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LRLRADAGSVFYRTQQARMLRIFLGATTFLYAYGVVFTLFPIRAGLTLSNPAGGIVAVGLGLGALAWLAA RPDKPAPATVTAIVATPIVMAFHRVIIAEFVCLIAPMFLAMYLRAFYSPRRGAALVAVLAGLSVAALAVA PTPKLSIDYAIFVIAIIGAAESFGLLTRALVTAACTDPLTGLLNRAGWEIATADLLSRTRSATATVTVVA LDIDNFKTLNDTEGHVAGDEYLVRCAAFWRQVAPAGAVLARFGGDEFAVCIADHHPTSAKADQFVASVRR HTPDTSVGTASGAGASADIASLYAAADAELYSAKRRRRDPGLRPARG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2738 | - | - | 100% (327) | diguanylate cyclase |
| M. avium 104 | MAV_1995 | - | 8e-16 | 29.71% (313) | diguanylate cyclase |
| M. avium 104 | MAV_1410 | - | 7e-15 | 29.59% (267) | cyclic diguanylate phosphodiesterase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-08 | 30.77% (156) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_1914 | - | 2e-24 | 33.03% (333) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-08 | 30.77% (156) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 2e-10 | 32.89% (149) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_0124 | - | 5e-20 | 42.14% (159) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 4e-07 | 28.67% (150) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3397 | - | 4e-40 | 34.64% (306) | PUTATIVE putative diguanylate cyclase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0374 | - | 1e-38 | 34.64% (306) | diguanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3397|M.thermoresistible__bu ---------------LDAMLRRRMLVAYLLILLVLYALAVGVAVAVDTPP
Mvan_0374|M.vanbaalenii_PYR-1 MVLTARSDADPPGRHLDERLRRKMLLINLGLLSAVYALAVVQALVLDSPR
Mb1389c|M.bovis_AF2122/97 --MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDV
Rv1354c|M.tuberculosis_H37Rv --MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDV
MLBr_01750|M.leprae_Br4923 -------MTRSLDELVTRVASKLMAATAATAVTISEGVLAILVEHFGVDV
MSMEG_2196|M.smegmatis_MC2_155 -------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFDVDV
MAV_2738|M.avium_104 -----MRLRADAGSVFYRTQQARMLRIFLGATTFLYAYGVVFTLFPIRAG
Mflv_1914|M.gilvum_PYR-GCK --MQRDQRHSDHYEWFSDFLQARGVAVYVRAGVAAIGLLMAVSSVILVLG
MAB_0124|M.abscessus_ATCC_1997 -MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFH
TH_3397|M.thermoresistible__bu SDARGE--------VLAVLLCVVGVAAATPRPLRGRRYVTALGCAGAAPT
Mvan_0374|M.vanbaalenii_PYR-1 SDARGE--------IVAVALTVAGLLVSLRAPLAGWRYVVALFCISAAPI
Mb1389c|M.bovis_AF2122/97 SFLRHN--------DRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPV
Rv1354c|M.tuberculosis_H37Rv SFLRHN--------DRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPV
MLBr_01750|M.leprae_Br4923 SFLRHN--------NHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPV
MSMEG_2196|M.smegmatis_MC2_155 SFLRHN--------DHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPV
MAV_2738|M.avium_104 LTLSNP--------AGGIVAVGLGLGALAWLAARPDKPAPATVTAIVATP
Mflv_1914|M.gilvum_PYR-GCK AGGPTSQPQVAMMWVAAAGGVASAALWVRRWPTRGQSAAFAAVTTCSITL
MAB_0124|M.abscessus_ATCC_1997 PLGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWADISMV
TH_3397|M.thermoresistible__bu VALLFHDQIAGQSWS-VVPPM--FMAVFLHTWHRG-ATARVASGAIAVAA
Mvan_0374|M.vanbaalenii_PYR-1 LSVLFHELIAAQIWS-VVPLM--FVAIFIRTWHSA-TTARVVVAGIAAAA
Mb1389c|M.bovis_AF2122/97 FALCEHAKEPLVFRPEPATED--YQRLIEEARGVP-VTSAAAVPLVSGEI
Rv1354c|M.tuberculosis_H37Rv FALCEHAKEPLVFRPEPATED--YQRLIEEARGVP-VTSAAAVPLVSGEI
MLBr_01750|M.leprae_Br4923 FAMAEYLKEPAVLRPEPANAD--YQRRIEEGASVP-AVSLACVPLLSGEI
MSMEG_2196|M.smegmatis_MC2_155 FAMAEHLKEPAVFRPEPLYDD--YQRTIEAGRHIP-ATSMACVPLLSGDV
MAV_2738|M.avium_104 IVMAFHRVIIAEFVC-LIAPM--FLAMYLRAFYSP-RRGAALVAVLAGLS
Mflv_1914|M.gilvum_PYR-GCK ACLAYPDALAALLGCITFMTIGAYLAFFHSTRSVLGVVALAIVVASLHAV
MAB_0124|M.abscessus_ATCC_1997 VGACTLSAPASRLGALAHMGLIGVFAAFLLGWRVLAVHCVFATVAIFGLM
TH_3397|M.thermoresistible__bu ATALLIAPAPVP---IMWVVLYVVCIPGAGEVYG------LASSALFAMA
Mvan_0374|M.vanbaalenii_PYR-1 VIALLVAPAPIP---VVWLAFYAVSVLGAAEVFG------LGNAALLDAA
Mb1389c|M.bovis_AF2122/97 TTGLLGFIKFGD---RKWHEAELNALMTIATLFAQVQARVAAEARLRYLA
Rv1354c|M.tuberculosis_H37Rv TTGLLGFIKFGD---RKWHEAELNALMTIATLFAQVQARVAAEARLRYLA
MLBr_01750|M.leprae_Br4923 TTGVLGFVKYGD---REWHDDELRALQAIATLFAQLQARIVAEEQLRYLA
MSMEG_2196|M.smegmatis_MC2_155 TTGVLGFVKFGD---REWLPAELNALKAIASLFAQVQARIEAEERLRYLA
MAV_2738|M.avium_104 VAALAVAPTPKL---SIDYAIFVIAIIGAAESFG------LLTRALVTAA
Mflv_1914|M.gilvum_PYR-GCK ELAVAGRPALAA---VDLFIVVQANLAMPLAIHSLLRALRGDLVHALTDA
MAB_0124|M.abscessus_ATCC_1997 GWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLAA
: : *
TH_3397|M.thermoresistible__bu LHDPLTTVWNRAGVELKAEQIISRARRRGRSVAVIVLDVDDFKTINDRDG
Mvan_0374|M.vanbaalenii_PYR-1 FRDPLTLVWNRAGVSRRVGRLVRQARRRSQEIAVLVFDVDDFKRVNDQRG
Mb1389c|M.bovis_AF2122/97 DHDDLTGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAINDYLG
Rv1354c|M.tuberculosis_H37Rv DHDDLTGLHNRRALLQHLDQRLAPGQPG--PVAALFLDLDRLKAINDYLG
MLBr_01750|M.leprae_Br4923 EHDDLTGLLNRRALIAHLDERLADGQRG--PVTLLFLGLDRLKAVNDYLG
MSMEG_2196|M.smegmatis_MC2_155 DHDHLTGLYNRRALMAHLEARLAPGQPG--PVAVMFFDLDRLKAINDYLG
MAV_2738|M.avium_104 CTDPLTGLLNRAGWEIATADLLSRTRSATATVTVVALDIDNFKTLNDTEG
Mflv_1914|M.gilvum_PYR-GCK NHDPLTGLLNRRAFRTQTLGLFERGGDG-HHLVVALIDLDKFKALNDTHG
MAB_0124|M.abscessus_ATCC_1997 HQDPLTGLLNRRGVQVALSSLLS-GQRATRIVAVVLVDVDELKELNDRLG
* ** : ** . . :. ..:* :* :** *
TH_3397|M.thermoresistible__bu HLVGDAVLVELTRRWAARVPASAALGRVGGDEFVVIAS------CDQHRA
Mvan_0374|M.vanbaalenii_PYR-1 HAAGDRLLTDLAGRWVAEIPRSSVMGRIGGDEFVLIVGG-----FDETQA
Mb1389c|M.bovis_AF2122/97 HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
Rv1354c|M.tuberculosis_H37Rv HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
MLBr_01750|M.leprae_Br4923 HNAGDRLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFA
MSMEG_2196|M.smegmatis_MC2_155 HTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALA
MAV_2738|M.avium_104 HVAGDEYLVRCAAFWRQVAPAGAVLARFGGDEFAVCIADHHP---TSAKA
Mflv_1914|M.gilvum_PYR-GCK HHVGDQALVAVADALRATATSSAVISRSGGEEFLIADVAPADEALARYQG
MAB_0124|M.abscessus_ATCC_1997 HDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVGFFD----HADEAT
* .** : : .* **:** :
TH_3397|M.thermoresistible__bu GELAAELVDGQAVH-------VSYGVAVGPADKCDFATLFAAADADLYRR
Mvan_0374|M.vanbaalenii_PYR-1 RALADQLTSGLPVP-------VTYGVAAGPPGHRALDTLFAAADRDLYER
Mb1389c|M.bovis_AF2122/97 ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
Rv1354c|M.tuberculosis_H37Rv ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
MLBr_01750|M.leprae_Br4923 HRLQTRLQKQVVIDGEILTRTVSIGVATGLPGRDTTSDLLRWADHAALSA
MSMEG_2196|M.smegmatis_MC2_155 YRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTA
MAV_2738|M.avium_104 DQFVASVRRHTPDT--------SVGTASGAGASADIASLYAAADAELYSA
Mflv_1914|M.gilvum_PYR-GCK -LCDAVAALHIPVTASVGTATAALDVVSDHDPDGVVDHLIAAADMAMYRA
MAB_0124|M.abscessus_ATCC_1997 GLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGA
: **
TH_3397|M.thermoresistible__bu KRSRKAVPGR----------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 KRLRKA--------------------------------------------
Mb1389c|M.bovis_AF2122/97 KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
Rv1354c|M.tuberculosis_H37Rv KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRT
MLBr_01750|M.leprae_Br4923 K-SDGSKVVVLDHGISAQHTLRTEVELHLAGMIDT-DLVLHYLPEVDMST
MSMEG_2196|M.smegmatis_MC2_155 KGSGGNRVAVFSDAMAMEIDFRNDIELHLQSVIEGGALVLHYLPEIDMRT
MAV_2738|M.avium_104 KRRRRDPGLRPARG------------------------------------
Mflv_1914|M.gilvum_PYR-GCK KRNGGNQCHHHGSWPTLGSPP-----------------------------
MAB_0124|M.abscessus_ATCC_1997 KIERRNGFHAVP--------------------------------------
*
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
Rv1354c|M.tuberculosis_H37Rv GDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEF
MLBr_01750|M.leprae_Br4923 GKVLGTEALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACAEF
MSMEG_2196|M.smegmatis_MC2_155 GEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACAEF
MAV_2738|M.avium_104 --------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
Rv1354c|M.tuberculosis_H37Rv SEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEI
MLBr_01750|M.leprae_Br4923 SRWRSAGVGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEI
MSMEG_2196|M.smegmatis_MC2_155 SRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCLEI
MAV_2738|M.avium_104 --------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
Rv1354c|M.tuberculosis_H37Rv TENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLK
MLBr_01750|M.leprae_Br4923 TENVVVQNIDATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIK
MSMEG_2196|M.smegmatis_MC2_155 TESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDTLK
MAV_2738|M.avium_104 --------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
Rv1354c|M.tuberculosis_H37Rv IDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQ
MLBr_01750|M.leprae_Br4923 IDKSFVAELGSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLLEL
MSMEG_2196|M.smegmatis_MC2_155 IDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLLRH
MAV_2738|M.avium_104 --------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
TH_3397|M.thermoresistible__bu ------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 ------------------------------------------------
Mb1389c|M.bovis_AF2122/97 RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv RCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MLBr_01750|M.leprae_Br4923 GCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MSMEG_2196|M.smegmatis_MC2_155 GCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----------
MAV_2738|M.avium_104 ------------------------------------------------
Mflv_1914|M.gilvum_PYR-GCK ------------------------------------------------
MAB_0124|M.abscessus_ATCC_1997 ------------------------------------------------