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AEQRQLHLAGFFSAGNVTHAHGAWRHVGATNGFLTGEFYKQIARTLERGKFDLLFLPDGLAIEDSYGENL ETGVGLGGQGAVALEPTSVIATMAAVTERLGLGATVSTTYYPPYHVARVFATLDNLSDGRISWNVVTSLN DSEARNFGVDEHLEHDIRYDRADEFLEAVKKLWSSWSEDALLLDKIGGRFADPKKVQYVNHRGHWLSVRG PLQVPRSRQGEPVILQAGLSPRGRRFAGRWAEAVFSVSPNLDIMRAVYQDIKAHVAAAGRDPEQTKVFTA VMPVLGETEQVARERLEYLNSLVHPEVGLSTLSSHSGLDLSKYPLDTKFSDIVADLGDRHVPTMLQMFSA VAGGGADLTLAELGRRYGTNVGFVPQWAGTAEQIADQLVSHFEAGAADGFIISAAYLPGIYEEFVDQVVP LLQQRGVFRTEYEGATLREHLGLARPEVGSI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3809 | - | - | 100% (452) | dibenzothiophene desulfurization enzyme A |
| M. avium 104 | MAV_0340 | - | e-112 | 47.07% (444) | nitrilotriacetate monooxygenase component A |
| M. avium 104 | MAV_4059 | - | 5e-78 | 38.27% (452) | monoxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1886c | - | 6e-08 | 24.76% (210) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 1e-78 | 37.47% (443) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv1855c | - | 6e-08 | 24.76% (210) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2482 | - | 3e-72 | 37.95% (448) | monooxygenase |
| M. marinum M | MMAR_0703 | - | 2e-73 | 38.36% (451) | FMNH2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_6641 | - | 1e-107 | 46.17% (444) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 2e-81 | 40.14% (416) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_3024 | - | 5e-11 | 26.56% (256) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 4e-73 | 37.59% (431) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3809|M.avium_104 --------MAEQR----QLHLAGFFSAGNVTHAHGAWRHVGATNG--FLT
MSMEG_6641|M.smegmatis_MC2_155 --------MGQRRT--DKMSLVAFMQAGSASVYAGSWRHPATEHG--YLD
Mflv_0250|M.gilvum_PYR-GCK ------MTDSAKR----KAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSR
MAB_2482|M.abscessus_ATCC_1997 MCGTRNLPGPDRRFPVSRIYLNAFDMACVGHQSPGLWRHP-DDQGHRYKS
TH_4079|M.thermoresistible__bu --------------------LPETRLSG-------------------ITD
Mvan_6020|M.vanbaalenii_PYR-1 ------------------MMHLITWLMGNSYHAAGWRHQLAWERT--AMR
MMAR_0703|M.marinum_M ------------------MIRKPVHLAAHFPGVNNTTVWADPGAG-SQIE
Mb1886c|M.bovis_AF2122/97 -----------------MTIRLGLQIPNFSYGTG------------VEKL
Rv1855c|M.tuberculosis_H37Rv -----------------MTIRLGLQIPNFSYGTG------------VEKL
MUL_3024|M.ulcerans_Agy99 -----------------MAIRLGFQIPSFSYGTG------------VDKL
MAV_3809|M.avium_104 GEFYKQIARTLERGKFDLLFLPDGLAIEDSYGENLETGVGLGGQGAVALE
MSMEG_6641|M.smegmatis_MC2_155 AAYYAKVGRQLEEGCFDLMFFDDRLAMPGIYGGSVAEAVRYGAR-PVKLD
Mflv_0250|M.gilvum_PYR-GCK PEYWRDLGRTMERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEP
MAB_2482|M.abscessus_ATCC_1997 LGYWTDLAKTLEAGGFDLLFLADVLGAYDVYGGSRDAAVADAAQFPVNDP
TH_4079|M.thermoresistible__bu IDHYLELARIAERGKLDAIFFADHPVLKGKTEFRPFDA----------LD
Mvan_6020|M.vanbaalenii_PYR-1 LDVLIEIAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSAR-PTVYD
MMAR_0703|M.marinum_M FESFVHLARTAERGLFDFFFLAEGLRLREHRGRIHDLDVVG------RPD
Mb1886c|M.bovis_AF2122/97 FPSVIAQAREAEAAGYDSLFVMDHFYQLPMLGTP----------DQPMLE
Rv1855c|M.tuberculosis_H37Rv FPSVIAQAREAEAAGYDSLFVMDHFYQLPMLGTP----------DQPMLE
MUL_3024|M.ulcerans_Agy99 FPSVIAQAREAEAAGFDSLFLMDHFYQLPMLGTP----------DQPMLE
.: * . * :*. :
MAV_3809|M.avium_104 PTSVIATMAAVTERLGLGATVS-TTYYPPYHVARVFATLDNLSDGRISWN
MSMEG_6641|M.smegmatis_MC2_155 LSVILGVLAQATSHIGLGATYS-TTYYQPFHVARTFASLDHLSRGRAAWN
Mflv_0250|M.gilvum_PYR-GCK -ASVVPIVGAFTKHLGIGITLS-TSFVPPYMMARQLSTLDHLTGGRVGWN
MAB_2482|M.abscessus_ATCC_1997 -TLAVSAMAAVTETLGFGLTLS-LTYEQPYALARRLTTLDHLTEGRVAWN
TH_4079|M.thermoresistible__bu PVTLVTALSTATTHIGLVATAS-TTYTEPYGLARRFATLDHVSRGRAGWN
Mvan_6020|M.vanbaalenii_PYR-1 PVTLMAAISQHTKHIGLVGTAS-TTYESPWVVARRFASLDHLSNGRASWN
MMAR_0703|M.marinum_M TFTLLAALAGVTDRIGLTGTIN-TTFNEPFEVARQFATLDHLSEGRAGWN
Mb1886c|M.bovis_AF2122/97 AYTALGALATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILG
Rv1855c|M.tuberculosis_H37Rv AYTALGALATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILG
MUL_3024|M.ulcerans_Agy99 AYTALGALATATERLQLGTLVTGNTYRNPALLAKIITTLDVVSAGRAVLG
: :. * : : . :: * :*: :::** :: ** .
MAV_3809|M.avium_104 VVTSLNDSEARNFGVDEHLEHDIRYDRADEFLEAVKKLWS-SWSEDALLL
MSMEG_6641|M.smegmatis_MC2_155 VVTSVNDSEAQNFGVDAHLGHDERYDRADEFLDVVTGLWD-TWDDDAIRH
Mflv_0250|M.gilvum_PYR-GCK IVTSYSKSEFQAMGKENLTPRDKRYEVVEEYMQLLYQLWD-SWDDDAIVY
MAB_2482|M.abscessus_ATCC_1997 IVTSYLDSAARNLGLDAQIPHDQRYDIAEEYLQVCYKLWEGSWESGAVVR
TH_4079|M.thermoresistible__bu IVTTANAAAAANFGRPAHPDPEHRYSRADEFLQVALRLWD-SWEDDAIVG
Mvan_6020|M.vanbaalenii_PYR-1 VVTGSNPGDSENFGLAHHPDRDSRYARAEEFVSACKALWN-SWDEDAFVE
MMAR_0703|M.marinum_M IVTSSDAFTGANFRRGGYLDHADRYQRAEEFLTVARKFWD-SWAPGAVLA
Mb1886c|M.bovis_AF2122/97 IGAGWFELEHRQLGFEFG-TFSDRFNRLEEALQILEPMVK----------
Rv1855c|M.tuberculosis_H37Rv IGAGWFELEHRQLGFEFG-TFSDRFNRLEEALQILEPMVK----------
MUL_3024|M.ulcerans_Agy99 IGAGWFELEHRQLGYEFG-TFTDRFNRLEEALQILDPIIK----------
: : : *: :* : : .
MAV_3809|M.avium_104 DKIGGRFADPKKVQYVNHRGHWLSVRGPLQVPRSRQGEPVILQAGLSPRG
MSMEG_6641|M.smegmatis_MC2_155 DRAGGMYADPDKVHELRHQGKYFSARGPLTVPRTPQGRPVILQAGSSGRG
Mflv_0250|M.gilvum_PYR-GCK DRDNGVFADPAKVREVNFQGEFFQSRGRHFVAPSPQKRPVLWQAGSSAQG
MAB_2482|M.abscessus_ATCC_1997 DRGRGVFTDPAKVHDIEHHGQYFTVPGPFLCEPSAQRTPLLFQAGASARG
TH_4079|M.thermoresistible__bu DKQAPRFVDPDKIHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSEPG
Mvan_6020|M.vanbaalenii_PYR-1 RKDTGQYLNARKVRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSEGG
MMAR_0703|M.marinum_M DIENGDYVDPERIRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSEQG
Mb1886c|M.bovis_AF2122/97 ------------GERPTFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKT
Rv1855c|M.tuberculosis_H37Rv ------------GERPTFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKT
MUL_3024|M.ulcerans_Agy99 ------------GERPTFSGSWYQAESAMAEPRYRDRIPILIGGGGEKKT
. . * . : *:: .* .
MAV_3809|M.avium_104 RRFAGRWAEAVFSVSPNLDIMRAVYQDIKAHVAAAGRDPEQTKVFTAVMP
MSMEG_6641|M.smegmatis_MC2_155 RDFASRWAELIFTGDPGLAIAREHYADQKARIAEAGRNPSAVRICPMVYA
Mflv_0250|M.gilvum_PYR-GCK REFASRHAESVFGIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQT
MAB_2482|M.abscessus_ATCC_1997 VRFAAAHAEAVFVSGPTPDVVRAPVRALRAEAARLGRDPRSVKVFTMVTP
TH_4079|M.thermoresistible__bu KQLAAKYAEAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSA
Mvan_6020|M.vanbaalenii_PYR-1 RRLAARHADCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAV
MMAR_0703|M.marinum_M RAFGARHADAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATF
Mb1886c|M.bovis_AF2122/97 FAIAARFADHLNIVAAVDELPR-KMRALAARCDEAGRDRSTLQTSLLLTV
Rv1855c|M.tuberculosis_H37Rv FAIAARFADHLNIVAAVDELPR-KMRALAARCDEAGRDRSTLQTSLLLTV
MUL_3024|M.ulcerans_Agy99 FRIAAHWADHLNIVAALDELPR-KMDAVAARCEEAGRDPSTLETSVMLTV
:.. *: : . : . * : .
MAV_3809|M.avium_104 VLGETEQVARER-LEYLNSLVHPEVGLSTLSSHSGLDLSKYPLDTKFS-D
MSMEG_6641|M.smegmatis_MC2_155 VVGESESHAKEREAMFLHDLVDPMASLTLLSELMNYDFAAHGLDDPVTDE
Mflv_0250|M.gilvum_PYR-GCK IIDRDKGRANDRYAEFV-ENVQIESALGILSGHTGFDFSTLGLDDNVV--
MAB_2482|M.abscessus_ATCC_1997 IVAESHDAAVAKLLEYR-RFVSAAGALALFGGWTGVDLARLDPDEPLR--
TH_4079|M.thermoresistible__bu IIGGTEEEARRIQRRLE-DLTVPDYGLEQLSRIVGYRVGRDDLDRRLQ--
Mvan_6020|M.vanbaalenii_PYR-1 YLGRTESEAVELYSELN-SLISPDLGVDFLAKAVSEDLTGYPVDGPMP--
MMAR_0703|M.marinum_M VIGDTPDQAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDI
Mb1886c|M.bovis_AF2122/97 MIDET---------------------------------------------
Rv1855c|M.tuberculosis_H37Rv MIDET---------------------------------------------
MUL_3024|M.ulcerans_Agy99 VVDAK---------------------------------------------
:
MAV_3809|M.avium_104 ---IVADLGDRHVPTMLQMFSAVAGGGADLTLAELGRRYGTNVGFVPQWA
MSMEG_6641|M.smegmatis_MC2_155 ---LIASVSG--VRGLVQNIRNHIGG-DTVTVRDLAGHRAT-LLQGPRFV
Mflv_0250|M.gilvum_PYR-GCK ----DADVQG--IRGLFDAILEAKDG-APVTVREAAQIYGV-SMGAPVAV
MAB_2482|M.abscessus_ATCC_1997 ----HVETEA--NRSALASFTNDPK--RTWTTRELAQEIGI-GGRGPVLV
TH_4079|M.thermoresistible__bu ---FGSDDPPAIHMQSRYALVRRLVSTENLTVRELLLRLSG-GRGHRVFA
Mvan_6020|M.vanbaalenii_PYR-1 ---DLS--APVVGGNSIRGQLDAIAKAEQLTVRQMYERVVP-TMGNTALI
MMAR_0703|M.marinum_M DPIADAAISQGRVRHADPVAVARRYRERSQAENLSIRELVIAVTSRQQFV
Mb1886c|M.bovis_AF2122/97 -----------------------------LSPDAIPAEMSG-----RVVV
Rv1855c|M.tuberculosis_H37Rv -----------------------------LSPDAIPAEMSG-----RVVV
MUL_3024|M.ulcerans_Agy99 -----------------------------AKVERLPAETSR-----RMVT
MAV_3809|M.avium_104 GTAEQIADQLVSHFEAGAADGFIISAAYLPGIYEEFVDQVVPLLQQRGVF
MSMEG_6641|M.smegmatis_MC2_155 GTGPQVADQMAEWFEAQACDGFVLAATHMPGAFEDVVRMVVPELQRRGLF
Mflv_0250|M.gilvum_PYR-GCK GTPADVADQMEQYLDEGDCNGFMMLATDTPGCFNDMTELLVPELQKRGRF
MAB_2482|M.abscessus_ATCC_1997 GTGSSIADELERWSDEADIDGFNVAYVTTPGTFADFARLVIPELRRRGRV
TH_4079|M.thermoresistible__bu GTPEQVADTIEEWFTTGAADGFNLIPPALPSSLTAFVDHVVPELQRRGLF
Mvan_6020|M.vanbaalenii_PYR-1 GTATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLF
MMAR_0703|M.marinum_M GTPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQERGAF
Mb1886c|M.bovis_AF2122/97 GSPAQIADQIQAKVLDAGVDGLIIN--------------LAPHGYLPGVI
Rv1855c|M.tuberculosis_H37Rv GSPAQIADQIQAKVLDAGVDGLIIN--------------LAPHGYLPGVI
MUL_3024|M.ulcerans_Agy99 GSPAQIADQVQTKVLDTGIDGVIMN--------------LSAHGHSPGLI
*: :** : :*. : : . * .
MAV_3809|M.avium_104 RTEYEGATLREHLGLARPEVGSI-------------
MSMEG_6641|M.smegmatis_MC2_155 RSAYEASTLRGHLGLERPASTRLSA-----------
Mflv_0250|M.gilvum_PYR-GCK RTRYPGTTLRESLREY--------------------
MAB_2482|M.abscessus_ATCC_1997 PHQRERCTLREQLGGSGPYLADTHPGTGYRRAPLPG
TH_4079|M.thermoresistible__bu RTEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS----
Mvan_6020|M.vanbaalenii_PYR-1 RRHYTGSTLRENLGLPPVDN-----SPFAT------
MMAR_0703|M.marinum_M RTAYTGQTLRDHLGLAGLPS----------------
Mb1886c|M.bovis_AF2122/97 TT--AAEALRPLLGV---------------------
Rv1855c|M.tuberculosis_H37Rv TT--AAEALRPLLGV---------------------
MUL_3024|M.ulcerans_Agy99 TT--VAEALRPLLTG---------------------
:** *