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DLGLRDATVVVVGGGRGMGLAAAHCFADDGARVALVGRTRDVLDEAAAQLRGRGSPDAVGVVADCADEAA VQRAFGELAERWNGELNVLVNAVGPTVRGTFDELSDADWRQAVDEGAMGMVRCVRAALPLLRAAEWARIV NFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVVSPGSIASEALVGWADSVGVDGSDPY ALMAAIDEHFGHPAHLPRAGLPTEIGSVVAFLASRRNSYMTGADINVDGGSDFT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4353 | - | - | 100% (265) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_1258 | - | 1e-24 | 32.68% (254) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2469 | - | 2e-24 | 30.95% (252) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 8e-23 | 31.15% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2766c | fabG | 8e-23 | 31.15% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-16 | 29.53% (254) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4632 | - | 3e-22 | 31.47% (251) | short chain dehydrogenase |
| M. marinum M | MMAR_1568 | - | 3e-69 | 51.49% (268) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_1587 | - | 1e-117 | 76.60% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2228 | - | 1e-116 | 76.23% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4608 | - | 1e-123 | 81.44% (264) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 2e-23 | 31.92% (260) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_1991 | - | 1e-138 | 92.45% (265) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4353|M.gilvum_PYR-GCK --------------MDLGLRDATVVVVGGGRGMGLAAAHCFADDGARVAL
Mvan_1991|M.vanbaalenii_PYR-1 --------------MDLGLRDATAVVVGGGRGMGLAAAHCFADDGARVAL
TH_4608|M.thermoresistible__bu --------------MDLGFTDAAAVVVGGGRGMGLAAAQCLADDGARVAV
MSMEG_2228|M.smegmatis_MC2_155 --------------MDLGFGGAAAAVVGGGRGMGFATAQCLADDGARVAV
MAV_1587|M.avium_104 --------------MDLGLANAAAVVVGGSRGMGLATARCLADEGARVAV
MMAR_1568|M.marinum_M --------------MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_0315|M.ulcerans_Agy99 ---------MRPD-SSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
Mb2788c|M.bovis_AF2122/97 -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Rv2766c|M.tuberculosis_H37Rv -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
MAB_4632|M.abscessus_ATCC_1997 -----------MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLI
:.*. *:* * *. : * *
Mflv_4353|M.gilvum_PYR-GCK VGRTRDVLDEAAAQLRGRGSPDAVGVVADCADEAAVQRAFGELAERWNGE
Mvan_1991|M.vanbaalenii_PYR-1 IGRSPEVLDGAAAQLRERGSPDAVGVVADTTDDAAVRRAFAELGERWNGE
TH_4608|M.thermoresistible__bu IGRTRSMLDEAAADLARRGSPDALGIVADIRDEQQVERVFAELGERWQGE
MSMEG_2228|M.smegmatis_MC2_155 IGRSKDVLETAASDLARRGSPDAIAIVADTGDAEQVERAFAEIGERWDGE
MAV_1587|M.avium_104 IGRSRDALDSAVTDLTRRGSPDALGLVADIGDDAAVGQAFGELARRWDGE
MMAR_1568|M.marinum_M IARGKRALDSAVERLSQAGAPDAVAISADMADAASITSAFAAVSERWG-Q
MLBr_01807|M.leprae_Br4923 THRASVVPDWF------------FGVECDVTDNDAIGAAFKAVEEHQG-P
MUL_0315|M.ulcerans_Agy99 LDLK--TPDGG------------LAFSADVTNRSQVDAALAAIRQRLG-P
Mb2788c|M.bovis_AF2122/97 TARRQEAADEAAAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFGSV
Rv2766c|M.tuberculosis_H37Rv TARRQEAADEAAAQVGDR----ALGVGAHAVDEDAARRCVDLTLERFGSV
MAB_4632|M.abscessus_ATCC_1997 ASRTESQLREVAAKVQAAGR-QAEVVVADLSDTEASAALAQKAVDRFGRL
. .. : :
Mflv_4353|M.gilvum_PYR-GCK LNVLVNAVGPTVRGTFDELSDADWRQAVDEGAMGMVRCVRAALPLLRAAE
Mvan_1991|M.vanbaalenii_PYR-1 LNILVNAVGPTVRGTFDELTDADWRQAVDEGAMGMVHCVRAALPLLRAAE
TH_4608|M.thermoresistible__bu LNVLINTVGPAVMGTVEELSDEQWRSAVDDGVLGMVHCVRSALPLLRQAE
MSMEG_2228|M.smegmatis_MC2_155 LNVLINTVGPGAAGDFEELTDGQWQEAFDAGVMGMVRCVRAALPLLRKAE
MAV_1587|M.avium_104 LNALVITVGPGAAGTFEDLTDEQWRQAVEDGVLGMVRCVRAALPLLRKAQ
MMAR_1568|M.marinum_M LNCLVHTIGPGD-GYFEELDDAAWDAAFTLGTMSGVRAIRAALPLLRAAD
MLBr_01807|M.leprae_Br4923 VEVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQR
MUL_0315|M.ulcerans_Agy99 VTILVNAAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAG
Mb2788c|M.bovis_AF2122/97 DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEH
Rv2766c|M.tuberculosis_H37Rv DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGEH
MAB_4632|M.abscessus_ATCC_1997 DVVVNNVGG-TMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLKSD
: . . . . .
Mflv_4353|M.gilvum_PYR-GCK WARIVNFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVV
Mvan_1991|M.vanbaalenii_PYR-1 WARIVNFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVV
TH_4608|M.thermoresistible__bu WARIVNLSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLAKDEILVNVV
MSMEG_2228|M.smegmatis_MC2_155 WARIVNFSAHSTQRQSTRLPAYTAAKAAVNSVSKNLSLLLAKDEIMVNVV
MAV_1587|M.avium_104 WARIVNFSAHSTQRQSVLLPAYTAAKSMLTSVSKNLSLLLAKDEILVNVI
MMAR_1568|M.marinum_M WARVVTLSAHSIQRQNPRLVAYTASKAALSSVTKNLSKSLAKEGILVNCV
MLBr_01807|M.leprae_Br4923 FGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVV
MUL_0315|M.ulcerans_Agy99 WGRIVNISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAV
Mb2788c|M.bovis_AF2122/97 GGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAI
Rv2766c|M.tuberculosis_H37Rv GGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNAI
MAB_4632|M.abscessus_ATCC_1997 NASVINITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGI
. : : * ::*. : :: : . * .* :
Mflv_4353|M.gilvum_PYR-GCK SPGSIAS----EALVGWADSVGVDGSDPYALMAAIDEHFGHPAHLPRAGL
Mvan_1991|M.vanbaalenii_PYR-1 SPGSIAS----EALLGWADSVGVDGSDPYALMAAIDEHFGHPAHLPRAGL
TH_4608|M.thermoresistible__bu SPGSIAS----EALVGWADSIGVDGTDPYALMSAIDEHFGHPAHLPRAGL
MSMEG_2228|M.smegmatis_MC2_155 SPGSISS----EALVGWAESVGVDGSDPYQLMAAIDEHFGHPAHLPRAGL
MAV_1587|M.avium_104 SPGSIAS----ESLVGWANSVGVDGRDPYALMEAIGKHFGHPAHMPRAGL
MMAR_1568|M.marinum_M CPGTIVTASFTEQLKDLLAADGLDATNPYDVMAWIDKYFHQPCDLGRAGL
MLBr_01807|M.leprae_Br4923 APGFIDT-----EMTRAMDSK----YQEAALQAIP---------LGRIGA
MUL_0315|M.ulcerans_Agy99 PPGFIDT-----PMLRNAAAQGHLGDIEQNIARTP---------VRRIGK
Mb2788c|M.bovis_AF2122/97 CPGVVRT--------RLAEALWKDHEDP--LAATIA--------LGRIGE
Rv2766c|M.tuberculosis_H37Rv CPGVVRT--------RLAEALWKDHEDP--LAATIA--------LGRIGE
MAB_4632|M.abscessus_ATCC_1997 APGSILT--------SALEVVAGNDEMRNTLEQNTP--------LHRLGD
** : : : : * *
Mflv_4353|M.gilvum_PYR-GCK PTEIGSVVAFLASRRNSYMTGADINVDGGSDFT-------------
Mvan_1991|M.vanbaalenii_PYR-1 PTEIGPVVAFLASRRNSYMTGANINVDGGSDFT-------------
TH_4608|M.thermoresistible__bu PEEIGPVIAFLASRRNSYMTGANVNVDGGSDFV-------------
MSMEG_2228|M.smegmatis_MC2_155 PSEIGPVAAFLASRRNSYMTGANINVDGGSDFT-------------
MAV_1587|M.avium_104 PEEIGPVAAFLASRRNSYMTGANINVDGGSDFT-------------
MMAR_1568|M.marinum_M PEEVASITAYLVSRRNGYVTGATVNADGGSDFI-------------
MLBr_01807|M.leprae_Br4923 VEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH------------
MUL_0315|M.ulcerans_Agy99 PEDIAAACAFLVSEEAGYITGQILGVNGGRNT--------------
Mb2788c|M.bovis_AF2122/97 PADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH
Rv2766c|M.tuberculosis_H37Rv PADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAAPSTEH
MAB_4632|M.abscessus_ATCC_1997 PADIAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA---
::. :*.* .:::* : :**