For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MASDFGPRIADLVEVAATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRMGSNA EFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGP SGGTLSVHLDAATEPNPATSTPEGLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDA TVAVMPLYHGHGLIASLLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERSATEP SGRKPAALRFIRSCSAPLTAQAALALQTEFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGR STGAQIRIVGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGR IKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPHQLYGEAVAAVIVPRESAPPTREELVQFCRERLA AFEIPASFQEASGLPHTAKGSLDRRAVAERFGHSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0119 | fadD7 | - | 100% (525) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 2e-47 | 28.79% (535) | AMP-binding domain protein |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 4e-45 | 27.22% (518) | chain-fatty-acid-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0123 | fadD7 | 0.0 | 100.00% (525) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 4e-56 | 32.82% (515) | AMP-dependent synthetase and ligase |
| M. leprae Br4923 | MLBr_02661 | - | 0.0 | 71.35% (520) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2247c | - | 2e-44 | 30.57% (530) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. marinum M | MMAR_0319 | fadD7 | 0.0 | 75.82% (521) | fatty-acid-CoA ligase FadD7 |
| M. avium 104 | MAV_5190 | - | 0.0 | 70.55% (523) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5295 | - | 1e-127 | 50.10% (513) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3626 | - | 1e-66 | 32.75% (513) | PUTATIVE putative fatty-acid-CoA ligase |
| M. ulcerans Agy99 | MUL_4803 | fadD7 | 0.0 | 75.05% (521) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 9e-52 | 31.65% (515) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0027|M.gilvum_PYR-GCK --------------------------------------MFHNLADIVRSH
Mvan_0943|M.vanbaalenii_PYR-1 --------------------------------------MIHNLADIIRVH
Rv0119|M.tuberculosis_H37Rv --------------MASD--------------------FGPRIADLVEVA
Mb0123|M.bovis_AF2122/97 --------------MASD--------------------FGPRIADLVEVA
MMAR_0319|M.marinum_M --------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELA
MUL_4803|M.ulcerans_Agy99 --------------MASDSITGGQAVPAHVGTQPCDSAAGPRLADLVELA
MLBr_02661|M.leprae_Br4923 --------------MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAA
MAV_5190|M.avium_104 --MDRYWTQRNAARHGGSDDTTGKDVAMTSEATPSATAAGPRLADLVEAA
MSMEG_5295|M.smegmatis_MC2_155 -----------MRFMGTAATPP--------------ATLLSGLFDVLDHH
TH_3626|M.thermoresistible__bu -----------------------------------MLSQSVHLVSLPDQR
MAB_2247c|M.abscessus_ATCC_199 MTQPRSTTTASSAATPALDGFVPFPSVRADEYRRAGYWTGNTVESLLRVS
: .:
Mflv_0027|M.gilvum_PYR-GCK GRNRPDAPALIVGDR--TVSYRELDERSNRTAQAFSRTGVGPGDRVAFVE
Mvan_0943|M.vanbaalenii_PYR-1 GRERPGAPALVVGDR--TVTYGELDDRSSRAAQAFAQAGVGVGDRVAFVD
Rv0119|M.tuberculosis_H37Rv ATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRM
Mb0123|M.bovis_AF2122/97 ATRLPEAPALVVTADRIAISHRDLARLVDELAGQLTRSGLLPGDRVALRM
MMAR_0319|M.marinum_M AARLPEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRPGERVALRS
MUL_4803|M.ulcerans_Agy99 AAQLSEATAVIFTADRVAVSYRDLVRLVDDLAGQLTRAGLRQGERVALRS
MLBr_02661|M.leprae_Br4923 AIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCA
MAV_5190|M.avium_104 AQRAPRAPALLVASERTPIAYADLVRLVDDLAARLRAAGLAPGDRVGLRA
MSMEG_5295|M.smegmatis_MC2_155 VRTRPDAPALVVTQQRIAVTYATLGRWADDVAAGLTADGLRRGEVIAVVD
TH_3626|M.thermoresistible__bu AASAPAAP--CLADDTVALSNAEFRHAVDSAAAVLRGHGVGAGDVVAVML
MAB_2247c|M.abscessus_ATCC_199 AARRPCHPAVIDEHR--ALSYRELDEAADNAAHAFLRLGIAPGDRVLLQL
. . :: : . : : *: *: : .
Mflv_0027|M.gilvum_PYR-GCK RNGIEFFDVAFGSAKLGAVAVPVNWRLTAPEMRHVIADCGASVVVVGQ--
Mvan_0943|M.vanbaalenii_PYR-1 KNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVVVGQ--
Rv0119|M.tuberculosis_H37Rv GSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA--
Mb0123|M.bovis_AF2122/97 GSNAEFVVALLAASRADLVVVPLDPALPITEQRVRSQAAGARVVLIDA--
MMAR_0319|M.marinum_M GSNLEFVVALLAASRANLIVVPLDPALPVADQRARAGAAGARVVLIDG--
MUL_4803|M.ulcerans_Agy99 GSNLEFVVALLAASRANLIVVPLDPALPVAYQRARAGAAGARVVLIDG--
MLBr_02661|M.leprae_Br4923 ASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLA
MAV_5190|M.avium_104 GSNPEFVVALLAASRADLVVAPLDPALPAADQLSRSRAVGARAVLVDR--
MSMEG_5295|M.smegmatis_MC2_155 VNTAEFVVALLAAARIGAVVAPLDPALADAEMTDRLARLGARAVLTGP--
TH_3626|M.thermoresistible__bu PNTVDLVVTLFAAWRLGAAVTPLNPALSVDESAYQIADAGAKVLVAGG--
MAB_2247c|M.abscessus_ATCC_199 PNRASFAVALFGLMRAGAIPVMCLPGHRAAELSHFIEVADAVGLVIPDSA
. .: :. : . . .. :
Mflv_0027|M.gilvum_PYR-GCK -EFTGRIEAIADDLDVEVVVIGKHRH-----WPTFDDLLAAAPAVDPGVV
Mvan_0943|M.vanbaalenii_PYR-1 -DFAGHLEAIEDGLDADIVVIGDHPR-----WPAFDDWVASHPPVDPGVV
Rv0119|M.tuberculosis_H37Rv -DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPE
Mb0123|M.bovis_AF2122/97 -DGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVHLDAATEPNPATSTPE
MMAR_0319|M.marinum_M -TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVASAPQ
MUL_4803|M.ulcerans_Agy99 -TGPGDRDEPAVRWWPIAVSVARDTG----ILSVHLDAAGEPTAVASAPQ
MLBr_02661|M.leprae_Br4923 LEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVTSTPD
MAV_5190|M.avium_104 -LGEGQTAPESAPCWPVTVTVGPDDS----APTVDLTVTAAPTHDVTAPQ
MSMEG_5295|M.smegmatis_MC2_155 --CEHALGTHRVRVTASRATVEPTRG-----------ATVEPTVRQAVDL
TH_3626|M.thermoresistible__bu --------NLPAPATPVVRPADLKTG----------------HGPVEVAP
MAB_2247c|M.abscessus_ATCC_199 GGFDYRALAVALSQRHPRLRTVVVEG-DAGPFASWTSLLKSVEPQGPLPT
Mflv_0027|M.gilvum_PYR-GCK TGPDDLVFLMYTSGTTGAPKGVMLSNANVVCKTAGVGGPWKFDADSVSLA
Mvan_0943|M.vanbaalenii_PYR-1 TGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQFDADAVSLA
Rv0119|M.tuberculosis_H37Rv GLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVA
Mb0123|M.bovis_AF2122/97 GLRPDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPRDATVA
MMAR_0319|M.marinum_M GLRADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYRLSPQDATVA
MUL_4803|M.ulcerans_Agy99 GLRADDAMIMFTGGTTGLPKMVPWTRANIATSIRSIIAGYRLSPQDATVA
MLBr_02661|M.leprae_Br4923 GLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGPQDATVV
MAV_5190|M.avium_104 GLRDDDAMIMFTGGTTGAPKMVPWTRHNIAASIRSIVAGYGLGPRDATVA
MSMEG_5295|M.smegmatis_MC2_155 GLGPDDALILFTSGTTGRAKMVPWTHANIAASVHGICAAYELGDGDATVA
TH_3626|M.thermoresistible__bu PADDRLALLIYTSGTTGRPKGVMLDHANIAAMCASIIEANELTSADSSLL
MAB_2247c|M.abscessus_ATCC_199 VQTDTPALLLVSGGTTAAPKLIPRTHEDYVYNATQAARVCGLTQDDVYLV
.::: :.***. .* : : . : :
Mflv_0027|M.gilvum_PYR-GCK VMPLFHMAGFGWA-LAGLWEGAVTVVLRD---VDPGAILDAVARHRVTNM
Mvan_0943|M.vanbaalenii_PYR-1 VMPLFHMAGSGWA-LAGLWQGATTVVLRD---VEPAAILDAIARHRITNM
Rv0119|M.tuberculosis_H37Rv VMPLYHGHGLIAS-LLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWY
Mb0123|M.bovis_AF2122/97 VMPLYHGHGLIAS-LLATLASGGAVSLPARGRFSAHTFWDDIKAVGATWY
MMAR_0319|M.marinum_M VMPLYHGHGLMAA-LLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWY
MUL_4803|M.ulcerans_Agy99 VMPLYHGHGLMAA-LLSTLVSGGTVLLPARGKFSAHTFWDDIHVAHATWY
MLBr_02661|M.leprae_Br4923 VMPLYHGHGLIAA-LLSTLASGGVVLLPARARFSARTFWDDIDAVAATWY
MAV_5190|M.avium_104 VMPLYHGHGLLAA-LLATLASGGAVLLPARGKFSAHTFWDDIAAVGATWY
MSMEG_5295|M.smegmatis_MC2_155 VMPFFHGHGLVAV-LLSTLAGGGKVLLPAHGRFSAHTFWADMRDADATWF
TH_3626|M.thermoresistible__bu ILPLFHVNGIVVG-TLSPLIAGGHVTIAG--RFDPRTFFDRVRRSRPTYF
MAB_2247c|M.abscessus_ATCC_199 ALPAGHNFPLACPGLLGAISTGATTVFLS--DPSPESAFATIARHRVSVT
:* * . . . : .. : : :
Mflv_0027|M.gilvum_PYR-GCK LLVPAVIQFLLDTTGLD------DTDLSRLRIVVYGASPITDDVLMRGID
Mvan_0943|M.vanbaalenii_PYR-1 LLVPAVIQFLLDTDGVA------EVDLSTLRVIVYGASPISDDVLVRGIE
Rv0119|M.tuberculosis_H37Rv TAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALALQT
Mb0123|M.bovis_AF2122/97 TAVPTIHQILLERSATE----PSGRKPAALRFIRSCSAPLTAQAALALQT
MMAR_0319|M.marinum_M TAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSAPLTPETAQALHD
MUL_4803|M.ulcerans_Agy99 TAVPTIHQILLERAKTEREADSSGRTRAALRFIRSCSGPLTPETAQALHD
MLBr_02661|M.leprae_Br4923 TAAPAIHRILLELASTQ----SFRSKRAKLRFIRSCSAPLTQETAQALRE
MAV_5190|M.avium_104 TAVPTIHQILLERARTE-----APRGTHALRFIRSCSAPLTAETAQALQD
MSMEG_5295|M.smegmatis_MC2_155 TAVPTIHQILLQRPDEE---------HPPLRFVRSCSAPLDPATAEAAER
TH_3626|M.thermoresistible__bu SAVPTIYTKLLELPEDP------TVDTSSLRFAACGAAPASAELLQRFEQ
MAB_2247c|M.abscessus_ATCC_199 AVVPSLAQLWAQATAWEP------VLPETLRLLQVGGAKLGADDARAVRE
.*:: : **. ..
Mflv_0027|M.gilvum_PYR-GCK RFGGIFAQVYGMTESTGSVTQLDGDE----HLPQLLRSCGRPYPWVQIRV
Mvan_0943|M.vanbaalenii_PYR-1 RFGPIFAQVYGMTETTGSITQLDGPD----HVPALLRSCGRPYPWVQIRI
Rv0119|M.tuberculosis_H37Rv EFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRI
Mb0123|M.bovis_AF2122/97 EFAAPVVCAFGMTEATHQVTTTQIEGIDQTETPVVSTGLVGRSTGAQIRI
MMAR_0319|M.marinum_M EFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRI
MUL_4803|M.ulcerans_Agy99 EFSAPVLCAFGMTEATHQVASTGVEGSGCDENPAESTGLVGRSTGPEIRI
MLBr_02661|M.leprae_Br4923 EFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQIRI
MAV_5190|M.avium_104 TFGAPVVCAFGMTEATHQVSTTAIDGAGHSENPGATPGLVGRSTGPDIRI
MSMEG_5295|M.smegmatis_MC2_155 RFGAPMLEAYGMTETTHQAASRRVR----THDPRMSVGPA--SGAARFQV
TH_3626|M.thermoresistible__bu RYGVPIIEGYGLSEGTCVSTANPLRG------PRKPGTVGLPLPGQQVRI
MAB_2247c|M.abscessus_ATCC_199 SLTQGLQQVFGMAEGLLCLTQPGDPTDILDNSQGRP-----MCDADEVRI
. :*::* : .::
Mflv_0027|M.gilvum_PYR-GCK VDPTGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDAG
Mvan_0943|M.vanbaalenii_PYR-1 VDETGADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGDAG
Rv0119|M.tuberculosis_H37Rv VGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFT-DGWLRTGDLG
Mb0123|M.bovis_AF2122/97 VGSDGLPLPAGAVGEIWLRGTTVVRGYLGDPTITAANFT-DGWLRTGDLG
MMAR_0319|M.marinum_M VGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFT-DGWLRTGDLG
MUL_4803|M.ulcerans_Agy99 VGPDGHPVGPGAVGEVWLHGPTVVRGYLGDPKITAANFT-DGWLRTGDLG
MLBr_02661|M.leprae_Br4923 VGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFT-HGWLRTGDLG
MAV_5190|M.avium_104 AGPDGQSLPADTVGEVWLRGATVVRGYLGDPAITAANFT-DGWLHTGDLG
MSMEG_5295|M.smegmatis_MC2_155 VRSDGGECTPAETGEVWVSGPAVVRGYLADPENTAQAFT-DGWFRTGDLG
TH_3626|M.thermoresistible__bu VDAEGRTLGANEIGEVLIAGPTVMRGYLNRPEETAKTLV-DGWLRTGDIG
MAB_2247c|M.abscessus_ATCC_199 VDEDGADVPAGETGELLVRGPYTLNGYYRADADNMRSFTVDGFYRSGDRV
. * . **: . : ** . :. .*: ::**
Mflv_0027|M.gilvum_PYR-GCK YLDRDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIPD
Mvan_0943|M.vanbaalenii_PYR-1 YVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGVPD
Rv0119|M.tuberculosis_H37Rv SLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPH
Mb0123|M.bovis_AF2122/97 SLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPH
MMAR_0319|M.marinum_M TLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVLENAVFGVPD
MUL_4803|M.ulcerans_Agy99 TLSQAGDLSIRGRIKELINRGGEKISPERVEGVLASHPGVQENAVFGVPD
MLBr_02661|M.leprae_Br4923 SLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDPD
MAV_5190|M.avium_104 TLSAAGDLVVRGRIKELINRGGEKISPERVEGVLAGHPDVLEAAVFGRPD
MSMEG_5295|M.smegmatis_MC2_155 ALDADGNLQLTGRIKNIINRGGEKISPEHVEGVLTGCDGVFEAVVFAIPD
TH_3626|M.thermoresistible__bu YLDDDGYLVLVDRAKDMIIRGGENIYPKEIEAVAHRLPEISEVAVVGRPH
MAB_2247c|M.abscessus_ATCC_199 RALPGGYLEVTGRIKDVILRGGESIAALDLESHLQTHPAVYAAAAVGLPD
* * : .* *::* ..*.: . :* : .... *.
Mflv_0027|M.gilvum_PYR-GCK TRWGEAVKAVVVAG--APVTEAELIAFAREQLAGFKLPKSVDFVDALPRN
Mvan_0943|M.vanbaalenii_PYR-1 RRWGEAVKAVVVAARGAQLTEAELIAFARDRIGGFKLPKSVDFVDVLPRN
Rv0119|M.tuberculosis_H37Rv QLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHT
Mb0123|M.bovis_AF2122/97 QLYGEAVAAVIVPRESAPPTREELVQFCRERLAAFEIPASFQEASGLPHT
MMAR_0319|M.marinum_M ALYGEAVAAVIVPREPAP-TAQELTEFCREKLASFEIPATFQMASELPHT
MUL_4803|M.ulcerans_Agy99 ALYGEAVAAVIVPREPAP-TAQELTEFCREKLASFEIPATFQMASELPHT
MLBr_02661|M.leprae_Br4923 KVYGETVTAVIVPREVIAPTPSELAVFCRDRLAAFEVPTRFQEASALPHT
MAV_5190|M.avium_104 QLYGETVAAVIVTRGSAAPTADELASFCRERLAPFEVPAEFRRAAELPHT
MSMEG_5295|M.smegmatis_MC2_155 ATYGEQVGAAVVP-AAAHVSADDILAQCRTGLAPYEVPARLDIVESLPHT
TH_3626|M.thermoresistible__bu PLYGEVPVMYVAAAPGAVVDTDAVRRHLAVSLAKYKQPVAIRVLDVLPKN
MAB_2247c|M.abscessus_ATCC_199 QYLGEIVCAAIVFKGKPVAAAELNQHLQARGAATHSRVDKLVAVSALPLT
** :. . .. . ** .
Mflv_0027|M.gilvum_PYR-GCK PSGKLLKRQLREPYWTDEDRHIG
Mvan_0943|M.vanbaalenii_PYR-1 PSGKLLKRALREPYWDGADRHIG
Rv0119|M.tuberculosis_H37Rv AKGSLDRRAVAERFGHSV-----
Mb0123|M.bovis_AF2122/97 AKGSLDRRAVAERFGHSV-----
MMAR_0319|M.marinum_M AKGSLDRRAVAQQFGGQA-----
MUL_4803|M.ulcerans_Agy99 AKGSLDRRAVAQQFGGQA-----
MLBr_02661|M.leprae_Br4923 AKGSLDRRAVAEQFAHRG-----
MAV_5190|M.avium_104 AKGSLDRRAVAEQFGESA-----
MSMEG_5295|M.smegmatis_MC2_155 AKGAIDRQAVKLLFAH-------
TH_3626|M.thermoresistible__bu AVGKIDKPAIRTLDATATQTA--
MAB_2247c|M.abscessus_ATCC_199 AVGKIDKRALLASLTG-------
. * : : :