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ALLFHWFLPTYGDSRGLVAGGHGLPMSGNRPATLRYLNQIAAAAESNGFEAVLTPAGLWCEDAWLTTAML VGTTKTLKFLVALRPGLVSPTLAAQMATTFQQQSGGRLLVNVVTGGEAHEQRAYGDFLDKQQRYRRTGEF LHVVRQLWASGQPVTFEGEHIHVHQAQLGRLPDPPPPVFFGGSSESAGAVAARYADTYLTWGEPLSAVGK KIDWIRGLAADHGRALSYGLRIHVITRDTAEEAWRVADRLLAGIDPADIERMQANLARSESEGQRRMAEL HGGVLDQLEIAPNLWAGVGLVRGGAGTALVGSHQEVAERIIEYARLGISHFILSGYPHLEEAYWFGEGVL PILERKRLWHRPHGSSPHSAALPVAHSSVN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | - | 100% (381) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. ulcerans Agy99 | MUL_0814 | - | 1e-11 | 27.23% (235) | flavin-dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_4079 | - | 9e-10 | 28.74% (174) | coenzyme F420-dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0137c | fgd2 | 2e-13 | 24.37% (238) | putative f420-dependant glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_5136 | - | 1e-124 | 60.00% (370) | alkanesulfonate monooxygenase |
| M. tuberculosis H37Rv | Rv0132c | fgd2 | 2e-13 | 24.37% (238) | putative f420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00348 | - | 2e-10 | 28.16% (174) | putative coenzyme F420-dependent oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2219 | - | 1e-117 | 57.89% (361) | putative alkanesulfonate monooxygenase |
| M. marinum M | MMAR_4200 | fgd2 | 0.0 | 98.95% (381) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. avium 104 | MAV_4628 | - | 1e-170 | 75.85% (381) | alkanesulfonate monoxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_2651 | - | 1e-125 | 60.66% (366) | alkanesulfonate monooxygenase family protein |
| M. thermoresistible (build 8) | TH_3352 | - | 1e-129 | 59.74% (385) | PUTATIVE Alkanesulfonate monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1200 | - | 1e-128 | 61.35% (370) | alkanesulfonate monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4507|M.ulcerans_Agy99 ----------------------------MALLFHWFLPTYGDSRGLVAGG
MMAR_4200|M.marinum_M ----------------------------MALSFHWFLPTYGDSRGLVAGG
MAV_4628|M.avium_104 ----------------------------MSLAFHWFLPTYGDSRNLVAGG
MSMEG_2651|M.smegmatis_MC2_155 --------------------------------MHWFLPTYGDSRLIVGGG
TH_3352|M.thermoresistible__bu ----------------------------VTIKLHWFLPTYGDSRLIVGGG
Mflv_5136|M.gilvum_PYR-GCK --------------------------MTHAIKLHWFLPTYGDSRHIVGGG
Mvan_1200|M.vanbaalenii_PYR-1 MCTVAVLQIPLTQTADLPTPSGHHLVVTSAIKLHWFLPTYGDSRLIVGGG
MAB_2219|M.abscessus_ATCC_1997 ----------------------------MAAKFFWFLPTNGDSRSIVGAS
Mb0137c|M.bovis_AF2122/97 -------------------------MTGISRRTFGLAAGFGAIGAGGLGG
Rv0132c|M.tuberculosis_H37Rv -------------------------MTGISRRTFGLAAGFGAIGAGGLGG
MLBr_00348|M.leprae_Br4923 -----------------------------------MVERANAMKLGLQLG
: . .
MUL_4507|M.ulcerans_Agy99 HG-LPMS---GNRPAT-------------LRYLNQIAAAAESNGFEAVLT
MMAR_4200|M.marinum_M HG-LPMS---GNRPAT-------------LRYLNQIAAAAESNGFEAVLT
MAV_4628|M.avium_104 HG-TPMS---GDRPAT-------------LRYLHQICSAAEDNGFEAVLT
MSMEG_2651|M.smegmatis_MC2_155 HG-TPLGAAGGDREAS-------------IDYLASIVRAAERFGFTGALI
TH_3352|M.thermoresistible__bu HG-TPAGAAGGDRDAS-------------IDYLASIVRAAETFGFTGALI
Mflv_5136|M.gilvum_PYR-GCK HG-TPAGSAHSDRDAS-------------IDYLASIVRAAETFGFTGALI
Mvan_1200|M.vanbaalenii_PYR-1 HG-TPAGAARGDRDAS-------------IDYLASIVRAAETFGFTGALI
MAB_2219|M.abscessus_ATCC_1997 HASTHHTVPEGYREPS-------------LRYLGEVARAADRLGFEGVLT
Mb0137c|M.bovis_AF2122/97 GCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWA
Rv0132c|M.tuberculosis_H37Rv GCSTRSGPTPTPEPASRGVGVVLSHEQFRTDRLVAHAQAAEQAGFRYVWA
MLBr_00348|M.leprae_Br4923 YW--------AAQPPG---------------NAAELVAAAEGAGFDAVFT
. . **: ** .
MUL_4507|M.ulcerans_Agy99 P--AGLWCED------AWLTTAMLVGTTKTLKFLVALRPGLVS--PTLAA
MMAR_4200|M.marinum_M P--AGLWCED------AWLTTAMLVGTTETLKFLVALRPGLVS--PTLAA
MAV_4628|M.avium_104 P--TGLWCED------AWLTTAMLVESTETLKFLVAFRPGLLS--PTLAA
MSMEG_2651|M.smegmatis_MC2_155 P--TGAWCED------AFVTAALLARETTSLAFLVAFRPGLVS--PTLSA
TH_3352|M.thermoresistible__bu P--TGAWCED------AFITAALLARETTSLGFLVAFRPGLVS--PTLSA
Mflv_5136|M.gilvum_PYR-GCK P--TGAWCED------AFITAALLARETSTLGFLVAFRPGLVS--PTLSA
Mvan_1200|M.vanbaalenii_PYR-1 P--TGAWCED------AFITAALLARETTSLAFLVAFRPGLVS--PTLSA
MAB_2219|M.abscessus_ATCC_1997 P--TGTWCED------AWLTAAGLLDQTERLKFLVAFRPGLVP--PTLAA
Mb0137c|M.bovis_AF2122/97 SDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVA
Rv0132c|M.tuberculosis_H37Rv SDHLQPWQDNEGHSMFPWLTLALVGNSTSSILFGTGVTCPIYRYHPATVA
MLBr_00348|M.leprae_Br4923 G---EAWGSD------AYTPLAWWGSSTQRVRLGTSVVQLSAR-TPTACA
* .: .: . * * : : ... *: *
MUL_4507|M.ulcerans_Agy99 QMATTFQQQSGGRLLVNVVTGGEAHEQRAYGDFLDKQQRYRRTGEFLHVV
MMAR_4200|M.marinum_M QMATTFQQQSGGRLLLNVVTGGEAHEQRAYGDFLDKQQRYRRTGEFLHVV
MAV_4628|M.avium_104 QMAGTFQRHSQGRLLLNVVTGGEPHEQRAYGDFLDKEARYARTAEFLHVV
MSMEG_2651|M.smegmatis_MC2_155 QMAATFAKHAPGRILLNVVVGGEAHEQRAFGDHLDKEERYARCDEFLDVV
TH_3352|M.thermoresistible__bu QMAATFARHAPGRILLNVVVGGESHEQRAFGDHLDKDERYRRADEFLEVV
Mflv_5136|M.gilvum_PYR-GCK QMAATFARHAPGRLLLNVVVGGEAHEQRSFGDHLDKDGRYARADEFLDVV
Mvan_1200|M.vanbaalenii_PYR-1 QMAATFARHAPGRILLNVVVGGEAHEQRSFGDYLDKEGRYARADEFLDVV
MAB_2219|M.abscessus_ATCC_1997 QQAATLQRFSNGRLLLNVVSGGDDAEQRRFGDWLTHDERYERTGEFLQIV
Mb0137c|M.bovis_AF2122/97 QAFASLAILNPGRVFLGLGTGKRLNEQAATDTFGNYRERHDRLIEAIVLI
Rv0132c|M.tuberculosis_H37Rv QAFASLAILNPGRVFLGLGTGERLNEQAATDTFGNYRERHDRLIEAIVLI
MLBr_00348|M.leprae_Br4923 MAALTLDHLSGGRHILGLGVSGPQVVEGWYGQPFPKP--LSRTREYIDIV
:: ** ::.: . : . * * : ::
MUL_4507|M.ulcerans_Agy99 RQLWASGQPVTFEGEHIHVHQAQLGRL-------PDPPP-----PVFFGG
MMAR_4200|M.marinum_M RQLWASGQPVTFEGEHIHVHQAQLGRL-------PDPPP-----PVFFGG
MAV_4628|M.avium_104 RQLWTSPQPVTFAGEHIRVEGAQLNNP-------PDPIP-----AVFFGG
MSMEG_2651|M.smegmatis_MC2_155 RRLWAG-ETVTHRGKYIDVEEASLAAP-------PNPVP-----PLYFGG
TH_3352|M.thermoresistible__bu RRLWAG-ETVTLHGRHIRVEDAALPTL-------PDPVP-----PLYFGG
Mflv_5136|M.gilvum_PYR-GCK RRLWDG-QTVSLDGEHIRVENASLPTV-------PAPVP-----PLYFGG
Mvan_1200|M.vanbaalenii_PYR-1 RRLWDG-QTVTLDGEHIRVEGASLATL-------PDPAP-----PLYFGG
MAB_2219|M.abscessus_ATCC_1997 RDIWRG-SPVDFSGKHYTVTDARVSEP-------PSPLP-----ELYFGG
Mb0137c|M.bovis_AF2122/97 RQLWSG-ERISFTGHYFRTDELKLYDT-------PAMPP-----PIFVAA
Rv0132c|M.tuberculosis_H37Rv RQLWSG-ERISFTGHYFRTDELKLYDT-------PAMPP-----PIFVAA
MLBr_00348|M.leprae_Br4923 RQVWAREAPVVSDGQHYPLPLTGAGATGLGKALKPITHPLRADIPIMLGA
* :* : *.: * * : ...
MUL_4507|M.ulcerans_Agy99 SSESAGAVAARYADTYLTWGEPLSAVGKKIDWIRG-LAADHGRALSYGLR
MMAR_4200|M.marinum_M SSESAGAVAARYADTYLTWGEPLSAVGKKIDWIRG-LAADHGRALSYGLR
MAV_4628|M.avium_104 SSASAGPVAAKHSDVYLTWGEPLTAVAKKLDWVRG-LAVDAGRILQYGLR
MSMEG_2651|M.smegmatis_MC2_155 SSAAAGPVAARHSDVYLTWGEPPEAVREKIEWIRK-LGEEQGRKLRFGIR
TH_3352|M.thermoresistible__bu SSTAAGPVAARHADVYLTWGEPPDAVREKIDWIRT-LAAAEGRRVRFGIR
Mflv_5136|M.gilvum_PYR-GCK SSAAAGPVAARHADVYLTWGEPPAAVAEKVEWIRR-AAAGQGRQLRFGIR
Mvan_1200|M.vanbaalenii_PYR-1 SSAAAGPVAARHADVYLTWGEPPAAVADKVDWIRR-LAAKQGRQVRFGIR
MAB_2219|M.abscessus_ATCC_1997 SSPAALPIAADHVDVYLTWGEPPAAAAAKIEAVRA-LAKERGRTLRFGIR
Mb0137c|M.bovis_AF2122/97 SGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAG-AQAAGRDPTTLGKR
Rv0132c|M.tuberculosis_H37Rv SGPQSATLAGRYGDGWIAQARDINDAKLLAAFAAG-AQAAGRDPTTLGKR
MLBr_00348|M.leprae_Br4923 EGPKNVALAAEICDGWLPIFFSPRMADMYNEWLDEGFARTGARRSREDFE
.. .:*. * ::. . . .
MUL_4507|M.ulcerans_Agy99 IHVITRDTAEEAWRVADRLLAGIDPADIERMQANLARSESEGQRRMAELH
MMAR_4200|M.marinum_M IHVITRDTAEEAWRVADRLLAGIDPADIERMQANLARSESEGQRRMAELH
MAV_4628|M.avium_104 IHVISRDTSAAAWAEADRLLSAIDPADIERVQASLARSESEGQRRMRELH
MSMEG_2651|M.smegmatis_MC2_155 LHTISRDTSEEAWAQADKLVAALDEETVRKAQEGLARSQSEGQRRMLALH
TH_3352|M.thermoresistible__bu LHTISRDTADEAWAQADKLIGALDEHTVRAAQAGLRRSESEGQRRMLALH
Mflv_5136|M.gilvum_PYR-GCK LHVITRDTAGAAWAEADRLVGALDDETVRNAQEGLGRSQSEGQRRMSALH
Mvan_1200|M.vanbaalenii_PYR-1 LHVITRDAADEAWSQADKLVSALDDETVRSAQAGLGRSQSEGQRRMLALH
MAB_2219|M.abscessus_ATCC_1997 LHTISRDTSEAAWAVANSLVGELTPDQIAKATALHSKSESEGQRRMTALH
Mb0137c|M.bovis_AF2122/97 AELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAE----------
Rv0132c|M.tuberculosis_H37Rv AELFAVVGDDKAAARAADLWRFTAGAVDQPNPVEIQRAAE----------
MLBr_00348|M.leprae_Br4923 ICASAQIVVTEDRAAAFAGIKPFLALYMGGMGAEGTNFHADVYRRMG---
: * .
MUL_4507|M.ulcerans_Agy99 GG--------VLDQLEIAPNLWAGVGLVRGGAGTALVGSHQEVAERIIEY
MMAR_4200|M.marinum_M GG--------ALDQLEIAPNLWAGVGLVRGGAGTALVGSHQEVAERIIEY
MAV_4628|M.avium_104 GG--------DSGKLLVGPNLWAGVGLVRGGAGTALVGSHAEVAERLAEY
MSMEG_2651|M.smegmatis_MC2_155 EANRLNGTWSDARSLEIAPNLWAGVGLVRGGAGTALVGSHTEVADRIAEY
TH_3352|M.thermoresistible__bu QANRADGSWRSARSLEVAPNLWAGVGLVRGGAGTALVGSHAEVADRIAEY
Mflv_5136|M.gilvum_PYR-GCK QAHRANGSWHDARTLEVAPNLWTGVGLVRGGAGTALVGSHSEVADRIAEY
Mvan_1200|M.vanbaalenii_PYR-1 EAHRADGSWHDARSLEIAPNLWAGVGLVRGGAGTALVGSHTEVADRIAEY
MAB_2219|M.abscessus_ATCC_1997 GG--------RLDKLEIYPNLWAGVGLVRGGAGTALVGSHEEVANLISEY
Mb0137c|M.bovis_AF2122/97 -----------SNPIEKVLANWA-VGTDPG--------VHIGAVQAVLDA
Rv0132c|M.tuberculosis_H37Rv -----------SNPIEKVLANWA-VGTDPG--------VHIGAVQAVLDA
MLBr_00348|M.leprae_Br4923 ----------YAEVVDEVTALFRSNQKDKAAEIIPNELVDSTMIVGDVDY
: : . . :
MUL_4507|M.ulcerans_Agy99 ARLGISHFILSGYPHLEEAYWFGEGVLPILERKRLWHRPHGSSPHSAALP
MMAR_4200|M.marinum_M ARLGISHFILSGYPHLEEAYWFGEGVLPILERKRLWHRPHGSSPHSAALP
MAV_4628|M.avium_104 AKLGITHFILSGYPHLEEAYWFGEGVLPLLERMGLWRHPNRRSRPAATTP
MSMEG_2651|M.smegmatis_MC2_155 AEIGIDEFIFSGYPHLEELFWFGEGVVPILRKRGLFD-AGALDCAPASIP
TH_3352|M.thermoresistible__bu AAAGIEEFIFSGYPHLEELFWFGEGVVPILRSRNLFDGAGDRSPVPAAIP
Mflv_5136|M.gilvum_PYR-GCK AEVGIDEFIFSGYPHLEELYWLGEGVVPLLRERGLFE-AGPKQAASASIP
Mvan_1200|M.vanbaalenii_PYR-1 AEAGIDEFVFSGYPHLEELFWFGEGVVPILRDRGLFT-ADVKGAAASSIP
MAB_2219|M.abscessus_ATCC_1997 HALGFDEFILSGYPHLEEAYWFAEGVLPLLKKRGALAA------------
Mb0137c|M.bovis_AF2122/97 GAVPFLHFPQD--DPITAIDFYRTNVLPELR-------------------
Rv0132c|M.tuberculosis_H37Rv GAVPFLHFPQD--DPITAIDFYRTNVLPELR-------------------
MLBr_00348|M.leprae_Br4923 VCKQIAAWSAAG---VTMMMVSASSVEQVRDLAGLF--------------
: : : .*
MUL_4507|M.ulcerans_Agy99 VAHSSVN---
MMAR_4200|M.marinum_M VAHSSVN---
MAV_4628|M.avium_104 FAVASAH---
MSMEG_2651|M.smegmatis_MC2_155 FVGAAR----
TH_3352|M.thermoresistible__bu FVGAAR----
Mflv_5136|M.gilvum_PYR-GCK FVGGTGRGRI
Mvan_1200|M.vanbaalenii_PYR-1 FVGAAR----
MAB_2219|M.abscessus_ATCC_1997 ----------
Mb0137c|M.bovis_AF2122/97 ----------
Rv0132c|M.tuberculosis_H37Rv ----------
MLBr_00348|M.leprae_Br4923 ----------