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MDFALLPPEINSARMYAGPGSGPMLAAAAAWDGLAAELHSTASSYQLVVAGLTTGPWVGPSSVSMAAAAA SYVAWTRITGTQAEQAASQAAAAVAAYEAAFAETVPPPEVAANRALLMMLVATNLFGQNTPAIASTEAQY AEMWAQDSAAMYGYAGSSASATQLTPFDSPPSDTAPSGLATQAAAVAQVAETSAGNVQSTVARTPQALAA VPNTLNSLAAPAALPTLTPLELLDLLADLSGLFIDPEIGAAGLGVDSFVGITALPYDIVGYLIGVHTDDI VSGWAGLETWPGLASVPPTPFPAAITNLGGSAISAGLGEANSISGLSVPSAWTVSAPAIRTLALELPGTS VAAAAEASSGGLLGQMALASVAGRAIAGTGGLGRPDRPGGATTRDQTAPQTGAPTGPITSIAAELRELAA LRDSGILTEEEFTEQKQRLLPH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2928 | - | - | 100% (442) | PPE family protein |
| M. marinum M | MMAR_1461 | - | 3e-90 | 50.87% (403) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 4e-85 | 47.73% (396) | PPE family protein, PPE32 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 2e-96 | 48.93% (419) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 9e-30 | 29.43% (435) | PPE protein |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 6e-96 | 48.69% (419) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-43 | 32.92% (407) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-29 | 29.10% (433) | PPE family protein |
| M. avium 104 | MAV_2746 | - | 1e-140 | 57.85% (465) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 4e-32 | 28.61% (423) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-33 | 32.19% (438) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 2e-84 | 47.47% (396) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-35 | 32.33% (433) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2928|M.marinum_M -------------MDFALLPPEINSARMYAGPGSGPMLAAAAAWDGLAAE
MAV_2746|M.avium_104 -------------MDFAVLPPEVNSARMYAGPGSGPMLAAAMAWDELAAT
Mb1837|M.bovis_AF2122/97 -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
Rv1808|M.tuberculosis_H37Rv -------------MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** :* : ***...: :*. :* *:
MMAR_2928|M.marinum_M LHSTASSYQLVVAGLTTGPWVGPSSVSMAAAAASYVAWTRITGTQAEQAA
MAV_2746|M.avium_104 LHSTADSYQAEITALTSGPWVGPSAAAMIAAITPYLTWMRTTGAQAEETA
Mb1837|M.bovis_AF2122/97 LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
Rv1808|M.tuberculosis_H37Rv LYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
: * : : * .: .* * . . ..
MMAR_2928|M.marinum_M SQAAAAVAAYEAAFAETVPPPEVAANRALLMMLVATNLFGQNTPAIASTE
MAV_2746|M.avium_104 NNARAAAFAYETAFAETVPPPVVTANRTLLAQLVATNILGQNTPAIATTE
Mb1837|M.bovis_AF2122/97 AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
Rv1808|M.tuberculosis_H37Rv AQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
: *. .: * : . : *:: *: :*::* *: .** *
MMAR_2928|M.marinum_M AQYAEMWAQDSAAMYGYAGSSASAT-QLTPFDSPPSDTAPSGLATQAA--
MAV_2746|M.avium_104 AEYAEMWARDAAAMYGYAGAAAAAT-RLTPFTQPDPTTNSG--ADQSQ--
Mb1837|M.bovis_AF2122/97 AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQTTNPSATAAQSA--
Rv1808|M.tuberculosis_H37Rv AHYAEMWAQDAAAMYGYAGSSATAS-QLAPFSEPPQTTNPSATAAQSA--
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAAS-ALTPFTEPPQTTNPVAGAAQSA--
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVV--
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*.* .** : ::.* * . : .
MMAR_2928|M.marinum_M ----AVAQVAETSAGNVQSTVARTPQALAAVPNTLNSLAA-PAALPTLT-
MAV_2746|M.avium_104 ----AVSKAAATAAGSTRNTVTQQP--FSAVPNMLNNLAVSPNALGDPS-
Mb1837|M.bovis_AF2122/97 ----VVAQAAGAAAS--SDITAQLSQLISLLPSTLQSLATTATATSAS--
Rv1808|M.tuberculosis_H37Rv ----VVAQAAGAAAS--SDITAQLSQLISLLPSTLQSLATTATATSAS--
MUL_3072|M.ulcerans_Agy99 ----AVAQASSTAAS--SDVVSQLAGLITSVPNALQTLATTSAAPTAASI
MLBr_01182|M.leprae_Br4923 ----EEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVD
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
.
MMAR_2928|M.marinum_M ------PLELLDLLADLSGLFIDPEIGAAGLG-----------------V
MAV_2746|M.avium_104 ------VTDLLGLESDLIAIFLDAPASVVGMG-----------------V
Mb1837|M.bovis_AF2122/97 -------AGWDTVLQSITTILANLTGPYSIIG-----------------L
Rv1808|M.tuberculosis_H37Rv -------AGWDTVLQSITTILANLTGPYSIIG-----------------L
MUL_3072|M.ulcerans_Agy99 LPEVSLPPWLATNLANWNTIMATLTGPFSLQG-----------------I
MLBr_01182|M.leprae_Br4923 VATP-QTAVPDSSSAAAPQLWGGFAQHLSPIND---------------TL
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
.
MMAR_2928|M.marinum_M DSFVGITALPYDIVGYLIGVHTDDIVSGWAGLETWPGLAS--VPPTPFPA
MAV_2746|M.avium_104 DAPSATIALPFDIAGALTGFHTDDIVSGWAGVQPWPGTGA--VPPSPFPV
Mb1837|M.bovis_AF2122/97 GAIPGGWWLTFGQILGLA--QNAPGVAALLGPKAAAGALSPLAPLR--GG
Rv1808|M.tuberculosis_H37Rv GAIPGGWWLTFGQILGLA--QNAPGVAALLGPKAAAGALSPLAPLR--GG
MUL_3072|M.ulcerans_Agy99 SSIPGGPFLSFGQVYAYV--QNAQGLNAFYSPKAITGTLAPLVPEISPGG
MLBr_01182|M.leprae_Br4923 SMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTG
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
MMAR_2928|M.marinum_M AITNLG--GSAISAGLGEANSISGLSVPSAWTVSAPAIRTLALELPGTSV
MAV_2746|M.avium_104 ITNPAGGFGTLASAGLGQAKTVGTLSVPPTWTAAAPAIRPAALALPATTV
Mb1837|M.bovis_AF2122/97 YIADITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPG-TG
Rv1808|M.tuberculosis_H37Rv YIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPG-TG
MUL_3072|M.ulcerans_Agy99 VGLTSASVSNSVSGTMGRAALVGSMSVPQGWTQAAPAMRLVSSVLSTNLA
MLBr_01182|M.leprae_Br4923 RGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARV
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. ..
MMAR_2928|M.marinum_M AAAAEASS-------GGLLGQMALASVAGRAIAGTGGLGR----------
MAV_2746|M.avium_104 TAAAETAATAAPAGTGSLFGEMAAAGLAGRAMAGTTGLGRERAR------
Mb1837|M.bovis_AF2122/97 AAPALAAEAP-----GALFGEMALSSLAGRALAGT---------------
Rv1808|M.tuberculosis_H37Rv AAPALAAEAP-----GALFGEMALSSLAGRALAGT---------------
MUL_3072|M.ulcerans_Agy99 AAPTAGLPGE-----AGVFGQMALSSLAGRAMGAS---------------
MLBr_01182|M.leprae_Br4923 AVATESESAP------LLGGGLPMAPMVPGGGSGT---------------
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
:
MMAR_2928|M.marinum_M ------PDRPG---GATTRDQTAPQTGAPTGPITSIAAELRELAALRDSG
MAV_2746|M.avium_104 AEAAKAPREPGQEPGKAPKQEPAAPAVSAGGPITSIAAELRELASLRDAG
Mb1837|M.bovis_AF2122/97 -----------------------AVRSGAG--AARVAGGSVTEDVASTTT
Rv1808|M.tuberculosis_H37Rv -----------------------AVRSGAG--AARVAGGSVTEDVASTTT
MUL_3072|M.ulcerans_Agy99 -----------------------TFGSSSGGAVANSLGGVVAEADPAAAT
MLBr_01182|M.leprae_Br4923 -------------------------------------GGVNTALRLQPRA
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGG
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGG
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATG
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---SAAG
.
MMAR_2928|M.marinum_M ILTEEEFTEQKQRLLPH------------------------------
MAV_2746|M.avium_104 ILTQQEFEEQKKRLLPS------------------------------
Mb1837|M.bovis_AF2122/97 IIVIPAD----------------------------------------
Rv1808|M.tuberculosis_H37Rv IIVIPAD----------------------------------------
MUL_3072|M.ulcerans_Agy99 IIVIPALDE--------------------------------------
MLBr_01182|M.leprae_Br4923 FVMPRNPAAG-------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 LSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---
: