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VDLQIRDKAFVIVGGTAGMGLAGAKALAAEGAAVAVIGRDKTRAKDAAALLSEAGAVGAHGLSFDVGRSG EAVMAVEAAVDLLGRLDGIAVTMGTAGMMPIDSDDDAWDAAFHDVLLATTRSVQAALPHLALTKGAIVTT AAYSARSPHEPRLPYASLKAAVATFTRGIARTHGKDGIRANCVAPGAVETDALHAIRGYVAESKGYPYEE ALERALREDFGFDAALNRPGRPDEIGALIAFLLSDVCGFVTGQTIYADGGAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1891 | - | - | 100% (262) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_2567 | - | e-118 | 82.56% (258) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_2438 | - | 3e-34 | 34.72% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3589c | - | 5e-19 | 29.92% (254) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4353 | - | 1e-28 | 34.47% (264) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3559c | - | 5e-19 | 30.98% (255) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 2e-14 | 27.00% (263) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0164 | - | 9e-23 | 32.54% (252) | short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1568 | - | 2e-34 | 35.32% (269) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_2228 | - | 1e-28 | 34.46% (267) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3956 | - | 5e-50 | 43.98% (266) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4844 | - | 1e-22 | 29.12% (261) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_1991 | - | 1e-27 | 34.85% (264) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_1891|M.avium_104 --------------------------------------------------
TH_3956|M.thermoresistible__bu --------------------------------------------------
Mflv_4353|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1991|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2228|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAB_0164|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_1891|M.avium_104 --------------------------------------------------
TH_3956|M.thermoresistible__bu --------------------------------------------------
Mflv_4353|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1991|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2228|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAB_0164|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_1891|M.avium_104 --------------------------------------------------
TH_3956|M.thermoresistible__bu --------------------------------------------------
Mflv_4353|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1991|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2228|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAB_0164|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
Mb3589c|M.bovis_AF2122/97 ---------------------------------------------MNLSV
Rv3559c|M.tuberculosis_H37Rv ---------------------------------------------MNLSV
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MAV_1891|M.avium_104 --------------------------------------------------
TH_3956|M.thermoresistible__bu --------------------------------------------------
Mflv_4353|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1991|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2228|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1568|M.marinum_M --------------------------------------------------
MAB_0164|M.abscessus_ATCC_1997 -------------------------------------------------M
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
Mb3589c|M.bovis_AF2122/97 APKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISDHHERR
Rv3559c|M.tuberculosis_H37Rv APKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISDHHERR
MUL_4844|M.ulcerans_Agy99 ------MTAELENKVAIITGACG-GIGLETSRVPACAGARVVLADLPETD
MAV_1891|M.avium_104 ------MDLQIRDKAFVIVGGTA-GMGLAGAKALAAEGAAVAVIGRDKTR
TH_3956|M.thermoresistible__bu ------MDLGLSGRNFVIVGGTT-GMGYAAAEQLARDGANVALLARDGDR
Mflv_4353|M.gilvum_PYR-GCK ------MDLGLRDATVVVVGGGR-GMGLAAAHCFADDGARVALVGRTRDV
Mvan_1991|M.vanbaalenii_PYR-1 ------MDLGLRDATAVVVGGGR-GMGLAAAHCFADDGARVALIGRSPEV
MSMEG_2228|M.smegmatis_MC2_155 ------MDLGFGGAAAAVVGGGR-GMGFATAQCLADDGARVAVIGRSKDV
MMAR_1568|M.marinum_M ------MDLGFSGSKAVVTGGSK-GMGLAIAETLAAEGASVAVIARGKRA
MAB_0164|M.abscessus_ATCC_1997 NLTDFQSLYDLSGRTAIVTGGTR-GIGYAIAEALGACGASVVVSSRKSDA
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAAR-GIGAAIAEVVARDGARVVAIDVES--
: . :... *:* :. ** *.
Mb3589c|M.bovis_AF2122/97 LGETAAELSALGLGRVEHVVCDVTS-TAQVDALIDSTTARMGRLDVLVNN
Rv3559c|M.tuberculosis_H37Rv LGETAAELSALGLGRVEHVVCDVTS-TAQVDALIDSTTARMGRLDVLVNN
MUL_4844|M.ulcerans_Agy99 LAGAAASVGRG----AVHHVVDLTN-EVSVRALIDFTIDTFGRLDIVDNN
MAV_1891|M.avium_104 AKDAAALLSEAGAVGAHGLSFDVGRSGEAV-MAVEAAVDLLGRLDGIAVT
TH_3956|M.thermoresistible__bu ATERAAGLAEQHGVRAVGISVDAAATGDGVRHAIDEAAERLGPLRGLAVT
Mflv_4353|M.gilvum_PYR-GCK LDEAAAQLRGRGSPDAVGVVADCADEAAVQRAFGELAERWNGELNVLVNA
Mvan_1991|M.vanbaalenii_PYR-1 LDGAAAQLRERGSPDAVGVVADTTDDAAVRRAFAELGERWNGELNILVNA
MSMEG_2228|M.smegmatis_MC2_155 LETAASDLARRGSPDAIAIVADTGDAEQVERAFAEIGERWDGELNVLINT
MMAR_1568|M.marinum_M LDSAVERLSQAGAPDAVAISADMADAASITSAFAAVSERW-GQLNCLVHT
MAB_0164|M.abscessus_ATCC_1997 CTAAAKELHDKG-YRALGVPAHMGELG-DIDALVTATVDEYGGVDIVVNA
MLBr_02565|M.leprae_Br4923 --AAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNN
. * :
Mb3589c|M.bovis_AF2122/97 AGLGG--QTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVI
Rv3559c|M.tuberculosis_H37Rv AGLGG--QTPVADMTDDEWDRVLDVSLTSVFRATRAALRYFRDAPHGGVI
MUL_4844|M.ulcerans_Agy99 AAHSDPADMLVSQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAG-GGAI
MAV_1891|M.avium_104 MGTAGM-MP--IDSDDDAWDAAFHDVLLATTRSVQAALP-HLALTKG-AI
TH_3956|M.thermoresistible__bu AGPMKQ-QGPFLEHADDSWDWYYQTILMATVRSCRAVIP-HLQRNGGGTI
Mflv_4353|M.gilvum_PYR-GCK VG-PTV-RGTFDELSDADWRQAVDEGAMGMVRCVRAALP-LLRAAEWARI
Mvan_1991|M.vanbaalenii_PYR-1 VG-PTV-RGTFDELTDADWRQAVDEGAMGMVHCVRAALP-LLRAAEWARI
MSMEG_2228|M.smegmatis_MC2_155 VG-PGA-AGDFEELTDGQWQEAFDAGVMGMVRCVRAALP-LLRKAEWARI
MMAR_1568|M.marinum_M IG-PGD--GYFEELDDAAWDAAFTLGTMSGVRAIRAALP-LLRAADWARV
MAB_0164|M.abscessus_ATCC_1997 AANPVA--QPMGSYTPEALGKSFDVNVRGPVFLVQAALP-HLTASEHASV
MLBr_02565|M.leprae_Br4923 AGITRD--KLLANMDDCRWDAVLEVNLLAPQRLTEGLVG-NGSISKGGRV
. . . . : :
Mb3589c|M.bovis_AF2122/97 VNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSI
Rv3559c|M.tuberculosis_H37Rv VNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSI
MUL_4844|M.ulcerans_Agy99 VNISSATAHAAYDMSTAYSCTKAAIETLTRYVATQYGRHGVRCNAIAPGL
MAV_1891|M.avium_104 VTTAAYSARSPHEPRLPYASLKAAVATFTRGIARTHGKDGIRANCVAPGA
TH_3956|M.thermoresistible__bu VTTAAYSVRAPKILIPPYNALKAAVLTLSKILAKTHGAEGIRVNTVCPGL
Mflv_4353|M.gilvum_PYR-GCK VNFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVVSPGS
Mvan_1991|M.vanbaalenii_PYR-1 VNFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVVSPGS
MSMEG_2228|M.smegmatis_MC2_155 VNFSAHSTQRQSTRLPAYTAAKAAVNSVSKNLSLLLAKDEIMVNVVSPGS
MMAR_1568|M.marinum_M VTLSAHSIQRQNPRLVAYTASKAALSSVTKNLSKSLAKEGILVNCVCPGT
MAB_0164|M.abscessus_ATCC_1997 LNVVSVAAFQYVPMLSMYAAMKATLMSFTRSMAAEYTARGIRVNALAPGT
MLBr_02565|M.leprae_Br4923 IVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGF
: : * ** : .:: : : * :.*.
Mb3589c|M.bovis_AF2122/97 AR-----------------HKFLDKTASAELLDRLVAGEAFGRAAEPWEV
Rv3559c|M.tuberculosis_H37Rv AR-----------------HKFLDKTASAELLDRLAAGEAFGRAAEPWEV
MUL_4844|M.ulcerans_Agy99 VR-----------------TPRLEVGLPQPIVDIFATHHLAGLIGEPHEI
MAV_1891|M.avium_104 VETDALHAIRGYVAESKGYPYEEALERALRED--FGFDAALNRPGRPDEI
TH_3956|M.thermoresistible__bu FDTEVNDFIRAQRAAEYNVAEEDAIYTHLSSNPAWNMRVALDRGGRPHEA
Mflv_4353|M.gilvum_PYR-GCK IA----SEALVGWADSVGVDGSDPYALMAAIDEHFGHPAHLPRAGLPTEI
Mvan_1991|M.vanbaalenii_PYR-1 IA----SEALLGWADSVGVDGSDPYALMAAIDEHFGHPAHLPRAGLPTEI
MSMEG_2228|M.smegmatis_MC2_155 IS----SEALVGWAESVGVDGSDPYQLMAAIDEHFGHPAHLPRAGLPSEI
MMAR_1568|M.marinum_M IVTASFTEQLKDLLAADGLDATNPYDVMAWIDKYFHQPCDLGRAGLPEEV
MAB_0164|M.abscessus_ATCC_1997 VD------------------TYMLQQNPQEIIDAMAAQSFMGRVAHTDEM
MLBr_02565|M.leprae_Br4923 IET------------------QMTAAIPLATREVGRRLNSLLQGGLPVDV
. . :
Mb3589c|M.bovis_AF2122/97 AATIAFLASDYSSYLTGEVISVSCQHP---------------------
Rv3559c|M.tuberculosis_H37Rv AATIAFLASDYSSYLTGEVISVSCQHP---------------------
MUL_4844|M.ulcerans_Agy99 AELVCFLASDRAAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
MAV_1891|M.avium_104 GALIAFLLSDVCGFVTGQTIYADGGAP---------------------
TH_3956|M.thermoresistible__bu GELIAFLLSDRAAYTTGAAINIDGGTDF--------------------
Mflv_4353|M.gilvum_PYR-GCK GSVVAFLASRRNSYMTGADINVDGGSDFT-------------------
Mvan_1991|M.vanbaalenii_PYR-1 GPVVAFLASRRNSYMTGANINVDGGSDFT-------------------
MSMEG_2228|M.smegmatis_MC2_155 GPVAAFLASRRNSYMTGANINVDGGSDFT-------------------
MMAR_1568|M.marinum_M ASITAYLVSRRNGYVTGATVNADGGSDFI-------------------
MAB_0164|M.abscessus_ATCC_1997 IGPALLLLSDAGSFITGQVIVADGGGGVQR------------------
MLBr_02565|M.leprae_Br4923 AETIAYFAIPASNAVTGNVIRVCGQAMLGA------------------
: ** :