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PNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPAMLLAASAIRFPDRAALIDDSGQL TYRDLQRRAEAVAAAVYARTPSAPRSVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRH EPDVLVYDDEYSQAVEESQYQGLRVLAWRENPQENRLTLDSLADQHHPKPPPVRRPVKLTLLTSGTTGLA KGVPRAIKPRQLALMCVTAMATVRLRSRDRVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAMTD IRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSSTVSGVLEAFGPILVNGYGSTEA GVVAIASPKDLVASPNTIGRTALGVSVRILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIV DGHVNTGDMGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGVPDDDFGQVLHAF VVAADGAPAPSEEVLKTHVRQGLERYKVPKRFIVLDEIPRNASGKVLRAKLNSPGAC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2539c | - | - | 100% (548) | fatty-acid-CoA ligase FadD |
| M. abscessus ATCC 19977 | MAB_4340c | - | 7e-88 | 36.33% (523) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_3489c | - | 1e-87 | 36.45% (513) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1462c | fadD12 | 2e-94 | 37.57% (543) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2427 | - | 1e-94 | 36.47% (521) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1427c | fadD12 | 2e-94 | 37.57% (543) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 3e-90 | 37.31% (528) | acyl-CoA synthetase |
| M. marinum M | MMAR_2233 | fadD12 | 2e-96 | 37.17% (538) | long-chain-fatty-acid--CoA ligase FadD12 |
| M. avium 104 | MAV_5220 | - | 1e-99 | 40.15% (528) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0304 | - | 1e-93 | 36.36% (528) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4130 | - | 1e-95 | 37.75% (543) | PUTATIVE putative cytochrome P450 superfamily protein |
| M. ulcerans Agy99 | MUL_4827 | fadD12_2 | 5e-95 | 38.68% (530) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4225 | - | 5e-96 | 37.88% (520) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1462c|M.bovis_AF2122/97 ----MRIR----QAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFT
Rv1427c|M.tuberculosis_H37Rv ----MRIR----QAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFT
MMAR_2233|M.marinum_M --MAPRID----QILGLITTLARSGLIAPMRPDRYLKIAAAMRREGMGFT
MSMEG_0304|M.smegmatis_MC2_155 MGLLDRITDPLIDTVGMVTTMRRAGLIAPLRPDKYLRIVAAMARENMSVT
Mflv_2427|M.gilvum_PYR-GCK ---MSSAA----DQFGLLATLWRARLIAPMRPDRYLRMGLAMRRAGLTAT
Mvan_4225|M.vanbaalenii_PYR-1 ------MA----DPLGLLATLWRARLIAPMRPDRYLRMGLAMRRAGLTAT
TH_4130|M.thermoresistible__bu ------MA----KTIDTLRTLTRAGLIAPLRPDKYLRMTAAVRRTGVSVT
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWG-DLA
MAV_5220|M.avium_104 ------MAP------TAARALVRSGLLNPPSPRAVLRLLREASRGGTNPY
MUL_4827|M.ulcerans_Agy99 -----MMAAG--VVTTAARALLGSGLLSPSSPAAALRLVRELYRGGTNLY
MAB_2539c|M.abscessus_ATCC_199 --MPNNLRESLRQWGAAIPAAVTSGAFTPVSPRALASLVRSFWQFGPTPA
: : : * : : .
Mb1462c|M.bovis_AF2122/97 AGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPR--
Rv1427c|M.tuberculosis_H37Rv AGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPR--
MMAR_2233|M.marinum_M AGFAAAAQRCPDRPGLVDELGTLTWRQLDERSNALAAALQALPAGSPK--
MSMEG_0304|M.smegmatis_MC2_155 SGFASAAQRCPDRPGLVDELGTLTWREIDQQADALAAGLQALSGGAPR--
Mflv_2427|M.gilvum_PYR-GCK VGFAAAAQRCPDRPGIIDELGTLTWKQLDDRCDALGVALQKE---KPK--
Mvan_4225|M.vanbaalenii_PYR-1 VGFAAAAQRCPDLPGIIDELGTLTWKQLDDRCDALAAALQKH---TPR--
TH_4130|M.thermoresistible__bu VGFAVAAQRCGDRIGLVDEIGELTWRELDDECNALAAALQDRAAGQGKDG
MLBr_02546|M.leprae_Br4923 MLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGD--
MAV_5220|M.avium_104 TLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTRDGVAPGR--
MUL_4827|M.ulcerans_Agy99 TPLAIAAARWPERTAIVDDDGALSYREIQTMTESVAGELTLAGIGPGQ--
MAB_2539c|M.abscessus_ATCC_199 MLLAASAIRFPDRAALIDDSGQLTYRDLQRRAEAVAAAVYARTPSAPR--
* .* * .::*: * *:::::: .::. :
Mb1462c|M.bovis_AF2122/97 -----VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTRE
Rv1427c|M.tuberculosis_H37Rv -----VVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTRE
MMAR_2233|M.marinum_M -----VVGIMCRNHRGFVEALVAANRIGADILLLNTAFAGPALADVVARE
MSMEG_0304|M.smegmatis_MC2_155 -----VLGIMARNHRGFVLSLIAANRIGADVLLLNTSFSGPALAEVVSRE
Mflv_2427|M.gilvum_PYR-GCK -----TVAVMCRNHRGFVEALVAANRIGADVLLLNTSFAGPAMAEVVERE
Mvan_4225|M.vanbaalenii_PYR-1 -----TVAVMCRNHRGFVEALVGANRIGADVLLLNTSFAGPAMAEVIERE
TH_4130|M.thermoresistible__bu GKGRGAIGIMCRNHRGFIEALVAADRIGATVLLLNTSFAGPALAEVVDRE
MLBr_02546|M.leprae_Br4923 -----GIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSERE
MAV_5220|M.avium_104 -----AVGVMCRNGRGFVTAVFAVTLLGADVVPISTEFRSDALAAALRAH
MUL_4827|M.ulcerans_Agy99 -----AVGVMCRNGRNFVAAAFAAGLVGADVVLVNTEFRATALAAALEAH
MAB_2539c|M.abscessus_ATCC_199 -----SVGIICRNHRGFAESMLAGAQLGAELVFINTELTPQQLGAILQRH
:.::.** * * : . :** :: :.: : : .
Mb1462c|M.bovis_AF2122/97 GVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD------EDHDLTVEKL
Rv1427c|M.tuberculosis_H37Rv GVDTVVYDEEFSATVDRALAEKPQA-TRIVAWTD------EDHDLTVEKL
MMAR_2233|M.marinum_M GVDTVIYDEEFTATVDRAFDGRPQA-TRIVAWSD------GQHDLTVEQL
MSMEG_0304|M.smegmatis_MC2_155 KVDAVIYDEEFTDTVDRALAGAPEAPTRIVAWTDT-----AAHDVTVAAL
Mflv_2427|M.gilvum_PYR-GCK GADIVIYDQEFTETVDRALADTCGA-RRIVAWVDDPA---QAGTATVEAL
Mvan_4225|M.vanbaalenii_PYR-1 GADIVIYDQEFTATVDRALRDVPGT-TRILAWTD--A---DDGSTTLEAL
TH_4130|M.thermoresistible__bu GVDTIVYDEEFTDIVDRALADRPTA-TRILAWVDEPASGPALPHPTVADL
MLBr_02546|M.leprae_Br4923 GAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEP--PGSTDETLAEL
MAV_5220|M.avium_104 HISTVVADNEFAERIAAADDAVAVI---------------DPATAGAEES
MUL_4827|M.ulcerans_Agy99 QMRVMLCDDEFVDQVAGTGESVLVI---------------DPSTVTARDC
MAB_2539c|M.abscessus_ATCC_199 EPDVLVYDDEYSQAVEESQYQGLRV----LAWREN----PQENRLTLDSL
:: *:*: : :
Mb1462c|M.bovis_AF2122/97 VAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG---GIGTLKA
Rv1427c|M.tuberculosis_H37Rv VAAHAGRRPEH---TGSHGKVILLTSGTTGTPKGARHSGG---GIGTLKA
MMAR_2233|M.marinum_M VNAHLGDQPER---TGRTGRLILLTSGTTGTPKGAKHSGGS-GGIGTLKA
MSMEG_0304|M.smegmatis_MC2_155 TEKFAGRQPQR---GGQKSKVILLTSGTTGTPKGAKHSGG---GPEILKA
Mflv_2427|M.gilvum_PYR-GCK IDAHLGQRPQP---ATRKSDVILLTSGTTGSPKGAKRSAGS-GGSGDLKA
Mvan_4225|M.vanbaalenii_PYR-1 IDAHLGQRPEP---ATRKSDIILLTSGTTGTPKGAKRSAGS-GGASDLKA
TH_4130|M.thermoresistible__bu VAEHRGRRPAKPAAGDEGSRIILLTSGTTGTPKGARAASS--GGAGELAA
MLBr_02546|M.leprae_Br4923 IARSSSAPAPK---VRKRASIIILTSGTTGTPKGANRNTP--ASLAPLGG
MAV_5220|M.avium_104 GGRPAVAAP---------GRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVT
MUL_4827|M.ulcerans_Agy99 A-RPKVAPS---------GRIVLLTSGTTGVPKGVPRKPKVSSGIGVSAT
MAB_2539c|M.abscessus_ATCC_199 ADQHHPKPPPVR----RPVKLTLLTSGTTGLAKGVPRAIKPRQLALMCVT
. : :******* .**.
Mb1462c|M.bovis_AF2122/97 ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATL
Rv1427c|M.tuberculosis_H37Rv ILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATL
MMAR_2233|M.marinum_M ILDRTPWRAEQPIVIVAPMFHAWGFSQLVLAASLACTIVTRRKFDPEATL
MSMEG_0304|M.smegmatis_MC2_155 ILDRTPWRAEEPVVIVAPMFHAWGFSQLAFAASMACTIITRRKFDPEATL
Mflv_2427|M.gilvum_PYR-GCK VLDRTPWRAEEPIVIAAPMFHAWGFSQLLFAALLACPIVTRRKFDPAATL
Mvan_4225|M.vanbaalenii_PYR-1 VLDRTPWRAGEPIVIAAPMFHAWGFSQLLFAALLACPIVTRRKFDPEATL
TH_4130|M.thermoresistible__bu ILGRVPWRAEQTTVIAAPMFHAWGYSQLLFSALLACTIVTRRRFDPEATL
MLBr_02546|M.leprae_Br4923 ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRRFKPATVL
MAV_5220|M.avium_104 ILDRTRLRTGSRISVAMPMFHGLGLGMLMLTIALGGTVLTHRHFDAEAAL
MUL_4827|M.ulcerans_Agy99 LLERTRLRVGSRMTLATPMFHGLGFGMLVLTISLGGTVLTRRHFDAEATL
MAB_2539c|M.abscessus_ATCC_199 AMATVRLRSRDRVLVAPPFFHGFGLAALLGPLALGGTVMCRRRFDAQQAM
: . * . : *:**. * . :. .:: :*:*.. .:
Mb1462c|M.bovis_AF2122/97 DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
Rv1427c|M.tuberculosis_H37Rv DLIDRHHATGLVVVPVMFDRIMDLPAEIRNRYDGRSLRFAAASGSRMRPD
MMAR_2233|M.marinum_M DLIDRHRATGLVVVPVMFDRIMELPTKVLNRYSGRTLRFAAASGSRMRPD
MSMEG_0304|M.smegmatis_MC2_155 ELVDRHRATGLCVVPVMFDRIMELPEDVLNRYDGRSLRFAAASGSRMRPD
Mflv_2427|M.gilvum_PYR-GCK ALVDKYRATGLAVVPVMFDRIMDLPDEVRNRYSGRSLRFATASGSRMRPD
Mvan_4225|M.vanbaalenii_PYR-1 ALIDRHRATGLAVVPVMFDRIMELPAEVRNRYSGRSLRFATASGSRMRPD
TH_4130|M.thermoresistible__bu QLVDRYRATGLVVVPVMLDRIMELPADVRDRYSGRSLRFVTASGSRMRPD
MLBr_02546|M.leprae_Br4923 EDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAE
MAV_5220|M.avium_104 AQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLRVVMSSGDRLDPT
MUL_4827|M.ulcerans_Agy99 AQTSLHRADGLSVVPIMLARILDLPDQVRARNPLPCLRAVISSGDRLDPS
MAB_2539c|M.abscessus_ATCC_199 TDIRRQRVTVLMAVPVMLQRILALADLDRRDARQLSLRMIVTGAAPISSS
:. : .**::: **: ** .. : .
Mb1462c|M.bovis_AF2122/97 VVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIR
Rv1427c|M.tuberculosis_H37Rv VVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIR
MMAR_2233|M.marinum_M VVVAFMNRFGDVIYNNYNATEAGMIATATPADLRAAPDTAGRPAEGTEIR
MSMEG_0304|M.smegmatis_MC2_155 VVIAFMDRFGDVIYNNYNATEAGMIATATPADLRAAPDTAGRPAEGTEIR
Mflv_2427|M.gilvum_PYR-GCK VVTAFMDQFGDVIYNNYNATEAGMIATATPEDLRAAPDTAGKAADGTELR
Mvan_4225|M.vanbaalenii_PYR-1 VVTAFMDQFGDVIYNNYNATEAGMIATATPADLRAAPDTAGRAADGTELR
TH_4130|M.thermoresistible__bu VVLDFMDRFGDVIYNNYNATEAGMIATATPADLRAAPSTAGKPADGTEIR
MLBr_02546|M.leprae_Br4923 LATRALEELGPVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVK
MAV_5220|M.avium_104 LGQRFMDTYGDILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVR
MUL_4827|M.ulcerans_Agy99 LARRFMEAYGDVLYNLYGSTEVGIGALATPAELRDWPETVGRPVAGCPVR
MAB_2539c|M.abscessus_ATCC_199 TVSGVLEAFGPILVNGYGSTEAGVVAIASPKDLVASPNTIGRTALGVSVR
:: * :: * *.:** .. : * * :* . * * . * ::
Mb1462c|M.bovis_AF2122/97 ILDQQFTEVPTGEVGTIYVRNDSQFDGYT-----SGAAKDFHAGFMSSGD
Rv1427c|M.tuberculosis_H37Rv ILDQQFTEVPTGEVGTIYVRNDSQFDGYT-----SGAAKDFHAGFMSSGD
MMAR_2233|M.marinum_M ILDQEFNEVPEGEVGSIFVCNDSQFDGYT-----SGTTKDFHAGFMSSGD
MSMEG_0304|M.smegmatis_MC2_155 ILDGDLRDLPTGEVGTIYVRNSTQFDGYT-----SGTTKDFHEGFMCSGD
Mflv_2427|M.gilvum_PYR-GCK ILDAEHRELPTGEVGQIFVRSGTLFDGYT-----SGSTKDFHDGFMASGD
Mvan_4225|M.vanbaalenii_PYR-1 ILDAEHRDVPTGEVGQIFVRSSTLFDGYT-----SGTTKAFHDGFMASGD
TH_4130|M.thermoresistible__bu ILDDALRPVPTGEVGQIFVRSNTLFDGYT-----SGTTKDFHEGFMASGD
MLBr_02546|M.leprae_Br4923 ILDDSGKEVPRGQVGRIFVGNAFPFEGYT-----GGGGKQIIDGLLSSGD
MAV_5220|M.avium_104 ILDRNNRPVGPRVTGRIFVGGELAGTRYT-----DGGGKAVVDGMTSTGD
MUL_4827|M.ulcerans_Agy99 IFDRNGRPVGARVTGRIFVGGELNSDGYS-----GGGGKAVIDGMASTGD
MAB_2539c|M.abscessus_ATCC_199 ILREDRRPAAPGETGMIFVRGGLEYEGYTPDKATRPTAKEIVDGHVNTGD
*: .* *:* . *: * . * :**
Mb1462c|M.bovis_AF2122/97 VGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGV
Rv1427c|M.tuberculosis_H37Rv VGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGV
MMAR_2233|M.marinum_M VGYLDRNGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPEVAEAAVIGV
MSMEG_0304|M.smegmatis_MC2_155 VGRLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKVLTTHPAVAEAAVIGV
Mflv_2427|M.gilvum_PYR-GCK LGYLDDAGRLFVVGRDDEMIVSGGENVYPIEVEKTLMSHPEVAEATVLGV
Mvan_4225|M.vanbaalenii_PYR-1 MGYLDGAGRLFVVGRDDEMIVSGGENVYPIEVEKTLTTHAAVAEAAVLGV
TH_4130|M.thermoresistible__bu LGRLDEDGRLFVVGRDDEMIVSGGENVYPIEVEQVLARHPDVAEATVIGV
MLBr_02546|M.leprae_Br4923 VGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGV
MAV_5220|M.avium_104 MGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGV
MUL_4827|M.ulcerans_Agy99 MGYLDESGRLYIVGREDDMIVSGGENVYPRSLENALASHPDVAENAVIGV
MAB_2539c|M.abscessus_ATCC_199 MGHFDADGRLYIDGRSDDMIVSGGENVFPGEVEDRLTTYPGITDAVVIGV
:* :* . *:: **.*:**:*****::* :*. : :. :.: ..:**
Mb1462c|M.bovis_AF2122/97 DDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVPRDIAVL
Rv1427c|M.tuberculosis_H37Rv DDQQYGQRLAAFVVLKP----GVSATPETLKQHVRDNLANYKVPRDIAVL
MMAR_2233|M.marinum_M DDEQYGQRLAAFVVLEPDADLDENAAPETLKQHVRDNLANYKVPREIAVL
MSMEG_0304|M.smegmatis_MC2_155 DDEQFGQRLAAFVVLSG------DATVDDLKSHVRDNLANYKVPRDITIL
Mflv_2427|M.gilvum_PYR-GCK EDSEYGQRLAAFVVLTD----GSGLTPEDLKQHVRANLANYKVPRDITIL
Mvan_4225|M.vanbaalenii_PYR-1 DDEQYGQRLAAFVVPAA----GASVTVEELKQHVRENLANYKVPRDITIM
TH_4130|M.thermoresistible__bu DDEQFGQRLAAFVVLRD----GAGATPDGLKQHVRDNLANYKVPRSISVL
MLBr_02546|M.leprae_Br4923 DDKEWGARLRAFVVKKQ----DATIDEDAIKAYVRDHLARYKVPREVIFL
MAV_5220|M.avium_104 PDERFGHRLAAFVVLHP----GSGVDAAQLRDYLKDRVSRFEQPRDINIV
MUL_4827|M.ulcerans_Agy99 ADEQFGQRLAAFVVARP----GCDIDADAIRDYLKGRVSRFEQPRDIYLV
MAB_2539c|M.abscessus_ATCC_199 PDDDFGQVLHAFVVAADG---APAPSEEVLKTHVRQGLERYKVPKRFIVL
*. :* * **** :: ::: : .:: *: . .:
Mb1462c|M.bovis_AF2122/97 DELPRGITGKILRTELQSRVGS----
Rv1427c|M.tuberculosis_H37Rv DELPRGITGKILRTELQSRVGS----
MMAR_2233|M.marinum_M DELPRGSTGKILRAELQAKVCGT---
MSMEG_0304|M.smegmatis_MC2_155 DELPRNSTGKIARRELQEKVNG----
Mflv_2427|M.gilvum_PYR-GCK PELPRGSTGKILRNELRGS-------
Mvan_4225|M.vanbaalenii_PYR-1 AELPRGSTGKILRNELRGR-------
TH_4130|M.thermoresistible__bu DELPRGSTGKILRTELQARAQSG---
MLBr_02546|M.leprae_Br4923 EELPRNPTGKVLKRELRDFEVH----
MAV_5220|M.avium_104 ASIPRNPTGKVLRKELPG--------
MUL_4827|M.ulcerans_Agy99 SSIPRNPAGKVLRKQLASYAEPEAQS
MAB_2539c|M.abscessus_ATCC_199 DEIPRNASGKVLRAKLNSPGAC----
.:**. :**: : :*