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PRHPLVQRIADVLDLEPHGRAIEYGGQWFSWAQLGATARQVAARTTGTEVGMLLRNRPWQVAAFLGVLLG GGTVVVVNPSRGDERTRADLARLRLPLIIGEPDDLAALVTDDTPTMPISRLADPPGPAAPPAAAPRSVAV RMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEPRRGVAIVNSPLVHIGGVFRVLQCIADARPFV LLERFELNAWAAAVRRHRPRAVSLVPAALRTVLHSDLPRADLESIQVVTCGTAPLSADDADAFTEKYGIP VLTSYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPGAALRVVAEDGTPLGPDEIGLMEVKPGQLGPD ADWLRTTDMARIDADGFVWIVGRADQAIIRGGFKVMPDDVRAALESHPAVAGAAVVARPDPRLGETPVAM VELRAPSTTDALVEHLRERLARYEIPTEIAIVDALPRTPSGKADLAAVRGYFAERPTVLRDHAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1580 | - | - | 100% (485) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_2596 | - | 8e-93 | 41.54% (479) | AMP-dependent synthetase and ligase |
| M. avium 104 | MAV_1880 | - | 2e-89 | 40.30% (469) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 2e-31 | 27.70% (491) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4362 | - | 1e-173 | 64.85% (478) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 5e-32 | 27.90% (491) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 4e-28 | 28.33% (480) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2539c | - | 2e-34 | 27.31% (465) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4025 | - | 0.0 | 71.58% (482) | long-chain fatty-acid CoA ligase |
| M. smegmatis MC2 155 | MSMEG_2217 | - | 0.0 | 69.58% (480) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_3559 | - | 1e-149 | 80.12% (332) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3890 | - | 0.0 | 70.75% (482) | long-chain fatty-acid CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_1982 | - | 1e-178 | 66.60% (479) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0172|M.bovis_AF2122/97 -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
Rv0166|M.tuberculosis_H37Rv -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
MAV_1580|M.avium_104 -----------------------------------------MPRHPLVQR
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M -----------------------------------------MSNHPLSQR
MUL_3890|M.ulcerans_Agy99 -----------------------------------------MSNHPLSQR
Mflv_4362|M.gilvum_PYR-GCK -------------------------------------------MHPLSRR
Mvan_1982|M.vanbaalenii_PYR-1 -----------------------------------------MMVHRLSQR
MSMEG_2217|M.smegmatis_MC2_155 ------------------------------------------MAHPLSQR
MLBr_01051|M.leprae_Br4923 --------------------------------------------MLLASL
MAB_2539c|M.abscessus_ATCC_199 MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAML
Mb0172|M.bovis_AF2122/97 LERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMI
Rv0166|M.tuberculosis_H37Rv LERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVMI
MAV_1580|M.avium_104 IADVLDLEPHGRAIEYGGQWFSWAQLGATARQVAARTTG------TEVGM
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M IADTLDLQPDARAVEYDRAWLSWGQLGAATRRVAALAARQPS---PEIGI
MUL_3890|M.ulcerans_Agy99 IAVTLDLQPDARAVEYDRAWLSLGQLGAATRRVAALAAKQPS---PEIGI
Mflv_4362|M.gilvum_PYR-GCK IAEVMALDASAPAIQFERRWVTWGQIAESARHVSTVVGS------GTAGI
Mvan_1982|M.vanbaalenii_PYR-1 IDDVLALAPAGRAIQFDGDWVTWEQIGTLAQRISDVVGT------ARAGI
MSMEG_2217|M.smegmatis_MC2_155 IADVLDLDPDAGAIQFDGQWSCWGQIAALAGHIEKITGP------ARVGI
MLBr_01051|M.leprae_Br4923 NPSVVTATDIADAVCVDGVVLSRSGLVGAATSVAERVGG-----ARLVAV
MAB_2539c|M.abscessus_ATCC_199 LAASAIRFPDRAALIDDSGQLTYRDLQRRAEAVAAAVYARTPSAPRSVGI
Mb0172|M.bovis_AF2122/97 LMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTEA
Rv0166|M.tuberculosis_H37Rv LMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTEA
MAV_1580|M.avium_104 LLRNRPWQVAAFLGVLLGGGTVVVVNPSRG---------DERTRADLARL
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M LLRSRPAQMAAFLGVLLSGATVVTINPSRG---------DERTRADIAAL
MUL_3890|M.ulcerans_Agy99 LLRNRPAQMAAFLGVLLAGATVVTINPSRG---------DERTRADIAAL
Mflv_4362|M.gilvum_PYR-GCK MLRNTPSHVAALLGVLSGGGTVVVINPSRG---------DERTRADIEAL
Mvan_1982|M.vanbaalenii_PYR-1 MLRNRPVHVAALLGVLRGGGTVVVINPSRG---------DDRTRSDVEAL
MSMEG_2217|M.smegmatis_MC2_155 MLRNHPVHVAALLGVLAAGGTVVVINPARG---------DDRTRADLEAL
MLBr_01051|M.leprae_Br4923 LATPTASTVLAITGCLIAGVPVVPVPADIG---------VVERRHMLTDS
MAB_2539c|M.abscessus_ATCC_199 ICRNHRGFAESMLAGAQLGAELVFINTELT---------PQQLGAILQRH
Mb0172|M.bovis_AF2122/97 ALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFGYEDLLNEAGDVHEPVDIP
Rv0166|M.tuberculosis_H37Rv ALAPVAIGVRNIQPLLSVIVVAGGSSQDSVFGYEDLLNEAGDVHEPVDIP
MAV_1580|M.avium_104 RLPLIIGEPDDLAALVT--DDTPTMPISRLADPP---GPAA--PPAAAPR
TH_3559|M.thermoresistible__bu --------------------------------------------------
MMAR_4025|M.marinum_M ELPLIAGSDEDLGLLVTNTTDSATVSLSDLFDHP---GEPGDHTTRGAGA
MUL_3890|M.ulcerans_Agy99 ELPLIAGSDEDLGLLVTNTTDSATVSLSDLFDHP---GEPGGHTTRGAGA
Mflv_4362|M.gilvum_PYR-GCK QLPTLIGLAEDLESLAPGTT--ATTMALGDIDTTPEITGGS-PSEGQHRP
Mvan_1982|M.vanbaalenii_PYR-1 NLPIIIGSSEDLAALAPDTA--ATTVAVDGFDEPPTLHRGN-ASDDAGRP
MSMEG_2217|M.smegmatis_MC2_155 ALPVVVGLAEDLAHLMPAHSPRTTRVAIAGLDTEPVVTAAESPATDAGGP
MLBr_01051|M.leprae_Br4923 GAQAWLGPGP------------SADSAPDGLPHIPVQLDARSWNRYPEPS
MAB_2539c|M.abscessus_ATCC_199 EPDVLVYDDEYSQAVEESQYQGLRVLAWRENPQENRLTLDSLADQHHPKP
Mb0172|M.bovis_AF2122/97 N---DSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSG---ANINS
Rv0166|M.tuberculosis_H37Rv N---DSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSG---ANINS
MAV_1580|M.avium_104 -----SVAVRMLTSGTTGPPKRIDLGYDMLARSVLGVEPGTAPAPTEPRR
TH_3559|M.thermoresistible__bu --------VRMLTSGTTGPPKRVDLTYDMLAHSVIGPDFREAGPPAELRR
MMAR_4025|M.marinum_M -----DVAVRMLTSGTTGPPKRVDLSYDMLARSVMGPAPDRDPAPTEPRR
MUL_3890|M.ulcerans_Agy99 -----DVAVRMLTSGTTGPPNRVDLSYDMLARSVMGPAPDRDPAPTEPRR
Mflv_4362|M.gilvum_PYR-GCK -----GVAVRMPTSGTTGPPKRVDLTYDMLARSVMGRDPDTAPSPTELRQ
Mvan_1982|M.vanbaalenii_PYR-1 -----GVAVWMLTSGTTGPPKRVDLTYDMLARSVMGPDSDHDSAPTDLRR
MSMEG_2217|M.smegmatis_MC2_155 -----GVAVWMLTSGTTGPPKRVDLTYDMLARSVMGREPEKCPAPTELRR
MLBr_01051|M.leprae_Br4923 P---DATAMVIYTSGTTGPPKGVLLSRRAIAVDLD----ALAQAWQWTAD
MAB_2539c|M.abscessus_ATCC_199 PPVRRPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVTAMATVRLRSRDR
: : *:**** .:
Mb0172|M.bovis_AF2122/97 DVGFVGVPLFHIAGIGN-MLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
Rv0166|M.tuberculosis_H37Rv DVGFVGVPLFHIAGIGN-MLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEK
MAV_1580|M.avium_104 GVAIVNSPLVHIGGVFR-VLQCIADARPFVLLER--FELNAWAAAVRRHR
TH_3559|M.thermoresistible__bu GVAIVNAPLVHIGGVYR-VLQCIAAGRRFVLLER--FELQRWAEAVRTHR
MMAR_4025|M.marinum_M GVAIVNSPLVHIGGVYR-VLQCIAQARPFVLLDR--FELNAWAAAVRKHR
MUL_3890|M.ulcerans_Agy99 GVAIVNSPLVHIGGVYR-VLQCIAQARPFVLLDR--FELNARAAAVRKHR
Mflv_4362|M.gilvum_PYR-GCK GVAIVNSPLVHVGGVFR-ILLCLAEARPFVLLPK--FELHSWAEAVREHR
Mvan_1982|M.vanbaalenii_PYR-1 GVAIVNSPLVHVGGVFR-VLLCVAEARPFVLLPK--FELKQWADAVREHR
MSMEG_2217|M.smegmatis_MC2_155 GVAIVNSPLVHVGGVFR-VLLCIAEARPFVLLPK--FELQRWAAAVREHR
MLBr_01051|M.leprae_Br4923 DVLVHGLPLFHVHGLVLGLLGSLRIGNRFVHTGKP--TPTAYAQACSEAG
MAB_2539c|M.abscessus_ATCC_199 --VLVAPPFFHGFGLAA-LLGPLALGGTVMCRRR--FDAQQAMTDIRRQR
. *:.* *: :* : . :
Mb0172|M.bovis_AF2122/97 VTGIFLVPAQWQAVCTEQQARPR---DLRLRVLSWGAAPAPDALLRQMSA
Rv0166|M.tuberculosis_H37Rv VTGIFLVPAQWQAVCTEQQARPR---DLRLRVLSWGAAPAPDALLRQMSA
MAV_1580|M.avium_104 PRAVSLVPAALRTVLHSDLPRAD---LESIQVVTCGTAPLSADDADAFTE
TH_3559|M.thermoresistible__bu PRAVSLVPAALRMVLHSDLTRED---LASIQAVTSGTAPLSADDADAFTE
MMAR_4025|M.marinum_M PRTVSLVPAALRTVLHSDLTRAD---LASVRTVTCGTAPLAPDDADAFTE
MUL_3890|M.ulcerans_Agy99 PRTVSLVPAALRTVLHSDPTRAD---LASVRTVTCGTAPLAPDDADAFTE
Mflv_4362|M.gilvum_PYR-GCK PAAVSLVPAALRMVLHSDLTRDD---LAGVRVVTSGTAPLSADDAEAFTA
Mvan_1982|M.vanbaalenii_PYR-1 PRAVSLVPAALRMVLHSDLTRED---LDGIRVVTSGTAPLSADDADAFTE
MSMEG_2217|M.smegmatis_MC2_155 PRAVSLVPAALRTVLHSDLTRED---LAGVRVVTSGTAPLSADDADAFTE
MLBr_01051|M.leprae_Br4923 GSLYFGVPTVWSRLVADEAVARA---LRPARLLVSGSASLPVPVFDRLAH
MAB_2539c|M.abscessus_ATCC_199 VTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSSTVSGVLE
**. : : : *:*. . .
Mb0172|M.bovis_AF2122/97 TFPETQILAAFGQTEMSPVTCMLLGEDA---IAKRGSVGRVIPTVAARVV
Rv0166|M.tuberculosis_H37Rv TFPETQILAAFGQTEMSPVTCMLLGEDA---IAKRGSVGRVIPTVAARVV
MAV_1580|M.avium_104 KYGIPVLTSYAATEFGGGVAGWTLADHRRYWRVKRGSVGRANPGAALRVV
TH_3559|M.thermoresistible__bu KFGIPVLTSYAATEFGGGVAGWTLADHRRYWRTKRGSSGRATGGAQLRVV
MMAR_4025|M.marinum_M KYGIPVLTSYAATEFGGGVAGWTLADHSRYWHTKRGSVGRANPGTQLRIV
MUL_3890|M.ulcerans_Agy99 KYGIPVLTSYAATEFGGGVAGWTLADHSRYWHTKRGSVGRANPGTQLRIV
Mflv_4362|M.gilvum_PYR-GCK KFGIPVLTSYAATEFGGGVAGWTLADHRKYWQDKRGSVGRANPGARLRVV
Mvan_1982|M.vanbaalenii_PYR-1 KFGIPVLTSYAATEFGGGVAGWTLKDHQRFWQHKRGSVGRANPGAQLRVV
MSMEG_2217|M.smegmatis_MC2_155 KFGIPVLTSYAATEFGGGVAGWTLPDHGKYWKDKRGSVGRANPGAQLRVV
MLBr_01051|M.leprae_Br4923 LTGHRPIERYGSTESLITLS--TLADGER----RAGWVGLPLAGVQTRLV
MAB_2539c|M.abscessus_ATCC_199 AFGPILVNGYGSTEAG-----VVAIASPKDLVASPNTIGRTALGVSVRIL
: . . * . *::
Mb0172|M.bovis_AF2122/97 DQNMNDVPVG--EVGEIVYRAPTLMSCYW-NNP-EATAEAFAGGWFHSGD
Rv0166|M.tuberculosis_H37Rv DQNMNDVPVG--EVGEIVYRAPTLMSCYW-NNP-EATAEAFAGGWFHSGD
MAV_1580|M.avium_104 AEDGTPLGPD--EIGLMEVKPGQLG---------------PDADWLRTTD
TH_3559|M.thermoresistible__bu DEQGNPLGPD--QPGVLEVKPGQLG---------------PDADWLRTTD
MMAR_4025|M.marinum_M DTEGAPVERA--SLGLLEVKPAQLG---------------VSAPWVRTTD
MUL_3890|M.ulcerans_Agy99 DTEGAPVERA--SLGLLEVKPAQLG---------------VSAPWVRTTD
Mflv_4362|M.gilvum_PYR-GCK DDNRDPVPPG--EPGLLEVIPAQLA---------------DTGEWMQTTD
Mvan_1982|M.vanbaalenii_PYR-1 DDNGEPVPPG--QQGLLEVIPAQLA---------------GRSGWMQTTD
MSMEG_2217|M.smegmatis_MC2_155 DENGAPLGPD--EPGLLEVIPAQMG---------------PGSPWMRTTD
MLBr_01051|M.leprae_Br4923 DESGGPVPYDGETVGRLQVRSPTMFGGYL-NRPEATAEAFDEDGWYRTGD
MAB_2539c|M.abscessus_ATCC_199 REDRRPAAPG--ETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHVNTGD
. * : .: *
Mb0172|M.bovis_AF2122/97 LVRMDSDGYVWVVDRKKDMIIS-GGENIYCAELENVLASHPDIAEVAVIG
Rv0166|M.tuberculosis_H37Rv LVRMDSDGYVWVVDRKKDMIIS-GGENIYCAELENVLASHPDIAEVAVIG
MAV_1580|M.avium_104 MARIDADGFVWIVGRADQAIIR-GGFKVMPDDVRAALESHPAVAGAAVVA
TH_3559|M.thermoresistible__bu LARIDADGFLWILGRADQAIIR-GGFKIMPDDVRAALERHPAVRGAAVVG
MMAR_4025|M.marinum_M VARIDADGFVWIVGRADQAIIR-GGFKVLPDDVGAALESHPAVAAAAVVG
MUL_3890|M.ulcerans_Agy99 VARIDADGFVWIVGRADQAIIR-GGFKVLPDDVRAALESHPAVAAAAVVG
Mflv_4362|M.gilvum_PYR-GCK VARIDEDGFLWILGRADQAIIR-GGFKVMPDDVRSALESHAAVAGAAVVG
Mvan_1982|M.vanbaalenii_PYR-1 LARIDEDGFVWILGRADQAIIR-GGFKVMPDDVKNALESHPAVAGASVVG
MSMEG_2217|M.smegmatis_MC2_155 LARIDADGFLWVLGRADQAIIR-GGFKVMPDDVRAALESHPAVLGASVIG
MLBr_01051|M.leprae_Br4923 VAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVG
MAB_2539c|M.abscessus_ATCC_199 MGHFDADGRLYIDGRSDDMIVS-GGENVFPGEVEDRLTTYPGITDAVVIG
: .* .* : .* . :: ** .: :: * :. : . *:.
Mb0172|M.bovis_AF2122/97 RADEKWGEVPIAVAAVTN-DDLRIE-DLGEFLTDRLARYKHPKALEIVDA
Rv0166|M.tuberculosis_H37Rv RADEKWGEVPIAVAAVTN-DDLRIE-DLGEFLTDRLARYKHPKALEIVDA
MAV_1580|M.avium_104 RPDPRLGETPVAMVELR--APSTTD-ALVEHLRERLARYEIPTEIAIVDA
TH_3559|M.thermoresistible__bu IPDARLGETPAALVELHDGAAAGTD-ELTAFLRERLAPYEVPTEIAVVDA
MMAR_4025|M.marinum_M RSDQRLGQTPVAMVELRGSADIGGA-ELVEYLRTRLSGYEIPTQISIVAE
MUL_3890|M.ulcerans_Agy99 RSDQRLGQTPVAMVELRGSADIGGA-ELVEYLRTRLSGYEIPTQISIVAE
Mflv_4362|M.gilvum_PYR-GCK RPDPRLGETPVALVELRPGATASPE-ELSAYLQTRLARYEIPTALILTDA
Mvan_1982|M.vanbaalenii_PYR-1 RPDPRLGETPVALVQLRPGMSAEPD-ELLNYLQKRLARYEIPGELVITDA
MSMEG_2217|M.smegmatis_MC2_155 VADERLGETPVAMVELRG--PATPD-ELAGYLQGRLARYEIPTRITIVDA
MLBr_01051|M.leprae_Br4923 LPDEDLGQR--IVAFVVGAEALDAD-ELINYVAQQLSIHKRPREVRFVDA
MAB_2539c|M.abscessus_ATCC_199 VPDDDFGQVLHAFVVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDE
.* *: .. * .: * :: * . .
Mb0172|M.bovis_AF2122/97 LPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv LPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MAV_1580|M.avium_104 LPRTPSGKADLAAVRGYFAERPTVLRDHAR-------------
TH_3559|M.thermoresistible__bu LPRTPSGKADLGAVR-----RTLAPAGHDG-------------
MMAR_4025|M.marinum_M IPRTASGKPDLGAIRHYFG-AAGSRTDHGG-------------
MUL_3890|M.ulcerans_Agy99 IPRTASGKPDLGAIRHYFG-AAGSRTDHGG-------------
Mflv_4362|M.gilvum_PYR-GCK IPRTPSGKPDLTAVR--------ARLAQP--------------
Mvan_1982|M.vanbaalenii_PYR-1 IPRTASGKPDLTAVR--------SHFAQS--------------
MSMEG_2217|M.smegmatis_MC2_155 IPRTPSGKADLRAVR--------DHLESGG-------------
MLBr_01051|M.leprae_Br4923 LPRNAMGKVLKKQLLFEG-------------------------
MAB_2539c|M.abscessus_ATCC_199 IPRNASGKVLRAKLNSPGAC-----------------------
:**.. ** :