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HYAIEGRSALIVGGSKGIGFEVAKMLAAEGCRVGVLARTKADVDAAVEAIRTEGGEAMGVCADVGDQDQL VDALHAVTTELGAPLIVVGQAKFQRPGDFADIDDLNVYRESFESHTMSQIFLLRAVLPAMQAAGWGRFVH IGSATAKEPAGNIHHAVANTSRPSTIGLLKTVADEYARYGITVNTVAPGWIETENSIAYLAKHLGTATEQ ARRDFMLGEARVPAARMGKPHEIASLVAYLCSDAAGYITGAWIEVDGGLHRSAF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1809 | - | - | 100% (265) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_2549 | - | e-125 | 81.51% (265) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_2438 | - | 9e-31 | 34.20% (269) | oxidoreductase, short chain dehydrogenase/reductase family |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 1e-25 | 32.05% (259) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1258 | - | 8e-33 | 35.02% (257) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1928c | - | 1e-25 | 32.05% (259) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-22 | 31.30% (262) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 3e-25 | 33.96% (268) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4715 | - | 5e-29 | 34.78% (253) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_1157 | - | 2e-30 | 33.58% (265) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2435 | - | 2e-29 | 35.16% (256) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 6e-28 | 34.13% (252) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_4593 | - | 2e-29 | 35.91% (259) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1963c|M.bovis_AF2122/97 ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Rv1928c|M.tuberculosis_H37Rv ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Mflv_1258|M.gilvum_PYR-GCK ------------------MVSRVAVVTGGASGLGEAICAGLAADGHRVAV
TH_2435|M.thermoresistible__bu -------------------------VTGGASGLGRAIAARLGDDGHRVAV
MMAR_4715|M.marinum_M ----------MK----------TAVVTGGASGIGLAIARRLRADGIDVAT
MUL_0315|M.ulcerans_Agy99 ----------MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0827|M.abscessus_ATCC_1997 --------------MTSPLKSRRAFVTGGSRGIGAGIVRRLAEDGARVVF
MAV_1809|M.avium_104 --------------MHYAIEGRSALIVGGSKGIGFEVAKMLAAEGCRVGV
MSMEG_1157|M.smegmatis_MC2_155 --------------MDLKIKDRVALVLASTAGLGAATARALAAEGAHVVI
Mvan_4593|M.vanbaalenii_PYR-1 -----------MSPNSTRLTGRTALVTGSTGGLGVTIAHALAADGAVVVV
: .. *:* * *
Mb1963c|M.bovis_AF2122/97 AARHLD-ALEKLADEIGTSGGKVVPVCCDVS--QHQQVTSMLDQVTAELG
Rv1928c|M.tuberculosis_H37Rv AARHLD-ALEKLADEIGTSGGKVVPVCCDVS--QHQQVTSMLDQVTAELG
Mflv_1258|M.gilvum_PYR-GCK LDLDAD-AANRVAASLRGNGASAVGVAVDVS--DEDAVVRAFDAVRTEFG
TH_2435|M.thermoresistible__bu LDIDHA-AAEQTAAELRAHGGDAVAVGADVA--DQDAVHDAFAAIRGSLG
MMAR_4715|M.marinum_M LDLKTP-DGE-------------LAFSADVT--NRSQVDAALTAIRQRLG
MUL_0315|M.ulcerans_Agy99 LDLKTP-DGG-------------LAFSADVT--NRSQVDAALAAIRQRLG
MLBr_01807|M.leprae_Br4923 THRASV-VPD-----------WFFGVECDVT--DNDAIGAAFKAVEEHQG
MAB_0827|M.abscessus_ATCC_1997 TYSSSVQQAADVVDDINEDGGWARAVKADVA--DPDQLGAAIGQAAEELG
MAV_1809|M.avium_104 LARTKA-DVDAAVEAIRTEGGEAMGVCADVG--DQDQLVDALHAVTTELG
MSMEG_1157|M.smegmatis_MC2_155 TGRNAE-RAERLAASLPS----ATAVPVDLT--EPRAVEHLLTATREAYG
Mvan_4593|M.vanbaalenii_PYR-1 TGRDVA-RGESVVAGIRADGASAHFVAADLGGADEQAIDGLAQRAAEAAS
. *: : : .
Mb1963c|M.bovis_AF2122/97 G-IDIAVCNAGIITVTPMLDMPLE-EFQRLQNTNVTGVFLTAQAAAKAMV
Rv1928c|M.tuberculosis_H37Rv G-IDIAVCNAGIITVTPMLDMPLE-EFQRLQNTNVTGVFLTAQAAAKAMV
Mflv_1258|M.gilvum_PYR-GCK P-VEILVTSAAIGGFTRFDKITLD-EWNRYLAVNLTGTFLSIRAALSDMV
TH_2435|M.thermoresistible__bu P-VHILVTSAAIAGFTRFDEITLD-EWNRYLAVNLTGTFLCVQAALTDMV
MMAR_4715|M.marinum_M P-VTILVNAAGLDGFKRFSNITFE-DWQRVIDVNLNGVFHTIQAVLPDMV
MUL_0315|M.ulcerans_Agy99 P-VTILVNAAGLDGFKRFSNITFE-DWQRVIDVNLNGVFHTIQAVLPDMV
MLBr_01807|M.leprae_Br4923 P-VEVLVANAGITSDMLIMRMSEE-QFQKVIDVNLTGVFRVAKLASRNMI
MAB_0827|M.abscessus_ATCC_1997 G-LDILVNNAGILSIGDVDTATLA-DFDEIVAVNVRAVFAGIKAASPHLT
MAV_1809|M.avium_104 A-PLIVVGQAKFQRPGDFADIDDLNVYRESFESHTMSQIFLLRAVLPAMQ
MSMEG_1157|M.smegmatis_MC2_155 E-PDIVVLNGPGPKPGAAADLDAEDIDTIG-DLLLKTHVRLVKAVLPHMR
Mvan_4593|M.vanbaalenii_PYR-1 AGIDILVNNAAKLLLPEPTATLSAGEVAEAFTVNVVAPMLLTGRLASAMA
: * . . :
Mb1963c|M.bovis_AF2122/97 KQGQGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHK
Rv1928c|M.tuberculosis_H37Rv KQGQGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHK
Mflv_1258|M.gilvum_PYR-GCK AAQWGRVVTISSAAG---QQGAPRQGHYSATKGGVIAMTKTVARDYARHG
TH_2435|M.thermoresistible__bu ADGWGRIVTISSAAG---QQGAHRQGHYAATKGGVIALTKTVALDYAAKG
MMAR_4715|M.marinum_M AAGWGRIVNISSSST---HSGTPYMTHYVAAKSAVNGLTKALALEYGPSG
MUL_0315|M.ulcerans_Agy99 AAGWGRIVNISSSST---HSGTPYMTHYVAAKSAVNGLTKALALEYGPSG
MLBr_01807|M.leprae_Br4923 KQRFGRYIFMGSVVG---LSGVPGQANYAASKSGLIGMARSLARELGSRS
MAB_0827|M.abscessus_ATCC_1997 EG--GRIVTIGSINGD--SSPTANLSLYSMTKAAVAGLTRGLAREFGPRG
MAV_1809|M.avium_104 AAGWGRFVHIGSATAKEPAGNI-HHAVANTSRPSTIGLLKTVADEYARYG
MSMEG_1157|M.smegmatis_MC2_155 AQGWGRILAIGSSGVQAPIP---MLAASNIGRAGLAAYLKTLASEVAADG
Mvan_4593|M.vanbaalenii_PYR-1 ARGSGSVVNIGSITGLRGTAG---SAVYDATKASVHSLTRSWAAEYGPSG
* : : : . : * : .
Mb1963c|M.bovis_AF2122/97 IRVNSVSPGYILTELVEP-----YT-------EYQPLWEPKIPLGRLGRP
Rv1928c|M.tuberculosis_H37Rv IRVNSVSPGYILTELVEP-----YT-------EYQPLWEPKIPLGRLGRP
Mflv_1258|M.gilvum_PYR-GCK ITANSLPPFAIETPMLRRQQSEGKL-------PPDEFLTQAIPAGRVGAP
TH_2435|M.thermoresistible__bu ITANTVPPFVIDSPMLREQQRRGTL-------PPAEYLTRAIPMGRLGVA
MMAR_4715|M.marinum_M ITVNAVPPGFIDTPMLRNAAAQGHL-------GDIEQNIARTPVRRIGKP
MUL_0315|M.ulcerans_Agy99 ITVNAVPPGFIDTPMLRNAAAQGHL-------GDIEQNIARTPVRRIGKP
MLBr_01807|M.leprae_Br4923 ITANVVAPGFIDTEMTRAMDSK-----------YQEAALQAIPLGRIGAV
MAB_0827|M.abscessus_ATCC_1997 ITINNVQPGPIGTDMNPEDG------------QLADILRPNIAVGRYGQP
MAV_1809|M.avium_104 ITVNTVAPGWIETENSIAYLAKHLGTATEQARRDFMLGEARVPAARMGKP
MSMEG_1157|M.smegmatis_MC2_155 VTVNLQLPGRIATDRVAALDEAAAQRQGRSPDEVRAASEASIPAGRYGTP
Mvan_4593|M.vanbaalenii_PYR-1 VRVNAVAPGPIATERAAEFAEHIAP------------ALARVPSRRMSTP
: * * * : . * .
Mb1963c|M.bovis_AF2122/97 EELAGLYLYLASEASSYMTGSDIVIDGGYTCP--
Rv1928c|M.tuberculosis_H37Rv EELAGLYLYLASEASSYMTGSDIVIDGGYTCP--
Mflv_1258|M.gilvum_PYR-GCK SDVAAVCSFLCSDAAGYVTGQVIGVNGGAVL---
TH_2435|M.thermoresistible__bu EDVAAVCSFLCSDAAGYLTGQVIGVNGGAIR---
MMAR_4715|M.marinum_M EDIAAACAFLVSEEAGYITGQILGVNGGRNT---
MUL_0315|M.ulcerans_Agy99 EDIAAACAFLVSEEAGYITGQILGVNGGRNT---
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-
MAB_0827|M.abscessus_ATCC_1997 RDIASLVSYLVSDEAWYITGTAINIDGGFTA---
MAV_1809|M.avium_104 HEIASLVAYLCSDAAGYITGAWIEVDGGLHRSAF
MSMEG_1157|M.smegmatis_MC2_155 DEFGALAAFLCSSAASYITGTAVRCDGGMLAHL-
Mvan_4593|M.vanbaalenii_PYR-1 QEVAAAVVFLASDDAANIQGAVLSVDGGWAAT--
:... :* *. : : * : :**