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MTSIDDALGRLWDADDGDRMLECDGRWASWGSVRSLTERIDRELTAAGCQTGGRVAVVLSNRMESVAALI AIFRGGRTLVTISPLQPPDRLSDDLGASAAPFVLAPAALWSDEVFNRVVADLGATGWRLDDGELDLQVRG TTEAVSGDPAVAIEMLTSGTTGAPKRIPLTRAQLEASLASALRHNDRPEVRTKPPLTGAVGLVTLPIVHI GGLWSLLQSLVAARPIAMLDRFTVPGWHAVVKQYRPAVAGLPPAAMRSVLDSDIPREDLASIRAINAGTS PVDPALVDAFFERYGIPILVVYGATEFSGAVAGWTVKDFHTRWTEKRGSVGRAFPGVRLRVVADDGAAVS RGVTGRLQVATLQAGLAGDWITTSDLGHLDEDGFLYIDGRADDVIVRGGFKVSPETVVRTLRAHPAVADA AVAPMPDQRLGQIPVAAVELRPGAAADGEALREHCRATLTPYEVPARIFVVDELPRGAALKVDRRRLIAL LEDLGVPIGQPAAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2596 | - | - | 100% (505) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1880 | - | 0.0 | 69.29% (495) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1580 | - | 8e-93 | 41.54% (479) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0123 | fadD7 | 1e-33 | 27.78% (486) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4362 | - | 8e-92 | 40.09% (464) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0119 | fadD7 | 1e-33 | 27.78% (486) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 1e-31 | 27.31% (498) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 1e-36 | 30.75% (465) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4025 | - | 5e-96 | 41.95% (472) | long-chain fatty-acid CoA ligase |
| M. smegmatis MC2 155 | MSMEG_2217 | - | 5e-92 | 40.12% (491) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3166 | - | 1e-93 | 40.29% (489) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3890 | - | 4e-93 | 42.19% (474) | long-chain fatty-acid CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_1982 | - | 7e-97 | 41.63% (466) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4362|M.gilvum_PYR-GCK -----------------------------MHPLSRRIAEVMALDAS----
Mvan_1982|M.vanbaalenii_PYR-1 ---------------------------MMVHRLSQRIDDVLALAPA----
MSMEG_2217|M.smegmatis_MC2_155 ----------------------------MAHPLSQRIADVLDLDPD----
MMAR_4025|M.marinum_M ---------------------------MSNHPLSQRIADTLDLQPD----
MUL_3890|M.ulcerans_Agy99 ---------------------------MSNHPLSQRIAVTLDLQPD----
TH_3166|M.thermoresistible__bu ---------------------------------------VLALDPS----
MAV_2596|M.avium_104 -----------------------------MTSIDDALGRLWDADDG----
Mb0123|M.bovis_AF2122/97 ---------------------------MASDFG-PRIADLVEVAATRLPE
Rv0119|M.tuberculosis_H37Rv ---------------------------MASDFG-PRIADLVEVAATRLPE
MLBr_02661|M.leprae_Br4923 --------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPS
MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML
Mflv_4362|M.gilvum_PYR-GCK --APAIQF--------ERRWVTWGQIAESARHVST---VVG---SGTAGI
Mvan_1982|M.vanbaalenii_PYR-1 --GRAIQF--------DGDWVTWEQIGTLAQRISD---VVG---TARAGI
MSMEG_2217|M.smegmatis_MC2_155 --AGAIQF--------DGQWSCWGQIAALAGHIEK---ITG---PARVGI
MMAR_4025|M.marinum_M --ARAVEY--------DRAWLSWGQLGAATRRVAA---LAARQPSPEIGI
MUL_3890|M.ulcerans_Agy99 --ARAVEY--------DRAWLSLGQLGAATRRVAA---LAAKQPSPEIGI
TH_3166|M.thermoresistible__bu --AEAVEY--------QGAWTDWKTVAHVAHAVESRLTAAGLGAGSPVGL
MAV_2596|M.avium_104 --DRMLEC--------DGRWASWGSVRSLTERIDRELTAAGCQTGGRVAV
Mb0123|M.bovis_AF2122/97 APALVVTA--------DRIAISHRDLARLVDELAGQLTRSGLLPGDRVAL
Rv0119|M.tuberculosis_H37Rv APALVVTA--------DRIAISHRDLARLVDELAGQLTRSGLLPGDRVAL
MLBr_02661|M.leprae_Br4923 APALVVTD--------NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVAL
MAB_2539c|M.abscessus_ATCC_199 LAASAIRFPDRAALIDDSGQLTYRDLQRRAEAVAAAVYARTPSAPRSVGI
: : : . : .:
Mflv_4362|M.gilvum_PYR-GCK MLRNTPSHVAALLGVLSGGGTVVVINPSR--GDERTRADIEALQLPTLIG
Mvan_1982|M.vanbaalenii_PYR-1 MLRNRPVHVAALLGVLRGGGTVVVINPSR--GDDRTRSDVEALNLPIIIG
MSMEG_2217|M.smegmatis_MC2_155 MLRNHPVHVAALLGVLAAGGTVVVINPAR--GDDRTRADLEALALPVVVG
MMAR_4025|M.marinum_M LLRSRPAQMAAFLGVLLSGATVVTINPSR--GDERTRADIAALELPLIAG
MUL_3890|M.ulcerans_Agy99 LLRNRPAQMAAFLGVLLAGATVVTINPSR--GDERTRADIAALELPLIAG
TH_3166|M.thermoresistible__bu ILRNHPAMVAALLGVLLVNGCVVTINASS--GDARLATDLEELRLPVVIG
MAV_2596|M.avium_104 VLSNRMESVAALIAIFRGGRTLVTISPLQ--PPDRLSDDLGASAAPFVLA
Mb0123|M.bovis_AF2122/97 RMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLID-
Rv0119|M.tuberculosis_H37Rv RMGSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLID-
MLBr_02661|M.leprae_Br4923 CAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDS
MAB_2539c|M.abscessus_ATCC_199 ICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVYDD
. .::. . :* :.. :
Mflv_4362|M.gilvum_PYR-GCK ------LAEDLE--SLAPGTT--ATTMALGDIDTTPEITGGS-PSEGQH-
Mvan_1982|M.vanbaalenii_PYR-1 ------SSEDLA--ALAPDTA--ATTVAVDGFDEPPTLHRGN-ASDDAG-
MSMEG_2217|M.smegmatis_MC2_155 ------LAEDLA--HLMPAHSPRTTRVAIAGLDTEPVVTAAESPATDAG-
MMAR_4025|M.marinum_M ------SDEDLG--LLVTNTT-DSATVSLSDLFDHPGEPGDH--TTRGA-
MUL_3890|M.ulcerans_Agy99 ------SDEDLG--LLVTNTT-DSATVSLSDLFDHPGEPGGH--TTRGA-
TH_3166|M.thermoresistible__bu ------LGADWGRPHIVEAAAGALGLEVAADPASVRTVTGRG--SVGAGP
MAV_2596|M.avium_104 ------PAALWSDEVFNRVVADLGATGWRLDDGELDLQVRGTTEAVSGD-
Mb0123|M.bovis_AF2122/97 --ADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATST
Rv0119|M.tuberculosis_H37Rv --ADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATST
MLBr_02661|M.leprae_Br4923 LALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTST
MAB_2539c|M.abscessus_ATCC_199 -----EYSQAVEESQYQGLRVLAWRENPQENRLTLDSLADQHHPKPPPVR
Mflv_4362|M.gilvum_PYR-GCK ----RPGVAVRMPTSGTTGPPKRVDLTYDMLARSVMGRDPDT----APSP
Mvan_1982|M.vanbaalenii_PYR-1 ----RPGVAVWMLTSGTTGPPKRVDLTYDMLARSVMGPDSDH----DSAP
MSMEG_2217|M.smegmatis_MC2_155 ----GPGVAVWMLTSGTTGPPKRVDLTYDMLARSVMGREPEK----CPAP
MMAR_4025|M.marinum_M ----GADVAVRMLTSGTTGPPKRVDLSYDMLARSVMGPAPDR----DPAP
MUL_3890|M.ulcerans_Agy99 ----GADVAVRMLTSGTTGPPNRVDLSYDMLARSVMGPAPDR----DPAP
TH_3166|M.thermoresistible__bu FRPDRPGVAVEMLTSGTTGPPKRVPLSYNAFQHTVAAAGAHYG-SGDNGQ
MAV_2596|M.avium_104 -----PAVAIEMLTSGTTGAPKRIPLTRAQLEASLASALRHNDRPEVRTK
Mb0123|M.bovis_AF2122/97 PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYR-------
Rv0119|M.tuberculosis_H37Rv PEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYR-------
MLBr_02661|M.leprae_Br4923 PDGLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQ-------
MAB_2539c|M.abscessus_ATCC_199 -----RPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMAT------V
: : *.**** .: : : ::
Mflv_4362|M.gilvum_PYR-GCK TELRQGVAIVNSPLVHVGGVFRILLCLAEARPFVLLPK---FELHSWAEA
Mvan_1982|M.vanbaalenii_PYR-1 TDLRRGVAIVNSPLVHVGGVFRVLLCVAEARPFVLLPK---FELKQWADA
MSMEG_2217|M.smegmatis_MC2_155 TELRRGVAIVNSPLVHVGGVFRVLLCIAEARPFVLLPK---FELQRWAAA
MMAR_4025|M.marinum_M TEPRRGVAIVNSPLVHIGGVYRVLQCIAQARPFVLLDR---FELNAWAAA
MUL_3890|M.ulcerans_Agy99 TEPRRGVAIVNSPLVHIGGVYRVLQCIAQARPFVLLDR---FELNARAAA
TH_3166|M.thermoresistible__bu VRLRSGVAIISSPLVHMSGLFRTLLNICEGRRIALLER---FRVDDFVDL
MAV_2596|M.avium_104 PPLTGAVGLVTLPIVHIGGLWSLLQSLVAARPIAMLDR---FTVPGWHAV
Mb0123|M.bovis_AF2122/97 -LSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDD
Rv0119|M.tuberculosis_H37Rv -LSPRDATVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDD
MLBr_02661|M.leprae_Br4923 -LGPQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDD
MAB_2539c|M.abscessus_ATCC_199 RLRSRDRVLVAPPFFHGFGLAALLGPLALGGTVMCRRR---FDAQQAMTD
: *: * *: * . *
Mflv_4362|M.gilvum_PYR-GCK VREHRPAAVSLVPAALRMVLHSDLT---RDDLAGVRVVTSGTAPLSADDA
Mvan_1982|M.vanbaalenii_PYR-1 VREHRPRAVSLVPAALRMVLHSDLT---REDLDGIRVVTSGTAPLSADDA
MSMEG_2217|M.smegmatis_MC2_155 VREHRPRAVSLVPAALRTVLHSDLT---REDLAGVRVVTSGTAPLSADDA
MMAR_4025|M.marinum_M VRKHRPRTVSLVPAALRTVLHSDLT---RADLASVRTVTCGTAPLAPDDA
MUL_3890|M.ulcerans_Agy99 VRKHRPRTVSLVPAALRTVLHSDPT---RADLASVRTVTCGTAPLAPDDA
TH_3166|M.thermoresistible__bu VVRHQPKAVSLVPSALAMVLDAGVP---PEVFSSVKVVTSGTAPLPVELQ
MAV_2596|M.avium_104 VKQYRPAVAGLPPAAMRSVLDSDIP---REDLASIRAINAGTSPVDPALV
Mb0123|M.bovis_AF2122/97 IKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAA
Rv0119|M.tuberculosis_H37Rv IKAVGATWYTAVPTIHQILLERSATEPSGRKPAALRFIRSCSAPLTAQAA
MLBr_02661|M.leprae_Br4923 IDAVAATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETA
MAB_2539c|M.abscessus_ATCC_199 IRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSSTV
: * :* :: : ::*:
Mflv_4362|M.gilvum_PYR-GCK EAFTAKFGIPVLTSYAATEFGGGVAGWTLADHRKYWQ--DKRGSVGRANP
Mvan_1982|M.vanbaalenii_PYR-1 DAFTEKFGIPVLTSYAATEFGGGVAGWTLKDHQRFWQ--HKRGSVGRANP
MSMEG_2217|M.smegmatis_MC2_155 DAFTEKFGIPVLTSYAATEFGGGVAGWTLPDHGKYWK--DKRGSVGRANP
MMAR_4025|M.marinum_M DAFTEKYGIPVLTSYAATEFGGGVAGWTLADHSRYWH--TKRGSVGRANP
MUL_3890|M.ulcerans_Agy99 DAFTEKYGIPVLTSYAATEFGGGVAGWTLADHSRYWH--TKRGSVGRANP
TH_3166|M.thermoresistible__bu EAFEERYDVAVLPSYGATEFAGGVAGWNLALHREWAK--IKRGSVGRPQR
MAV_2596|M.avium_104 DAFFERYGIPILVVYGATEFSGAVAGWTVKDFHTRWT--EKRGSVGRAFP
Mb0123|M.bovis_AF2122/97 LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRS-T
Rv0119|M.tuberculosis_H37Rv LALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRS-T
MLBr_02661|M.leprae_Br4923 QALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQS-T
MAB_2539c|M.abscessus_ATCC_199 SGVLEAFGPILVNGYGSTEAG-VVAIASPKDLVASPN------TIGRTAL
.. : :: :. ** *: :*:.
Mflv_4362|M.gilvum_PYR-GCK GARLRVVD-DNRDPVPPGEPGLLEVIPAQLADTGE---------------
Mvan_1982|M.vanbaalenii_PYR-1 GAQLRVVD-DNGEPVPPGQQGLLEVIPAQLAGRSG---------------
MSMEG_2217|M.smegmatis_MC2_155 GAQLRVVD-ENGAPLGPDEPGLLEVIPAQMGPGSP---------------
MMAR_4025|M.marinum_M GTQLRIVD-TEGAPVERASLGLLEVKPAQLGVSAP---------------
MUL_3890|M.ulcerans_Agy99 GTQLRIVD-TEGAPVERASLGLLEVKPAQLGVSAP---------------
TH_3166|M.thermoresistible__bu GREVRIVSPEDGAELPPGTQGQIEVR----TRGGE---------------
MAV_2596|M.avium_104 GVRLRVVA-DDGAAVSRGVTGRLQVATLQAGLAGD---------------
Mb0123|M.bovis_AF2122/97 GAQIRIVG-SDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI--TAANFTDG
Rv0119|M.tuberculosis_H37Rv GAQIRIVG-SDGLPLPAGAVGEIWLRGTTVVRGYLGDPTI--TAANFTDG
MLBr_02661|M.leprae_Br4923 GVQIRIVG-SDGQPLPPDTVGEVWLRGSTVVRGYLGDPAI--TAANFTHG
MAB_2539c|M.abscessus_ATCC_199 GVSVRILR-EDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDG
* :*:: : * : :
Mflv_4362|M.gilvum_PYR-GCK WMQTTDVARIDEDGFLWILGRADQAIIRGGFKVMPDDVRSALESHAAVAG
Mvan_1982|M.vanbaalenii_PYR-1 WMQTTDLARIDEDGFVWILGRADQAIIRGGFKVMPDDVKNALESHPAVAG
MSMEG_2217|M.smegmatis_MC2_155 WMRTTDLARIDADGFLWVLGRADQAIIRGGFKVMPDDVRAALESHPAVLG
MMAR_4025|M.marinum_M WVRTTDVARIDADGFVWIVGRADQAIIRGGFKVLPDDVGAALESHPAVAA
MUL_3890|M.ulcerans_Agy99 WVRTTDVARIDADGFVWIVGRADQAIIRGGFKVLPDDVRAALESHPAVAA
TH_3166|M.thermoresistible__bu WVRTTDLGRLDSDGFLFVDGRTDDAIIRGGFKISPADIANALRSHPAVRD
MAV_2596|M.avium_104 WITTSDLGHLDEDGFLYIDGRADDVIVRGGFKVSPETVVRTLRAHPAVAD
Mb0123|M.bovis_AF2122/97 WLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVME
Rv0119|M.tuberculosis_H37Rv WLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVME
MLBr_02661|M.leprae_Br4923 WLRTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVME
MAB_2539c|M.abscessus_ATCC_199 HVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITD
: * *:. :. * : : ** .: * .* :: * : * :: :
Mflv_4362|M.gilvum_PYR-GCK AAVVGRPDPRLGETPVALVELRPGATASPE-ELSAYLQTRLARYEIPTAL
Mvan_1982|M.vanbaalenii_PYR-1 ASVVGRPDPRLGETPVALVQLRPGMSAEPD-ELLNYLQKRLARYEIPGEL
MSMEG_2217|M.smegmatis_MC2_155 ASVIGVADERLGETPVAMVELRG--PATPD-ELAGYLQGRLARYEIPTRI
MMAR_4025|M.marinum_M AAVVGRSDQRLGQTPVAMVELRGSADIGGA-ELVEYLRTRLSGYEIPTQI
MUL_3890|M.ulcerans_Agy99 AAVVGRSDQRLGQTPVAMVELRGSADIGGA-ELVEYLRTRLSGYEIPTQI
TH_3166|M.thermoresistible__bu AGVTGLPDPRLGAVPVAAVELAGGAQAEPD-ELLDFLRQRLTRYQVPARL
MAV_2596|M.avium_104 AAVAPMPDQRLGQIPVAAVELRPGAAADGE-ALREHCRATLTPYEVPARI
Mb0123|M.bovis_AF2122/97 AAVFGVPHQLYGEAVAAVIVPRESAPPTRE-ELVQFCRERLAAFEIPASF
Rv0119|M.tuberculosis_H37Rv AAVFGVPHQLYGEAVAAVIVPRESAPPTRE-ELVQFCRERLAAFEIPASF
MLBr_02661|M.leprae_Br4923 VAVFGDPDKVYGETVTAVIVPREVIAPTPS-ELAVFCRDRLAAFEVPTRF
MAB_2539c|M.abscessus_ATCC_199 AVVIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRF
. * .. * * : * . : * :::* :
Mflv_4362|M.gilvum_PYR-GCK ILTDAIPRTPSGKPDLTAVRARLAQP-----------
Mvan_1982|M.vanbaalenii_PYR-1 VITDAIPRTASGKPDLTAVRSHFAQS-----------
MSMEG_2217|M.smegmatis_MC2_155 TIVDAIPRTPSGKADLRAVRDHLESGG----------
MMAR_4025|M.marinum_M SIVAEIPRTASGKPDLGAIRHYFGAAGSRTDHGG---
MUL_3890|M.ulcerans_Agy99 SIVAEIPRTASGKPDLGAIRHYFGAAGSRTDHGG---
TH_3166|M.thermoresistible__bu LVLDELPRTPSLKVSQPALRELFEQEPT---------
MAV_2596|M.avium_104 FVVDELPRGAALKVDRRRLIALLEDLGVPIGQPAAAG
Mb0123|M.bovis_AF2122/97 QEASGLPHTAKGSLDRRAVAERFGHSV----------
Rv0119|M.tuberculosis_H37Rv QEASGLPHTAKGSLDRRAVAERFGHSV----------
MLBr_02661|M.leprae_Br4923 QEASALPHTAKGSLDRRAVAEQFAHRG----------
MAB_2539c|M.abscessus_ATCC_199 IVLDEIPRNASGKVLRAKLNSPGAC------------
:*: . . :