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MDLGFGGAAAAVVGGGRGMGFATAQCLADDGARVAVIGRSKDVLETAASDLARRGSPDAIAIVADTGDAE QVERAFAEIGERWDGELNVLINTVGPGAAGDFEELTDGQWQEAFDAGVMGMVRCVRAALPLLRKAEWARI VNFSAHSTQRQSTRLPAYTAAKAAVNSVSKNLSLLLAKDEIMVNVVSPGSISSEALVGWAESVGVDGSDP YQLMAAIDEHFGHPAHLPRAGLPSEIGPVAAFLASRRNSYMTGANINVDGGSDFT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2228 | - | - | 100% (265) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_3994 | - | 8e-30 | 31.42% (261) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4800 | - | 3e-27 | 32.94% (252) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1519 | fabG1 | 2e-22 | 28.63% (262) | 3-oxoacyl- |
| M. gilvum PYR-GCK | Mflv_4353 | - | 1e-116 | 76.23% (265) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1483 | fabG1 | 2e-22 | 28.63% (262) | 3-oxoacyl- |
| M. leprae Br4923 | MLBr_01740 | - | 1e-15 | 28.63% (227) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4632 | - | 4e-23 | 30.98% (255) | short chain dehydrogenase |
| M. marinum M | MMAR_1568 | - | 4e-76 | 54.48% (268) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_1587 | - | 1e-119 | 77.74% (265) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_4608 | - | 1e-121 | 80.30% (264) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 1e-25 | 32.82% (259) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_1991 | - | 1e-118 | 77.74% (265) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1519|M.bovis_AF2122/97 MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVT-----
Rv1483|M.tuberculosis_H37Rv MTATATEGAKPPFVSRSVLVTGGNRGIGLAIAQRLAADGHKVAVT-----
MUL_0315|M.ulcerans_Agy99 ----MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVATL-----
Mflv_4353|M.gilvum_PYR-GCK --------MDLGLRDATVVVVGGGRGMGLAAAHCFADDGARVALVGRTRD
Mvan_1991|M.vanbaalenii_PYR-1 --------MDLGLRDATAVVVGGGRGMGLAAAHCFADDGARVALIGRSPE
TH_4608|M.thermoresistible__bu --------MDLGFTDAAAVVVGGGRGMGLAAAQCLADDGARVAVIGRTRS
MSMEG_2228|M.smegmatis_MC2_155 --------MDLGFGGAAAAVVGGGRGMGFATAQCLADDGARVAVIGRSKD
MAV_1587|M.avium_104 --------MDLGLANAAAVVVGGSRGMGLATARCLADEGARVAVIGRSRD
MMAR_1568|M.marinum_M --------MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAVIARGKR
MAB_4632|M.abscessus_ATCC_1997 -----MILDRFKLDGNVAVVTGAGRGLGAAIAEAFAQAGADVLIASRTES
MLBr_01740|M.leprae_Br4923 -----MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCD
*.*. *:* * * :: * :
Mb1519|M.bovis_AF2122/97 -------HRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQG-PVEVLVS
Rv1483|M.tuberculosis_H37Rv -------HRGSGAPKGLFGVECDVTDSDAVDRAFTAVEEHQG-PVEVLVS
MUL_0315|M.ulcerans_Agy99 -------DLKT--PDGGLAFSADVTNRSQVDAALAAIRQRLG-PVTILVN
Mflv_4353|M.gilvum_PYR-GCK VLDEAAAQLRGRGSPDAVGVVADCADEAAVQRAFGELAERWNGELNVLVN
Mvan_1991|M.vanbaalenii_PYR-1 VLDGAAAQLRERGSPDAVGVVADTTDDAAVRRAFAELGERWNGELNILVN
TH_4608|M.thermoresistible__bu MLDEAAADLARRGSPDALGIVADIRDEQQVERVFAELGERWQGELNVLIN
MSMEG_2228|M.smegmatis_MC2_155 VLETAASDLARRGSPDAIAIVADTGDAEQVERAFAEIGERWDGELNVLIN
MAV_1587|M.avium_104 ALDSAVTDLTRRGSPDALGLVADIGDDAAVGQAFGELARRWDGELNALVI
MMAR_1568|M.marinum_M ALDSAVERLSQAGAPDAVAISADMADAASITSAFAAVSERWG-QLNCLVH
MAB_4632|M.abscessus_ATCC_1997 QLREVAAKVQAAGRQAEV-VVADLSDTEASAALAQKAVDRFG-RLDVVVN
MLBr_01740|M.leprae_Br4923 GLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHP-SMDIVMN
* : : : ::
Mb1519|M.bovis_AF2122/97 NAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNKF-GRMI
Rv1483|M.tuberculosis_H37Rv NAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASRSMQRNKF-GRMI
MUL_0315|M.ulcerans_Agy99 AAGLDGFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGW-GRIV
Mflv_4353|M.gilvum_PYR-GCK AVGPTVRGTFDELSDADWRQAVDEGAMGMVRCVRAALPLLRAAEW-ARIV
Mvan_1991|M.vanbaalenii_PYR-1 AVGPTVRGTFDELTDADWRQAVDEGAMGMVHCVRAALPLLRAAEW-ARIV
TH_4608|M.thermoresistible__bu TVGPAVMGTVEELSDEQWRSAVDDGVLGMVHCVRSALPLLRQAEW-ARIV
MSMEG_2228|M.smegmatis_MC2_155 TVGPGAAGDFEELTDGQWQEAFDAGVMGMVRCVRAALPLLRKAEW-ARIV
MAV_1587|M.avium_104 TVGPGAAGTFEDLTDEQWRQAVEDGVLGMVRCVRAALPLLRKAQW-ARIV
MMAR_1568|M.marinum_M TIGPGD-GYFEELDDAAWDAAFTLGTMSGVRAIRAALPLLRAADW-ARVV
MAB_4632|M.abscessus_ATCC_1997 NVGGTMPKPFLDTTNDDLAEAFSFNVLSGHALLRAAVPHLLKSDN-ASVI
MLBr_01740|M.leprae_Br4923 IAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLV
* . .. . . . : . ::
Mb1519|M.bovis_AF2122/97 FIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAPG--
Rv1483|M.tuberculosis_H37Rv FIGSVSGSWGIGNQANYAASKAGVIGMARSIARELSKANVTANVVAPG--
MUL_0315|M.ulcerans_Agy99 NISSSSTHSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPPG--
Mflv_4353|M.gilvum_PYR-GCK NFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVVSPGSI
Mvan_1991|M.vanbaalenii_PYR-1 NFSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLARDEILVNVVSPGSI
TH_4608|M.thermoresistible__bu NLSAHSTQRQSVILPAYTAAKAMVTSISKNLSLLLAKDEILVNVVSPGSI
MSMEG_2228|M.smegmatis_MC2_155 NFSAHSTQRQSTRLPAYTAAKAAVNSVSKNLSLLLAKDEIMVNVVSPGSI
MAV_1587|M.avium_104 NFSAHSTQRQSVLLPAYTAAKSMLTSVSKNLSLLLAKDEILVNVISPGSI
MMAR_1568|M.marinum_M TLSAHSIQRQNPRLVAYTASKAALSSVTKNLSKSLAKEGILVNCVCPGTI
MAB_4632|M.abscessus_ATCC_1997 NITSTMGRLPGRAFLGYCTAKGALAHYTRTAAMDLSPR-IRVNGIAPG--
MLBr_01740|M.leprae_Br4923 NVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAV
. : * ::* : :. . : .. : **
Mb1519|M.bovis_AF2122/97 -----------YIDTDMTRALDE-----RIQQGALQF-----IPAKRVGT
Rv1483|M.tuberculosis_H37Rv -----------YIDTDMTRALDE-----RIQQGALQF-----IPAKRVGT
MUL_0315|M.ulcerans_Agy99 -----------FIDTPMLRNAAA-----QGHLGDIEQNIAR-TPVRRIGK
Mflv_4353|M.gilvum_PYR-GCK AS----EALVGWADSVGVDGSDP-----YALMAAIDEHFGHPAHLPRAGL
Mvan_1991|M.vanbaalenii_PYR-1 AS----EALLGWADSVGVDGSDP-----YALMAAIDEHFGHPAHLPRAGL
TH_4608|M.thermoresistible__bu AS----EALVGWADSIGVDGTDP-----YALMSAIDEHFGHPAHLPRAGL
MSMEG_2228|M.smegmatis_MC2_155 SS----EALVGWAESVGVDGSDP-----YQLMAAIDEHFGHPAHLPRAGL
MAV_1587|M.avium_104 AS----ESLVGWANSVGVDGRDP-----YALMEAIGKHFGHPAHMPRAGL
MMAR_1568|M.marinum_M VTASFTEQLKDLLAADGLDATNP-----YDVMAWIDKYFHQPCDLGRAGL
MAB_4632|M.abscessus_ATCC_1997 --------------SILTSALEV-----VAGNDEMRNTLEQNTPLHRLGD
MLBr_01740|M.leprae_Br4923 RTP-----LVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGV
*
Mb1519|M.bovis_AF2122/97 PAE------VAGVVSFLASEDASYISGAVIPVDGGMGMGH----------
Rv1483|M.tuberculosis_H37Rv PAE------VAGVVSFLASEDASYISGAVIPVDGGMGMGH----------
MUL_0315|M.ulcerans_Agy99 PED------IAAACAFLVSEEAGYITGQILGVNGGRNT------------
Mflv_4353|M.gilvum_PYR-GCK PTE------IGSVVAFLASRRNSYMTGADINVDGGSDFT-----------
Mvan_1991|M.vanbaalenii_PYR-1 PTE------IGPVVAFLASRRNSYMTGANINVDGGSDFT-----------
TH_4608|M.thermoresistible__bu PEE------IGPVIAFLASRRNSYMTGANVNVDGGSDFV-----------
MSMEG_2228|M.smegmatis_MC2_155 PSE------IGPVAAFLASRRNSYMTGANINVDGGSDFT-----------
MAV_1587|M.avium_104 PEE------IGPVAAFLASRRNSYMTGANINVDGGSDFT-----------
MMAR_1568|M.marinum_M PEE------VASITAYLVSRRNGYVTGATVNADGGSDFI-----------
MAB_4632|M.abscessus_ATCC_1997 PAD------IAAAAVYLASPAGSFLTGKVLEVDGGLIAPNLDIPLPDLA-
MLBr_01740|M.leprae_Br4923 AKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMR
. : .: . : : .
Mb1519|M.bovis_AF2122/97 -----------------------
Rv1483|M.tuberculosis_H37Rv -----------------------
MUL_0315|M.ulcerans_Agy99 -----------------------
Mflv_4353|M.gilvum_PYR-GCK -----------------------
Mvan_1991|M.vanbaalenii_PYR-1 -----------------------
TH_4608|M.thermoresistible__bu -----------------------
MSMEG_2228|M.smegmatis_MC2_155 -----------------------
MAV_1587|M.avium_104 -----------------------
MMAR_1568|M.marinum_M -----------------------
MAB_4632|M.abscessus_ATCC_1997 -----------------------
MLBr_01740|M.leprae_Br4923 CVEPIKVGVYSQPRSGEGGKSGN