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ARGDRSPRDAHADRVRNALLNAALNLFSTNGYDETTTDQIAESVGVSPRTFFRYFPTKESVLFFGEYDFI DAVSGVYLAQPEEASDFEALANSFALLAPGLKRIRKRIAQYHDAVASSLVLLGRERKNHEANAETVAQVI AERRRMPAPDSECRLLAAVGMLLVERALNQWLSTPGRSLDDLIRQEFAALPAVLK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2657 | - | - | 100% (196) | transcriptional regulator |
| M. avium 104 | MAV_1952 | - | 4e-77 | 78.98% (176) | transcriptional regulator |
| M. avium 104 | MAV_0474 | - | 3e-17 | 30.26% (195) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3860c | - | 2e-11 | 27.69% (195) | transcriptional regulatory protein TetR-family |
| M. gilvum PYR-GCK | Mflv_1728 | - | 1e-15 | 32.07% (184) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3830c | - | 2e-11 | 27.69% (195) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_00717 | - | 7e-06 | 25.65% (191) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3837 | - | 7e-08 | 25.53% (188) | transcriptional regulatory protein TetR |
| M. marinum M | MMAR_0222 | - | 7e-15 | 31.07% (177) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5673 | - | 3e-12 | 39.76% (83) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3524 | - | 4e-16 | 35.23% (176) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4892 | - | 7e-15 | 31.07% (177) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1927 | - | 1e-17 | 32.22% (180) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1728|M.gilvum_PYR-GCK MAEPRGEPVLGLRERKKRRTRATLIDAAMGLCDRQGFDATTVDQIAAIAE
MSMEG_5673|M.smegmatis_MC2_155 MAYQTQQP--GLRERKKQRTRATLISAAIDLCVRQGYEQTTVEQIAAAAE
MMAR_0222|M.marinum_M MSPPPAAT--SLAERKRTATRQRIATAAAQLVADLGLAAATVERIADTAD
MUL_4892|M.ulcerans_Agy99 MSPPPAAT--ALAERKRTATRQRIATAAAQLVADLGLVAATVERIADTAD
Mb3860c|M.bovis_AF2122/97 MVRPPQTA-------RSERTREALRQAALVRFLAQGVEATSAEQIAEDAG
Rv3830c|M.tuberculosis_H37Rv MVRPPQTA-------RSERTREALRQAALVRFLAQGVEATSAEQIAEDAG
MAV_2657|M.avium_104 MARGDRSP----RDAHADRVRNALLNAALNLFSTNGYDETTTDQIAESVG
TH_3524|M.thermoresistible__bu --------------VRGHRNREALIAAAIDLFTVNGYEQTTVEQIAEAAG
Mvan_1927|M.vanbaalenii_PYR-1 MSAAVIPGYDRRMSRWQPNARERLEQAALELYTRQGFDQTTVDDIAQRAG
MAB_3837|M.abscessus_ATCC_1997 MNAQPARVG-----RRPSTTRDEITAVAMTLFAQHGFDEVSVDDIAAAAG
MLBr_00717|M.leprae_Br4923 MTTARRRLS-------PEDRRAELLALGAEVFGKRPYDEVRIDEIAERAG
* : . . : ** .
Mflv_1728|M.gilvum_PYR-GCK VSPRTFSRYFATK-DAIALALIDEVLDSAAAELARQPLDIGNFEALRRAY
MSMEG_5673|M.smegmatis_MC2_155 VSARTFSRYFATK-DAVMLAFLDDVVDLVAGELAQQPPELGELDAVFCAH
MMAR_0222|M.marinum_M ISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHLSAVEAVVGAF
MUL_4892|M.ulcerans_Agy99 ISRATFFRYFNSKEDAVAEGMTAHWLDRIATALAAQPEHQSAVEAVVGAF
Mb3860c|M.bovis_AF2122/97 VSLRTFYRHFRSK-HDLLFADYDAGLHWFRAALDARPADESIIDSVQAAI
Rv3830c|M.tuberculosis_H37Rv VSLRTFYRHFRSK-HDLLFADYDAGLHWFRAALDARPADESIIDSVQAAI
MAV_2657|M.avium_104 VSPRTFFRYFPTK-ESVLFFGEYDFIDAVSGVYLAQPEEASDFEALANSF
TH_3524|M.thermoresistible__bu VAPRTFFRHFAAKEDILFHGYADRLAEATRRFRAARSG--SLWKALAEAS
Mvan_1927|M.vanbaalenii_PYR-1 LTERTFFRHFADK-REVLFSGQAALIDLVTASVAAQEDTDPPLDVVAAAL
MAB_3837|M.abscessus_ATCC_1997 IARRTVFRYYSSK-NAIVWGDFDSHLGVMRALLDETADTVDTSTALRQAV
MLBr_00717|M.leprae_Br4923 VSRALMYHYFPDKRAFFAAVVKDEADRLYAATNIPPPAGLTMFEEVRVGV
:: . ::: * . : .
Mflv_1728|M.gilvum_PYR-GCK IAMARNTKLAAAGALTSERMLQILRIVMSS----GTLRQATVEYRA---S
MSMEG_5673|M.smegmatis_MC2_155 ITAFEKTRVAMPGQLTDDRLLAAARIFTSS----PSLMQATMGFRP---A
MMAR_0222|M.marinum_M G------GLAVGFAEMEDQVRELATLTRSS----ETLEAWTLHIYVRYES
MUL_4892|M.ulcerans_Agy99 G------GLAVGFAEMEDQVRELATLTRSS----ETLEAWTLHIYVRYES
Mb3860c|M.bovis_AF2122/97 FSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNC
Rv3830c|M.tuberculosis_H37Rv FSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNC
MAV_2657|M.avium_104 A------LLAPGLKRIRKRIAQYHDAVASS----LVLLGRERKNHEANAE
TH_3524|M.thermoresistible__bu E------AVATAIAENPGIFLVRARMYGEL----PALRATMLRINDDWID
Mvan_1927|M.vanbaalenii_PYR-1 T------AAGSALDGRGDRARQRQAVIDAN----PGLRERELIKLA----
MAB_3837|M.abscessus_ATCC_1997 LT-----FNDFPVDETPRHRMRMRMILEVP-----ALQAYSMLMYTGWRD
MLBr_00717|M.leprae_Br4923 LAYMAYHKQNPEAAWAAYVGLGRSDPVLLG--IDDEAKNRQMEHIMSRIG
Mflv_1728|M.gilvum_PYR-GCK KVDRLLAERMG-TSVHDRRVKLLAAVWGAVLITAMDDLAR-KHVSGISVD
MSMEG_5673|M.smegmatis_MC2_155 PLFEVLAKRMG-VSADDRKIALIASLWNAIMTTALVQLVPDVDWATVTVE
MMAR_0222|M.marinum_M AIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLG---QGGSLPD
MUL_4892|M.ulcerans_Agy99 AIADLIAPRIPNLVPQDPRPRLVGALAMAVVRIALDDWLG---QGGSLPD
Mb3860c|M.bovis_AF2122/97 DIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSLGELARVCHVALE
Rv3830c|M.tuberculosis_H37Rv DIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSLGELARVCHVALE
MAV_2657|M.avium_104 TVAQVIAERRR-MPAPDSECRLLAAVGMLLVERALNQWLS--TPGRSLDD
TH_3524|M.thermoresistible__bu QMTTEVARWLGSDAAVDVRPRLAATVINGANRTAIDLWVS-ADGKGDLVE
Mvan_1927|M.vanbaalenii_PYR-1 TLADTLAEALRQRGVEAPAARLAAEVGLAVFRVAFERWVQ-SPGGAPLPT
MAB_3837|M.abscessus_ATCC_1997 VIAQFVARRSG-TDPGSLLPQTVAWTLLGVALAAYEQWLA--DESSKLTT
MLBr_00717|M.leprae_Br4923 DVVSVVPESKLHPDIERDLRVIVHGWLAFTFEVCRQRIMDPSTDADRLAD
: .
Mflv_1728|M.gilvum_PYR-GCK DVISAFDDTYAEFAGEIAGIGQPV---------
MSMEG_5673|M.smegmatis_MC2_155 RIVNQMRTTYAEFL-EVAGRRHEFA--------
MMAR_0222|M.marinum_M RVQQGLAAIVIA---------------------
MUL_4892|M.ulcerans_Agy99 RVQQGLAAIVIA---------------------
Mb3860c|M.bovis_AF2122/97 SLRVGISDTWTTLTVSS----------------
Rv3830c|M.tuberculosis_H37Rv SLRVGISDTWTTLTVSS----------------
MAV_2657|M.avium_104 LIRQEFAALPAVLK-------------------
TH_3524|M.thermoresistible__bu LMADAVRLVRPTLDRIERESRTVANPVRRRDVV
Mvan_1927|M.vanbaalenii_PYR-1 LIAAAFADLRRIVA-------------------
MAB_3837|M.abscessus_ATCC_1997 LLGKGFDAAEVGLRALR----------------
MLBr_00717|M.leprae_Br4923 SCAHALLDAIARVPEISKELADAMAIARQPPQ-
.