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VLTARSDADPPGRHLDERLRRKMLLINLGLLSAVYALAVVQALVLDSPRSDARGEIVAVALTVAGLLVSL RAPLAGWRYVVALFCISAAPILSVLFHELIAAQIWSVVPLMFVAIFIRTWHSATTARVVVAGIAAAAVIA LLVAPAPIPVVWLAFYAVSVLGAAEVFGLGNAALLDAAFRDPLTLVWNRAGVSRRVGRLVRQARRRSQEI AVLVFDVDDFKRVNDQRGHAAGDRLLTDLAGRWVAEIPRSSVMGRIGGDEFVLIVGGFDETQARALADQL TSGLPVPVTYGVAAGPPGHRALDTLFAAADRDLYERKRLRKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0374 | - | - | 100% (323) | diguanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_1152 | - | 7e-19 | 34.15% (164) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
| M. vanbaalenii PYR-1 | Mvan_0796 | - | 8e-18 | 30.91% (275) | diguanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 5e-12 | 30.34% (234) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_3822 | - | 1e-21 | 31.85% (336) | diguanylate cyclase |
| M. tuberculosis H37Rv | Rv1354c | - | 5e-12 | 30.34% (234) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 2e-11 | 31.45% (159) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 5e-20 | 31.16% (292) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2738 | - | 9e-39 | 34.64% (306) | diguanylate cyclase |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-10 | 31.58% (152) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_3397 | - | 6e-89 | 52.27% (308) | PUTATIVE putative diguanylate cyclase |
| M. ulcerans Agy99 | MUL_1212 | - | 7e-05 | 26.97% (178) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0374|M.vanbaalenii_PYR-1 ----------------MVLTARSDADPPGRHLDERLRRKMLLINLGLLSA
TH_3397|M.thermoresistible__bu -------------------------------LDAMLRRRMLVAYLLILLV
Mflv_3822|M.gilvum_PYR-GCK -----------MSRIRQRWAQPDHYHWLSGYLGDRNLQGFTRRMMGLINL
MAB_3940c|M.abscessus_ATCC_199 MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHARKLDRTVRNLIGGYAL
Mb1389c|M.bovis_AF2122/97 ------------------MCNDTATPQLEELVTTVANQLMTVDAATSAEV
Rv1354c|M.tuberculosis_H37Rv ------------------MCNDTATPQLEELVTTVANQLMTVDAATSAEV
MSMEG_2196|M.smegmatis_MC2_155 -----------------------MSESLDVLVTSVATQLMAVEAATSVSV
MAV_2738|M.avium_104 ---------------------MRLRADAGSVFYRTQQARMLRIFLGATTF
MLBr_00397|M.leprae_Br4923 -------------------------------MDHTTKCDAEQYFQAIVTS
MUL_1212|M.ulcerans_Agy99 --------------------MSGTVMPIVRVAILADSRLTEVALPAELPL
Mvan_0374|M.vanbaalenii_PYR-1 VYALAVVQALVLDSPRSDARGEIVAVALTVAGLLVSLRAPLAGWRYVVAL
TH_3397|M.thermoresistible__bu LYALAVGVAVAVDTPPSDARGEVLAVLLCVVGVAAATPRPLRGRRYVTAL
Mflv_3822|M.gilvum_PYR-GCK VLAIVPALMVLSPSGPDTGFG-VAAGLVVSVLCALMAGVWFLHWPTRAES
MAB_3940c|M.abscessus_ATCC_199 IFAAICIAVQFSDTGPRSMIGRVIVGLCAVGSLGWALRWAVGPWPSLREA
Mb1389c|M.bovis_AF2122/97 SQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLI
Rv1354c|M.tuberculosis_H37Rv SQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLI
MSMEG_2196|M.smegmatis_MC2_155 SQQVLAELVSFFDVDVSFLRHNDHRAHATRLVAEWPPRPVDAATDPIAVV
MAV_2738|M.avium_104 LYAYGVVFTLFPIRAGLTLSNPAGGIVAVGLGLGALAWLAARPDKPAPAT
MLBr_00397|M.leprae_Br4923 MADGVIVVDIDGRIESINPAATRILGLRAHDVVDMKHGHPFCFYDTDNQR
MUL_1212|M.ulcerans_Agy99 REILPAVQRLVIPVAEDGDAGSADLGIAGHLSLAPVGGAPFSLDASLDTV
Mvan_0374|M.vanbaalenii_PYR-1 FCISAAPILSVLFHELIAAQIWS-------VVPLMFVAIFIRTWHSATTA
TH_3397|M.thermoresistible__bu GCAGAAPTVALLFHDQIAGQSWS-------VVPPMFMAVFLHTWHRGATA
Mflv_3822|M.gilvum_PYR-GCK IAFSILSNISIAVVALSWPDPLTGLLGCITFAALAGYVAFFHSSHYLVMV
MAB_3940c|M.abscessus_ATCC_199 VAFVAFADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANRLLVAH
Mb1389c|M.bovis_AF2122/97 YFADADPVFALCEHAKEPLVFRP-------EPATEDYQRLIEEARGVPVT
Rv1354c|M.tuberculosis_H37Rv YFADADPVFALCEHAKEPLVFRP-------EPATEDYQRLIEEARGVPVT
MSMEG_2196|M.smegmatis_MC2_155 HFADADPVFAMAEHLKEPAVFRP-------EPLYDDYQRTIEAGRHIPAT
MAV_2738|M.avium_104 VTAIVATPIVMAFHRVIIAEFVC-------LIAPMFLAMYLRAFYSPRRG
MLBr_00397|M.leprae_Br4923 VDLEREVMRVVRREVTTVSKVVG-----------------IDQHSGQRLW
MUL_1212|M.ulcerans_Agy99 GVVDGDLLVLQPVPTGPAAPGIVED---IADAAMIFSTSRLRPWDARHLQ
:
Mvan_0374|M.vanbaalenii_PYR-1 RVVVAGIAAAAVIALLVAP-------APIPVVWLAFYAVSVLGAAEVFGL
TH_3397|M.thermoresistible__bu RVASGAIAVAAATALLIAP-------APVPIMWVVLYVVCIPGAGEVYGL
Mflv_3822|M.gilvum_PYR-GCK LATAAGVAIICTADITAG---GDAYLAAVAFMMIAVAVLAVPFSAQVLVH
MAB_3940c|M.abscessus_ATCC_199 VAWCAPMIIALSSRLFAEGTVGAAMTALVKVTSMLLVVVLIPAVIQFGIA
Mb1389c|M.bovis_AF2122/97 SAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARVA
Rv1354c|M.tuberculosis_H37Rv SAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARVA
MSMEG_2196|M.smegmatis_MC2_155 SMACVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIASLFAQVQARIE
MAV_2738|M.avium_104 AALVAVLAGLSVAALAVAP-------TPKLSIDYAIFVIAIIGAAESFGL
MLBr_00397|M.leprae_Br4923 LSVNVSLLAYKAPP--------------------HSALVVSFSDISAHHL
MUL_1212|M.ulcerans_Agy99 RGALAALIGVALAGSGLAVAYRVATGALAGLLIVSVIAVAMALAGLLLGA
:
Mvan_0374|M.vanbaalenii_PYR-1 GNAALLDAAFRDPLTLVWNRAGVSRRVGRLVRQARRRSQE-----IAVLV
TH_3397|M.thermoresistible__bu ASSALFAMALHDPLTTVWNRAGVELKAEQIISRARRRGRS-----VAVIV
Mflv_3822|M.gilvum_PYR-GCK LLGDDALHSHTDPLTGLRNRRGFYRSVRRLL----RAAPDRDLNFLTVAM
MAB_3940c|M.abscessus_ATCC_199 VVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAI
Mb1389c|M.bovis_AF2122/97 AEARLRYLADHDDLTGLHNRRALLQHLDQRLAP---GQPGP----VAALF
Rv1354c|M.tuberculosis_H37Rv AEARLRYLADHDDLTGLHNRRALLQHLDQRLAP---GQPGP----VAALF
MSMEG_2196|M.smegmatis_MC2_155 AEERLRYLADHDHLTGLYNRRALMAHLEARLAP---GQPGP----VAVMF
MAV_2738|M.avium_104 LTRALVTAACTDPLTGLLNRAGWEIATADLLSRTRSATAT-----VTVVA
MLBr_00397|M.leprae_Br4923 SIERLTYEATHDCLTGLANRRFAEDQITKSLQHDERSRLA------AVLL
MUL_1212|M.ulcerans_Agy99 RSPRTGIALSIAALAPVGAALALAVPGSFGAAQVLLAAAGVTAWSLICLM
*: :
Mvan_0374|M.vanbaalenii_PYR-1 FDVDDFKRVNDQR--GHAAGDRLLTDLAGRWVAEIPRSSVMGRIGGDEFV
TH_3397|M.thermoresistible__bu LDVDDFKTINDRD--GHLVGDAVLVELTRRWAARVPASAALGRVGGDEFV
Mflv_3822|M.gilvum_PYR-GCK IDLDRFKQINDTR--GHATGDRLLVSISGCLCHCARGEAVVGRVGGEEFL
MAB_3940c|M.abscessus_ATCC_199 VDIDRFKSINDRY--GHGTGDRVLIDVAHALTCGTTGTSVVGRSGGEEFL
Mb1389c|M.bovis_AF2122/97 LDLDRLKAINDYL--GHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFV
Rv1354c|M.tuberculosis_H37Rv LDLDRLKAINDYL--GHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFV
MSMEG_2196|M.smegmatis_MC2_155 FDLDRLKAINDYL--GHTAGDAFISILAQRLQRGDDAPKLIARLGGDEFV
MAV_2738|M.avium_104 LDIDNFKTLNDTE--GHVAGDEYLVRCAAFWRQVAPAGAVLARFGGDEFA
MLBr_00397|M.leprae_Br4923 LDLDDFKVINDSL--GHDVGDAVLQTVAQRLRSAVRPDDVVARLGGDEFI
MUL_1212|M.ulcerans_Agy99 VPGEQRERIVALFTAVAVVGAALLLAAGVELLWQLPVSSIGCGLIVAALL
. : : : .* : :
Mvan_0374|M.vanbaalenii_PYR-1 LIVGG---------FDETQARALADQLTSG---LPVPVTYGVAAGPPG--
TH_3397|M.thermoresistible__bu VIAS----------CDQHRAGELAAELVDG---QAVHVSYGVAVGPAD--
Mflv_3822|M.gilvum_PYR-GCK IAEATRD--DDAEALAERLRLAIASTS------WGITASVGVACRRLN--
MAB_3940c|M.abscessus_ATCC_199 VVTVCPA--SAVAEFATRLRQAVTASMPAG---IAVTASVGVAAQAVSRV
Mb1389c|M.bovis_AF2122/97 LIPASPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPG--
Rv1354c|M.tuberculosis_H37Rv LIPASPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPG--
MSMEG_2196|M.smegmatis_MC2_155 VVPDDPMSLDEATALAYRLQSVLRERVTVDGEMLTRTVSIGIAQGIPG--
MAV_2738|M.avium_104 VCIA-----------DHHPTSAKADQFVASVRRHTPDTSVGTASGAGA--
MLBr_00397|M.leprae_Br4923 VLLRGPLSDMNANDVAKRLHTTLSESLVVDQLTVPIGASVGILEVRPD--
MUL_1212|M.ulcerans_Agy99 VTIQAAQLSAVWARFPLPVIPAPGDPTPSAPSLRVLEDLPRRVRVSDAHQ
:
Mvan_0374|M.vanbaalenii_PYR-1 -----HRALDTLFAAADRDLYERKRLR-----KA----------------
TH_3397|M.thermoresistible__bu -----KCDFATLFAAADADLYRRKRSR-----KAVPGR------------
Mflv_3822|M.gilvum_PYR-GCK GDADTRELLGDLIEAADSAMYEAKRSG-----GNQYRRARESAA------
MAB_3940c|M.abscessus_ATCC_199 VSATSQEAIEVLTACADRAMYEAKHDG-----GDQSRILHADDDSEGRYL
Mb1389c|M.bovis_AF2122/97 -----QHTPSDLLRRADQAALAAKHAG-----GDSVAIFTADMSVSGELR
Rv1354c|M.tuberculosis_H37Rv -----QHTPSDLLRRADQAALAAKHAG-----GDSVAIFTADMSVSGELR
MSMEG_2196|M.smegmatis_MC2_155 -----KDSTSDVLNRADHAVLTAKGSG-----GNRVAVFSDAMAMEIDFR
MAV_2738|M.avium_104 -----SADIASLYAAADAELYSAKRRR-----RDPGLRPARG--------
MLBr_00397|M.leprae_Br4923 ----DRRRAADILRDADSAMYAAKNKKQCAVTPQQLVPFVALIALFVFFT
MUL_1212|M.ulcerans_Agy99 SGFIAAAVLLSVLGSVAIALRPDTVSA----LGWYVVAATAATATLRARI
: . .
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 WRSGA---------------------------------------------
Mb1389c|M.bovis_AF2122/97 NDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAP
Rv1354c|M.tuberculosis_H37Rv NDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAP
MSMEG_2196|M.smegmatis_MC2_155 NDIELHLQSVIEGGALVLHYLPEIDMRTGEVLAAEALVRWEHPTRGLLSP
MAV_2738|M.avium_104 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 AAAGAKFYAPSNLLVILQQTVVLAIVGYGMTFVIMAGSVDLSVGSIVALT
MUL_1212|M.ulcerans_Agy99 WDSAACKAWLLTQPYLVGGTLLVLYAATGHFIAAFGALVVLAVLAVAWVV
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQ
Rv1354c|M.tuberculosis_H37Rv GCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQ
MSMEG_2196|M.smegmatis_MC2_155 DSFIGVAESINLAGELGRWVLRTACAEFSRWRANGVGRNIVLRINVSPVQ
MAV_2738|M.avium_104 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GVTAALVAAQNQFAAIVTALLVGLAAGMVNGIVFAYGKIPSFVSTLGMLQ
MUL_1212|M.ulcerans_Agy99 VALNPVIASPESYSLPLRRLLGFLAAGLDASLIPVMAYLAGLFTWVLNR-
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 LVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEV
Rv1354c|M.tuberculosis_H37Rv LVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEV
MSMEG_2196|M.smegmatis_MC2_155 LVTDGFVESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNV
MAV_2738|M.avium_104 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 VCRGITLMISDSSAKPMPFHGILGAMGAMPWILIVCLFVTILAGILFQFT
MUL_1212|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 GVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGI
Rv1354c|M.tuberculosis_H37Rv GVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGI
MSMEG_2196|M.smegmatis_MC2_155 GVQVAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRAV
MAV_2738|M.avium_104 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 MFGRWVKAIG-GNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRL
MUL_1212|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3397|M.thermoresistible__bu --------------------------------------------------
Mflv_3822|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 MTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHM
Rv1354c|M.tuberculosis_H37Rv MTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHM
MSMEG_2196|M.smegmatis_MC2_155 IALAGAFGLQLVAEGVETERAALTLLRHGCYRAQGFLLSKPILGSEMQTL
MAV_2738|M.avium_104 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 GAGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGM
MUL_1212|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0374|M.vanbaalenii_PYR-1 -----------------------------------
TH_3397|M.thermoresistible__bu -----------------------------------
Mflv_3822|M.gilvum_PYR-GCK -----------------------------------
MAB_3940c|M.abscessus_ATCC_199 -----------------------------------
Mb1389c|M.bovis_AF2122/97 LSARRLPPTCIPATDPALS----------------
Rv1354c|M.tuberculosis_H37Rv LSARRLPPTCIPATDPALS----------------
MSMEG_2196|M.smegmatis_MC2_155 LAKGRVPVHFSAAPRM-------------------
MAV_2738|M.avium_104 -----------------------------------
MLBr_00397|M.leprae_Br4923 VFMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK
MUL_1212|M.ulcerans_Agy99 -----------------------------------