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MMHLITWLMGNSYHAAGWRHQLAWERTAMRLDVLIEIAKIAEEAKLDALFVADGNGVRNMDKVGLFEANT PSARPTVYDPVTLMAAISQHTKHIGLVGTASTTYESPWVVARRFASLDHLSNGRASWNVVTGSNPGDSEN FGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYLNARKVRVPDYKGRHLSVKGPLNVSR SPQGRPVLFHAGQSEGGRRLAARHADCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLG RTESEAVELYSELNSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLSAPVVGGNSIRGQLDAIAKAEQLT VRQMYERVVPTMGNTALIGTATQIADVMEEWYTTGACDGFVLGASISPFTLLLIRDELVPELQRRGLFRR HYTGSTLRENLGLPPVDNSPFAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | - | 100% (443) | xenobiotic compound DszA family monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_3887 | - | 1e-42 | 30.53% (416) | putative monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_1200 | - | 5e-11 | 23.48% (362) | alkanesulfonate monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0815c | - | 4e-09 | 25.32% (237) | hypothetical protein Mb0815c |
| M. gilvum PYR-GCK | Mflv_0250 | - | 7e-59 | 32.18% (404) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv0791c | - | 4e-09 | 25.32% (237) | hypothetical protein Rv0791c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4125 | - | 2e-68 | 36.55% (446) | putative nitrilotriacetate monooxygenase |
| M. marinum M | MMAR_0703 | - | 3e-67 | 34.69% (418) | FMNH2-utilizing oxygenase |
| M. avium 104 | MAV_0340 | - | 8e-76 | 37.64% (433) | nitrilotriacetate monooxygenase component A |
| M. smegmatis MC2 155 | MSMEG_1162 | - | 7e-91 | 41.61% (435) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 3e-93 | 44.33% (406) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 9e-07 | 29.01% (131) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1162|M.smegmatis_MC2_155 ---MTAQPRQLHLNAFLMG--VGHHEAAWRHPRTD-ARNLTDVKHFQRLA
TH_4079|M.thermoresistible__bu ------------------------------LPETR-LSGITDIDHYLELA
Mvan_6020|M.vanbaalenii_PYR-1 ---------MMHLITWLMG--NSYHAAGWRHQLAW-ERTAMRLDVLIEIA
Mflv_0250|M.gilvum_PYR-GCK --MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEYWRDLG
MAV_0340|M.avium_104 -----MRTDKMALVAFMQAGSTSVYAGSWRHPAN--EHRYLDAAYYAKIG
MMAR_0703|M.marinum_M -----MIRKPVHLAAHFPG---VNNTTVWADPGAG---SQIEFESFVHLA
MAB_4125|M.abscessus_ATCC_1997 --MSSRNGRQLHLLAFGNVR----AGGAWRLPGVR-NGPANQLNTLVATA
Mb0815c|M.bovis_AF2122/97 MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVWLCDHFL
Rv0791c|M.tuberculosis_H37Rv MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVWLCDHFL
MUL_4507|M.ulcerans_Agy99 ------MALLFHWFLPTYGDSRGLVAGGHGLPMSG--NRPATLRYLNQIA
MSMEG_1162|M.smegmatis_MC2_155 QLAERGRLDSVFFADTLAVG---------PRVKHNSQTIFEPITLLTAMA
TH_4079|M.thermoresistible__bu RIAERGKLDAIFFADHPVLK---------GKTEFRPFDALDPVTLVTALS
Mvan_6020|M.vanbaalenii_PYR-1 KIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAAIS
Mflv_0250|M.gilvum_PYR-GCK RTMERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEPASVVPIVG
MAV_0340|M.avium_104 RQLEEGCFDLMFFDDRLAMPGVYGGSVGEAVRYGARPVKLDLGVILGVLA
MMAR_0703|M.marinum_M RTAERGLFDFFFLAEGLRLREHRG-----RIHDLDVVGRPDTFTLLAALA
MAB_4125|M.abscessus_ATCC_1997 KAAEAAKFDAVFFADGLNFGP-------KATWAHKSTEDFEPLTATSYLA
Mb0815c|M.bovis_AF2122/97 TISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALS
Rv0791c|M.tuberculosis_H37Rv TISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALS
MUL_4507|M.ulcerans_Agy99 AAAESNGFEAVLTPAG--------------------LWCEDAWLTTAMLV
. : :
MSMEG_1162|M.smegmatis_MC2_155 AVTEHIGLIATAST-GYNAPYTLARAFASLDHISGGRAGWNIVTSAGEDE
TH_4079|M.thermoresistible__bu TATTHIGLVATAST-TYTEPYGLARRFATLDHVSRGRAGWNIVTTANAAA
Mvan_6020|M.vanbaalenii_PYR-1 QHTKHIGLVGTAST-TYESPWVVARRFASLDHLSNGRASWNVVTGSNPGD
Mflv_0250|M.gilvum_PYR-GCK AFTKHLGIGITLST-SFVPPYMMARQLSTLDHLTGGRVGWNIVTSYSKSE
MAV_0340|M.avium_104 QATSRIGLGATYST-TYYPPFHVARTFASLDHLSGGRAAWNVVTSVNDSE
MMAR_0703|M.marinum_M GVTDRIGLTGTINT-TFNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFT
MAB_4125|M.abscessus_ATCC_1997 AVTERLGLVVTGSS-TFQPPYHLARQLLSLDHLSSGRAGWNLVTSFAQAA
Mb0815c|M.bovis_AF2122/97 RDTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRRE
Rv0791c|M.tuberculosis_H37Rv RDTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRRE
MUL_4507|M.ulcerans_Agy99 GTTKTLKFLVALRP-GLVSPTLAAQMATTFQQQSGGRLLVNVVTGGEAHE
* : : : * *: ::: : ** .: :
MSMEG_1162|M.smegmatis_MC2_155 AANFGYHGIPDHTGRYARAAEFLDVTTALWDSWEDDALVLDEHSGIFADP
TH_4079|M.thermoresistible__bu AANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAPRFVDP
Mvan_6020|M.vanbaalenii_PYR-1 SENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYLNA
Mflv_0250|M.gilvum_PYR-GCK FQAMGKENLTPRDKRYEVVEEYMQLLYQLWDSWDDDAIVYDRDNGVFADP
MAV_0340|M.avium_104 AQNFGVDAHLGHDERYDRADEFMDVVTGLWDTWEDDAVLHDRVSGRYADP
MMAR_0703|M.marinum_M GANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYVDP
MAB_4125|M.abscessus_ATCC_1997 AANFGERGFLPHDERYRLAEETLQVVKSLWHSLEPDTVIEDRAAGIYSDI
Mb0815c|M.bovis_AF2122/97 SQAYGIP-FPPVGDRVSALAESLQVIKAVWTEPNP---------------
Rv0791c|M.tuberculosis_H37Rv SQAYGIP-FPPVGDRVSALAESLQVIKAVWTEPNP---------------
MUL_4507|M.ulcerans_Agy99 QRAYG--DFLDKQQRYRRTGEFLHVVRQLWASGQP---------------
* * : .*
MSMEG_1162|M.smegmatis_MC2_155 TKVHRIDHDGERFRIRGPLNSPRSPQG-HPLLVQAGSSETGKDFAARYAE
TH_4079|M.thermoresistible__bu DKIHAIDHRGEHFSVAGPLEVPRSPQG-HPVLFQAGSSEPGKQLAAKYAE
Mvan_6020|M.vanbaalenii_PYR-1 RKVRVPDYKGRHLSVKGPLNVSRSPQG-RPVLFHAGQSEGGRRLAARHAD
Mflv_0250|M.gilvum_PYR-GCK AKVREVNFQGEFFQSRGRHFVAPSPQK-RPVLWQAGSSAQGREFASRHAE
MAV_0340|M.avium_104 AKVHELGHVGEFFSARGPLTVPRTPQG-RPVIIQAGSSGRGREFASRWAE
MMAR_0703|M.marinum_M ERIRSVEHSGPQFEVRGFATLPAGPQG-HPVLLQAGDSEQGRAFGARHAD
MAB_4125|M.abscessus_ATCC_1997 NKIHVANHDGEFHKVKGPLGVTPSRQG-HPVIFQAGSSTTGRAFAARHAE
Mb0815c|M.bovis_AF2122/97 ------TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQRIAAKHAQ
Rv0791c|M.tuberculosis_H37Rv ------TYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQRIAAKHAQ
MUL_4507|M.ulcerans_Agy99 -----VTFEGEHIHVHQAQLGRLPDPP--PPVFFGGSSESAGAVAARYAD
. * * : .*.. ..:: *:
MSMEG_1162|M.smegmatis_MC2_155 AIFTAQRSLDEGKAFYRDVKARAVRFGRSPDDVKILPGVVVYLGETARAA
TH_4079|M.thermoresistible__bu AIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEEA
Mvan_6020|M.vanbaalenii_PYR-1 CIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESEA
Mflv_0250|M.gilvum_PYR-GCK SVFGIFPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIIDRDKGRA
MAV_0340|M.avium_104 LIFTGDPGIDVARSHYADQKDRIADAGRDPAAVRICPMAYAVVGESEAHA
MMAR_0703|M.marinum_M AMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQA
MAB_4125|M.abscessus_ATCC_1997 VVFTGQTDVERAKNFYRQLHQEARAAGRTFAPL-VTPSLGVVVGSTEAEA
Mb0815c|M.bovis_AF2122/97 GLNVRWWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGE--
Rv0791c|M.tuberculosis_H37Rv GLNVRWWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGE--
MUL_4507|M.ulcerans_Agy99 TYLTWGEPLSAVGKKIDWIRGLAADHGR---ALSYGLRIHVITRDTAEEA
* :
MSMEG_1162|M.smegmatis_MC2_155 QELEQE-FTDLISPEYSLRQLSQMLGVDLTAHSLDAPLPPLPPIEQIQGN
TH_4079|M.thermoresistible__bu RRIQRR-LEDLTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSDDPPAIHM
Mvan_6020|M.vanbaalenii_PYR-1 VELYSE-LNSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--APVVGG
Mflv_0250|M.gilvum_PYR-GCK NDRYAEFVEN-VQIESALGILSGHTGFDFSTLGLDDNVVD----ADVQGI
MAV_0340|M.avium_104 KDREAMLLNDLVHPMASLTLLSELMNYDFAQHDLDDPVTDDI-LASVSGI
MMAR_0703|M.marinum_M GEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAIS
MAB_4125|M.abscessus_ATCC_1997 LAAEST-IYEHFIPEYQAGWLLEVD-VNVVGADLDGPVPASAFPDSTETH
Mb0815c|M.bovis_AF2122/97 --------------------------------------------------
Rv0791c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4507|M.ulcerans_Agy99 WRVADR-------------LLAGIDPADIERMQANLARSESE-------G
MSMEG_1162|M.smegmatis_MC2_155 KSRYQLVKDLAAGESLTVRQLIAKLGG------GRGHRTFAGTPEQVADN
TH_4079|M.thermoresistible__bu QSRYALVRRLVSTENLTVRELLLRLSG------GRGHRVFAGTPEQVADT
Mvan_6020|M.vanbaalenii_PYR-1 NSIRGQLDAIAKAEQLTVRQMYERVVP------TMGNTALIGTATQIADV
Mflv_0250|M.gilvum_PYR-GCK RGLFDAILEAKDGAPVTVREAAQIYGV------SMGAPVAVGTPADVADQ
MAV_0340|M.avium_104 RGLVQNLRAHIGGDAVTVRDLANHRAT------LLQGPRFVGTGPQVADQ
MMAR_0703|M.marinum_M QGRVRHADPVAVARRYRERSQAENLSIRELVIAVTSRQQFVGTPSHIADE
MAB_4125|M.abscessus_ATCC_1997 QTALAGYKHLATVGNPTVREFLYRTLN-------AFGTRFVGSAEQVADQ
Mb0815c|M.bovis_AF2122/97 -------------EEVRIREEFASIPE---------PGLIVGTPDRCVER
Rv0791c|M.tuberculosis_H37Rv -------------EEVRIREEFASIPE---------PGLIVGTPDRCVER
MUL_4507|M.ulcerans_Agy99 QRRMAELHGGVLDQLEIAPNLWAGVGLVR----GGAGTALVGSHQEVAER
. *: .:
MSMEG_1162|M.smegmatis_MC2_155 LEEWFTEGAADGFNVMPPYLPGGLEDFI-EHVVPILQRRGLFRTEYTATT
TH_4079|M.thermoresistible__bu IEEWFTTGAADGFNLIPPALPSSLTAFV-DHVVPELQRRGLFRTEYTGTT
Mvan_6020|M.vanbaalenii_PYR-1 MEEWYTTGACDGFVLGASISPFTLLLIR-DELVPELQRRGLFRRHYTGST
Mflv_0250|M.gilvum_PYR-GCK MEQYLDEGDCNGFMMLATDTPGCFNDMT-ELLVPELQKRGRFRTRYPGTT
MAV_0340|M.avium_104 MADWFQTGACDGFVLAATHLPGAFEDVV-RMVVPELQRRGLFRTEYRSAT
MMAR_0703|M.marinum_M IDRYVQADACDGFILVPHLTPHGLDEFV-DRVVPLLQERGAFRTAYTGQT
MAB_4125|M.abscessus_ATCC_1997 IELWFSEGAADGFILSTSGLPGQFELFT-EHVVPILVRRGLFRAEYTGST
Mb0815c|M.bovis_AF2122/97 IREYQDRGVGHFLFTIPHVVKSDYLHIIGSDIIPRVKTEVTIP-------
Rv0791c|M.tuberculosis_H37Rv IREYQDRGVGHFLFTIPHVVKSDYLHIIGSDIIPRVKTEVTIP-------
MUL_4507|M.ulcerans_Agy99 IIEYARLG-ISHFILSGYPHLEEAYWFG-EGVLPILERKRLWHRPHGSSP
: : . : . ::* : .
MSMEG_1162|M.smegmatis_MC2_155 LRGHYGLAYQPSRHSRTAAESTA-
TH_4079|M.thermoresistible__bu LRDHLGLPRPRNRFTTGRPVAAAS
Mvan_6020|M.vanbaalenii_PYR-1 LRENLGLPPVDN-----SPFAT--
Mflv_0250|M.gilvum_PYR-GCK LRESLREY----------------
MAV_0340|M.avium_104 LRGHLGLPRPAN-----ARVAHA-
MMAR_0703|M.marinum_M LRDHLGLAGLPS------------
MAB_4125|M.abscessus_ATCC_1997 LREHLALPWPVP----ARPPALLA
Mb0815c|M.bovis_AF2122/97 ------------------------
Rv0791c|M.tuberculosis_H37Rv ------------------------
MUL_4507|M.ulcerans_Agy99 HSAALPVAHSSVN-----------