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KAERSKHIHLGARLPASFDSWDSLVHLARTAERGLFDFVLVDDGARRREQRSDALTMLAALAAVTDRVGL VGTVDTGATEPFEVARRIATLDHLSDGRVGWHRAGADVRRAGEFLAVARLFWDSWAEDAVLADHDAGRYV DPDRIRAVEHRGPHFDVRGFATLPRPPQRHPVLVQDDDSEDGTAFAAAHADAVITPHAGLEARQRYVADV RTKVAAAGRNPDSVTVFALTKLSPGSPAKVADEMDLHVRSGACDGFLLVPDPTPHGLDEFVDDVVPLLQE RGSLRTGYCGHTLRDHLAQPAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0214 | - | - | 100% (303) | fmnh2-utilizing oxygenase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 2e-27 | 31.33% (233) | hypothetical protein Mflv_0250 |
| M. gilvum PYR-GCK | Mflv_1269 | - | 3e-21 | 29.07% (258) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0978c | - | 3e-05 | 27.76% (245) | oxidoreductase |
| M. tuberculosis H37Rv | Rv0953c | - | 3e-05 | 27.76% (245) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4232c | - | 3e-54 | 45.30% (287) | putative oxygenase |
| M. marinum M | MMAR_0703 | - | 6e-66 | 49.82% (281) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_2048 | - | 2e-66 | 48.83% (299) | fmnh2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_2175 | - | 3e-45 | 39.01% (282) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 8e-43 | 40.69% (231) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 2e-32 | 31.40% (258) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0703|M.marinum_M -------------MIRKPVHLAAHFPGVNNTTVWADPGAGSQIEFESFVH
MAV_2048|M.avium_104 -------MTTRKARRRKQIHLGAHFPGVNNTTVWSDPSAGSQIAFESFVH
MAB_4232c|M.abscessus_ATCC_199 MSNPADAVRTREGKDRKPVHLAAHFPGVNNTTVWSDPASGSQIDFDSFVH
MSMEG_2175|M.smegmatis_MC2_155 -----------MSKPTKQIHLAAHFPGVNNTTVWSDPASGSHIDFASFVH
Mflv_0214|M.gilvum_PYR-GCK ----------MKAERSKHIHLGARLP-------------ASFDSWDSLVH
TH_4079|M.thermoresistible__bu ------------LPETRLSG---------------------ITDIDHYLE
Mvan_6020|M.vanbaalenii_PYR-1 ----------MMHLITWLMGNSYHAAGWRHQLAW----ERTAMRLDVLIE
Mb0978c|M.bovis_AF2122/97 -------------MHYGLVLFTSD-------------------RGITPAA
Rv0953c|M.tuberculosis_H37Rv -------------MHYGLVLFTSD-------------------RGITPAA
MMAR_0703|M.marinum_M LARTAERGLFDFFFLAEG--LRLREHRGRIHDLDVVGRP-------DTFT
MAV_2048|M.avium_104 LARTAERGLFDFFFLAEG--LRLREHRGKIHDLDVVGRP-------DTFT
MAB_4232c|M.abscessus_ATCC_199 LARTAERGLFDFFFLAEG--LRLREHRERIYDLDVVGRP-------DTFT
MSMEG_2175|M.smegmatis_MC2_155 FAQTAERGKFDFMFLAEG--LRLREQGGAIYDLDVVGRP-------DTFT
Mflv_0214|M.gilvum_PYR-GCK LARTAERGLFDFVLVDDG--ARRREQ-----------RS-------DALT
TH_4079|M.thermoresistible__bu LARIAERGKLDAIFFADHPVLKGKTEFRPFDA-------------LDPVT
Mvan_6020|M.vanbaalenii_PYR-1 IAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPT----VYDPVT
Mb0978c|M.bovis_AF2122/97 AARLAESHGFRTFYVPEHTHIPVKRQAAHPTTGDASLPDDRYMRTLDPWV
Rv0953c|M.tuberculosis_H37Rv AARLAESHGFRTFYVPEHTHIPVKRQAAHPTTGDASLPDDRYMRTLDPWV
*: ** : . . : . *. .
MMAR_0703|M.marinum_M LLAALAGVTDRIGLTGTINTTFN-EPFEVARQFATLDHLSEGRAGWNIVT
MAV_2048|M.avium_104 VLAALAAVTERLGLAGTINTTFN-EPYEVARQFATLDHLSDGRAAWNMVT
MAB_4232c|M.abscessus_ATCC_199 VLAALGAVTERLGLVGTINTTFN-EPFNVARQFASLDHLSDGRAGWNMVT
MSMEG_2175|M.smegmatis_MC2_155 VLAALAAVTDRLGLTGTINSTFN-EPYEVARQFASLDHLSDGRAAWNVVT
Mflv_0214|M.gilvum_PYR-GCK MLAALAAVTDRVGLVGTVDTGAT-EPFEVARRIATLDHLSDGRVGWHR--
TH_4079|M.thermoresistible__bu LVTALSTATTHIGLVATASTTYT-EPYGLARRFATLDHVSRGRAGWNIVT
Mvan_6020|M.vanbaalenii_PYR-1 LMAAISQHTKHIGLVGTASTTYE-SPWVVARRFASLDHLSNGRASWNVVT
Mb0978c|M.bovis_AF2122/97 SLGAASAVTSRIRLATAVALPVEHDPITLAKSIATLDHLSHGRVSVGVGF
Rv0953c|M.tuberculosis_H37Rv SLGAASAVTSRIRLATAVALPVEHDPITLAKSIATLDHLSHGRVSVGVGF
: * . * :: *. : .* :*: :*:***:* **..
MMAR_0703|M.marinum_M SSDAFTGANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIEN
MAV_2048|M.avium_104 SSDAFTGENFRRGGFLAHADRYRRAEEFITVARKFWDSWSPGAVIADVDA
MAB_4232c|M.abscessus_ATCC_199 SSDAFTGENFRRGGFLDHADRYRRAEEFITVARKFWDSWDAAGEPLPVN-
MSMEG_2175|M.smegmatis_MC2_155 SWDAFTGENFRRGGFLPEHQRYERAESFLAAAHTLFDSWRGDEIIADKAT
Mflv_0214|M.gilvum_PYR-GCK -----AGADVRR------------AGEFLAVARLFWDSWAEDAVLADHDA
TH_4079|M.thermoresistible__bu TANAAAAANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQA
Mvan_6020|M.vanbaalenii_PYR-1 GSNPGDSENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDT
Mb0978c|M.bovis_AF2122/97 GWNTDELVDHGVP----PGRRRTMLREYLEAMRALWTQEEAC--------
Rv0953c|M.tuberculosis_H37Rv GWNTDELVDHGVP----PGRRRTMLREYLEAMRALWTQEEAC--------
: .:: . :: .
MMAR_0703|M.marinum_M GDYVDPERIRSVEHSGPQFEVRGFATLPAGPQ-GHPVLLQAGDSEQGRAF
MAV_2048|M.avium_104 GTYADPARIGVVEHHGRQFDVRGVASLPAGPQ-GHPVLLQAGDSSDGRDF
MAB_4232c|M.abscessus_ATCC_199 -------------HRGPQFTVRGVATAPASPQ-RHPVLLQAGDSADGRDF
MSMEG_2175|M.smegmatis_MC2_155 GVFLSDPTAGEFSYHNDHFDISGRFNVPRSPQ-GRPVIFQAGDSDHGREF
Mflv_0214|M.gilvum_PYR-GCK GRYVDPDRIRAVEHRGPHFDVRGFATLPRPPQ-RHPVLVQDDDSEDGTAF
TH_4079|M.thermoresistible__bu PRFVDPDKIHAIDHRGEHFSVAGPLEVPRSPQ-GHPVLFQAGSSEPGKQL
Mvan_6020|M.vanbaalenii_PYR-1 GQYLNARKVRVPDYKGRHLSVKGPLNVSRSPQ-GRPVLFHAGQSEGGRRL
Mb0978c|M.bovis_AF2122/97 -------------YDGEFVKFGPSWAWPKPVQPHIPVLVGAAGTEKNFKW
Rv0953c|M.tuberculosis_H37Rv -------------YDGEFVKFGPSWAWPKPVQPHIPVLVGAAGTEKNFKW
: . . . . * **:. : .
MMAR_0703|M.marinum_M GARHADAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIG
MAV_2048|M.avium_104 GAKHADALFTLHGSLEAGQRYYADVKSRAAAHGRDPEQLKVLPGATFALG
MAB_4232c|M.abscessus_ATCC_199 GAKHADALFTIHSSIPAGQKYYADVKARAVAHGRNPDQLKVFPGVTYVLG
MSMEG_2175|M.smegmatis_MC2_155 AAAAADAIFSRHGTLEAGQQFFADVKGRLAKYGRRHSDLLILPAATFVLG
Mflv_0214|M.gilvum_PYR-GCK AAAHADAVITPHAGLEARQRYVADVRTKVAAAGRNPDSVTVFALTKLSP-
TH_4079|M.thermoresistible__bu AAKYAEAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIG
Mvan_6020|M.vanbaalenii_PYR-1 AARHADCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLG
Mb0978c|M.bovis_AF2122/97 IARSADGWITTPRDVDIDEPVKLLQDIWAAAGRDGLPQIVALD-------
Rv0953c|M.tuberculosis_H37Rv IARSADGWITTPRDVDIDEPVKLLQDIWAAAGRDGLPQIVALD-------
* *: : : . : :
MMAR_0703|M.marinum_M DTPDQAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDP-
MAV_2048|M.avium_104 DTPAEAADNARHIREQQVSGPTAIAFLEQVWGVDLSAYDPDGPLPDVEP-
MAB_4232c|M.abscessus_ATCC_199 DTEQEAIEKAAYIRDQQVGPQTAIAYLEQVWGRDLSEYDPEGPLPDVDP-
MSMEG_2175|M.smegmatis_MC2_155 DTDAEAADIAHEVRLAQVSPATAIKFLEQLWNRDLSDHDPDGPLPSVDPV
Mflv_0214|M.gilvum_PYR-GCK --------------------------------------------------
TH_4079|M.thermoresistible__bu GTEEEARRIQRRLED-LTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSD-
Mvan_6020|M.vanbaalenii_PYR-1 RTESEAVELYSELNS-LISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--
Mb0978c|M.bovis_AF2122/97 --------------------------------------------------
Rv0953c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0703|M.marinum_M IADAAISQGRVR---HADPVAVARRYRERSQAENLSIRELVIAVT---SR
MAV_2048|M.avium_104 VENPTITRGRVR---HGDPKTVAETWRARARAENLSIRELIIEVT---SR
MAB_4232c|M.abscessus_ATCC_199 TGDASITRGKAR---HGDPREIAAKYREIAEAKKLSIRELIKEVT---SR
MSMEG_2175|M.smegmatis_MC2_155 VGENTIAKGRASVRMYRDPIATANEWRAKAEAENLTTRELIIEVT---GR
Mflv_0214|M.gilvum_PYR-GCK --------------------------------------------------
TH_4079|M.thermoresistible__bu -DPPAIHMQSRY-----------ALVRRLVSTENLTVRELLLRLSGGRGH
Mvan_6020|M.vanbaalenii_PYR-1 --APVVGGNSIR-----------GQLDAIAKAEQLTVRQMYERVVPTMGN
Mb0978c|M.bovis_AF2122/97 --------------------------------------------------
Rv0953c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0703|M.marinum_M QQFVGTPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQE
MAV_2048|M.avium_104 QQFVGTPQQVAAEIDHYVQSDACDGFILVPHLTPHGLDEFVDKVVPLLQE
MAB_4232c|M.abscessus_ATCC_199 QQFIGTPSQVATEVDRYIQADACDGFILVPHLTPGGLDDFVDTVVPLLQE
MSMEG_2175|M.smegmatis_MC2_155 QNFIGSPTTVAEQIDHLVQSDASDGFILVPHVTPGGLDPFVDKVVPLLQE
Mflv_0214|M.gilvum_PYR-GCK ----GSPAKVADEMDLHVRSGACDGFLLVPDPTPHGLDEFVDDVVPLLQE
TH_4079|M.thermoresistible__bu RVFAGTPEQVADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQR
Mvan_6020|M.vanbaalenii_PYR-1 TALIGTATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQR
Mb0978c|M.bovis_AF2122/97 ------VKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAAKLAC
Rv0953c|M.tuberculosis_H37Rv ------VKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAAKLAC
:. : .. : : . . : :.. *
MMAR_0703|M.marinum_M RGAFRTAYTGQTLRDHLGLAGLPS--------------
MAV_2048|M.avium_104 RGSFRAEYRGITLREHLGLAPAPGSAPGADLESHCATG
MAB_4232c|M.abscessus_ATCC_199 RGAFRAEYEHETLREHLGLDPISRASGDFRRETASA--
MSMEG_2175|M.smegmatis_MC2_155 RGVFRTEYEGTTLRDHLDLAHPDRGA-----EPAAATG
Mflv_0214|M.gilvum_PYR-GCK RGSLRTGYCGHTLRDHLAQPAL----------------
TH_4079|M.thermoresistible__bu RGLFRTEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS--
Mvan_6020|M.vanbaalenii_PYR-1 RGLFRRHYTGSTLRENLGLPPVDN-----SPFAT----
Mb0978c|M.bovis_AF2122/97 CV------------------------------------
Rv0953c|M.tuberculosis_H37Rv CV------------------------------------