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MRTDKMALVAFMQAGSTSVYAGSWRHPANEHRYLDAAYYAKIGRQLEEGCFDLMFFDDRLAMPGVYGGSV GEAVRYGARPVKLDLGVILGVLAQATSRIGLGATYSTTYYPPFHVARTFASLDHLSGGRAAWNVVTSVND SEAQNFGVDAHLGHDERYDRADEFMDVVTGLWDTWEDDAVLHDRVSGRYADPAKVHELGHVGEFFSARGP LTVPRTPQGRPVIIQAGSSGRGREFASRWAELIFTGDPGIDVARSHYADQKDRIADAGRDPAAVRICPMA YAVVGESEAHAKDREAMLLNDLVHPMASLTLLSELMNYDFAQHDLDDPVTDDILASVSGIRGLVQNLRAH IGGDAVTVRDLANHRATLLQGPRFVGTGPQVADQMADWFQTGACDGFVLAATHLPGAFEDVVRMVVPELQ RRGLFRTEYRSATLRGHLGLPRPANARVAHA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0340 | - | - | 100% (451) | nitrilotriacetate monooxygenase component A |
| M. avium 104 | MAV_3809 | - | e-112 | 47.07% (444) | dibenzothiophene desulfurization enzyme A |
| M. avium 104 | MAV_4059 | - | 5e-76 | 38.10% (441) | monoxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1886c | - | 1e-05 | 21.53% (274) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0250 | - | 3e-85 | 39.45% (436) | hypothetical protein Mflv_0250 |
| M. tuberculosis H37Rv | Rv1855c | - | 1e-05 | 21.53% (274) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3401 | - | 8e-73 | 37.59% (423) | putative monooxygenase |
| M. marinum M | MMAR_0703 | - | 8e-68 | 36.17% (412) | FMNH2-utilizing oxygenase |
| M. smegmatis MC2 155 | MSMEG_6641 | - | 0.0 | 85.71% (448) | nitrilotriacetate monooxygenase component A |
| M. thermoresistible (build 8) | TH_4079 | - | 1e-87 | 44.10% (424) | PUTATIVE nitrilotriacetate monooxygenase component A |
| M. ulcerans Agy99 | MUL_0814 | - | 2e-07 | 24.35% (230) | flavin-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_6020 | - | 1e-75 | 37.64% (433) | xenobiotic compound DszA family monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1886c|M.bovis_AF2122/97 --MTIRLGLQIPNFSYGTG-----------------VEKLFPSVIAQARE
Rv1855c|M.tuberculosis_H37Rv --MTIRLGLQIPNFSYGTG-----------------VEKLFPSVIAQARE
MAV_0340|M.avium_104 ---MRTDKMALVAFMQAGSTSVYAGSWRHPANEH--RYLDAAYYAKIGRQ
MSMEG_6641|M.smegmatis_MC2_155 MGQRRTDKMSLVAFMQAGSASVYAGSWRHPATEH--GYLDAAYYAKVGRQ
Mflv_0250|M.gilvum_PYR-GCK MTDSAKRKAHLLGFVQHGVMNHASTMWAHPRDKVGYHWSRPEYWRDLGRT
MAB_3401|M.abscessus_ATCC_1997 MTRVIRFNAFDMNCVAH----QSPGLWRHPDDQS-WRYKDLSYWTNLATL
TH_4079|M.thermoresistible__bu -----LPETRLSG------------------------ITDIDHYLELARI
Mvan_6020|M.vanbaalenii_PYR-1 ---MMHLITWLMGNSYHAAGWRHQLAWERT-------AMRLDVLIEIAKI
MMAR_0703|M.marinum_M ---MIRKPVHLAAHFPG---VNNTTVWADPGAGS---QIEFESFVHLART
MUL_0814|M.ulcerans_Agy99 ----MRFSIAIPQ-------------------------LDTDGFDAAGLR
.
Mb1886c|M.bovis_AF2122/97 AEAAGYDSLFVMDHFYQLPMLG---------TPDQPMLEAYTALGALATA
Rv1855c|M.tuberculosis_H37Rv AEAAGYDSLFVMDHFYQLPMLG---------TPDQPMLEAYTALGALATA
MAV_0340|M.avium_104 LEEGCFDLMFFDDRLAMPGVYGGSVGEAVRYGARPVKLDLGVILGVLAQA
MSMEG_6641|M.smegmatis_MC2_155 LEEGCFDLMFFDDRLAMPGIYGGSVAEAVRYGARPVKLDLSVILGVLAQA
Mflv_0250|M.gilvum_PYR-GCK MERGLFDAMFIADELAPYTTYKGSSDPVVKFAGQCPVHEPASVVPIVGAF
MAB_3401|M.abscessus_ATCC_1997 LERGRFDGLFIADVLGTYDIYGASDEAAIRQAAQIPVADPLLLVSAMALV
TH_4079|M.thermoresistible__bu AERGKLDAIFFADHPVLKGKTEFRPFDA---------LDPVTLVTALSTA
Mvan_6020|M.vanbaalenii_PYR-1 AEEAKLDALFVADGNGVRNMDKVGLFEANTPSARPTVYDPVTLMAAISQH
MMAR_0703|M.marinum_M AERGLFDFFFLAEGLRLREHRG-----RIHDLDVVGRPDTFTLLAALAGV
MUL_0814|M.ulcerans_Agy99 AYLARAEELGFEGGWGLEQIIG-----------SSPLLAPLQLLAYCAAC
. : : . : .
Mb1886c|M.bovis_AF2122/97 TERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFELEHR
Rv1855c|M.tuberculosis_H37Rv TERLQLGALVTGNTYRSPTLLAKIITTLDVVSAGRAILGIGAGWFELEHR
MAV_0340|M.avium_104 TSRIGLGATYS-TTYYPPFHVARTFASLDHLSGGRAAWNVVTSVNDSEAQ
MSMEG_6641|M.smegmatis_MC2_155 TSHIGLGATYS-TTYYQPFHVARTFASLDHLSRGRAAWNVVTSVNDSEAQ
Mflv_0250|M.gilvum_PYR-GCK TKHLGIGITLS-TSFVPPYMMARQLSTLDHLTGGRVGWNIVTSYSKSEFQ
MAB_3401|M.abscessus_ATCC_1997 TEHLGFGVTTG-TGFEHPYPFARRLSTLDHLTGGRVGWNVVTGYLPAAAR
TH_4079|M.thermoresistible__bu TTHIGLVATAS-TTYTEPYGLARRFATLDHVSRGRAGWNIVTTANAAAAA
Mvan_6020|M.vanbaalenii_PYR-1 TKHIGLVGTAS-TTYESPWVVARRFASLDHLSNGRASWNVVTGSNPGDSE
MMAR_0703|M.marinum_M TDRIGLTGTIN-TTFNEPFEVARQFATLDHLSEGRAGWNIVTSSDAFTGA
MUL_0814|M.ulcerans_Agy99 TNRLRLGVAVLVTSLHDPLQLASSVTAVDRLSNGRLDLGVAAGGGSRKFA
* :: : . * .* .:::* :: ** .: :
Mb1886c|M.bovis_AF2122/97 QLG-FEFGTFSDRFNRLEEALQILEPMVK---------------------
Rv1855c|M.tuberculosis_H37Rv QLG-FEFGTFSDRFNRLEEALQILEPMVK---------------------
MAV_0340|M.avium_104 NFGVDAHLGHDERYDRADEFMDVVTGLWD-TWEDDAVLHDRVSGRYADPA
MSMEG_6641|M.smegmatis_MC2_155 NFGVDAHLGHDERYDRADEFLDVVTGLWD-TWDDDAIRHDRAGGMYADPD
Mflv_0250|M.gilvum_PYR-GCK AMGKENLTPRDKRYEVVEEYMQLLYQLWD-SWDDDAIVYDRDNGVFADPA
MAB_3401|M.abscessus_ATCC_1997 NMGQTDQPAHDARYDHADEYLEVLYKLWEGSWEDDAVVRDAARGVFTDPD
TH_4079|M.thermoresistible__bu NFGRPAHPDPEHRYSRADEFLQVALRLWD-SWEDDAIVGDKQAPRFVDPD
Mvan_6020|M.vanbaalenii_PYR-1 NFGLAHHPDRDSRYARAEEFVSACKALWN-SWDEDAFVERKDTGQYLNAR
MMAR_0703|M.marinum_M NFRRGGYLDHADRYQRAEEFLTVARKFWD-SWAPGAVLADIENGDYVDPE
MUL_0814|M.ulcerans_Agy99 AFG----VDRATHVSYFTEGLQLMKAAWS---------------------
: : * : .
Mb1886c|M.bovis_AF2122/97 -GERPTFFGDWYTTESAMAEPRYRDR-IPILIGGGGEKKTFAIAARFADH
Rv1855c|M.tuberculosis_H37Rv -GERPTFFGDWYTTESAMAEPRYRDR-IPILIGGGGEKKTFAIAARFADH
MAV_0340|M.avium_104 KVHELGHVGEFFSARGPLTVPRTPQG-RPVIIQAGSSGRGREFASRWAEL
MSMEG_6641|M.smegmatis_MC2_155 KVHELRHQGKYFSARGPLTVPRTPQG-RPVILQAGSSGRGRDFASRWAEL
Mflv_0250|M.gilvum_PYR-GCK KVREVNFQGEFFQSRGRHFVAPSPQK-RPVLWQAGSSAQGREFASRHAES
MAB_3401|M.abscessus_ATCC_1997 KVHHIGHEGTHFTVPGVHLVEPSPQR-TPVIYQAGSSPRGVRFAAENAEA
TH_4079|M.thermoresistible__bu KIHAIDHRGEHFSVAGPLEVPRSPQG-HPVLFQAGSSEPGKQLAAKYAEA
Mvan_6020|M.vanbaalenii_PYR-1 KVRVPDYKGRHLSVKGPLNVSRSPQG-RPVLFHAGQSEGGRRLAARHADC
MMAR_0703|M.marinum_M RIRSVEHSGPQFEVRGFATLPAGPQG-HPVLLQAGDSEQGRAFGARHADA
MUL_0814|M.ulcerans_Agy99 DEPRVRFHGRFRDVDDLPIQPKRVQRPHPPIWFGGRAPKALARAVRHGDA
. * . : * : .* . . .:
Mb1886c|M.bovis_AF2122/97 LNIV-AAVDELPRKMRA-LAARCDEAGRDRSTLQTSLLLTVMIDET----
Rv1855c|M.tuberculosis_H37Rv LNIV-AAVDELPRKMRA-LAARCDEAGRDRSTLQTSLLLTVMIDET----
MAV_0340|M.avium_104 IFTG-DPGIDVARSHYADQKDRIADAGRDPAAVRICPMAYAVVGESEAHA
MSMEG_6641|M.smegmatis_MC2_155 IFTG-DPGLAIAREHYADQKARIAEAGRNPSAVRICPMVYAVVGESESHA
Mflv_0250|M.gilvum_PYR-GCK VFGI-FPTPKSMRAYATDIRTRASDAGRDPESVKLIYGLQTIIDRDKGRA
MAB_3401|M.abscessus_ATCC_1997 VFTA-APTKELLRQTVTTIRRELELAGRDPYSAKIFNLTTVVTGENSEAA
TH_4079|M.thermoresistible__bu IFTA-QPTVEEARQFYADVKARVRQHGRDPDRVHILPGLSAIIGGTEEEA
Mvan_6020|M.vanbaalenii_PYR-1 IFEA-AASVEAAREFYADLKRRRVEIGGEPDHLRIIVSVAVYLGRTESEA
MMAR_0703|M.marinum_M MFTL-HSSLRDGQRYYADVKGRARSYGRDPDQLKVFPAATFVIGDTPDQA
MUL_0814|M.ulcerans_Agy99 FLGAGSSTTADFATAVTTLRHELAEQGRDPAGFTIGKRVYLMVDDDPERA
. . : . * : .
Mb1886c|M.bovis_AF2122/97 -----------LSPDAIPAEMSG---------------------------
Rv1855c|M.tuberculosis_H37Rv -----------LSPDAIPAEMSG---------------------------
MAV_0340|M.avium_104 KDREAMLLNDLVHPMASLTLLSELMNYDFAQHDLDDPVTDDILASVSGIR
MSMEG_6641|M.smegmatis_MC2_155 KEREAMFLHDLVDPMASLTLLSELMNYDFAAHGLDDPVTDELIASVSGVR
Mflv_0250|M.gilvum_PYR-GCK NDRYAEFVEN-VQIESALGILSGHTGFDFSTLGLDDNVVD---ADVQGIR
MAB_3401|M.abscessus_ATCC_1997 HAKHAELLGY-GSAEGALVFMSGWMGVDLARYGLDEPIGN---VDSNAIL
TH_4079|M.thermoresistible__bu R-RIQRRLEDLTVPDYGLEQLSRIVGYRVGRDDLDRRLQFGSDDPPAIHM
Mvan_6020|M.vanbaalenii_PYR-1 V-ELYSELNSLISPDLGVDFLAKAVSEDLTGYPVDGPMPDLS--APVVGG
MMAR_0703|M.marinum_M GEKARQISYQQVSGATAIAMLEQVWGRDLSDYDPDGPLPDIDPIADAAIS
MUL_0814|M.ulcerans_Agy99 R----------ERVLAGLRSIYGKMG------------------------
:
Mb1886c|M.bovis_AF2122/97 -------------------------------------RVVVGSPAQIADQ
Rv1855c|M.tuberculosis_H37Rv -------------------------------------RVVVGSPAQIADQ
MAV_0340|M.avium_104 GLVQNLRAHI-GGDAVTVRDLANHRAT------LLQGPRFVGTGPQVADQ
MSMEG_6641|M.smegmatis_MC2_155 GLVQNIRNHI-GGDTVTVRDLAGHRAT------LLQGPRFVGTGPQVADQ
Mflv_0250|M.gilvum_PYR-GCK GLFDAILEAK-DGAPVTVREAAQIYGV------SMGAPVAVGTPADVADQ
MAB_3401|M.abscessus_ATCC_1997 SAVAAFQAATADGREWKVRDIAEWGEI------GGMGPRIVGSGTEVADT
TH_4079|M.thermoresistible__bu QSRYALVRRLVSTENLTVRELLLRLSG------GRGHRVFAGTPEQVADT
Mvan_6020|M.vanbaalenii_PYR-1 NSIRGQLDAIAKAEQLTVRQMYERVVP------TMGNTALIGTATQIADV
MMAR_0703|M.marinum_M QGRVRHADPVAVARRYRERSQAENLSIRELVIAVTSRQQFVGTPSHIADE
MUL_0814|M.ulcerans_Agy99 ---------------------------------GLDAVAVAGTPDDVTRG
*: .::
Mb1886c|M.bovis_AF2122/97 IQAKVLDAGVDGLIINLAPHGYLPGVITTAAEALRPLLGV----------
Rv1855c|M.tuberculosis_H37Rv IQAKVLDAGVDGLIINLAPHGYLPGVITTAAEALRPLLGV----------
MAV_0340|M.avium_104 MADWFQTGACDGFVLAAT---HLPGAFEDVVRMVVPELQRRGLFRTEYRS
MSMEG_6641|M.smegmatis_MC2_155 MAEWFEAQACDGFVLAAT---HMPGAFEDVVRMVVPELQRRGLFRSAYEA
Mflv_0250|M.gilvum_PYR-GCK MEQYLDEGDCNGFMMLAT---DTPGCFNDMTELLVPELQKRGRFRTRYPG
MAB_3401|M.abscessus_ATCC_1997 LQEWVEETDVDGFNLAYA---ITPGTFEDFIEYVVPVLTERGAYQSSYTP
TH_4079|M.thermoresistible__bu IEEWFTTGAADGFNLIPP---ALPSSLTAFVDHVVPELQRRGLFRTEYTG
Mvan_6020|M.vanbaalenii_PYR-1 MEEWYTTGACDGFVLGAS---ISPFTLLLIRDELVPELQRRGLFRRHYTG
MMAR_0703|M.marinum_M IDRYVQADACDGFILVPH---LTPHGLDEFVDRVVPLLQERGAFRTAYTG
MUL_0814|M.ulcerans_Agy99 LAEVIAAGAQTLLLNPVG---PDVGQNHEQTERLAAEVIPRLR-------
: : : . :
Mb1886c|M.bovis_AF2122/97 --------------------------------------------------
Rv1855c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0340|M.avium_104 ATLRGHLG------------------------LPRPANARVAHA------
MSMEG_6641|M.smegmatis_MC2_155 STLRGHLG------------------------LERPASTRLSA-------
Mflv_0250|M.gilvum_PYR-GCK TTLRESLREY----------------------------------------
MAB_3401|M.abscessus_ATCC_1997 GTLRHKLLGHGDRLPEEHRGAKYRIGGPLSTIIDRPSTVPSSSGSTAPAP
TH_4079|M.thermoresistible__bu TTLRDHLG------------------------LPRPRNRFTTGRPVAAAS
Mvan_6020|M.vanbaalenii_PYR-1 STLRENLG------------------------LPPVDN-----SPFAT--
MMAR_0703|M.marinum_M QTLRDHLG------------------------LAGLPS------------
MUL_0814|M.ulcerans_Agy99 --------------------------------------------------
Mb1886c|M.bovis_AF2122/97 ----
Rv1855c|M.tuberculosis_H37Rv ----
MAV_0340|M.avium_104 ----
MSMEG_6641|M.smegmatis_MC2_155 ----
Mflv_0250|M.gilvum_PYR-GCK ----
MAB_3401|M.abscessus_ATCC_1997 TPGR
TH_4079|M.thermoresistible__bu ----
Mvan_6020|M.vanbaalenii_PYR-1 ----
MMAR_0703|M.marinum_M ----
MUL_0814|M.ulcerans_Agy99 ----