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MVHRLSQRIDDVLALAPAGRAIQFDGDWVTWEQIGTLAQRISDVVGTARAGIMLRNRPVHVAALLGVLRG GGTVVVINPSRGDDRTRSDVEALNLPIIIGSSEDLAALAPDTAATTVAVDGFDEPPTLHRGNASDDAGRP GVAVWMLTSGTTGPPKRVDLTYDMLARSVMGPDSDHDSAPTDLRRGVAIVNSPLVHVGGVFRVLLCVAEA RPFVLLPKFELKQWADAVREHRPRAVSLVPAALRMVLHSDLTREDLDGIRVVTSGTAPLSADDADAFTEK FGIPVLTSYAATEFGGGVAGWTLKDHQRFWQHKRGSVGRANPGAQLRVVDDNGEPVPPGQQGLLEVIPAQ LAGRSGWMQTTDLARIDEDGFVWILGRADQAIIRGGFKVMPDDVKNALESHPAVAGASVVGRPDPRLGET PVALVQLRPGMSAEPDELLNYLQKRLARYEIPGELVITDAIPRTASGKPDLTAVRSHFAQS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1982 | - | - | 100% (482) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_5064 | - | 5e-76 | 36.51% (482) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | 2e-41 | 28.54% (515) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 1e-38 | 27.01% (485) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4362 | - | 0.0 | 76.20% (479) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 1e-38 | 27.01% (485) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 5e-36 | 29.28% (461) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 4e-42 | 28.77% (504) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4025 | - | 1e-172 | 64.45% (481) | long-chain fatty-acid CoA ligase |
| M. avium 104 | MAV_1580 | - | 1e-178 | 66.60% (479) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_2217 | - | 0.0 | 74.58% (480) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3559 | - | 1e-140 | 72.92% (336) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3890 | - | 1e-168 | 63.54% (480) | long-chain fatty-acid CoA ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1982|M.vanbaalenii_PYR-1 -----------------------------------MMVHRLSQRIDDVLA
Mflv_4362|M.gilvum_PYR-GCK -------------------------------------MHPLSRRIAEVMA
MSMEG_2217|M.smegmatis_MC2_155 ------------------------------------MAHPLSQRIADVLD
MAV_1580|M.avium_104 -----------------------------------MPRHPLVQRIADVLD
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M -----------------------------------MSNHPLSQRIADTLD
MUL_3890|M.ulcerans_Agy99 -----------------------------------MSNHPLSQRIAVTLD
Mb1462c|M.bovis_AF2122/97 MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGFAGAAR
Rv1427c|M.tuberculosis_H37Rv MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGFAGAAR
MAB_4569c|M.abscessus_ATCC_199 ----------------MTDTIDATVQSAGLAQPYRARRQNWCNQLARHAL
MLBr_02661|M.leprae_Br4923 ------------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAI
Mvan_1982|M.vanbaalenii_PYR-1 LAPAGRAIQFDGD--WVTWEQIGTLAQRISDVVGT------ARAGIMLRN
Mflv_4362|M.gilvum_PYR-GCK LDASAPAIQFERR--WVTWGQIAESARHVSTVVGS------GTAGIMLRN
MSMEG_2217|M.smegmatis_MC2_155 LDPDAGAIQFDGQ--WSCWGQIAALAGHIEKITGP------ARVGIMLRN
MAV_1580|M.avium_104 LEPHGRAIEYGGQ--WFSWAQLGATARQVAARTTG------TEVGMLLRN
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M LQPDARAVEYDRA--WLSWGQLGAATRRVAALAARQPS---PEIGILLRS
MUL_3890|M.ulcerans_Agy99 LQPDARAVEYDRA--WLSLGQLGAATRRVAALAAKQPS---PEIGILLRN
Mb1462c|M.bovis_AF2122/97 RCPDRPGLIDELG--TLTWRQLDERGNALAAALQALPAGPPRVVGIMCRN
Rv1427c|M.tuberculosis_H37Rv RCPDRPGLIDELG--TLTWRQLDERGNALAAALQALPAGPPRVVGIMCRN
MAB_4569c|M.abscessus_ATCC_199 MQPDATAIRYLGH--SISWAELHQRVQALADALSRRGVGFGDRVLILMLN
MLBr_02661|M.leprae_Br4923 RNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAAS
Mvan_1982|M.vanbaalenii_PYR-1 RPVHVAALLGVLRGGGTVVVINPSRGD-------DRTRSDVEALN--LPI
Mflv_4362|M.gilvum_PYR-GCK TPSHVAALLGVLSGGGTVVVINPSRGD-------ERTRADIEALQ--LPT
MSMEG_2217|M.smegmatis_MC2_155 HPVHVAALLGVLAAGGTVVVINPARGD-------DRTRADLEALA--LPV
MAV_1580|M.avium_104 RPWQVAAFLGVLLGGGTVVVVNPSRGD-------ERTRADLARLR--LPL
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M RPAQMAAFLGVLLSGATVVTINPSRGD-------ERTRADIAALE--LPL
MUL_3890|M.ulcerans_Agy99 RPAQMAAFLGVLLAGATVVTINPSRGD-------ERTRADIAALE--LPL
Mb1462c|M.bovis_AF2122/97 HRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYD--EEF
Rv1427c|M.tuberculosis_H37Rv HRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYD--EEF
MAB_4569c|M.abscessus_ATCC_199 RPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITETVLAP
MLBr_02661|M.leprae_Br4923 NIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALE
Mvan_1982|M.vanbaalenii_PYR-1 IIGSSEDLAA----LAPDTA--ATTVAVDGFDEPPTLHRGN-ASDDAGRP
Mflv_4362|M.gilvum_PYR-GCK LIGLAEDLES----LAPGTT--ATTMALGDIDTTPEITGGS-PSEGQHRP
MSMEG_2217|M.smegmatis_MC2_155 VVGLAEDLAH----LMPAHSPRTTRVAIAGLDTEPVVTAAESPATDAGGP
MAV_1580|M.avium_104 IIGEPDDLAA----LVT--DDTPTMPISRLADPP---GPAA--PPAAAPR
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M IAGSDEDLGL----LVTNTTDSATVSLSDLFDHP---GEPGDHTTRGAGA
MUL_3890|M.ulcerans_Agy99 IAGSDEDLGL----LVTNTTDSATVSLSDLFDHP---GEPGGHTTRGAGA
Mb1462c|M.bovis_AF2122/97 SATVDRALAE----KPQATRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGS
Rv1427c|M.tuberculosis_H37Rv SATVDRALAE----KPQATRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGS
MAB_4569c|M.abscessus_ATCC_199 VAAAVRQQAP----ALETVIVAGSASENGVLGYEEVIAEPGEPHAEVDLP
MLBr_02661|M.leprae_Br4923 GVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPDGL
Mvan_1982|M.vanbaalenii_PYR-1 --GVAVWMLTSGTTGPPKRVDLTYDMLARSVMGPDSDHDSAPTDLRRGVA
Mflv_4362|M.gilvum_PYR-GCK --GVAVRMPTSGTTGPPKRVDLTYDMLARSVMGRDPDTAPSPTELRQGVA
MSMEG_2217|M.smegmatis_MC2_155 --GVAVWMLTSGTTGPPKRVDLTYDMLARSVMGREPEKCPAPTELRRGVA
MAV_1580|M.avium_104 --SVAVRMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEPRRGVA
TH_3559|M.thermoresistible__bu -----VRMLTSGTTGPPKRVDLTYDMLAHSVIGPDFREAGPPAELRRGVA
MMAR_4025|M.marinum_M --DVAVRMLTSGTTGPPKRVDLSYDMLARSVMGPAPDRDPAPTEPRRGVA
MUL_3890|M.ulcerans_Agy99 --DVAVRMLTSGTTGPPNRVDLSYDMLARSVMGPAPDRDPAPTEPRRGVA
Mb1462c|M.bovis_AF2122/97 --HGKVILLTSGTTGTPKGARHSGGGIG--TLKAILDRTPWRAE---EVT
Rv1427c|M.tuberculosis_H37Rv --HGKVILLTSGTTGTPKGARHSGGGIG--TLKAILDRTPWRAE---EVT
MAB_4569c|M.abscessus_ATCC_199 GDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTT---VDLNSDVG
MLBr_02661|M.leprae_Br4923 RHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQD----AT
: : *.**** *: :. . : .
Mvan_1982|M.vanbaalenii_PYR-1 IVNSPLVHVGGVFRVLLCVAEARPFVLLPK---FELKQWADAVREHRPRA
Mflv_4362|M.gilvum_PYR-GCK IVNSPLVHVGGVFRILLCLAEARPFVLLPK---FELHSWAEAVREHRPAA
MSMEG_2217|M.smegmatis_MC2_155 IVNSPLVHVGGVFRVLLCIAEARPFVLLPK---FELQRWAAAVREHRPRA
MAV_1580|M.avium_104 IVNSPLVHIGGVFRVLQCIADARPFVLLER---FELNAWAAAVRRHRPRA
TH_3559|M.thermoresistible__bu IVNAPLVHIGGVYRVLQCIAAGRRFVLLER---FELQRWAEAVRTHRPRA
MMAR_4025|M.marinum_M IVNSPLVHIGGVYRVLQCIAQARPFVLLDR---FELNAWAAAVRKHRPRT
MUL_3890|M.ulcerans_Agy99 IVNSPLVHIGGVYRVLQCIAQARPFVLLDR---FELNARAAAVRKHRPRT
Mb1462c|M.bovis_AF2122/97 VIVAPMFHAWGFSQLVLASSLACTIVTRRR---FDPEATLDLIDRHHATG
Rv1427c|M.tuberculosis_H37Rv VIVAPMFHAWGFSQLVLASSLACTIVTRRR---FDPEATLDLIDRHHATG
MAB_4569c|M.abscessus_ATCC_199 FIGVPMFHIAGVGNMITGLLLGLPTVIHPLGA-FDPGALLDVLESEGVTG
MLBr_02661|M.leprae_Br4923 VVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDAVAATW
.: *: * *. : . * *. :
Mvan_1982|M.vanbaalenii_PYR-1 VSLVPAALRMVLHS---DLTREDLDGIRVVTSGTAPLSADDADAFTEKFG
Mflv_4362|M.gilvum_PYR-GCK VSLVPAALRMVLHS---DLTRDDLAGVRVVTSGTAPLSADDAEAFTAKFG
MSMEG_2217|M.smegmatis_MC2_155 VSLVPAALRTVLHS---DLTREDLAGVRVVTSGTAPLSADDADAFTEKFG
MAV_1580|M.avium_104 VSLVPAALRTVLHS---DLPRADLESIQVVTCGTAPLSADDADAFTEKYG
TH_3559|M.thermoresistible__bu VSLVPAALRMVLHS---DLTREDLASIQAVTSGTAPLSADDADAFTEKFG
MMAR_4025|M.marinum_M VSLVPAALRTVLHS---DLTRADLASVRTVTCGTAPLAPDDADAFTEKYG
MUL_3890|M.ulcerans_Agy99 VSLVPAALRTVLHS---DPTRADLASVRTVTCGTAPLAPDDADAFTEKYG
Mb1462c|M.bovis_AF2122/97 LVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFG
Rv1427c|M.tuberculosis_H37Rv LVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFG
MAB_4569c|M.abscessus_ATCC_199 IFLVPAQWQAVCAA---QQANPRKVRLKTLSWGAAPATDVLLRTMSETFP
MLBr_02661|M.leprae_Br4923 YTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETAQALREEFL
.*. : . :: : :: :
Mvan_1982|M.vanbaalenii_PYR-1 IP-VLTSYAATEFGGGVAGWTLKDHQRFWQ-HKRGSVGRANPGAQLRVVD
Mflv_4362|M.gilvum_PYR-GCK IP-VLTSYAATEFGGGVAGWTLADHRKYWQ-DKRGSVGRANPGARLRVVD
MSMEG_2217|M.smegmatis_MC2_155 IP-VLTSYAATEFGGGVAGWTLPDHGKYWK-DKRGSVGRANPGAQLRVVD
MAV_1580|M.avium_104 IP-VLTSYAATEFGGGVAGWTLADHRRYWR-VKRGSVGRANPGAALRVVA
TH_3559|M.thermoresistible__bu IP-VLTSYAATEFGGGVAGWTLADHRRYWR-TKRGSSGRATGGAQLRVVD
MMAR_4025|M.marinum_M IP-VLTSYAATEFGGGVAGWTLADHSRYWH-TKRGSVGRANPGTQLRIVD
MUL_3890|M.ulcerans_Agy99 IP-VLTSYAATEFGGGVAGWTLADHSRYWH-TKRGSVGRANPGTQLRIVD
Mb1462c|M.bovis_AF2122/97 DV-IYNNYNATEAG-MIATATPADLR-----TAPDTAGRPAEGTEIRILD
Rv1427c|M.tuberculosis_H37Rv DV-IYNNYNATEAG-MIATATPADLR-----TAPDTAGRPAEGTEIRILD
MAB_4569c|M.abscessus_ATCC_199 DARILAAFGQTEMSPVTCMLMGDDAIR-----KMGSVGRVIPTVSARVVD
MLBr_02661|M.leprae_Br4923 AP-VICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRIVG
: : ** . . *::
Mvan_1982|M.vanbaalenii_PYR-1 DNGEPVPPGQQGLLEVIP-------------AQLAGRSGWMQTTDLARID
Mflv_4362|M.gilvum_PYR-GCK DNRDPVPPGEPGLLEVIP-------------AQLADTGEWMQTTDVARID
MSMEG_2217|M.smegmatis_MC2_155 ENGAPLGPDEPGLLEVIP-------------AQMGPGSPWMRTTDLARID
MAV_1580|M.avium_104 EDGTPLGPDEIGLMEVKP-------------GQLGPDADWLRTTDMARID
TH_3559|M.thermoresistible__bu EQGNPLGPDQPGVLEVKP-------------GQLGPDADWLRTTDLARID
MMAR_4025|M.marinum_M TEGAPVERASLGLLEVKP-------------AQLGVSAPWVRTTDVARID
MUL_3890|M.ulcerans_Agy99 TEGAPVERASLGLLEVKP-------------AQLGVSAPWVRTTDVARID
Mb1462c|M.bovis_AF2122/97 QQFTEVPTGEVGTIYVRNDSQFD---GYTSGAAKDFHAGFMSSGDVGYLD
Rv1427c|M.tuberculosis_H37Rv QQFTEVPTGEVGTIYVRNDSQFD---GYTSGAAKDFHAGFMSSGDVGYLD
MAB_4569c|M.abscessus_ATCC_199 DNMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGGWFHSGDLVRQD
MLBr_02661|M.leprae_Br4923 SDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTHGWLRTGDLGSLS
: : * : :. : *: .
Mvan_1982|M.vanbaalenii_PYR-1 EDGFVWILGRADQAIIRGGFKVMPDDVKNALESHPAVAGASVVGRPDPRL
Mflv_4362|M.gilvum_PYR-GCK EDGFLWILGRADQAIIRGGFKVMPDDVRSALESHAAVAGAAVVGRPDPRL
MSMEG_2217|M.smegmatis_MC2_155 ADGFLWVLGRADQAIIRGGFKVMPDDVRAALESHPAVLGASVIGVADERL
MAV_1580|M.avium_104 ADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPAVAGAAVVARPDPRL
TH_3559|M.thermoresistible__bu ADGFLWILGRADQAIIRGGFKIMPDDVRAALERHPAVRGAAVVGIPDARL
MMAR_4025|M.marinum_M ADGFVWIVGRADQAIIRGGFKVLPDDVGAALESHPAVAAAAVVGRSDQRL
MUL_3890|M.ulcerans_Agy99 ADGFVWIVGRADQAIIRGGFKVLPDDVRAALESHPAVAAAAVVGRSDQRL
Mb1462c|M.bovis_AF2122/97 ENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGVDDQQY
Rv1427c|M.tuberculosis_H37Rv ENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGVDDQQY
MAB_4569c|M.abscessus_ATCC_199 EDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEKW
MLBr_02661|M.leprae_Br4923 VTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPDKVY
* : : .* .: * .* :: * .* * : .:*.. .
Mvan_1982|M.vanbaalenii_PYR-1 GETPVALVQLRPGMSAEPDELLNYLQKRLARYEIPGELVITDAIPRTASG
Mflv_4362|M.gilvum_PYR-GCK GETPVALVELRPGATASPEELSAYLQTRLARYEIPTALILTDAIPRTPSG
MSMEG_2217|M.smegmatis_MC2_155 GETPVAMVELRG--PATPDELAGYLQGRLARYEIPTRITIVDAIPRTPSG
MAV_1580|M.avium_104 GETPVAMVELR--APSTTDALVEHLRERLARYEIPTEIAIVDALPRTPSG
TH_3559|M.thermoresistible__bu GETPAALVELHDGAAAGTDELTAFLRERLAPYEVPTEIAVVDALPRTPSG
MMAR_4025|M.marinum_M GQTPVAMVELRGSADIGGAELVEYLRTRLSGYEIPTQISIVAEIPRTASG
MUL_3890|M.ulcerans_Agy99 GQTPVAMVELRGSADIGGAELVEYLRTRLSGYEIPTQISIVAEIPRTASG
Mb1462c|M.bovis_AF2122/97 GQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELPRGITG
Rv1427c|M.tuberculosis_H37Rv GQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELPRGITG
MAB_4569c|M.abscessus_ATCC_199 GEVPVAVAAIHG-AALTLAELDGFLTARLARYKHPKDLVIVDALPRNPSG
MLBr_02661|M.leprae_Br4923 GETVTAVIVPREVIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHTAKG
*: .*. : * . .*: :: * : :*: .*
Mvan_1982|M.vanbaalenii_PYR-1 KPDLTAVR--------SHFAQS-
Mflv_4362|M.gilvum_PYR-GCK KPDLTAVR--------ARLAQP-
MSMEG_2217|M.smegmatis_MC2_155 KADLRAVR--------DHLESGG
MAV_1580|M.avium_104 KADLAAVRGYFAERPTVLRDHAR
TH_3559|M.thermoresistible__bu KADLGAVR-----RTLAPAGHDG
MMAR_4025|M.marinum_M KPDLGAIRHYFG-AAGSRTDHGG
MUL_3890|M.ulcerans_Agy99 KPDLGAIRHYFG-AAGSRTDHGG
Mb1462c|M.bovis_AF2122/97 KILRTELQ--------SRVGS--
Rv1427c|M.tuberculosis_H37Rv KILRTELQ--------SRVGS--
MAB_4569c|M.abscessus_ATCC_199 KVLKTELR--------QRFGIAD
MLBr_02661|M.leprae_Br4923 SLDRRAVA--------EQFAHRG
. :