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MHFAVLPPEVNSGRMYSGPGSGSMLAAASAWDELANELHVTAANIESVISGLTSEPWQGPSAAAVTAAAA TQVEWLTATAEQAAQTGAQLKAAATAYESAYAMTVPPSVVAANRSRLASLVATNLLGQNTPAIAATEVAY GEMWAQDVAAMYGYAGAAQAASRVTPFTPPQRTTNEAGMGAQNASVAQAAGTSAGHVQSAVSNSNAMSAV PNALQNLASSSSSSSAASGLSDFSSFLNPYNLVSLGSAFFGNGTGLIGVSGAAGFISDAEHKMTEPSAKS KAVAAPERLEPPAGSRSSGATTVSAGMGRASSLGGMSVPQGWSTAAPELRLTALQAPAAAAAPPGRPGPF GEMPLFGGAPLMGLPGRGAADSRDGRSSGDAGTAGRGRRAAASHGPAGAARTASTGTTAELREITDLLGK LAELRATGALTDTEFAEQKQRLLRAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2006 | - | - | 100% (446) | PPE family protein |
| M. avium 104 | MAV_2746 | - | 1e-85 | 45.47% (464) | PPE family protein |
| M. avium 104 | MAV_2910 | - | 6e-79 | 43.16% (424) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1829 | PPE29 | 3e-84 | 46.67% (420) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-28 | 35.85% (212) | PPE protein |
| M. tuberculosis H37Rv | Rv1801 | PPE29 | 3e-84 | 46.67% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-47 | 34.60% (396) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-30 | 29.01% (424) | PPE family protein |
| M. marinum M | MMAR_2928 | - | 7e-88 | 44.61% (464) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 9e-32 | 27.59% (435) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-34 | 29.70% (431) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 2e-79 | 44.66% (421) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-30 | 37.04% (216) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1829|M.bovis_AF2122/97 -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
Rv1801|M.tuberculosis_H37Rv -------------MDFGLLPPEINSGRMYTGPGPGPMLAAATAWDGLAVE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MMAR_2928|M.marinum_M -------------MDFALLPPEINSARMYAGPGSGPMLAAAAAWDGLAAE
MAV_2006|M.avium_104 -------------MHFAVLPPEVNSGRMYSGPGSGSMLAAASAWDELANE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : ***...: :*. * *. .
Mb1829|M.bovis_AF2122/97 LHATAAGYASELSALTGA-WSGPSSTSMASAAAPYVAWMSATAVHAELAG
Rv1801|M.tuberculosis_H37Rv LHATAAGYASELSALTGA-WSGPSSTSMASAAAPYVAWMSATAVHAELAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MMAR_2928|M.marinum_M LHSTASSYQLVVAGLTTGPWVGPSSVSMAAAAASYVAWTRITGTQAEQAA
MAV_2006|M.avium_104 LHVTAANIESVISGLTSEPWQGPSAAAVTAAAATQVEWLTATAEQAAQTG
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
* : : * .: . . * . . .
Mb1829|M.bovis_AF2122/97 AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
Rv1801|M.tuberculosis_H37Rv AQARLAIAAYEAAFAATVPPPVIAANRAQLMVLIATNIFGQNTPAIMMTE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MMAR_2928|M.marinum_M SQAAAAVAAYEAAFAETVPPPEVAANRALLMMLVATNLFGQNTPAIASTE
MAV_2006|M.avium_104 AQLKAAATAYESAYAMTVPPSVVAANRSRLASLVATNLLGQNTPAIAATE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
* * *: :* : . : *:: *: :*::* *: .* *
Mb1829|M.bovis_AF2122/97 AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
Rv1801|M.tuberculosis_H37Rv AQYMEMWAQDAAAMYGYAGSSATASRMTAFTEPPQTTNHGQLGAQSSAVA
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVA
MMAR_2928|M.marinum_M AQYAEMWAQDSAAMYGYAGSSASATQLTPFDSPPSDTAPSGLATQAAAVA
MAV_2006|M.avium_104 VAYGEMWAQDVAAMYGYAGAAQAASRVTPFTPPQRTTNEAGMGAQNASVA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
. * .** * ::* * * : .
Mb1829|M.bovis_AF2122/97 QTAATAAG--GNLQSAFPQLLSAVPRALQGLALPTASQSAS---------
Rv1801|M.tuberculosis_H37Rv QTAATAAG--GNLQSAFPQLLSAVPRALQGLALPTASQSAS---------
MUL_3072|M.ulcerans_Agy99 QASSTAAS--SDVVSQLAGLITSVPNALQTLATTSAAPTAASILPEV---
MMAR_2928|M.marinum_M QVAETSAGNVQSTVARTPQALAAVPNTLNSLAAPAALPTLT---------
MAV_2006|M.avium_104 QAAGTSAGHVQSAVSNS-NAMSAVPNALQNLASSSSSSSAA---------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP--
Mb1829|M.bovis_AF2122/97 ----------------ATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSG
Rv1801|M.tuberculosis_H37Rv ----------------ATPQWVTDLGNLSTFLGGAVTGPYTFPGVLPPSG
MUL_3072|M.ulcerans_Agy99 ---------------SLPPWLATNLANWNTIMA-TLTGPFSLQGISSIPG
MMAR_2928|M.marinum_M -----------------PLELLDLLADLSGLFIDPEIGAAGL-GVDSFVG
MAV_2006|M.avium_104 ----------------------SGLSDFSSFLN-----PYNLVSLGS---
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MLBr_01182|M.leprae_Br4923 -----------------QTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMI
:
Mb1829|M.bovis_AF2122/97 VPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLA-EFALHTPILG
Rv1801|M.tuberculosis_H37Rv VPYLLGIQSVLVTQNGQGVSALLGKIGGKPITGALAPLA-EFALHTPILG
MUL_3072|M.ulcerans_Agy99 GPFLSFGQVYAYVQNAQGLNAFY---SPKAITGTLAPLVPEISPGGVGLT
MMAR_2928|M.marinum_M ITALP-YDIVGYLIGVHTDDIVSGWAGLETWPG-LASVP--PTPFPAAIT
MAV_2006|M.avium_104 -AFFGNGTGLIGVSGAAGFISDAEHKMTEPSAKSKAVAA--PERLEPPAG
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MLBr_01182|M.leprae_Br4923 NNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGL
Mb1829|M.bovis_AF2122/97 SEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAA
Rv1801|M.tuberculosis_H37Rv SEGLGGGSVSAGIGRAGLVGKLSVPQGWTVAAPEIPSPAAALQATRLAAA
MUL_3072|M.ulcerans_Agy99 SASVSN-SVSGTMGRAALVGSMSVPQGWTQAAPAMR-LVSSVLSTNLAAA
MMAR_2928|M.marinum_M N--LGGSAISAGLGEANSISGLSVPSAWTVSAPAIRTLALELPGTSVAAA
MAV_2006|M.avium_104 SRSSGATTVSAGMGRASSLGGMSVPQGWSTAAPELRLTALQAPAAAAAPP
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MLBr_01182|M.leprae_Br4923 LGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVA
. . .
Mb1829|M.bovis_AF2122/97 PIAATDGAGALLGGMALSGLAGRAAAGST---------GHPIGSAAAPAV
Rv1801|M.tuberculosis_H37Rv PIAATDGAGALLGGMALSGLAGRAAAGST---------GHPIGSAAAPAV
MUL_3072|M.ulcerans_Agy99 PTAGLPGEAGVFGQMALSSLAGRAMGASTF--------GSSSGGAVANSL
MMAR_2928|M.marinum_M AEASS---GGLLGQMALASVAGRAIAGTGGLGRPDRPGGATTRDQTAPQT
MAV_2006|M.avium_104 GRPGPFGEMPLFGGAPLMGLPGRGAADSRDGRSSGDAGTAGRGRRAAASH
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MLBr_01182|M.leprae_Br4923 TESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-
*
Mb1829|M.bovis_AF2122/97 GA--------------------------------AAAAVEDLATE-----
Rv1801|M.tuberculosis_H37Rv GA--------------------------------AAAAVEDLATE-----
MUL_3072|M.ulcerans_Agy99 GG--------------------------------VVAEADPAA-------
MMAR_2928|M.marinum_M GAP-------------------------TGPITSIAAELRELAALR----
MAV_2006|M.avium_104 GPAGAA----------------------RTASTGTTAELREITDLLGKLA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb1829|M.bovis_AF2122/97 ----ANIFVIPAMDD-----------------------------------
Rv1801|M.tuberculosis_H37Rv ----ANIFVIPAMDD-----------------------------------
MUL_3072|M.ulcerans_Agy99 ----ATIIVIPALDE-----------------------------------
MMAR_2928|M.marinum_M ---DSGILTEEEFTEQKQRLLPH---------------------------
MAV_2006|M.avium_104 ELRATGALTDTEFAEQKQRLLRAR--------------------------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mb1829|M.bovis_AF2122/97 ---------------
Rv1801|M.tuberculosis_H37Rv ---------------
MUL_3072|M.ulcerans_Agy99 ---------------
MMAR_2928|M.marinum_M ---------------
MAV_2006|M.avium_104 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------
MLBr_01182|M.leprae_Br4923 ---------------