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MIRKPVHLAAHFPGVNNTTVWADPGAGSQIEFESFVHLARTAERGLFDFFFLAEGLRLREHRGRIHDLDV VGRPDTFTLLAALAGVTDRIGLTGTINTTFNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGANFRRG GYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYVDPERIRSVEHSGPQFEVRGFATLPAGPQG HPVLLQAGDSEQGRAFGARHADAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPD QAGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAISQGRVRHADPVAVARRYRE RSQAENLSIRELVIAVTSRQQFVGTPSHIADEIDRYVQADACDGFILVPHLTPHGLDEFVDRVVPLLQER GAFRTAYTGQTLRDHLGLAGLPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0703 | - | - | 100% (443) | FMNH2-utilizing oxygenase |
| M. marinum M | MMAR_0701 | - | 1e-32 | 32.88% (292) | oxidoreductase |
| M. marinum M | MMAR_4200 | fgd2 | 1e-08 | 28.80% (191) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1886c | - | 7e-07 | 24.43% (262) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0214 | - | 8e-66 | 49.82% (281) | fmnh2-utilizing oxygenase |
| M. tuberculosis H37Rv | Rv1855c | - | 7e-07 | 24.43% (262) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4232c | - | 0.0 | 73.00% (437) | putative oxygenase |
| M. avium 104 | MAV_2048 | - | 0.0 | 77.27% (440) | fmnh2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_2175 | - | 1e-156 | 60.23% (440) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 2e-82 | 40.88% (411) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_3024 | - | 4e-09 | 26.06% (284) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 3e-67 | 34.69% (418) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0703|M.marinum_M -------------MIRKPVHLAAHFPGVNNTTVWADPGAGSQIEFESFVH
MAV_2048|M.avium_104 -------MTTRKARRRKQIHLGAHFPGVNNTTVWSDPSAGSQIAFESFVH
MAB_4232c|M.abscessus_ATCC_199 MSNPADAVRTREGKDRKPVHLAAHFPGVNNTTVWSDPASGSQIDFDSFVH
MSMEG_2175|M.smegmatis_MC2_155 -----------MSKPTKQIHLAAHFPGVNNTTVWSDPASGSHIDFASFVH
Mflv_0214|M.gilvum_PYR-GCK ----------MKAERSKHIHLGARLP-------------ASFDSWDSLVH
TH_4079|M.thermoresistible__bu ------------LPETRLSG---------------------ITDIDHYLE
Mvan_6020|M.vanbaalenii_PYR-1 ----------MMHLITWLMGNSYHAAGWRHQLAW----ERTAMRLDVLIE
Mb1886c|M.bovis_AF2122/97 ----------------MTIRLGLQIPNFSYG-------TGVEKLFPSVIA
Rv1855c|M.tuberculosis_H37Rv ----------------MTIRLGLQIPNFSYG-------TGVEKLFPSVIA
MUL_3024|M.ulcerans_Agy99 ----------------MAIRLGFQIPSFSYG-------TGVDKLFPSVIA
:
MMAR_0703|M.marinum_M LARTAERGLFDFFFLAEG--LRLREHRGRIHDLDVVGRP---DTFTLLAA
MAV_2048|M.avium_104 LARTAERGLFDFFFLAEG--LRLREHRGKIHDLDVVGRP---DTFTVLAA
MAB_4232c|M.abscessus_ATCC_199 LARTAERGLFDFFFLAEG--LRLREHRERIYDLDVVGRP---DTFTVLAA
MSMEG_2175|M.smegmatis_MC2_155 FAQTAERGKFDFMFLAEG--LRLREQGGAIYDLDVVGRP---DTFTVLAA
Mflv_0214|M.gilvum_PYR-GCK LARTAERGLFDFVLVDDG--ARRREQ-----------RS---DALTMLAA
TH_4079|M.thermoresistible__bu LARIAERGKLDAIFFADHPVLKGKTEFRPFDA---------LDPVTLVTA
Mvan_6020|M.vanbaalenii_PYR-1 IAKIAEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAA
Mb1886c|M.bovis_AF2122/97 QAREAEAAGYDSLFVMDH--FYQLPMLGTPDQP-------MLEAYTALGA
Rv1855c|M.tuberculosis_H37Rv QAREAEAAGYDSLFVMDH--FYQLPMLGTPDQP-------MLEAYTALGA
MUL_3024|M.ulcerans_Agy99 QAREAEAAGFDSLFLMDH--FYQLPMLGTPDQP-------MLEAYTALGA
*: ** . * .:. : :. * : *
MMAR_0703|M.marinum_M LAGVTDRIGLTGTIN-TTFNEPFEVARQFATLDHLSEGRAGWNIVTSSDA
MAV_2048|M.avium_104 LAAVTERLGLAGTIN-TTFNEPYEVARQFATLDHLSDGRAAWNMVTSSDA
MAB_4232c|M.abscessus_ATCC_199 LGAVTERLGLVGTIN-TTFNEPFNVARQFASLDHLSDGRAGWNMVTSSDA
MSMEG_2175|M.smegmatis_MC2_155 LAAVTDRLGLTGTIN-STFNEPYEVARQFASLDHLSDGRAAWNVVTSWDA
Mflv_0214|M.gilvum_PYR-GCK LAAVTDRVGLVGTVD-TGATEPFEVARRIATLDHLSDGRVGWHR------
TH_4079|M.thermoresistible__bu LSTATTHIGLVATAS-TTYTEPYGLARRFATLDHVSRGRAGWNIVTTANA
Mvan_6020|M.vanbaalenii_PYR-1 ISQHTKHIGLVGTAS-TTYESPWVVARRFASLDHLSNGRASWNVVTGSNP
Mb1886c|M.bovis_AF2122/97 LATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFE
Rv1855c|M.tuberculosis_H37Rv LATATERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFE
MUL_3024|M.ulcerans_Agy99 LATATERLQLGTLVTGNTYRNPALLAKIITTLDVVSAGRAVLGIGAGWFE
:. * :: * . .* :*: :::** :* **.
MMAR_0703|M.marinum_M FTGANFRRGGYLDHADRYQRAEEFLTVARKFWDSWAPGAVLADIENGDYV
MAV_2048|M.avium_104 FTGENFRRGGFLAHADRYRRAEEFITVARKFWDSWSPGAVIADVDAGTYA
MAB_4232c|M.abscessus_ATCC_199 FTGENFRRGGFLDHADRYRRAEEFITVARKFWDSWDAAGEPLPVN-----
MSMEG_2175|M.smegmatis_MC2_155 FTGENFRRGGFLPEHQRYERAESFLAAAHTLFDSWRGDEIIADKATGVFL
Mflv_0214|M.gilvum_PYR-GCK -AGADVRR------------AGEFLAVARLFWDSWAEDAVLADHDAGRYV
TH_4079|M.thermoresistible__bu AAAANFGRPAHPDPEHRYSRADEFLQVALRLWDSWEDDAIVGDKQAPRFV
Mvan_6020|M.vanbaalenii_PYR-1 GDSENFGLAHHPDRDSRYARAEEFVSACKALWNSWDEDAFVERKDTGQYL
Mb1886c|M.bovis_AF2122/97 LEHRQLGFEFG-TFSDRFNRLEEALQILEPMVKGERP-------------
Rv1855c|M.tuberculosis_H37Rv LEHRQLGFEFG-TFSDRFNRLEEALQILEPMVKGERP-------------
MUL_3024|M.ulcerans_Agy99 LEHRQLGYEFG-TFTDRFNRLEEALQILDPIIKGERP-------------
:. . : : ..
MMAR_0703|M.marinum_M DPERIRSVEHSGPQFEVRGFATLPAGPQGHPVLLQAGDSEQGRAFGARHA
MAV_2048|M.avium_104 DPARIGVVEHHGRQFDVRGVASLPAGPQGHPVLLQAGDSSDGRDFGAKHA
MAB_4232c|M.abscessus_ATCC_199 ---------HRGPQFTVRGVATAPASPQRHPVLLQAGDSADGRDFGAKHA
MSMEG_2175|M.smegmatis_MC2_155 SDPTAGEFSYHNDHFDISGRFNVPRSPQGRPVIFQAGDSDHGREFAAAAA
Mflv_0214|M.gilvum_PYR-GCK DPDRIRAVEHRGPHFDVRGFATLPRPPQRHPVLVQDDDSEDGTAFAAAHA
TH_4079|M.thermoresistible__bu DPDKIHAIDHRGEHFSVAGPLEVPRSPQGHPVLFQAGSSEPGKQLAAKYA
Mvan_6020|M.vanbaalenii_PYR-1 NARKVRVPDYKGRHLSVKGPLNVSRSPQGRPVLFHAGQSEGGRRLAARHA
Mb1886c|M.bovis_AF2122/97 --------TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFA
Rv1855c|M.tuberculosis_H37Rv --------TFFGDWYTTESAMAEPRYRDRIPILIGGGGEKKTFAIAARFA
MUL_3024|M.ulcerans_Agy99 --------TFSGSWYQAESAMAEPRYRDRIPILIGGGGEKKTFRIAAHWA
. . . . : *::. . . :.* *
MMAR_0703|M.marinum_M DAMFTLHSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQ
MAV_2048|M.avium_104 DALFTLHGSLEAGQRYYADVKSRAAAHGRDPEQLKVLPGATFALGDTPAE
MAB_4232c|M.abscessus_ATCC_199 DALFTIHSSIPAGQKYYADVKARAVAHGRNPDQLKVFPGVTYVLGDTEQE
MSMEG_2175|M.smegmatis_MC2_155 DAIFSRHGTLEAGQQFFADVKGRLAKYGRRHSDLLILPAATFVLGDTDAE
Mflv_0214|M.gilvum_PYR-GCK DAVITPHAGLEARQRYVADVRTKVAAAGRNPDSVTVFALTKLSP------
TH_4079|M.thermoresistible__bu EAIFTAQPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEE
Mvan_6020|M.vanbaalenii_PYR-1 DCIFEAAASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESE
Mb1886c|M.bovis_AF2122/97 DHLN-IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDETLSP
Rv1855c|M.tuberculosis_H37Rv DHLN-IVAAVDELPRKMRALAARCDEAGRDRSTLQTSLLLTVMIDETLSP
MUL_3024|M.ulcerans_Agy99 DHLN-IVAALDELPRKMDAVAARCEEAGRDPSTLETSVMLTVVVDAKAKV
: : : . : : * . :
MMAR_0703|M.marinum_M AGEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDP-IADAA
MAV_2048|M.avium_104 AADNARHIREQQVSGPTAIAFLEQVWGVDLSAYDPDGPLPDVEP-VENPT
MAB_4232c|M.abscessus_ATCC_199 AIEKAAYIRDQQVGPQTAIAYLEQVWGRDLSEYDPEGPLPDVDP-TGDAS
MSMEG_2175|M.smegmatis_MC2_155 AADIAHEVRLAQVSPATAIKFLEQLWNRDLSDHDPDGPLPSVDPVVGENT
Mflv_0214|M.gilvum_PYR-GCK --------------------------------------------------
TH_4079|M.thermoresistible__bu ARRIQRRLED-LTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSD--DPPA
Mvan_6020|M.vanbaalenii_PYR-1 AVELYSELNS-LISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS----APV
Mb1886c|M.bovis_AF2122/97 DAIPAEMSGR----------------------------------------
Rv1855c|M.tuberculosis_H37Rv DAIPAEMSGR----------------------------------------
MUL_3024|M.ulcerans_Agy99 ERLPAETSRR----------------------------------------
MMAR_0703|M.marinum_M ISQGRVR---HADPVAVARRYRERSQAENLSIRELVIAVT---SRQQFVG
MAV_2048|M.avium_104 ITRGRVR---HGDPKTVAETWRARARAENLSIRELIIEVT---SRQQFVG
MAB_4232c|M.abscessus_ATCC_199 ITRGKAR---HGDPREIAAKYREIAEAKKLSIRELIKEVT---SRQQFIG
MSMEG_2175|M.smegmatis_MC2_155 IAKGRASVRMYRDPIATANEWRAKAEAENLTTRELIIEVT---GRQNFIG
Mflv_0214|M.gilvum_PYR-GCK -------------------------------------------------G
TH_4079|M.thermoresistible__bu IHMQSRY-----------ALVRRLVSTENLTVRELLLRLSGGRGHRVFAG
Mvan_6020|M.vanbaalenii_PYR-1 VGGNSIR-----------GQLDAIAKAEQLTVRQMYERVVPTMGNTALIG
Mb1886c|M.bovis_AF2122/97 ----------------------------------------------VVVG
Rv1855c|M.tuberculosis_H37Rv ----------------------------------------------VVVG
MUL_3024|M.ulcerans_Agy99 ----------------------------------------------MVTG
*
MMAR_0703|M.marinum_M TPSHIADEIDRYVQADACDGFILVPHLT---PHGLDEFVDRVVPLLQERG
MAV_2048|M.avium_104 TPQQVAAEIDHYVQSDACDGFILVPHLT---PHGLDEFVDKVVPLLQERG
MAB_4232c|M.abscessus_ATCC_199 TPSQVATEVDRYIQADACDGFILVPHLT---PGGLDDFVDTVVPLLQERG
MSMEG_2175|M.smegmatis_MC2_155 SPTTVAEQIDHLVQSDASDGFILVPHVT---PGGLDPFVDKVVPLLQERG
Mflv_0214|M.gilvum_PYR-GCK SPAKVADEMDLHVRSGACDGFLLVPDPT---PHGLDEFVDDVVPLLQERG
TH_4079|M.thermoresistible__bu TPEQVADTIEEWFTTGAADGFNLIPPAL---PSSLTAFVDHVVPELQRRG
Mvan_6020|M.vanbaalenii_PYR-1 TATQIADVMEEWYTTGACDGFVLGASIS---PFTLLLIRDELVPELQRRG
Mb1886c|M.bovis_AF2122/97 SPAQIADQIQAKVLDAGVDGLIINLAPHGYLPGVITTAAEALRPLLGV--
Rv1855c|M.tuberculosis_H37Rv SPAQIADQIQAKVLDAGVDGLIINLAPHGYLPGVITTAAEALRPLLGV--
MUL_3024|M.ulcerans_Agy99 SPAQIADQVQTKVLDTGIDGVIMNLSAHGHSPGLITTVAEALRPLLTG--
:. :* :: . **. : * : : : * *
MMAR_0703|M.marinum_M AFRTAYTGQTLRDHLGLAGLPS--------------
MAV_2048|M.avium_104 SFRAEYRGITLREHLGLAPAPGSAPGADLESHCATG
MAB_4232c|M.abscessus_ATCC_199 AFRAEYEHETLREHLGLDPISRASGDFRRETASA--
MSMEG_2175|M.smegmatis_MC2_155 VFRTEYEGTTLRDHLDLAHPDRGA-----EPAAATG
Mflv_0214|M.gilvum_PYR-GCK SLRTGYCGHTLRDHLAQPAL----------------
TH_4079|M.thermoresistible__bu LFRTEYTGTTLRDHLGLPRPRNRFTTGRPVAAAS--
Mvan_6020|M.vanbaalenii_PYR-1 LFRRHYTGSTLRENLGLPPVDN-----SPFAT----
Mb1886c|M.bovis_AF2122/97 ------------------------------------
Rv1855c|M.tuberculosis_H37Rv ------------------------------------
MUL_3024|M.ulcerans_Agy99 ------------------------------------