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DFGALPPEINSGRMYSGPGPASLLAAAAGWESLAAELADGAGNYQAVIAGLTNESWLGPASLSMAGAVMP YVSWLTAVAEQCGRAAAQATAAASAFEAAYAMTVPPPLIAANRARLLALVQSNIFGQNTPAIMATEAEYS EMWAQDATAMYGYAANSASASALSPVPSPPQPTNPAAAGHLAAAAHAAVQSGSSAHTTTAHWMSSVPQTL QGLSTPGSTPGNGLSPTAMGTGAALGSSGPFSSLSSLTGASGKGATKSASTGAGAGLASALAAGPAADGA AAGLAEEAAGYGADGAGLIADGGGIGIDLYGLDLDYQGLALDEAGAGSILGAEAGTGIAGTAGLGSLEPP AGLGQGASASVGQAGALSTLSVPPSWATTVSTVTPLPSPNSGPVPGGWAAAPTASPGPAVSRLPLGGMVG RESEGPVHRVGQRVSLIPQVIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1998 | - | - | 100% (443) | PPE family protein |
| M. avium 104 | MAV_2928 | - | 8e-76 | 41.78% (438) | PPE family protein |
| M. avium 104 | MAV_2910 | - | 2e-67 | 40.28% (427) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 2e-74 | 41.39% (447) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 7e-30 | 36.89% (206) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 2e-74 | 41.39% (447) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 8e-39 | 28.29% (456) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-30 | 29.82% (399) | PPE family protein |
| M. marinum M | MMAR_1849 | - | 2e-78 | 40.40% (453) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 6e-31 | 40.39% (203) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 3e-31 | 30.80% (448) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4672 | - | 3e-74 | 46.29% (391) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-31 | 39.32% (206) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MMAR_1849|M.marinum_M -------------MDYAALPPEVNSARMYTGPGSGPMLAAALAWDGLSTE
MAV_1998|M.avium_104 -------------MDFGALPPEINSGRMYSGPGPASLLAAAAGWESLAAE
MUL_4672|M.ulcerans_Agy99 ------------MIDFGALPPEINSARIYTGPGPGSLSAAAANWASLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
* .** :* : ***...: :*. * *. .
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MMAR_1849|M.marinum_M LSSAAADYSSALAAMTSGPWRGPASTSMASAAAPYIAWMAGTATQALQAS
MAV_1998|M.avium_104 LADGAGNYQAVIAGLTNESWLGPASLSMAGAVMPYVSWLTAVAEQCGRAA
MUL_4672|M.ulcerans_Agy99 LQTAAGYYQSVVSGLTSGGWLGPASLSMASAFWPYVTWTSMVATQAREAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* : : : * .: . ** * : .
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MMAR_1849|M.marinum_M LQAKAAAGAYEAAFAVTVPPPMIAANRALLASLVATNLLGQNTPAIAAAE
MAV_1998|M.avium_104 AQATAAASAFEAAYAMTVPPPLIAANRARLLALVQSNIFGQNTPAIMATE
MUL_4672|M.ulcerans_Agy99 SQATLAVGAYETALAMTVPPPVVAANRVQLATLTATNFFGQNSPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* *. *. :* : . : *:. * :*.:* *: .* *
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASASAVTPFSTPPQIANPTAQGTQAAAVA
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASASAVTPFSTPPQIANPTAQGTQAAAVA
MMAR_1849|M.marinum_M ATYGEMWAQDAAAMYGYAACCATATRLTPFADPPPTTSPEAG-LIAQAAT
MAV_1998|M.avium_104 AEYSEMWAQDATAMYGYAANSASASALSPVPSPPQPTNPA-AAGHLAAAA
MUL_4672|M.ulcerans_Agy99 AAYSEMWAQDALAMYDYAANSASACALTVLNSPPEVVNPVGAATQTTAVT
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * .** * : :* * * : ..
Mb1817|M.bovis_AF2122/97 TAAGTAQSTLTEMIT-----------------------------------
Rv1789|M.tuberculosis_H37Rv TAAGTAQSTLTEMIT-----------------------------------
MMAR_1849|M.marinum_M TSSAQSQASLSQVMS-----------------------------------
MAV_1998|M.avium_104 HAAVQSGSSAHTTTAH----------------------------------
MUL_4672|M.ulcerans_Agy99 HATAASGAQAAAVTG-----------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQA-----------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb1817|M.bovis_AF2122/97 ---------------GLPNALQSLTSP-------LLQSSNG--------P
Rv1789|M.tuberculosis_H37Rv ---------------GLPNALQSLTSP-------LLQSSNG--------P
MMAR_1849|M.marinum_M ---------------MVPTALQGLASPSAS--GVTITEVAG--------A
MAV_1998|M.avium_104 ------------WMSSVPQTLQGLSTPGSTPGNGLSPTAMGTGAALGSSG
MUL_4672|M.ulcerans_Agy99 ---------------TDQLSLAGLVS--------AVPTMLG--------G
MLBr_01182|M.leprae_Br4923 ---------------ISQAALDQAVNEG------MEATVVP--------Q
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
: .
Mb1817|M.bovis_AF2122/97 LSWLWQILFGTPNFPTSISALLTDLQPYASFFYN---TEGLPY-------
Rv1789|M.tuberculosis_H37Rv LSWLWQILFGTPNFPTSISALLTDLQPYASFFYN---TEGLPY-------
MMAR_1849|M.marinum_M LGLGAPQLDGIQSWLGLQGIDLTTPSGLLAFFNG---TDGSPLGTAVNAI
MAV_1998|M.avium_104 PFSSLSSLTGASGKGATKSASTGAGAGLASALAAGPAADGAAAGLAEEAA
MUL_4672|M.ulcerans_Agy99 LASPTSALTAATSSLLPELGTTPIYALPSYFMAAGTPLYAMSS-------
MLBr_01182|M.leprae_Br4923 VDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMIN----
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Mb1817|M.bovis_AF2122/97 FSIGMGNNFIQAAKTLG------------LIGSAAPAAVAAAGDAAKGLP
Rv1789|M.tuberculosis_H37Rv FSIGMGNNFIQSAKTLG------------LIGSAAPAAVAAAGDAAKGLP
MMAR_1849|M.marinum_M TTNAIGSGFYTPGNFFGTMCDFFGLSSFSAMDAAEDAAIAASSGLGGAAP
MAV_1998|M.avium_104 GYGADGAGLIADGGGIGIDLYGLDLDYQGLALDEAGAGSILGAEAGTGIA
MUL_4672|M.ulcerans_Agy99 -------------------ILGMAQTAQGLANGAAAA--VQGAAAGAASS
MLBr_01182|M.leprae_Br4923 NHAGMANAGLSLVNGMG-----SAMKSLAPTTTKAAESAFKAMGSAVQST
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
.
Mb1817|M.bovis_AF2122/97 GLGGML------------GGG-PVAAGLGNAASVGKLSVPPVWSGPLPGS
Rv1789|M.tuberculosis_H37Rv GLGGML------------GGG-PVAAGLGNAASVGKLSVPPVWSGPLPGS
MMAR_1849|M.marinum_M GLGGFG------------GLGTAVSAGVGNAASIGSLSVPPTWAATSP--
MAV_1998|M.avium_104 GTAGLGSLEPP------AGLGQGASASVGQAGALSTLSVPPSWATTVS-T
MUL_4672|M.ulcerans_Agy99 GASALG------------SLGSGVVGGLGNAASLGPLSVPANWTSVIP-T
MLBr_01182|M.leprae_Br4923 GRGLLGS-----------SSGGHVTAQLGRAASIGSLRVPQTWTTASQPV
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
:
Mb1817|M.bovis_AF2122/97 VTPGAAPLP----------------------------VSTVSAAPEAAPG
Rv1789|M.tuberculosis_H37Rv VTPGAAPLP----------------------------VSTVSAAPEAAPG
MMAR_1849|M.marinum_M VGAAVATLPS---------------------------VAAGAPLTAHGPA
MAV_1998|M.avium_104 VTPLPSPNSGP-------------------------VPGGWAAAPTASPG
MUL_4672|M.ulcerans_Agy99 LN--GGAISG--------------------------LPNAGLDAANAAP-
MLBr_01182|M.leprae_Br4923 TAATRALSP-----------------------------ARVAVATESESA
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
.
Mb1817|M.bovis_AF2122/97 SLLGG-------LPLAGAGGAGAG--PRYGFRPTVMARPPFAG-------
Rv1789|M.tuberculosis_H37Rv SLLGG-------LPLAGAGGAGAG--PRYGFRPTVMARPPFAG-------
MMAR_1849|M.marinum_M SMLGG-------LPLSGFGGRGFSEVPRYGFKPTVVMHPPAAG-------
MAV_1998|M.avium_104 PAVSR-------LPLGGMVGR-ESEGPVHRVGQRVSLIPQVIG-------
MUL_4672|M.ulcerans_Agy99 TVLGA-------APRGALAGAPRSPGPRYGVVPTIMSRPPSDGYA-----
MLBr_01182|M.leprae_Br4923 PLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
.
Mb1817|M.bovis_AF2122/97 ---------------
Rv1789|M.tuberculosis_H37Rv ---------------
MMAR_1849|M.marinum_M ---------------
MAV_1998|M.avium_104 ---------------
MUL_4672|M.ulcerans_Agy99 ---------------
MLBr_01182|M.leprae_Br4923 ---------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------