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VTMTSIQEALGRLWHADKDARMLQCDGQWVTWGQVRTLTERIASELAAAGCGPGGRVAVVLGNRMESVAT LIAIFRTERTLVTISPLQPAERLAADLVASGADYVLAPQSLWAERVFADAVAELGGSAFSVDGSEVVARS AATRDARDGDAAIAIEMLTSGTTGPAKRVPLGRKQLEVSLSAALRHNDRPDVRDKPPLTGAVGMVTLPIV HIGGLWALLQALVAARPIVMLERFSLDGWHNAIKDHKPILIGLPPPAIREVLNSDIPREDLASVRAVNSG TAPVDPVLVDGFLERYGIPILITYGATEFAGAVAGWTLKDFHASWTEKKGSVGRPFPGVRMQVIDEGGTV LPPGQSGRLQVASAQVADSAERWVTTSDLAHIDEDGYLYIDGRADDVIVRGGFKIAPETVVRALRSHGAV ADAAVAGLPDDRLGQIPVAAVELKSAMTATGDELRAHCRASLTPYEVPAQVFVVDELPRGAALKVDRRRL VATLEKLTAVTQSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1880 | - | - | 100% (504) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2596 | - | 0.0 | 69.29% (495) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1580 | - | 3e-89 | 40.30% (469) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 8e-39 | 28.01% (482) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4362 | - | 4e-93 | 39.11% (496) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 8e-39 | 28.01% (482) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 2e-31 | 27.36% (497) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 1e-38 | 33.79% (364) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4025 | - | 2e-93 | 42.16% (472) | long-chain fatty-acid CoA ligase |
| M. smegmatis MC2 155 | MSMEG_2217 | - | 3e-93 | 41.37% (481) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3166 | - | 5e-91 | 39.71% (486) | PUTATIVE putative AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3890 | - | 2e-89 | 41.00% (478) | long-chain fatty-acid CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_1982 | - | 4e-98 | 41.58% (469) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4362|M.gilvum_PYR-GCK -------------------------------------------MHPLSRR
Mvan_1982|M.vanbaalenii_PYR-1 -----------------------------------------MMVHRLSQR
MSMEG_2217|M.smegmatis_MC2_155 ------------------------------------------MAHPLSQR
MMAR_4025|M.marinum_M -----------------------------------------MSNHPLSQR
MUL_3890|M.ulcerans_Agy99 -----------------------------------------MSNHPLSQR
TH_3166|M.thermoresistible__bu --------------------------------------------------
MAV_1880|M.avium_104 -----------------------------------------MTMTSIQEA
Mb1462c|M.bovis_AF2122/97 ------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAG
Rv1427c|M.tuberculosis_H37Rv ------MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAG
MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML
MLBr_02661|M.leprae_Br4923 ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL
Mflv_4362|M.gilvum_PYR-GCK IAEVMALDASAPAIQFERR--WVTWGQIAESARHVST---VVG---SGTA
Mvan_1982|M.vanbaalenii_PYR-1 IDDVLALAPAGRAIQFDGD--WVTWEQIGTLAQRISD---VVG---TARA
MSMEG_2217|M.smegmatis_MC2_155 IADVLDLDPDAGAIQFDGQ--WSCWGQIAALAGHIEK---ITG---PARV
MMAR_4025|M.marinum_M IADTLDLQPDARAVEYDRA--WLSWGQLGAATRRVAA---LAARQPSPEI
MUL_3890|M.ulcerans_Agy99 IAVTLDLQPDARAVEYDRA--WLSLGQLGAATRRVAA---LAAKQPSPEI
TH_3166|M.thermoresistible__bu ---VLALDPSAEAVEYQGA--WTDWKTVAHVAHAVESRLTAAGLGAGSPV
MAV_1880|M.avium_104 LGRLWHADKDARMLQCDGQ--WVTWGQVRTLTERIASELAAAGCGPGGRV
Mb1462c|M.bovis_AF2122/97 FAGAARRCPDRPGLIDELG--TLTWRQLDERGNALAAALQALPAGPPRVV
Rv1427c|M.tuberculosis_H37Rv FAGAARRCPDRPGLIDELG--TLTWRQLDERGNALAAALQALPAGPPRVV
MAB_2539c|M.abscessus_ATCC_199 LAASAIRFPDRAALIDDSG--QLTYRDLQRRAEAVAAAVYARTPSAPRSV
MLBr_02661|M.leprae_Br4923 VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV
: : :
Mflv_4362|M.gilvum_PYR-GCK GIMLRNTPSHVAALLGVLSGGGTVVVINPSRGDERTRADIEALQLPTLIG
Mvan_1982|M.vanbaalenii_PYR-1 GIMLRNRPVHVAALLGVLRGGGTVVVINPSRGDDRTRSDVEALNLPIIIG
MSMEG_2217|M.smegmatis_MC2_155 GIMLRNHPVHVAALLGVLAAGGTVVVINPARGDDRTRADLEALALPVVVG
MMAR_4025|M.marinum_M GILLRSRPAQMAAFLGVLLSGATVVTINPSRGDERTRADIAALELPLIAG
MUL_3890|M.ulcerans_Agy99 GILLRNRPAQMAAFLGVLLAGATVVTINPSRGDERTRADIAALELPLIAG
TH_3166|M.thermoresistible__bu GLILRNHPAMVAALLGVLLVNGCVVTINASSGDARLATDLEELRLPVVIG
MAV_1880|M.avium_104 AVVLGNRMESVATLIAIFRTERTLVTISPLQPAERLAADLVASGADYVLA
Mb1462c|M.bovis_AF2122/97 GIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVY
Rv1427c|M.tuberculosis_H37Rv GIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVY
MAB_2539c|M.abscessus_ATCC_199 GIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRHEPDVLVY
MLBr_02661|M.leprae_Br4923 ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV
.: . ::. :: :..
Mflv_4362|M.gilvum_PYR-GCK LAEDLE--SLAPGTT--ATTMALGDI--DTTPE------ITGGS-PSEGQ
Mvan_1982|M.vanbaalenii_PYR-1 SSEDLA--ALAPDTA--ATTVAVDGF--DEPPT------LHRGN-ASDDA
MSMEG_2217|M.smegmatis_MC2_155 LAEDLA--HLMPAHSPRTTRVAIAGL--DTEPV------VTAAESPATDA
MMAR_4025|M.marinum_M SDEDLG--LLVTNTT-DSATVSLSDL--FDHPG------EPGDH--TTRG
MUL_3890|M.ulcerans_Agy99 SDEDLG--LLVTNTT-DSATVSLSDL--FDHPG------EPGGH--TTRG
TH_3166|M.thermoresistible__bu LGADWGRPHIVEAAAGALGLEVAADP--ASVRT------VTGRG--SVGA
MAV_1880|M.avium_104 PQSLWAERVFADAVAELGGSAFSVDG--SEVVA------RSAATRDARDG
Mb1462c|M.bovis_AF2122/97 DEEFSATVDRALAEKPQATRIVAWTD--EDHDL------TVEKLVAAHAG
Rv1427c|M.tuberculosis_H37Rv DEEFSATVDRALAEKPQATRIVAWTD--EDHDL------TVEKLVAAHAG
MAB_2539c|M.abscessus_ATCC_199 DDEYSQAVE---ESQYQGLRVLAWRENPQENRL------TLDSLADQHHP
MLBr_02661|M.leprae_Br4923 DSLALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPVT
Mflv_4362|M.gilvum_PYR-GCK H-----RPGVAVRMPTSGTTGPPKRVDLTYDMLARSVMGRDPDT---APS
Mvan_1982|M.vanbaalenii_PYR-1 G-----RPGVAVWMLTSGTTGPPKRVDLTYDMLARSVMGPDSDH---DSA
MSMEG_2217|M.smegmatis_MC2_155 G-----GPGVAVWMLTSGTTGPPKRVDLTYDMLARSVMGREPEK---CPA
MMAR_4025|M.marinum_M A-----GADVAVRMLTSGTTGPPKRVDLSYDMLARSVMGPAPDR---DPA
MUL_3890|M.ulcerans_Agy99 A-----GADVAVRMLTSGTTGPPNRVDLSYDMLARSVMGPAPDR---DPA
TH_3166|M.thermoresistible__bu GPFRPDRPGVAVEMLTSGTTGPPKRVPLSYNAFQHTVAAAGAHYGSGDNG
MAV_1880|M.avium_104 D------AAIAIEMLTSGTTGPAKRVPLGRKQLEVSLSAALRHNDRPDVR
Mb1462c|M.bovis_AF2122/97 RRPEHTGSHGKVILLTSGTTGTPKGARHSGGG---IGTLKAILD------
Rv1427c|M.tuberculosis_H37Rv RRPEHTGSHGKVILLTSGTTGTPKGARHSGGG---IGTLKAILD------
MAB_2539c|M.abscessus_ATCC_199 K-PPPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMA------
MLBr_02661|M.leprae_Br4923 STPDGLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAY------
: : *.**** .: .
Mflv_4362|M.gilvum_PYR-GCK PTE-LRQGVAIVNSPLVHVGGVFRILLCLAEARPFVLL---PKFELHSWA
Mvan_1982|M.vanbaalenii_PYR-1 PTD-LRRGVAIVNSPLVHVGGVFRVLLCVAEARPFVLL---PKFELKQWA
MSMEG_2217|M.smegmatis_MC2_155 PTE-LRRGVAIVNSPLVHVGGVFRVLLCIAEARPFVLL---PKFELQRWA
MMAR_4025|M.marinum_M PTE-PRRGVAIVNSPLVHIGGVYRVLQCIAQARPFVLL---DRFELNAWA
MUL_3890|M.ulcerans_Agy99 PTE-PRRGVAIVNSPLVHIGGVYRVLQCIAQARPFVLL---DRFELNARA
TH_3166|M.thermoresistible__bu QVR-LRSGVAIISSPLVHMSGLFRTLLNICEGRRIALL---ERFRVDDFV
MAV_1880|M.avium_104 DKPPLTGAVGMVTLPIVHIGGLWALLQALVAARPIVML---ERFSLDGWH
Mb1462c|M.bovis_AF2122/97 RTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTR---RRFDPEATL
Rv1427c|M.tuberculosis_H37Rv RTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTR---RRFDPEATL
MAB_2539c|M.abscessus_ATCC_199 TVRLRSRDRVLVAPPFFHGFGLAALLGPLALGGTVMCR---RRFDAQQAM
MLBr_02661|M.leprae_Br4923 --QLGPQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFW
:: *: * *. : . . :*
Mflv_4362|M.gilvum_PYR-GCK EAVREHRPAAVSLVPAALRMVLHSDLT---RDDLAGVRVVTSGTAPLSAD
Mvan_1982|M.vanbaalenii_PYR-1 DAVREHRPRAVSLVPAALRMVLHSDLT---REDLDGIRVVTSGTAPLSAD
MSMEG_2217|M.smegmatis_MC2_155 AAVREHRPRAVSLVPAALRTVLHSDLT---REDLAGVRVVTSGTAPLSAD
MMAR_4025|M.marinum_M AAVRKHRPRTVSLVPAALRTVLHSDLT---RADLASVRTVTCGTAPLAPD
MUL_3890|M.ulcerans_Agy99 AAVRKHRPRTVSLVPAALRTVLHSDPT---RADLASVRTVTCGTAPLAPD
TH_3166|M.thermoresistible__bu DLVVRHQPKAVSLVPSALAMVLDAGVP---PEVFSSVKVVTSGTAPLPVE
MAV_1880|M.avium_104 NAIKDHKPILIGLPPPAIREVLNSDIP---REDLASVRAVNSGTAPVDPV
Mb1462c|M.bovis_AF2122/97 DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
Rv1427c|M.tuberculosis_H37Rv DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
MAB_2539c|M.abscessus_ATCC_199 TDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSS
MLBr_02661|M.leprae_Br4923 DDIDAVAATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQE
: * :: :: : :
Mflv_4362|M.gilvum_PYR-GCK DAEAFTAKFGIPVLTSYAATEFGGGVAGWTLADHRK-YWQDKRGSVGRAN
Mvan_1982|M.vanbaalenii_PYR-1 DADAFTEKFGIPVLTSYAATEFGGGVAGWTLKDHQR-FWQHKRGSVGRAN
MSMEG_2217|M.smegmatis_MC2_155 DADAFTEKFGIPVLTSYAATEFGGGVAGWTLPDHGK-YWKDKRGSVGRAN
MMAR_4025|M.marinum_M DADAFTEKYGIPVLTSYAATEFGGGVAGWTLADHSR-YWHTKRGSVGRAN
MUL_3890|M.ulcerans_Agy99 DADAFTEKYGIPVLTSYAATEFGGGVAGWTLADHSR-YWHTKRGSVGRAN
TH_3166|M.thermoresistible__bu LQEAFEERYDVAVLPSYGATEFAGGVAGWNLALHRE-WAKIKRGSVGRPQ
MAV_1880|M.avium_104 LVDGFLERYGIPILITYGATEFAGAVAGWTLKDFHA-SWTEKKGSVGRPF
Mb1462c|M.bovis_AF2122/97 VVIAFMDQFGDVIYNNYNATEAG-----MIATATPA-DLRTAPDTAGRPA
Rv1427c|M.tuberculosis_H37Rv VVIAFMDQFGDVIYNNYNATEAG-----MIATATPA-DLRTAPDTAGRPA
MAB_2539c|M.abscessus_ATCC_199 TVSGVLEAFGPILVNGYGSTEAG-----VVAIASPK-DLVASPNTIGRTA
MLBr_02661|M.leprae_Br4923 TAQALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQS
.. : : : ** .
Mflv_4362|M.gilvum_PYR-GCK PGARLRVVD-DNRDPVPPGEPGLLEVIPA--------------QLADTGE
Mvan_1982|M.vanbaalenii_PYR-1 PGAQLRVVD-DNGEPVPPGQQGLLEVIPA--------------QLAGRSG
MSMEG_2217|M.smegmatis_MC2_155 PGAQLRVVD-ENGAPLGPDEPGLLEVIPA--------------QMGPGSP
MMAR_4025|M.marinum_M PGTQLRIVD-TEGAPVERASLGLLEVKPA--------------QLGVSAP
MUL_3890|M.ulcerans_Agy99 PGTQLRIVD-TEGAPVERASLGLLEVKPA--------------QLGVSAP
TH_3166|M.thermoresistible__bu RGREVRIVSPEDGAELPPGTQGQIEVR------------------TRGGE
MAV_1880|M.avium_104 PGVRMQVID-EGGTVLPPGQSGRLQVASA--------------QVADSAE
Mb1462c|M.bovis_AF2122/97 EGTEIRILD-QQFTEVPTGEVGTIYVRNDSQFDGYTSG-----AAKDFHA
Rv1427c|M.tuberculosis_H37Rv EGTEIRILD-QQFTEVPTGEVGTIYVRNDSQFDGYTSG-----AAKDFHA
MAB_2539c|M.abscessus_ATCC_199 LGVSVRILR-EDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVD
MLBr_02661|M.leprae_Br4923 TGVQIRIVG-SDGQPLPPDTVGEVWLRGSTVVRGYLGDP--AITAANFTH
* :::: * : :
Mflv_4362|M.gilvum_PYR-GCK -WMQTTDVARIDEDGFLWILGRADQAIIRGGFKVMPDDVRSALESHAAVA
Mvan_1982|M.vanbaalenii_PYR-1 -WMQTTDLARIDEDGFVWILGRADQAIIRGGFKVMPDDVKNALESHPAVA
MSMEG_2217|M.smegmatis_MC2_155 -WMRTTDLARIDADGFLWVLGRADQAIIRGGFKVMPDDVRAALESHPAVL
MMAR_4025|M.marinum_M -WVRTTDVARIDADGFVWIVGRADQAIIRGGFKVLPDDVGAALESHPAVA
MUL_3890|M.ulcerans_Agy99 -WVRTTDVARIDADGFVWIVGRADQAIIRGGFKVLPDDVRAALESHPAVA
TH_3166|M.thermoresistible__bu -WVRTTDLGRLDSDGFLFVDGRTDDAIIRGGFKISPADIANALRSHPAVR
MAV_1880|M.avium_104 RWVTTSDLAHIDEDGYLYIDGRADDVIVRGGFKIAPETVVRALRSHGAVA
Mb1462c|M.bovis_AF2122/97 GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
Rv1427c|M.tuberculosis_H37Rv GFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVA
MAB_2539c|M.abscessus_ATCC_199 GHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGIT
MLBr_02661|M.leprae_Br4923 GWLRTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVM
: : *:. :. * : : ** .: * .* :: * : * :: :
Mflv_4362|M.gilvum_PYR-GCK GAAVVGRPDPRLGETPVALVELRPGATASP-EELSAYLQTRLARYEIPTA
Mvan_1982|M.vanbaalenii_PYR-1 GASVVGRPDPRLGETPVALVQLRPGMSAEP-DELLNYLQKRLARYEIPGE
MSMEG_2217|M.smegmatis_MC2_155 GASVIGVADERLGETPVAMVELRG--PATP-DELAGYLQGRLARYEIPTR
MMAR_4025|M.marinum_M AAAVVGRSDQRLGQTPVAMVELRGSADIGG-AELVEYLRTRLSGYEIPTQ
MUL_3890|M.ulcerans_Agy99 AAAVVGRSDQRLGQTPVAMVELRGSADIGG-AELVEYLRTRLSGYEIPTQ
TH_3166|M.thermoresistible__bu DAGVTGLPDPRLGAVPVAAVELAGGAQAEP-DELLDFLRQRLTRYQVPAR
MAV_1880|M.avium_104 DAAVAGLPDDRLGQIPVAAVELKSAMTATG-DELRAHCRASLTPYEVPAQ
Mb1462c|M.bovis_AF2122/97 EAAVIGVDDQQYGQRLAAFVVLKPGVSATP-ETLKQHVRDNLANYKVPRD
Rv1427c|M.tuberculosis_H37Rv EAAVIGVDDQQYGQRLAAFVVLKPGVSATP-ETLKQHVRDNLANYKVPRD
MAB_2539c|M.abscessus_ATCC_199 DAVVIGVPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKR
MLBr_02661|M.leprae_Br4923 EVAVFGDPDKVYGETVTAVIVPREVIAPTP-SELAVFCRDRLAAFEVPTR
. * * * * * : * . : * :::*
Mflv_4362|M.gilvum_PYR-GCK LILTDAIPRTPSGKPDLTAVRARLAQP--------
Mvan_1982|M.vanbaalenii_PYR-1 LVITDAIPRTASGKPDLTAVRSHFAQS--------
MSMEG_2217|M.smegmatis_MC2_155 ITIVDAIPRTPSGKADLRAVRDHLESGG-------
MMAR_4025|M.marinum_M ISIVAEIPRTASGKPDLGAIRHYFGAAGSRTDHGG
MUL_3890|M.ulcerans_Agy99 ISIVAEIPRTASGKPDLGAIRHYFGAAGSRTDHGG
TH_3166|M.thermoresistible__bu LLVLDELPRTPSLKVSQPALRELFEQEPT------
MAV_1880|M.avium_104 VFVVDELPRGAALKVDRRRLVATLEKLTAVTQSG-
Mb1462c|M.bovis_AF2122/97 IAVLDELPRGITGKILRTELQSRVGS---------
Rv1427c|M.tuberculosis_H37Rv IAVLDELPRGITGKILRTELQSRVGS---------
MAB_2539c|M.abscessus_ATCC_199 FIVLDEIPRNASGKVLRAKLNSPGAC---------
MLBr_02661|M.leprae_Br4923 FQEASALPHTAKGSLDRRAVAEQFAHRG-------
. :*: . :