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TRSLDELVTRVASKLMAATAATAVTISEGVLAILVEHFGVDVSFLRHNNHDIHETKLIVEWPPRDYVPDP DPIGVVYFADADPVFAMAEYLKEPAVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGVLGFVK YGDREWHDDELRALQAIATLFAQLQARIVAEEQLRYLAEHDDLTGLLNRRALIAHLDERLADGQRGPVTL LFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFAHRLQ TRLQKQVVIDGEILTRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDGSKVVVLDHGISAQHTLRTEV ELHLAGMIDTDLVLHYLPEVDMSTGKVLGTEALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSA CAEFSRWRSAGVGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCLEITENVVVQNIDATRKTL AGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDTIKIDKSFVAELGSNASDLAIVRAIMALAKEFELEVVAE GVETAVAAQVLLELGCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01750 | - | - | 100% (623) | hypothetical protein MLBr_01750 |
| M. leprae Br4923 | MLBr_01752 | - | 2e-33 | 36.17% (235) | hypothetical protein MLBr_01752 |
| M. leprae Br4923 | MLBr_00397 | - | 2e-23 | 37.14% (175) | putative transporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 0.0 | 63.14% (605) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_4377 | - | 0.0 | 65.95% (608) | diguanylate cyclase/phosphodiesterase with GAF sensor |
| M. tuberculosis H37Rv | Rv1354c | - | 0.0 | 63.14% (605) | hypothetical protein Rv1354c |
| M. abscessus ATCC 19977 | MAB_0124 | - | 2e-13 | 35.97% (139) | hypothetical protein MAB_0124 |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 0.0 | 66.83% (618) | GGDEF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 0.0 | 64.91% (607) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 0.0 | 66.56% (607) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1967 | - | 0.0 | 66.50% (606) | diguanylate cyclase/phosphodiesterase with GAF sensor |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01750|M.leprae_Br4923 -----MTRS-----LDELVTRVASKLMAATAATAVTISEGVLAILVEHFG
MAV_3132|M.avium_104 -----MSGT-----LDHLVTAAAAELMAATAADAAQISERVLADLVSHFG
Mflv_4377|M.gilvum_PYR-GCK -----MSES-----LDLVVTSVATRLMGAGAATWAEASQQVLADLVEHFG
Mvan_1967|M.vanbaalenii_PYR-1 -----MSDSDTLRSLDLVITSVATKLMAANAATSVEVSQRVLAELVDYLG
MSMEG_2196|M.smegmatis_MC2_155 -----MSES-----LDVLVTSVATQLMAVEAATSVSVSQQVLAELVSFFD
TH_0811|M.thermoresistible__bu -----VSTE-----LDLLVTGVATKLMAADAATARDVSRRVLADLVRAFE
Mb1389c|M.bovis_AF2122/97 -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
Rv1354c|M.tuberculosis_H37Rv -----MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLG
MAB_0124|M.abscessus_ATCC_1997 MGAGEMTFGQEYRFATRALTVTRNLVPLKIAIGLLCLSIVVLGTLIQFHP
: :* . : * * **. *:
MLBr_01750|M.leprae_Br4923 VDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADPVF
MAV_3132|M.avium_104 VNFG----FLRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADSVF
Mflv_4377|M.gilvum_PYR-GCK VDVS----FLRRNDHTIRASVLVAEWPVRPGIPDPDPLAVVYFADADPVF
Mvan_1967|M.vanbaalenii_PYR-1 VDVS----FLRYNDHKIRASRLVAEWPVRPGVPDPDPLALVYFADADPVF
MSMEG_2196|M.smegmatis_MC2_155 VDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADPVF
TH_0811|M.thermoresistible__bu LDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADPVF
Mb1389c|M.bovis_AF2122/97 VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
Rv1354c|M.tuberculosis_H37Rv VDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVF
MAB_0124|M.abscessus_ATCC_1997 LGPHGLWPRLIHGVLVASALVVGMCWVVLPWPRRRVAIAFVWWADISMVV
:. * . : * .: .: : . . *.
MLBr_01750|M.leprae_Br4923 AMAEYLKEPAVLRPEPANADYQRRIEEGASVPAVSLACVPLLSGEITTGV
MAV_3132|M.avium_104 ARVETMKEPDVLRPEPANADYQRNIEDGTGIPEVSLAAVPLLSGDVTTGT
Mflv_4377|M.gilvum_PYR-GCK ALAEFQKEPLVFRPDANTDEYQKTIEEGRQVPQVSMAAVPLLSGDVTTGV
Mvan_1967|M.vanbaalenii_PYR-1 AQSEHGKKPMVFRPEPATDDYQKRIEETRAVPATSMAAAPLVSGELTTGV
MSMEG_2196|M.smegmatis_MC2_155 AMAEHLKEPAVFRPEPLYDDYQRTIEAGRHIPATSMACVPLLSGDVTTGV
TH_0811|M.thermoresistible__bu ALAEHAKEIHIFRPEPATDEFQRLIEESSGVPASTVAAVPLVSGEITTGV
Mb1389c|M.bovis_AF2122/97 ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
Rv1354c|M.tuberculosis_H37Rv ALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGL
MAB_0124|M.abscessus_ATCC_1997 GACTLSAPASRLGALAHMGLIG--VFAAFLLGWRVLAVHCVFATVAIFGL
. : . . : : * :.: *
MLBr_01750|M.leprae_Br4923 LGF-VKYGDREWHDDELR---ALQAIATLFAQLQARIVAEEQ----LRYL
MAV_3132|M.avium_104 LGF-VKFGDREWLSEELN---ALQAIAALFAQLQARVVAEEQ----IHYL
Mflv_4377|M.gilvum_PYR-GCK LGF-VKFGDRDWTGVELN---ALKAIASLFAQVQARVEAETQ----LRYL
Mvan_1967|M.vanbaalenii_PYR-1 LGF-IKFGDREWTAEELN---GLEAIASLFAQVQARVQAEEQ----LRYL
MSMEG_2196|M.smegmatis_MC2_155 LGF-VKFGDREWLPAELN---ALKAIASLFAQVQARIEAEER----LRYL
TH_0811|M.thermoresistible__bu LGF-VKYGDRQWHPDELN---ALKAIASLFAQVQARVEAEER----LRYL
Mb1389c|M.bovis_AF2122/97 LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
Rv1354c|M.tuberculosis_H37Rv LGF-IKFGDRKWHEAELN---ALMTIATLFAQVQARVAAEAR----LRYL
MAB_0124|M.abscessus_ATCC_1997 MGWNVRLGEATWFDQYVYSAPALSSVVLLPIIIQVVVEGGRRSLKAISLA
:*: :: *: * : .* ::. * :*. : . : :
MLBr_01750|M.leprae_Br4923 AEHDDLTGLLNRRALIAHLDERLADGQRG-PVTLLFLGLDRLKAVNDYLG
MAV_3132|M.avium_104 AEHDELTGLLNRRALIAHLDKRLAPGQPG-PVPVVFLAIDRFKVINGRLG
Mflv_4377|M.gilvum_PYR-GCK AEHDDLTGLNNRRALLSHLDGRLAEGQPG-PVSALFFDLDRLKAINDYLG
Mvan_1967|M.vanbaalenii_PYR-1 AEHDDLTGLYNRRALLAHLDERLAEGRPG-PVSALFFDLDRLKAINDYLG
MSMEG_2196|M.smegmatis_MC2_155 ADHDHLTGLYNRRALMAHLEARLAPGQPG-PVAVMFFDLDRLKAINDYLG
TH_0811|M.thermoresistible__bu AEHDDLTGLHNRRALLAHLDARLAAGQPG-PVSALYFDLDRLKAVNDYLG
Mb1389c|M.bovis_AF2122/97 ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
Rv1354c|M.tuberculosis_H37Rv ADHDDLTGLHNRRALLQHLDQRLAPGQPG-PVAALFLDLDRLKAINDYLG
MAB_0124|M.abscessus_ATCC_1997 AHQDPLTGLLNRRGVQVALSSLLSGQRATRIVAVVLVDVDELKELNDRLG
*.:* **** ***.: *. *: : *. : . :*.:* :*. **
MLBr_01750|M.leprae_Br4923 HNAGDRLIEVFADRLREAAESLTVIARFGGDEFVVVPAESVSVDVAESFA
MAV_3132|M.avium_104 QDAGDRFIDAFAALLREATEIPSVIARFGGDEFGVVPAAPMDVEAAESFA
Mflv_4377|M.gilvum_PYR-GCK HTAGDWFIRVLAERLREGADPRALIARLGGDEFVVVPAGPMDGEAAESLA
Mvan_1967|M.vanbaalenii_PYR-1 HTAGDWFIRVLAERLRRGADCPNIIARLGGDEFVLVPTVPMDGAAAEALA
MSMEG_2196|M.smegmatis_MC2_155 HTAGDAFISILAQRLQRGDDAPKLIARLGGDEFVVVPDDPMSLDEATALA
TH_0811|M.thermoresistible__bu HTVGDWFIRVLAERLREGAGPDDLIARLGGDEFVVVPSGPVDADAALELA
Mb1389c|M.bovis_AF2122/97 HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
Rv1354c|M.tuberculosis_H37Rv HAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLA
MAB_0124|M.abscessus_ATCC_1997 HDAGDESIRAVAAMLATTTRASDLTARMGGDEFMVVG----FFDHADEAT
: .** * .* : : **:***** :: * :
MLBr_01750|M.leprae_Br4923 HRLQTRLQKQVVIDGEILTRTVSIGVATGLPGRDTTSDLLRWADHAALSA
MAV_3132|M.avium_104 HSLHERLHHPIAIDDEMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSA
Mflv_4377|M.gilvum_PYR-GCK HQLQSTLKERVSIDGEMLTRTVSIGVAVGIPGQDTTSDLLRRADQAVLTA
Mvan_1967|M.vanbaalenii_PYR-1 HRLQSTLRERVSIDGEMLTRTVSIGVAQGIPGRDTTSDLLRRADQAVLTA
MSMEG_2196|M.smegmatis_MC2_155 YRLQSVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTA
TH_0811|M.thermoresistible__bu NRLRSRLQQQVCVDGEMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTA
Mb1389c|M.bovis_AF2122/97 ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
Rv1354c|M.tuberculosis_H37Rv ERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAA
MAB_0124|M.abscessus_ATCC_1997 GLIERIGARRFGIGPHRASVSMGSAMRSTSVAGFDFESLRRAADEELRGA
:. . :. . : : . .: . ..: . .*. *
MLBr_01750|M.leprae_Br4923 KSDG-SKVVVLDHGISAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDM
MAV_3132|M.avium_104 KAAGGNNVATFRPEMSTIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDM
Mflv_4377|M.gilvum_PYR-GCK KNSGGNRVTVFTEEMSLKQEFNNDIELHLQSVIEN--GALLLHYLPEIDM
Mvan_1967|M.vanbaalenii_PYR-1 KGSGGNEVVVFTDDMSMRHEFNNDIELHLQSVIEN--GALLLHYLPEVDM
MSMEG_2196|M.smegmatis_MC2_155 KGSGGNRVAVFSDAMAMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDM
TH_0811|M.thermoresistible__bu KSAGGNQITVFTDDMSLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDM
Mb1389c|M.bovis_AF2122/97 KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDL
Rv1354c|M.tuberculosis_H37Rv KHAGGDSVAIFTADMSVSGELRNDIELHLRRGIES--DALRLVYLPEVDL
MAB_0124|M.abscessus_ATCC_1997 KIERRNGFHAVP--------------------------------------
* . . .
MLBr_01750|M.leprae_Br4923 STGKVLGTEALVRWQHPTRGLLFPDSFIPVAESINLAGKLGRMVMHSACA
MAV_3132|M.avium_104 RTGEILGTEALTRWQHPTLGLLMPDSFIQVAESINLGAKLGRLVMRSACA
Mflv_4377|M.gilvum_PYR-GCK RTGDILAMEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACT
Mvan_1967|M.vanbaalenii_PYR-1 RTGEILACEALVRWQHPTRGLLSPESFIGVAESINLAGELGRWVMRSACA
MSMEG_2196|M.smegmatis_MC2_155 RTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLAGELGRWVLRTACA
TH_0811|M.thermoresistible__bu RTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLAGELGRWVMRTACG
Mb1389c|M.bovis_AF2122/97 RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
Rv1354c|M.tuberculosis_H37Rv RTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACN
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01750|M.leprae_Br4923 EFSRWRSAGVGLDALLRINVSPVQLVAEGFVDNVAGTLDEFGLDGSMVCL
MAV_3132|M.avium_104 QFGQWRSRGVGQGTVLRINVSPVQLVTAGIVDTVAATLDEFGLDPSTVCL
Mflv_4377|M.gilvum_PYR-GCK DFARWRALGIGKDAIMRINVSPVQLVTDGFVESVAGIVDEFGLEHGSVCL
Mvan_1967|M.vanbaalenii_PYR-1 DFAGWRARGIGTGTVMRINVSPVQLVTDGFVESVAGIVDEFDLDEGSVCL
MSMEG_2196|M.smegmatis_MC2_155 EFSRWRANGVGRNIVLRINVSPVQLVTDGFVESVAGIMKEFGLPRGSVCL
TH_0811|M.thermoresistible__bu EFAKWRAEGIGLDAVLRINVSPVQLVTDGFVASVADIIDEFGLDGSSVCL
Mb1389c|M.bovis_AF2122/97 EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
Rv1354c|M.tuberculosis_H37Rv EFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01750|M.leprae_Br4923 EITENVVVQNIDATRKTLAGLKEVGVHLAIDDFGTGYSVLTHLKSLPVDT
MAV_3132|M.avium_104 EITESVVVQDIDATRQTLFGLKDIGVQIAIDDFGTGYSVLTYLKSLPVDS
Mflv_4377|M.gilvum_PYR-GCK EITESVVVQDIETTRVTLNGLKKAGVLVAIDDFGTGYSALSHLKSLPVDT
Mvan_1967|M.vanbaalenii_PYR-1 EITESVVVQDIETTRVTLKGLKEAGVRIAIDDFGTGYSALSHLKSLPVDT
MSMEG_2196|M.smegmatis_MC2_155 EITESVVVQDIETTRTTLTGLHNVGVQVAIDDFGTGYSVLSLLKSLPVDT
TH_0811|M.thermoresistible__bu EITESVVVQDIKTTRITLEGLNEVGVQVAIDDFGTGYSVLSHLKTLPVDT
Mb1389c|M.bovis_AF2122/97 EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
Rv1354c|M.tuberculosis_H37Rv EITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDT
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01750|M.leprae_Br4923 IKIDKSFVAELGSNASDLAIVRAIMALAKEFELEVVAEGVETAVAAQVLL
MAV_3132|M.avium_104 LKIDKGFVQSLDTNPGDLAIVRSTLALADAFGLDVVAEGVETVAAAETLL
Mflv_4377|M.gilvum_PYR-GCK LKIDKSFVRELGSDPGDLAIVRAIIALAEAFGLELVAEGVETDVGALTLL
Mvan_1967|M.vanbaalenii_PYR-1 LKIDKSFVRELGSDPGDLAIVRAVIALAEAFGLELVAEGVETEAAAMTLL
MSMEG_2196|M.smegmatis_MC2_155 LKIDRSFVAELGSNPGDLPIVRAVIALAGAFGLQLVAEGVETERAALTLL
TH_0811|M.thermoresistible__bu LKIDKGFVQDLGNSPGDLAIVRAIIALAEAFGLQLVAEGVETEAAALTLL
Mb1389c|M.bovis_AF2122/97 LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
Rv1354c|M.tuberculosis_H37Rv LKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILL
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01750|M.leprae_Br4923 ELGCNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSEHQIHRS
MAV_3132|M.avium_104 SLGCHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQHVV---
Mflv_4377|M.gilvum_PYR-GCK RHGCHRAQGFLLSRPIPTDAMETLLAQGRIPVSFSKG-------------
Mvan_1967|M.vanbaalenii_PYR-1 RHGCHRAQGFLLSRPIDGAAMKALLARGRVPVSFAKS-------------
MSMEG_2196|M.smegmatis_MC2_155 RHGCYRAQGFLLSKPILGSEMQTLLAKGRVPVHFSAAPRM----------
TH_0811|M.thermoresistible__bu RHGCHRAQGFLLSRPIPSNEMRELLARGRIPMRFSATP------------
Mb1389c|M.bovis_AF2122/97 DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
Rv1354c|M.tuberculosis_H37Rv DQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-------
MAB_0124|M.abscessus_ATCC_1997 --------------------------------------------------