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MSNHPLSQRIADTLDLQPDARAVEYDRAWLSWGQLGAATRRVAALAARQPSPEIGILLRSRPAQMAAFLG VLLSGATVVTINPSRGDERTRADIAALELPLIAGSDEDLGLLVTNTTDSATVSLSDLFDHPGEPGDHTTR GAGADVAVRMLTSGTTGPPKRVDLSYDMLARSVMGPAPDRDPAPTEPRRGVAIVNSPLVHIGGVYRVLQC IAQARPFVLLDRFELNAWAAAVRKHRPRTVSLVPAALRTVLHSDLTRADLASVRTVTCGTAPLAPDDADA FTEKYGIPVLTSYAATEFGGGVAGWTLADHSRYWHTKRGSVGRANPGTQLRIVDTEGAPVERASLGLLEV KPAQLGVSAPWVRTTDVARIDADGFVWIVGRADQAIIRGGFKVLPDDVGAALESHPAVAAAAVVGRSDQR LGQTPVAMVELRGSADIGGAELVEYLRTRLSGYEIPTQISIVAEIPRTASGKPDLGAIRHYFGAAGSRTD HGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4025 | - | - | 100% (493) | long-chain fatty-acid CoA ligase |
| M. marinum M | MMAR_1606 | - | 1e-36 | 27.16% (475) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_0466 | - | 7e-33 | 30.92% (346) | long-chain-fatty-acid-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 2e-35 | 27.07% (495) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4362 | - | 1e-170 | 64.36% (477) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 2e-35 | 27.07% (495) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 1e-25 | 28.06% (474) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 1e-34 | 26.39% (504) | fatty-acid-CoA ligase FadD |
| M. avium 104 | MAV_1580 | - | 0.0 | 71.58% (482) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_2217 | - | 1e-177 | 65.23% (486) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3559 | - | 1e-137 | 71.68% (339) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3890 | - | 0.0 | 97.97% (493) | long-chain fatty-acid CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_1982 | - | 1e-172 | 64.45% (481) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4025|M.marinum_M -----------------------------------MSNHPLSQRIADTLD
MUL_3890|M.ulcerans_Agy99 -----------------------------------MSNHPLSQRIAVTLD
MAV_1580|M.avium_104 -----------------------------------MPRHPLVQRIADVLD
TH_3559|M.thermoresistible__bu --------------------------------------------------
Mflv_4362|M.gilvum_PYR-GCK -------------------------------------MHPLSRRIAEVMA
Mvan_1982|M.vanbaalenii_PYR-1 -----------------------------------MMVHRLSQRIDDVLA
MSMEG_2217|M.smegmatis_MC2_155 ------------------------------------MAHPLSQRIADVLD
Mb1462c|M.bovis_AF2122/97 MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGFAGAAR
Rv1427c|M.tuberculosis_H37Rv MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGFAGAAR
MAB_4569c|M.abscessus_ATCC_199 ----------------MTDTIDATVQSAGLAQPYRARRQNWCNQLARHAL
MLBr_01051|M.leprae_Br4923 --------------------------------------MLLASLNPSVVT
MMAR_4025|M.marinum_M LQPDARAVEYDRAWLSWGQLGAATRRVAALAARQPS---PEIGILLRSRP
MUL_3890|M.ulcerans_Agy99 LQPDARAVEYDRAWLSLGQLGAATRRVAALAAKQPS---PEIGILLRNRP
MAV_1580|M.avium_104 LEPHGRAIEYGGQWFSWAQLGATARQVAARTTG------TEVGMLLRNRP
TH_3559|M.thermoresistible__bu --------------------------------------------------
Mflv_4362|M.gilvum_PYR-GCK LDASAPAIQFERRWVTWGQIAESARHVSTVVGS------GTAGIMLRNTP
Mvan_1982|M.vanbaalenii_PYR-1 LAPAGRAIQFDGDWVTWEQIGTLAQRISDVVGT------ARAGIMLRNRP
MSMEG_2217|M.smegmatis_MC2_155 LDPDAGAIQFDGQWSCWGQIAALAGHIEKITGP------ARVGIMLRNHP
Mb1462c|M.bovis_AF2122/97 RCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHR
Rv1427c|M.tuberculosis_H37Rv RCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHR
MAB_4569c|M.abscessus_ATCC_199 MQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVLILMLNRP
MLBr_01051|M.leprae_Br4923 ATDIADAVCVDGVVLSRSGLVGAATSVAERVGG-----ARLVAVLATPTA
MMAR_4025|M.marinum_M AQMAAFLGVLLSGATVVTINPSRGD-------ERTRADIAALE--LPLIA
MUL_3890|M.ulcerans_Agy99 AQMAAFLGVLLAGATVVTINPSRGD-------ERTRADIAALE--LPLIA
MAV_1580|M.avium_104 WQVAAFLGVLLGGGTVVVVNPSRGD-------ERTRADLARLR--LPLII
TH_3559|M.thermoresistible__bu --------------------------------------------------
Mflv_4362|M.gilvum_PYR-GCK SHVAALLGVLSGGGTVVVINPSRGD-------ERTRADIEALQ--LPTLI
Mvan_1982|M.vanbaalenii_PYR-1 VHVAALLGVLRGGGTVVVINPSRGD-------DRTRSDVEALN--LPIII
MSMEG_2217|M.smegmatis_MC2_155 VHVAALLGVLAAGGTVVVINPARGD-------DRTRADLEALA--LPVVV
Mb1462c|M.bovis_AF2122/97 GFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYD--EEFSA
Rv1427c|M.tuberculosis_H37Rv GFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYD--EEFSA
MAB_4569c|M.abscessus_ATCC_199 EYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITETVLAPVA
MLBr_01051|M.leprae_Br4923 STVLAITGCLIAGVPVVPVP----------------ADIGVVER----RH
MMAR_4025|M.marinum_M GSDEDLGLLVTNTTDSATVSLSDLFDHP---GEPGDHTTRGAGA--DVAV
MUL_3890|M.ulcerans_Agy99 GSDEDLGLLVTNTTDSATVSLSDLFDHP---GEPGGHTTRGAGA--DVAV
MAV_1580|M.avium_104 GEPDDLAALVT--DDTPTMPISRLADPP---GPAA--PPAAAPR--SVAV
TH_3559|M.thermoresistible__bu -------------------------------------------------V
Mflv_4362|M.gilvum_PYR-GCK GLAEDLESLAPGTT--ATTMALGDIDTTPEITGGS-PSEGQHRP--GVAV
Mvan_1982|M.vanbaalenii_PYR-1 GSSEDLAALAPDTA--ATTVAVDGFDEPPTLHRGN-ASDDAGRP--GVAV
MSMEG_2217|M.smegmatis_MC2_155 GLAEDLAHLMPAHSPRTTRVAIAGLDTEPVVTAAESPATDAGGP--GVAV
Mb1462c|M.bovis_AF2122/97 TVDRALAEKPQATRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGS--HGKV
Rv1427c|M.tuberculosis_H37Rv TVDRALAEKPQATRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGS--HGKV
MAB_4569c|M.abscessus_ATCC_199 AAVRQQAPALETVIVAGSASENGVLGYEEVIAEPGEPHAEVDLPGDTPAL
MLBr_01051|M.leprae_Br4923 MLTDSGAQAWLGPGPSADSAPDGLPHIPVQLDARSWNRYPEPSP-DATAM
:
MMAR_4025|M.marinum_M RMLTSGTTGPPKRVDLSYDMLARSVMGPAPDRDPAPTEPRRGVAIVNSPL
MUL_3890|M.ulcerans_Agy99 RMLTSGTTGPPNRVDLSYDMLARSVMGPAPDRDPAPTEPRRGVAIVNSPL
MAV_1580|M.avium_104 RMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEPRRGVAIVNSPL
TH_3559|M.thermoresistible__bu RMLTSGTTGPPKRVDLTYDMLAHSVIGPDFREAGPPAELRRGVAIVNAPL
Mflv_4362|M.gilvum_PYR-GCK RMPTSGTTGPPKRVDLTYDMLARSVMGRDPDTAPSPTELRQGVAIVNSPL
Mvan_1982|M.vanbaalenii_PYR-1 WMLTSGTTGPPKRVDLTYDMLARSVMGPDSDHDSAPTDLRRGVAIVNSPL
MSMEG_2217|M.smegmatis_MC2_155 WMLTSGTTGPPKRVDLTYDMLARSVMGREPEKCPAPTELRRGVAIVNSPL
Mb1462c|M.bovis_AF2122/97 ILLTSGTTGTPKGARHSGGGIG--TLKAILDRTPWRAE---EVTVIVAPM
Rv1427c|M.tuberculosis_H37Rv ILLTSGTTGTPKGARHSGGGIG--TLKAILDRTPWRAE---EVTVIVAPM
MAB_4569c|M.abscessus_ATCC_199 IMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTT---VDLNSDVGFIGVPM
MLBr_01051|M.leprae_Br4923 VIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADD----VLVHGLPL
: ****** *: :. : * . *:
MMAR_4025|M.marinum_M VHIGGVYR-VLQCIAQARPFVLLDR--FELNAWAAAVRKHRPRTVSLVPA
MUL_3890|M.ulcerans_Agy99 VHIGGVYR-VLQCIAQARPFVLLDR--FELNARAAAVRKHRPRTVSLVPA
MAV_1580|M.avium_104 VHIGGVFR-VLQCIADARPFVLLER--FELNAWAAAVRRHRPRAVSLVPA
TH_3559|M.thermoresistible__bu VHIGGVYR-VLQCIAAGRRFVLLER--FELQRWAEAVRTHRPRAVSLVPA
Mflv_4362|M.gilvum_PYR-GCK VHVGGVFR-ILLCLAEARPFVLLPK--FELHSWAEAVREHRPAAVSLVPA
Mvan_1982|M.vanbaalenii_PYR-1 VHVGGVFR-VLLCVAEARPFVLLPK--FELKQWADAVREHRPRAVSLVPA
MSMEG_2217|M.smegmatis_MC2_155 VHVGGVFR-VLLCIAEARPFVLLPK--FELQRWAAAVREHRPRAVSLVPA
Mb1462c|M.bovis_AF2122/97 FHAWGFSQ-LVLASSLACTIVTRRR--FDPEATLDLIDRHHATGLVVVPV
Rv1427c|M.tuberculosis_H37Rv FHAWGFSQ-LVLASSLACTIVTRRR--FDPEATLDLIDRHHATGLVVVPV
MAB_4569c|M.abscessus_ATCC_199 FHIAGVGN-MITGLLLGLPTVIHPLGAFDPGALLDVLESEGVTGIFLVPA
MLBr_01051|M.leprae_Br4923 FHVHGLVLGLLGSLRIGNRFVHTGKP--TPTAYAQACSEAGGSLYFGVPT
.* *. :: . * **.
MMAR_4025|M.marinum_M ALRTVLHS---DLTRADLASVRTVTCGTAPLAPDDADAFTEKYGIP-VLT
MUL_3890|M.ulcerans_Agy99 ALRTVLHS---DPTRADLASVRTVTCGTAPLAPDDADAFTEKYGIP-VLT
MAV_1580|M.avium_104 ALRTVLHS---DLPRADLESIQVVTCGTAPLSADDADAFTEKYGIP-VLT
TH_3559|M.thermoresistible__bu ALRMVLHS---DLTREDLASIQAVTSGTAPLSADDADAFTEKFGIP-VLT
Mflv_4362|M.gilvum_PYR-GCK ALRMVLHS---DLTRDDLAGVRVVTSGTAPLSADDAEAFTAKFGIP-VLT
Mvan_1982|M.vanbaalenii_PYR-1 ALRMVLHS---DLTREDLDGIRVVTSGTAPLSADDADAFTEKFGIP-VLT
MSMEG_2217|M.smegmatis_MC2_155 ALRTVLHS---DLTREDLAGVRVVTSGTAPLSADDADAFTEKFGIP-VLT
Mb1462c|M.bovis_AF2122/97 MFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFGDV-IYN
Rv1427c|M.tuberculosis_H37Rv MFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPDVVIAFMDQFGDV-IYN
MAB_4569c|M.abscessus_ATCC_199 QWQAVCAA---QQANPRKVRLKTLSWGAAPATDVLLRTMSETFPDARILA
MLBr_01051|M.leprae_Br4923 VWSRLVAD---EAVARALRPARLLVSGSASLPVPVFDRLAHLTGHR-PIE
: : . : :
MMAR_4025|M.marinum_M SYAATEFGGGVAGWTLADHSRYWHTKRGSVGRANPGTQLRIVDTEGAPVE
MUL_3890|M.ulcerans_Agy99 SYAATEFGGGVAGWTLADHSRYWHTKRGSVGRANPGTQLRIVDTEGAPVE
MAV_1580|M.avium_104 SYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPGAALRVVAEDGTPLG
TH_3559|M.thermoresistible__bu SYAATEFGGGVAGWTLADHRRYWRTKRGSSGRATGGAQLRVVDEQGNPLG
Mflv_4362|M.gilvum_PYR-GCK SYAATEFGGGVAGWTLADHRKYWQDKRGSVGRANPGARLRVVDDNRDPVP
Mvan_1982|M.vanbaalenii_PYR-1 SYAATEFGGGVAGWTLKDHQRFWQHKRGSVGRANPGAQLRVVDDNGEPVP
MSMEG_2217|M.smegmatis_MC2_155 SYAATEFGGGVAGWTLPDHGKYWKDKRGSVGRANPGAQLRVVDENGAPLG
Mb1462c|M.bovis_AF2122/97 NYNATEAG-MIATATPADLR----TAPDTAGRPAEGTEIRILDQQFTEVP
Rv1427c|M.tuberculosis_H37Rv NYNATEAG-MIATATPADLR----TAPDTAGRPAEGTEIRILDQQFTEVP
MAB_4569c|M.abscessus_ATCC_199 AFGQTEMSPVTCMLMGDDAIR----KMGSVGRVIPTVSARVVDDNMNDVP
MLBr_01051|M.leprae_Br4923 RYGSTESLITLSTLADGERR------AGWVGLPLAGVQTRLVDESGGPVP
: ** . : . * . *:: . :
MMAR_4025|M.marinum_M RA--SLGLLEVKP-------------AQLGVS-APWVRTTDVARIDADGF
MUL_3890|M.ulcerans_Agy99 RA--SLGLLEVKP-------------AQLGVS-APWVRTTDVARIDADGF
MAV_1580|M.avium_104 PD--EIGLMEVKP-------------GQLGPD-ADWLRTTDMARIDADGF
TH_3559|M.thermoresistible__bu PD--QPGVLEVKP-------------GQLGPD-ADWLRTTDLARIDADGF
Mflv_4362|M.gilvum_PYR-GCK PG--EPGLLEVIP-------------AQLADT-GEWMQTTDVARIDEDGF
Mvan_1982|M.vanbaalenii_PYR-1 PG--QQGLLEVIP-------------AQLAGR-SGWMQTTDLARIDEDGF
MSMEG_2217|M.smegmatis_MC2_155 PD--EPGLLEVIP-------------AQMGPG-SPWMRTTDLARIDADGF
Mb1462c|M.bovis_AF2122/97 TG--EVGTIYVRNDSQFD---GYTSGAAKDFH-AGFMSSGDVGYLDENGR
Rv1427c|M.tuberculosis_H37Rv TG--EVGTIYVRNDSQFD---GYTSGAAKDFH-AGFMSSGDVGYLDENGR
MAB_4569c|M.abscessus_ATCC_199 VG--EVGEIVYRAPTLMQGYWNNPEATADAFA-GGWFHSGDLVRQDEDGF
MLBr_01051|M.leprae_Br4923 YDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGM
* : : : *: * .*
MMAR_4025|M.marinum_M VWIVGR-ADQAIIRGGFKVLPDDVGAALESHPAVAAAAVVGRSDQRLGQT
MUL_3890|M.ulcerans_Agy99 VWIVGR-ADQAIIRGGFKVLPDDVRAALESHPAVAAAAVVGRSDQRLGQT
MAV_1580|M.avium_104 VWIVGR-ADQAIIRGGFKVMPDDVRAALESHPAVAGAAVVARPDPRLGET
TH_3559|M.thermoresistible__bu LWILGR-ADQAIIRGGFKIMPDDVRAALERHPAVRGAAVVGIPDARLGET
Mflv_4362|M.gilvum_PYR-GCK LWILGR-ADQAIIRGGFKVMPDDVRSALESHAAVAGAAVVGRPDPRLGET
Mvan_1982|M.vanbaalenii_PYR-1 VWILGR-ADQAIIRGGFKVMPDDVKNALESHPAVAGASVVGRPDPRLGET
MSMEG_2217|M.smegmatis_MC2_155 LWVLGR-ADQAIIRGGFKVMPDDVRAALESHPAVLGASVIGVADERLGET
Mb1462c|M.bovis_AF2122/97 LFVVGR-DDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGVDDQQYGQR
Rv1427c|M.tuberculosis_H37Rv LFVVGR-DDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGVDDQQYGQR
MAB_4569c|M.abscessus_ATCC_199 VWVVDR-KKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEKWGEV
MLBr_01051|M.leprae_Br4923 HRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQR
::.* : * ** .: :: :* * : .:*:. . *:
MMAR_4025|M.marinum_M PVAMVELRGSADIGGAELVEYLRTRLSGYEIPTQISIVAEIPRTASGKPD
MUL_3890|M.ulcerans_Agy99 PVAMVELRGSADIGGAELVEYLRTRLSGYEIPTQISIVAEIPRTASGKPD
MAV_1580|M.avium_104 PVAMVELR--APSTTDALVEHLRERLARYEIPTEIAIVDALPRTPSGKAD
TH_3559|M.thermoresistible__bu PAALVELHDGAAAGTDELTAFLRERLAPYEVPTEIAVVDALPRTPSGKAD
Mflv_4362|M.gilvum_PYR-GCK PVALVELRPGATASPEELSAYLQTRLARYEIPTALILTDAIPRTPSGKPD
Mvan_1982|M.vanbaalenii_PYR-1 PVALVQLRPGMSAEPDELLNYLQKRLARYEIPGELVITDAIPRTASGKPD
MSMEG_2217|M.smegmatis_MC2_155 PVAMVELRG--PATPDELAGYLQGRLARYEIPTRITIVDAIPRTPSGKAD
Mb1462c|M.bovis_AF2122/97 LAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELPRGITGKIL
Rv1427c|M.tuberculosis_H37Rv LAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELPRGITGKIL
MAB_4569c|M.abscessus_ATCC_199 PVAVAAIHG-AALTLAELDGFLTARLARYKHPKDLVIVDALPRNPSGKVL
MLBr_01051|M.leprae_Br4923 IVAFVVGAE--ALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVL
.*.. * .: .*: :: * : . :** **
MMAR_4025|M.marinum_M LGAIRHYFG-AAGSRTDHGG
MUL_3890|M.ulcerans_Agy99 LGAIRHYFG-AAGSRTDHGG
MAV_1580|M.avium_104 LAAVRGYFAERPTVLRDHAR
TH_3559|M.thermoresistible__bu LGAVR-----RTLAPAGHDG
Mflv_4362|M.gilvum_PYR-GCK LTAVR--------ARLAQP-
Mvan_1982|M.vanbaalenii_PYR-1 LTAVR--------SHFAQS-
MSMEG_2217|M.smegmatis_MC2_155 LRAVR--------DHLESGG
Mb1462c|M.bovis_AF2122/97 RTELQ--------SRVGS--
Rv1427c|M.tuberculosis_H37Rv RTELQ--------SRVGS--
MAB_4569c|M.abscessus_ATCC_199 KTELR--------QRFGIAD
MLBr_01051|M.leprae_Br4923 KKQLLFEG------------
: