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VAEPRGEPVLGLRERKKRRTRATLIDAAMGLCDRQGFDATTVDQIAAIAEVSPRTFSRYFATKDAIALAL IDEVLDSAAAELARQPLDIGNFEALRRAYIAMARNTKLAAAGALTSERMLQILRIVMSSGTLRQATVEYR ASKVDRLLAERMGTSVHDRRVKLLAAVWGAVLITAMDDLARKHVSGISVDDVISAFDDTYAEFAGEIAGI GQPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1728 | - | - | 100% (214) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0350 | - | 6e-14 | 32.14% (168) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_5173 | - | 3e-13 | 45.45% (88) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3860c | - | 7e-07 | 30.67% (163) | transcriptional regulatory protein TetR-family |
| M. tuberculosis H37Rv | Rv3830c | - | 8e-07 | 30.67% (163) | transcriptional regulatory protein TetR-family |
| M. leprae Br4923 | MLBr_00064 | - | 9e-05 | 32.47% (77) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0248c | - | 6e-10 | 34.86% (109) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3438 | - | 2e-13 | 31.22% (221) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4894 | - | 1e-15 | 33.90% (177) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5673 | - | 3e-48 | 49.50% (200) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_4253 | - | 3e-41 | 45.31% (192) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2714 | - | 1e-13 | 31.22% (221) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5023 | - | 3e-75 | 71.92% (203) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1728|M.gilvum_PYR-GCK ----MAEPRGEPVLGLRERKKRRTRATLIDAAMGLCDRQG-FDATTVDQI
Mvan_5023|M.vanbaalenii_PYR-1 ---------------MRERKKRRTRATLIDAAVGLCDRQG-YDATTVDQI
MSMEG_5673|M.smegmatis_MC2_155 ----MAYQTQQP--GLRERKKQRTRATLISAAIDLCVRQG-YEQTTVEQI
TH_4253|M.thermoresistible__bu --------------------------MLTDAAVELFLRHG-YENTTVDQI
Mb3860c|M.bovis_AF2122/97 -----------MVRPPQTARSERTREALRQAALVRFLAQG-VEATSAEQI
Rv3830c|M.tuberculosis_H37Rv -----------MVRPPQTARSERTREALRQAALVRFLAQG-VEATSAEQI
MMAR_3438|M.marinum_M ------MPDDHPPTGLRQRKKADTRRALSDAALALAFERG-LDNVTREDI
MUL_2714|M.ulcerans_Agy99 ------MPDDHPPTGLRQRKKADTRRALSDAALALAFERG-LDNVTREDI
MAB_0248c|M.abscessus_ATCC_199 ---------MRPASGLREQKKSETKLALSRAALELALDRGDLAAVTVDDI
MAV_4894|M.avium_104 ------MPASEAPPGLRERKKIKTRQAIRREAFRLIEQNG-YAATTVEQI
MLBr_00064|M.leprae_Br4923 MINSTAGQTSQSRSRRSTRPSGDDRELAILATAEQLLEDRPLTEISVDYL
: : : :
Mflv_1728|M.gilvum_PYR-GCK AAIAEVSPRTFSRYFATKDAIALALIDEVLDSAAAELA--RQPLDIGNFE
Mvan_5023|M.vanbaalenii_PYR-1 AHVAEVSPRTFSRYFATKDAIALALIDEVLVHTAVELV--RQPRYLPHME
MSMEG_5673|M.smegmatis_MC2_155 AAAAEVSARTFSRYFATKDAVMLAFLDDVVDLVAGELA--QQPPELGELD
TH_4253|M.thermoresistible__bu AAVADVSPRTFSRYFATKDAVIVTLLDENLDQGARALR--EQPADMNHYD
Mb3860c|M.bovis_AF2122/97 AEDAGVSLRTFYRHFRSKHDLLFADYDAGLHWFRAALD--ARPADESIID
Rv3830c|M.tuberculosis_H37Rv AEDAGVSLRTFYRHFRSKHDLLFADYDAGLHWFRAALD--ARPADESIID
MMAR_3438|M.marinum_M ANVAGVSLRTFNNYFTGKYEALAYRQTERMRRSIAALR--ERPAGEPLWT
MUL_2714|M.ulcerans_Agy99 ANVAGVSLRTFNNYFTGKYEALAYRQTERMRRSIAALR--ERPAGEPLWT
MAB_0248c|M.abscessus_ATCC_199 ADAVRVSARTFRNYFTSKEDAVLFSLRGIEDNAVALLR--QRPQHEHVVD
MAV_4894|M.avium_104 AEAADVSPSTFFRYFGSKESLLLA--DDLDPLILDALK--AQPRELSLPQ
MLBr_00064|M.leprae_Br4923 AKSAGISRPTFYFYFASKEAVLLTLLDRVFNKANAALETLIKNRDNKRGN
* . :* ** :* * * :
Mflv_1728|M.gilvum_PYR-GCK ALRRAYIAMARNTKLAAAGA---LTSERMLQILRIVMSSGTLRQATVEYR
Mvan_5023|M.vanbaalenii_PYR-1 ALRRAYVAMAEASKLAPPGA---LSAQRLLQILRIIVSSPTLRQAAVGYR
MSMEG_5673|M.smegmatis_MC2_155 AVFCAHITAFEKTRVAMPGQ---LTDDRLLAAARIFTSSPSLMQATMGFR
TH_4253|M.thermoresistible__bu ALFCAYRLFYARTKDAGPDD---LTSDRVVAMTRIIMCSPTLRQAVGEFR
Mb3860c|M.bovis_AF2122/97 SVQAAIFSFPYDVDAVTKIA---SLRRGELEPSRIVRHMREVEADFADAI
Rv3830c|M.tuberculosis_H37Rv SVQAAIFSFPYDVDAVTKIA---SLRRGELEPSRIVRHMREVEADFADAI
MMAR_3438|M.marinum_M AIAHAVLEPLQADLHEATADEDRLPSRGELAEVRKLLMNPQIREAASREL
MUL_2714|M.ulcerans_Agy99 AIAHAVLEPLQADLHEATADEDRLPSRGELAEVRKLLMNPQIREAASREL
MAB_0248c|M.abscessus_ATCC_199 SLEAVMLDLATSEAFSTTVA----VTRLSAQNPGLAAHDAARSEDVGTVV
MAV_4894|M.avium_104 AFRRAYATVLSQLPDD--------QLEFESTRQRLMFSIPELKAAMYDEY
MLBr_00064|M.leprae_Br4923 KWRTGINVFFETFGSHKAVTCAGQVTRDNTEVRKLWSTFMQKWISYTAAV
Mflv_1728|M.gilvum_PYR-GCK A---SKVDRLLAERMGTSVH-DRRVKLLAAVWGAVLITAMDDLAR-KHVS
Mvan_5023|M.vanbaalenii_PYR-1 A---GPVDAVVAERMGATVD-DRRVKLVAAVWGVVLMTALQDVCR-SAVD
MSMEG_5673|M.smegmatis_MC2_155 P---APLFEVLAKRMGVSAD-DRKIALIASLWNAIMTTALVQLVPDVDWA
TH_4253|M.thermoresistible__bu P---HAVNVALAERMAVDLE-DSRLRLVSSVWDAIMWASQQDLGPHTDWD
Mb3860c|M.bovis_AF2122/97 Q---AQLRRRNCDIAGAPDA-RLHIAVTARCVAAAVFGAMEAWMLGSDRS
Rv3830c|M.tuberculosis_H37Rv Q---AQLRRRNCDIAGAPDA-RLHIAVTARCVAAAVFGAMEAWMLGSDRS
MMAR_3438|M.marinum_M L---EDWRDAIAERTGTDPENDMYPRLVVAVVRAVGDAAMDTYAT--ADP
MUL_2714|M.ulcerans_Agy99 L---EDWRDAIAERTGTDPENDMYPRLVVAVVRAVGDAAMDTYAT--ADP
MAB_0248c|M.abscessus_ATCC_199 L---TEVSR----RAGLDPDVDLYPRLVCNAAYAVLATVIQLAVS-GSKL
MAV_4894|M.avium_104 YRTVTVAAEAIAHRIGRAAD-DFEVRVFAGALTGAMMAAFDSAPTTPETI
MLBr_00064|M.leprae_Br4923 ID--AERKRGVAPDTLPATELATALNLMNERALFASFTAEQPHVPESRVL
:
Mflv_1728|M.gilvum_PYR-GCK GISVDDVISAFDDTYAEFAGEIAGIGQPV-
Mvan_5023|M.vanbaalenii_PYR-1 -FGVDDVIAAVEATYAEFAGEIAGVVQPV-
MSMEG_5673|M.smegmatis_MC2_155 TVTVERIVNQMRTTYAEFL-EVAGRRHEFA
TH_4253|M.thermoresistible__bu TVTVDNLIERMEHTYRQFVAQASAIGRPV-
Mb3860c|M.bovis_AF2122/97 LGELARVCHVALESLRVGISDTWTTLTVSS
Rv3830c|M.tuberculosis_H37Rv LGELARVCHVALESLRVGISDTWTTLTVSS
MMAR_3438|M.marinum_M PVAITELIRAGFASVAAGLPEPAKPGEQRG
MUL_2714|M.ulcerans_Agy99 PVAITELIRAGFASVAAGLPEPAKPGEQRG
MAB_0248c|M.abscessus_ATCC_199 SKDPGALVAQGFQRLRDGLA----------
MAV_4894|M.avium_104 YRALDFMDAGMPLD----------------
MLBr_00064|M.leprae_Br4923 DTLVHIWVSSIYNEIR--------------