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TTRKARRRKQIHLGAHFPGVNNTTVWSDPSAGSQIAFESFVHLARTAERGLFDFFFLAEGLRLREHRGKI HDLDVVGRPDTFTVLAALAAVTERLGLAGTINTTFNEPYEVARQFATLDHLSDGRAAWNMVTSSDAFTGE NFRRGGFLAHADRYRRAEEFITVARKFWDSWSPGAVIADVDAGTYADPARIGVVEHHGRQFDVRGVASLP AGPQGHPVLLQAGDSSDGRDFGAKHADALFTLHGSLEAGQRYYADVKSRAAAHGRDPEQLKVLPGATFAL GDTPAEAADNARHIREQQVSGPTAIAFLEQVWGVDLSAYDPDGPLPDVEPVENPTITRGRVRHGDPKTVA ETWRARARAENLSIRELIIEVTSRQQFVGTPQQVAAEIDHYVQSDACDGFILVPHLTPHGLDEFVDKVVP LLQERGSFRAEYRGITLREHLGLAPAPGSAPGADLESHCATG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2048 | - | - | 100% (463) | fmnh2-utilizing oxygenase |
| M. avium 104 | MAV_3809 | - | 2e-74 | 38.78% (459) | dibenzothiophene desulfurization enzyme A |
| M. avium 104 | MAV_0340 | - | 2e-70 | 36.75% (419) | nitrilotriacetate monooxygenase component A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1886c | - | 7e-07 | 29.38% (160) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0214 | - | 3e-66 | 48.83% (299) | fmnh2-utilizing oxygenase |
| M. tuberculosis H37Rv | Rv1855c | - | 7e-07 | 29.38% (160) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4232c | - | 0.0 | 74.77% (444) | putative oxygenase |
| M. marinum M | MMAR_0703 | - | 0.0 | 77.27% (440) | FMNH2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_2175 | - | 1e-165 | 65.63% (451) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 1e-78 | 39.23% (413) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 1e-07 | 26.88% (186) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 3e-70 | 34.53% (446) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1886c|M.bovis_AF2122/97 ----------------MTIRLGLQIPNFSYG-------TGVEKLFPSVIA
Rv1855c|M.tuberculosis_H37Rv ----------------MTIRLGLQIPNFSYG-------TGVEKLFPSVIA
MAV_2048|M.avium_104 -------MTTRKARRRKQIHLGAHFPGVNNTTVWSDPSAGSQIAFESFVH
MMAR_0703|M.marinum_M -------------MIRKPVHLAAHFPGVNNTTVWADPGAGSQIEFESFVH
MAB_4232c|M.abscessus_ATCC_199 MSNPADAVRTREGKDRKPVHLAAHFPGVNNTTVWSDPASGSQIDFDSFVH
MSMEG_2175|M.smegmatis_MC2_155 -----------MSKPTKQIHLAAHFPGVNNTTVWSDPASGSHIDFASFVH
Mflv_0214|M.gilvum_PYR-GCK ----------MKAERSKHIHLGARLP-------------ASFDSWDSLVH
TH_4079|M.thermoresistible__bu ------------LPETRLSG---------------------ITDIDHYLE
Mvan_6020|M.vanbaalenii_PYR-1 ----------MMHLITWLMGNSYHAAGWRHQLAW----ERTAMRLDVLIE
MUL_4507|M.ulcerans_Agy99 ----------MALLFHWFLPTYGDSRGLVAGGHGLPMSGNRPATLRYLNQ
Mb1886c|M.bovis_AF2122/97 QAREAEAAGYDSLFVMDH--FYQLPMLGTPDQP-------MLEAYTALGA
Rv1855c|M.tuberculosis_H37Rv QAREAEAAGYDSLFVMDH--FYQLPMLGTPDQP-------MLEAYTALGA
MAV_2048|M.avium_104 LARTAERGLFDFFFLAEG--LRLREHRGKIHDLDVVGRP---DTFTVLAA
MMAR_0703|M.marinum_M LARTAERGLFDFFFLAEG--LRLREHRGRIHDLDVVGRP---DTFTLLAA
MAB_4232c|M.abscessus_ATCC_199 LARTAERGLFDFFFLAEG--LRLREHRERIYDLDVVGRP---DTFTVLAA
MSMEG_2175|M.smegmatis_MC2_155 FAQTAERGKFDFMFLAEG--LRLREQGGAIYDLDVVGRP---DTFTVLAA
Mflv_0214|M.gilvum_PYR-GCK LARTAERGLFDFVLVDDG--ARRREQ-----------RS---DALTMLAA
TH_4079|M.thermoresistible__bu LARIAERGKLDAIFFADHPVLKGKTEFRPFDA---------LDPVTLVTA
Mvan_6020|M.vanbaalenii_PYR-1 IAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAA
MUL_4507|M.ulcerans_Agy99 IAAAAESNGFEAVLTPAG--------------------LWCEDAWLTTAM
* ** : .: :.
Mb1886c|M.bovis_AF2122/97 LATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFE
Rv1855c|M.tuberculosis_H37Rv LATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFE
MAV_2048|M.avium_104 LAAVTERLGLAGTIN-TTFNEPYEVARQFATLDHLSDGRAAWNMVTSSDA
MMAR_0703|M.marinum_M LAGVTDRIGLTGTIN-TTFNEPFEVARQFATLDHLSEGRAGWNIVTSSDA
MAB_4232c|M.abscessus_ATCC_199 LGAVTERLGLVGTIN-TTFNEPFNVARQFASLDHLSDGRAGWNMVTSSDA
MSMEG_2175|M.smegmatis_MC2_155 LAAVTDRLGLTGTIN-STFNEPYEVARQFASLDHLSDGRAAWNVVTSWDA
Mflv_0214|M.gilvum_PYR-GCK LAAVTDRVGLVGTVD-TGATEPFEVARRIATLDHLSDGRVGWHR------
TH_4079|M.thermoresistible__bu LSTATTHIGLVATAS-TTYTEPYGLARRFATLDHVSRGRAGWNIVTTANA
Mvan_6020|M.vanbaalenii_PYR-1 ISQHTKHIGLVGTAS-TTYESPWVVARRFASLDHLSNGRASWNVVTGSNP
MUL_4507|M.ulcerans_Agy99 LVGTTKTLKFLVALR-PGLVSPTLAAQMATTFQQQSGGRLLVNVVTGGEA
: * : : .* *: :::: * **
Mb1886c|M.bovis_AF2122/97 LEHRQLGFEFG-TFSDRFNRLEEALQILEPMVKGERP-------------
Rv1855c|M.tuberculosis_H37Rv LEHRQLGFEFG-TFSDRFNRLEEALQILEPMVKGERP-------------
MAV_2048|M.avium_104 FTGENFRRGGFLAHADRYRRAEEFITVARKFWDSWSPGAVIADVDAGTYA
MMAR_0703|M.marinum_M FTGANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYV
MAB_4232c|M.abscessus_ATCC_199 FTGENFRRGGFLDHADRYRRAEEFITVARKFWDSWDAAGEPLPVN-----
MSMEG_2175|M.smegmatis_MC2_155 FTGENFRRGGFLPEHQRYERAESFLAAAHTLFDSWRGDEIIADKATGVFL
Mflv_0214|M.gilvum_PYR-GCK -AGADVRR------------AGEFLAVARLFWDSWAEDAVLADHDAGRYV
TH_4079|M.thermoresistible__bu AAAANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAPRFV
Mvan_6020|M.vanbaalenii_PYR-1 GDSENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYL
MUL_4507|M.ulcerans_Agy99 HEQRAYGD--FLDKQQRYRRTGEFLHVVRQLWASGQP-------------
. : : .
Mb1886c|M.bovis_AF2122/97 --------TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFA
Rv1855c|M.tuberculosis_H37Rv --------TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFA
MAV_2048|M.avium_104 DPARIGVVEHHGRQFDVRGVASLPAGPQGHPVLLQAGDSSDGRDFGAKHA
MMAR_0703|M.marinum_M DPERIRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSEQGRAFGARHA
MAB_4232c|M.abscessus_ATCC_199 ---------HRGPQFTVRGVATAPASPQRHPVLLQAGDSADGRDFGAKHA
MSMEG_2175|M.smegmatis_MC2_155 SDPTAGEFSYHNDHFDISGRFNVPRSPQGRPVIFQAGDSDHGREFAAAAA
Mflv_0214|M.gilvum_PYR-GCK DPDRIRAVEHRGPHFDVRGFATLPRPPQRHPVLVQDDDSEDGTAFAAAHA
TH_4079|M.thermoresistible__bu DPDKIHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSEPGKQLAAKYA
Mvan_6020|M.vanbaalenii_PYR-1 NARKVRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSEGGRRLAARHA
MUL_4507|M.ulcerans_Agy99 -------VTFEGEHIHVH-QAQLGRLPDPPPPVFFGGSSESAGAVAARYA
. . : * :. . . ..* *
Mb1886c|M.bovis_AF2122/97 DHLN-IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDETLSP
Rv1855c|M.tuberculosis_H37Rv DHLN-IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDETLSP
MAV_2048|M.avium_104 DALFTLHGSLEAGQRYYADVKSRAAAHGRDPEQLKVLPGATFALGDTPAE
MMAR_0703|M.marinum_M DAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQ
MAB_4232c|M.abscessus_ATCC_199 DALFTIHSSIPAGQKYYADVKARAVAHGRNPDQLKVFPGVTYVLGDTEQE
MSMEG_2175|M.smegmatis_MC2_155 DAIFSRHGTLEAGQQFFADVKGRLAKYGRRHSDLLILPAATFVLGDTDAE
Mflv_0214|M.gilvum_PYR-GCK DAVITPHAGLEARQRYVADVRTKVAAAGRNPDSVTVFALTKLSP------
TH_4079|M.thermoresistible__bu EAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEE
Mvan_6020|M.vanbaalenii_PYR-1 DCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESE
MUL_4507|M.ulcerans_Agy99 DTYLTWGEPLSAVGKKIDWIRGLAADHGR---ALSYGLRIHVITRDTAEE
: : . : * :
Mb1886c|M.bovis_AF2122/97 DAIPAEMSG-----------------------------------------
Rv1855c|M.tuberculosis_H37Rv DAIPAEMSG-----------------------------------------
MAV_2048|M.avium_104 AADNARHIREQQVSGPTAIAFLEQVWGVDLSAYDPDGPLPDVEP-VENPT
MMAR_0703|M.marinum_M AGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDP-IADAA
MAB_4232c|M.abscessus_ATCC_199 AIEKAAYIRDQQVGPQTAIAYLEQVWGRDLSEYDPEGPLPDVDP-TGDAS
MSMEG_2175|M.smegmatis_MC2_155 AADIAHEVRLAQVSPATAIKFLEQLWNRDLSDHDPDGPLPSVDPVVGENT
Mflv_0214|M.gilvum_PYR-GCK --------------------------------------------------
TH_4079|M.thermoresistible__bu ARRIQRRLED-LTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSD--DPPA
Mvan_6020|M.vanbaalenii_PYR-1 AVELYSELNS-LISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS----APV
MUL_4507|M.ulcerans_Agy99 AWRVADRLLAGIDPADIERMQANLARSESEGQRRMAELHG----------
Mb1886c|M.bovis_AF2122/97 ---------------------------------------------RVVVG
Rv1855c|M.tuberculosis_H37Rv ---------------------------------------------RVVVG
MAV_2048|M.avium_104 ITRGRVR---HGDPKTVAETWRARARAENLSIRELIIEVT---SRQQFVG
MMAR_0703|M.marinum_M ISQGRVR---HADPVAVARRYRERSQAENLSIRELVIAVT---SRQQFVG
MAB_4232c|M.abscessus_ATCC_199 ITRGKAR---HGDPREIAAKYREIAEAKKLSIRELIKEVT---SRQQFIG
MSMEG_2175|M.smegmatis_MC2_155 IAKGRASVRMYRDPIATANEWRAKAEAENLTTRELIIEVT---GRQNFIG
Mflv_0214|M.gilvum_PYR-GCK -------------------------------------------------G
TH_4079|M.thermoresistible__bu IHMQSRY-----------ALVRRLVSTENLTVRELLLRLSGGRGHRVFAG
Mvan_6020|M.vanbaalenii_PYR-1 VGGNSIR-----------GQLDAIAKAEQLTVRQMYERVVPTMGNTALIG
MUL_4507|M.ulcerans_Agy99 ------------------GVLDQLEIAPNLWAGVGLVRGG---AGTALVG
*
Mb1886c|M.bovis_AF2122/97 SPAQIADQIQAKVLDAGVDGLIIN--------------LAPHGYLPGVIT
Rv1855c|M.tuberculosis_H37Rv SPAQIADQIQAKVLDAGVDGLIIN--------------LAPHGYLPGVIT
MAV_2048|M.avium_104 TPQQVAAEIDHYVQSDACDGFILVPHLTPHGLDEFVDKVVPLLQERGSFR
MMAR_0703|M.marinum_M TPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAFR
MAB_4232c|M.abscessus_ATCC_199 TPSQVATEVDRYIQADACDGFILVPHLTPGGLDDFVDTVVPLLQERGAFR
MSMEG_2175|M.smegmatis_MC2_155 SPTTVAEQIDHLVQSDASDGFILVPHVTPGGLDPFVDKVVPLLQERGVFR
Mflv_0214|M.gilvum_PYR-GCK SPAKVADEMDLHVRSGACDGFLLVPDPTPHGLDEFVDDVVPLLQERGSLR
TH_4079|M.thermoresistible__bu TPEQVADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLFR
Mvan_6020|M.vanbaalenii_PYR-1 TATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLFR
MUL_4507|M.ulcerans_Agy99 SHQEVAERIIEYARLGISH-FILSGYPHLEEAYWFGEGVLPILERKRLWH
: :* : . : : : *
Mb1886c|M.bovis_AF2122/97 TA--AEALRPLLGV-------------------
Rv1855c|M.tuberculosis_H37Rv TA--AEALRPLLGV-------------------
MAV_2048|M.avium_104 AEYRGITLREHLGLAPAPGSAPGADLESHCATG
MMAR_0703|M.marinum_M TAYTGQTLRDHLGLAGLPS--------------
MAB_4232c|M.abscessus_ATCC_199 AEYEHETLREHLGLDPISRASGDFRRETASA--
MSMEG_2175|M.smegmatis_MC2_155 TEYEGTTLRDHLDLAHPDRGA-----EPAAATG
Mflv_0214|M.gilvum_PYR-GCK TGYCGHTLRDHLAQPAL----------------
TH_4079|M.thermoresistible__bu TEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS--
Mvan_6020|M.vanbaalenii_PYR-1 RHYTGSTLRENLGLPPVDN-----SPFAT----
MUL_4507|M.ulcerans_Agy99 RPHGSSPHSAALPVAHSSVN-------------
. *