_M PAMRLVSSVLSTN-LAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGS
MUL_3072|M.ulcerans_Agy99 PAMRLVSSVLSTN-LAAAPTAGLPGEAGVFGQMALSSLAGRAMGASTFGS
MAV_2910|M.avium_104 PAIRTLAQVLPGN-MAAAP-AAMAGEEGVFSQMALSSLAGRAVAAAATRP
MLBr_01182|M.leprae_Br4923 QPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTA
. .
Mflv_0325|M.gilvum_PYR-GCK G--YADAYADYEELPDDGP-PEQPAPRVTASTRGAGPMGFAGTVSRGD--
Mvan_0415|M.vanbaalenii_PYR-1 A--YADAYADYEPEPDDEP-PVRQEPRIAATERGAGPMGFAGTVSRDA--
MSMEG_0619|M.smegmatis_MC2_155 G--YADAYMDYEE-PDEDP-APQPEPRVRASERGSDAMGFTGTVTRHD--
MAB_0047|M.abscessus_ATCC_1997 A--PQFMDMNSSVAPDFSESAARQTTGVGASARGAGRLGFAGTAPAAAGT
TH_3113|M.thermoresistible__bu AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGI
Rv1801|M.tuberculosis_H37Rv I-----------------------------GSAAAPAVGAAAAAVEDL--
Mb1829|M.bovis_AF2122/97 I-----------------------------GSAAAPAVGAAAAAVEDL--
MMAR_2684|M.marinum_M S-----------------------------SGGAVAN-SLGGVVAEAD--
MUL_3072|M.ulcerans_Agy99 S-----------------------------SGGAVAN-SLGGVVAEAD--
MAV_2910|M.avium_104 V-----------------------------GGAASAASSLGGVAAEAD--
MLBr_01182|M.leprae_Br4923 LR------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK EQAGGLT---TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHD
Mvan_0415|M.vanbaalenii_PYR-1 AQAGGLT---TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHD
MSMEG_0619|M.smegmatis_MC2_155 VTAAGLT---TLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPE
MAB_0047|M.abscessus_ATCC_1997 TAAAGLVERDSGTAEALDGARTVPMLPTSWGTDSEHGP-------DRPAE
TH_3113|M.thermoresistible__bu RVLGGAG----RISRTRGSVPHAEITPGDPTEPSSPTDR-----AHRPAE
Rv1801|M.tuberculosis_H37Rv -----------------ATEANIFVIPAMDD-------------------
Mb1829|M.bovis_AF2122/97 -----------------ATEANIFVIPAMDD-------------------
MMAR_2684|M.marinum_M -----------------PAAATIIVIPALDE-------------------
MUL_3072|M.ulcerans_Agy99 -----------------PAAATIIVIPALDE-------------------
MAV_2910|M.avium_104 -----------------PAAATIIVIPCIEE-------------------
MLBr_01182|M.leprae_Br4923 ------------------LQPRAFVMPRNPAAG-----------------
: *
Mflv_0325|M.gilvum_PYR-GCK GKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GKDSQ
MSMEG_0619|M.smegmatis_MC2_155 GGPRR
MAB_0047|M.abscessus_ATCC_1997 GGSST
TH_3113|M.thermoresistible__bu PN---
Rv1801|M.tuberculosis_H37Rv -----
Mb1829|M.bovis_AF2122/97 -----
MMAR_2684|M.marinum_M -----
MUL_3072|M.ulcerans_Agy99 -----
MAV_2910|M.avium_104 -----
MLBr_01182|M.leprae_Br4923 -----