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MTAELENKVAIITGACGGIGLETSRVPACAGARVVLADLPETDLAGAAASVGRGAVHHVVDLTNEVSVRA LIDFTIDTFGRLDIVDNNAAHSDPADMLVSQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIVNI SSATAHAAYDMSTAYSCTKAAIETLTRYVATQYGRHGVRCNAIAPGLVRTPRLEVGLPQPIVDIFATHHL AGLIGEPHEIAELVCFLASDRAAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4844 | - | - | 100% (268) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_2885 | - | 1e-33 | 34.65% (254) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_3168 | - | 7e-32 | 36.44% (247) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 6e-34 | 35.97% (253) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_2001 | - | 2e-49 | 38.71% (248) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 6e-34 | 35.97% (253) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_02565 | fabG | 1e-18 | 29.11% (237) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 7e-33 | 36.40% (250) | Short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0271 | - | 1e-147 | 98.13% (268) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_4177 | - | 9e-39 | 39.20% (250) | putative short-chain type dehydrogenase/reductase y4lA |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 4e-36 | 35.02% (257) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3954 | - | 1e-34 | 40.89% (247) | PUTATIVE 3-oxoacyl-[acyl-carrier-protein] reductase |
| M. vanbaalenii PYR-1 | Mvan_2281 | - | 5e-34 | 33.20% (256) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2281|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2281|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2281|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
TH_3954|M.thermoresistible__bu --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4844|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0271|M.marinum_M --------------------------------------------------
MAV_4177|M.avium_104 --------------------------------------------------
MSMEG_2598|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2281|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2001|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 -------------------------------------------------M
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
TH_3954|M.thermoresistible__bu -----------------MPSAL----------------------------
Mb1976|M.bovis_AF2122/97 -----MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAA
Rv1941|M.tuberculosis_H37Rv -----MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADIDGDAA
MUL_4844|M.ulcerans_Agy99 ------MTAELENKVAIITGACGGIGLETSRVPACAGARVVLADLPETDL
MMAR_0271|M.marinum_M ------MTAELENKVAIITGACGGIGLETSRVLARAGARVVLADLPETDL
MAV_4177|M.avium_104 -----MGLRGLADKVAVVVGGATGIGAATAARLAGEGCRVVIGDVAVDAA
MSMEG_2598|M.smegmatis_MC2_155 ----MDLTQRLAGKVAVITGGASGIGLATGRRLRAEGATVVVGDIDPTTG
Mvan_2281|M.vanbaalenii_PYR-1 ----MDLGQRLKDKVAVITGGASGIGLATAKRMQAEGAIVVIGDVDASTG
Mflv_2001|M.gilvum_PYR-GCK -----MTGQRLASKRVVITGAASGIGRAAAQLMIGEGARVLIADLDADAA
MAB_0833|M.abscessus_ATCC_1997 NRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYACAGANVVVASRKPEAC
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
TH_3954|M.thermoresistible__bu ----------LAEKVAVVTGAGRGIGREIARVLHAHGAEVVLADLD--AD
* : .::.*. *** . *. *: .
Mb1976|M.bovis_AF2122/97 DAAATKIGCG---AAACRVDVSDEQQIIAMVDACVAAFG-GVDKLVANAG
Rv1941|M.tuberculosis_H37Rv DAAATKIGCG---AAACRVDVSDEQQIIAMVDACVAAFG-GVDKLVANAG
MUL_4844|M.ulcerans_Agy99 AGAAASVGRG---AVHHVVDLTNEVSVRALIDFTIDTFG-RLDIVDNNAA
MMAR_0271|M.marinum_M AGAAASVGRG---AVHHVVDLTNEVSVRALIDFTIDTFG-RLDIVDNNAA
MAV_4177|M.avium_104 RQTADRIGAAGGTATQVAFDLADPASVATLIDCAATTYG-GVDLLFNVGA
MSMEG_2598|M.smegmatis_MC2_155 KAAADEL--E---GLFVPVDVSEQEAVDNLFDTAASTFG-RVDIAFNNAG
Mvan_2281|M.vanbaalenii_PYR-1 KSVANDM--N---VTFVQVDVADQVAVDHLFDTAFEVHG-GVDIAFNNAG
Mflv_2001|M.gilvum_PYR-GCK AAAASDIGGN---AIGVAANVLDDKSVAAMIDRAVTEFG-GIDVLCNHVG
MAB_0833|M.abscessus_ATCC_1997 TEAVERLRSLGARALGVPTHTGDIHSLEELVRATAEEFG-GIDIVVNNAA
MLBr_02565|M.leprae_Br4923 ALDETANRVG---GTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAG
TH_3954|M.thermoresistible__bu AAAQAAAEVD---GTGVGCDVTAEDQMKRLVADTVAKHG-RLDLFVNNAG
. : : * * .
Mb1976|M.bovis_AF2122/97 VVHL----ASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIV
Rv1941|M.tuberculosis_H37Rv VVHL----ASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERGGGAIV
MUL_4844|M.ulcerans_Agy99 HSD--PADMLVSQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIV
MMAR_0271|M.marinum_M HSD--PADMLVTQMTVDVWDDTFTVNARGTMLMCKYAIPRLISAGGGAIV
MAV_4177|M.avium_104 DMSTIRADTDVVDIDFDVWDRVMTVSLRGYVAAMKYAIPRMLDRGGGAIV
MSMEG_2598|M.smegmatis_MC2_155 ISPP-EDDL-IENTDLPAWQRVQDINLKSVYLSCRAALRHMVPAGKGSII
Mvan_2281|M.vanbaalenii_PYR-1 ISPP-EDDL-IENTGVDAWDRVQDINLKSVFFCCKAALRHMVPAQKGSII
Mflv_2001|M.gilvum_PYR-GCK GSNP-HKDLDLLRLDLDEWDRAMALNARSTVVASRLALPHMIAEGGGSII
MAB_0833|M.abscessus_ATCC_1997 NALT----EPVGAFTVDGWDKSFGVNLRGPVFLVQAALPHLVASPHAAVL
MLBr_02565|M.leprae_Br4923 ITRD----KLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVI
TH_3954|M.thermoresistible__bu ITRD----ASLKRMTVADFDAVVTVHLRGTWLGVREATAVMREQKSGSIV
: :: : . . . ::
Mb1976|M.bovis_AF2122/97 NLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPAF
Rv1941|M.tuberculosis_H37Rv NLSSLAGQVA-VGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPAF
MUL_4844|M.ulcerans_Agy99 NISSATAHAA-YDMSTAYSCTKAAIETLTRYVATQYGRHGVRCNAIAPGL
MMAR_0271|M.marinum_M NISSATAHAA-YDMSTAYACTKAAIETLTRYVATQYGRHGVRCNAIAPGL
MAV_4177|M.avium_104 NMSSAAAFQG-EPARPAYATAKAGIGALTRHVASRWGKDNIRCNAVAPGF
MSMEG_2598|M.smegmatis_MC2_155 NTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIRVNALCPGP
Mvan_2281|M.vanbaalenii_PYR-1 NTASFVAVMGSATSQISYTASKGGVLAMSRELGVQYARQGIRVNALCPGP
Mflv_2001|M.gilvum_PYR-GCK NTVSVAGLTG-DTLQCAYGASKAAVIRLTQYIATQYGRKGVRCNAVAPGA
MAB_0833|M.abscessus_ATCC_1997 NVVSVGAFMF-GQGVSMYSAAKAALVSYTRSAAAELASRGVRVNALAPGA
MLBr_02565|M.leprae_Br4923 VLSSMAGIAG-NRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGF
TH_3954|M.thermoresistible__bu NISSLSGKSG-NPGQTNYSAAKAGIIGLTKAAAKEVAHHNVRVNAIQPGL
* . * :*..: :: . .: *:: *.
Mb1976|M.bovis_AF2122/97 VDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDD
Rv1941|M.tuberculosis_H37Rv VDTPMQQTAMAMFDGALGAGGARSMIARLQGRMAAPEEMAGIVVFLLSDD
MUL_4844|M.ulcerans_Agy99 VRTPRLEVGLP-----QPIVDIFATHHLAG-LIGEPHEIAELVCFLASDR
MMAR_0271|M.marinum_M VRTPRLEVGLP-----QPIVDIFATHHLAG-RIGEPHEIAELVCFLASDR
MAV_4177|M.avium_104 TATETIRSVPQ-----WPELEAAALKRIRGPRVGDPADVAALVAFLLSAE
MSMEG_2598|M.smegmatis_MC2_155 VNTPLLQELFAK----DPERAARRLVHIPLGRFAEPEELAAAVAFLASDD
Mvan_2281|M.vanbaalenii_PYR-1 VNTPLLQELFAK----DPERAARRLVHVPVGRFAEPEELAAAVAFLASDD
Mflv_2001|M.gilvum_PYR-GCK VMTPALADNVPA----AVIDNIR--SHNALDLIGSPEDIGWAMVYLASDE
MAB_0833|M.abscessus_ATCC_1997 IDTDMVRKTPP-------AEVERMANTNHLKRLGLPDEMVGTALLLTSDA
MLBr_02565|M.leprae_Br4923 IETQMTAAIPL-------ATREVGRRLNSLLQGGLPVDVAETIAYFAIPA
TH_3954|M.thermoresistible__bu IRTPMTETMPA-------EVFAEREAAVPMKRAGEPAEVAGAVVFLGSDL
* . * :: :
Mb1976|M.bovis_AF2122/97 ASMITGTTQIADGGTIAALW-----------------
Rv1941|M.tuberculosis_H37Rv ASMITGTTQIADGGTIAALW-----------------
MUL_4844|M.ulcerans_Agy99 AAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
MMAR_0271|M.marinum_M AAFITGQVIAADSGLLAHLPGLPQIRASVAELQSQPS
MAV_4177|M.avium_104 GDWINGQVINIDGGTVLR-------------------
MSMEG_2598|M.smegmatis_MC2_155 ASFITGSTFLVDGGISSAYVTPL--------------
Mvan_2281|M.vanbaalenii_PYR-1 ASFITASSFLVDGGISGHYVTPL--------------
Mflv_2001|M.gilvum_PYR-GCK SRYMTGQTLVLDGGLTAQSPIAASRRS----------
MAB_0833|M.abscessus_ATCC_1997 GSYITGQTIIADGGLVAR-------------------
MLBr_02565|M.leprae_Br4923 SNAVTGNVIRVCGQAMLGA------------------
TH_3954|M.thermoresistible__bu SSYITGSVIEVGGGRYM--------------------
. :.. .