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M. bovis AF2122 / 97 Mb0172 (fadD5)

annotation: acyl-CoA synthetase
coordinates: 195185 - 196849
length: 554

LTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSG
RGVGFGDRVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTEAALAPVAIGV
RNIQPLLSVIVVAGGSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTG
QAMTALYTSGANINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFL
VPAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPVTCMLLGEDAI
AKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDLVRMDS
DGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGEVPIAVAAVTNDDLRIEDLG
EFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0172fadD5-100% (554)acyl-CoA synthetase
M. bovis AF2122 / 97Mb3116fadD133e-7336.14% (487) chain-fatty-acid-CoA ligase
M. bovis AF2122 / 97Mb2533cfadD351e-5934.36% (486) AMP-binding domain protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0714-0.070.95% (537) acyl-CoA synthetase
M. tuberculosis H37RvRv0166fadD50.099.64% (554) acyl-CoA synthetase
M. leprae Br4923MLBr_02661-1e-3929.38% (514) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4569c-0.073.24% (512) fatty-acid-CoA ligase FadD
M. marinum MMMAR_0409fadD50.082.45% (547) fatty-acid-CoA ligase FadD5
M. avium 104MAV_5018-0.082.83% (530) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_0131-0.072.37% (532) acyl-CoA synthetase
M. thermoresistible (build 8)TH_2878-0.073.73% (533) PUTATIVE AMP-binding enzyme, putative
M. ulcerans Agy99MUL_0650fadD82e-5432.05% (521) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_0131-0.074.38% (523) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0714|M.gilvum_PYR-GCK          MTRTTSCLIKCHTSANPSTMERKTLTDPTGLSGSATEQPNLARRRNWANQ
Mvan_0131|M.vanbaalenii_PYR-1       -------MFDQISSFRNPSMEQKTLTEAIQQPGFATEQPYLARRQNWTNQ
MSMEG_0131|M.smegmatis_MC2_155      ----------------------------MTAEPSQIEQPYLARRQNWVNQ
TH_2878|M.thermoresistible__bu      -----------------------------------LQQPYLARRQNWVNH
Mb0172|M.bovis_AF2122/97            -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
Rv0166|M.tuberculosis_H37Rv         -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
MMAR_0409|M.marinum_M               -------------------MTAELASHLPQAA-HALEQPYLARRQNWVNQ
MAV_5018|M.avium_104                --------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVNQ
MAB_4569c|M.abscessus_ATCC_199      -------------------MTDTIDATVQSAG---LAQPYRARRQNWCNQ
MUL_0650|M.ulcerans_Agy99           ------------------------------------MSDDLLRNPTHNGH
MLBr_02661|M.leprae_Br4923          ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL
                                                                              .  .  . 

Mflv_0714|M.gilvum_PYR-GCK          LSRHALMQPDTVALRFLG--RSTTWGELDRRVTALAGALHERGVGFGDRV
Mvan_0131|M.vanbaalenii_PYR-1       LARHALMQPDQPALRFLG--NTTTWGELDRRVSALAGALHKRGVGFGDRV
MSMEG_0131|M.smegmatis_MC2_155      LTRHAMMQPDKTALRFLG--RTTTWRELDDRVTRLAGALNRRGVGFGDRV
TH_2878|M.thermoresistible__bu      LARHALMQPDATALRFMG--QTTTWADLHHRVNRLAGALRRRGVEFGDRV
Mb0172|M.bovis_AF2122/97            LERHAMMQPDAPALRFVG--NTMTWADLRRRVAALAGALSGRGVGFGDRV
Rv0166|M.tuberculosis_H37Rv         LERHAMMQPDAPALRFVG--NTMTWADLRRRVAALAGALSGRGVGFGDRV
MMAR_0409|M.marinum_M               LERHAMMQPRATAIRYLG--HTVTWADLRYRVAALAGSLSRRGVGFGDRV
MAV_5018|M.avium_104                LERHALMQPNATALRFLG--KGLTWGELHGRVRALADALSRRGVGFGDRV
MAB_4569c|M.abscessus_ATCC_199      LARHALMQPDATAIRYLG--HSISWAELHQRVQALADALSRRGVGFGDRV
MUL_0650|M.ulcerans_Agy99           LLVGALERHKNRPVLFLGD-TTLTGGQLAERISQYIQAFEALGAGTGVTV
MLBr_02661|M.leprae_Br4923          VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV
                                    :   *: .    .:   .     :  :*   :      :   *   *  *

Mflv_0714|M.gilvum_PYR-GCK          LILMLNRTEFMESVLAVNKLGGIAVPVNFRMTPSEIAFLVSDCAAEVVIT
Mvan_0131|M.vanbaalenii_PYR-1       LILMLNRTEFIEAVLATNKLGAIAVPVNFRMTPAEIAFLVSDCEAKAIIT
MSMEG_0131|M.smegmatis_MC2_155      LILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLVSDCEAHVVVT
TH_2878|M.thermoresistible__bu      LILMLNRTEFIETMLAANRLGAIAVPVNFRMTPPEIAFLAKDCEAKVIAT
Mb0172|M.bovis_AF2122/97            MILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLT
Rv0166|M.tuberculosis_H37Rv         MILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLT
MMAR_0409|M.marinum_M               MILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVIT
MAV_5018|M.avium_104                MVLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVIT
MAB_4569c|M.abscessus_ATCC_199      LILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAIT
MUL_0650|M.ulcerans_Agy99           GLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALII
MLBr_02661|M.leprae_Br4923          ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV
                                     :   .. * :    * .  *    .:.   .  : .     .       

Mflv_0714|M.gilvum_PYR-GCK          ES--VLENVATAVRDIDPKLATVIVAG---GTSRDNVLDYDDVLASTT-A
Mvan_0131|M.vanbaalenii_PYR-1       EA--VLANVATAVRDIDPTLATVISAG---GSG-DDVLDYDDVLAENA-P
MSMEG_0131|M.smegmatis_MC2_155      EP--VLAGVATAVRDLDATLQTVIVAGGATEDG---VLGYDDLIAEEG-E
TH_2878|M.thermoresistible__bu      EP--VLAGVATAVRDLAPSLSSVIVAGAADGSDTPDVLDYEALIAEPG-E
Mb0172|M.bovis_AF2122/97            EA--ALAPVAIGVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAG-D
Rv0166|M.tuberculosis_H37Rv         EA--ALAPVAIGVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAG-D
MMAR_0409|M.marinum_M               EE--VLAQVAVGVREIAPALSTIVVAG---GASDPTVVGYDELISETG-D
MAV_5018|M.avium_104                EA--VLAPVATGVRDIESLLDTVVVAG---GSSDDAVLGYDDLIDETG-A
MAB_4569c|M.abscessus_ATCC_199      ET--VLAPVAAAVRQQAPALETVIVAG---SASENGVLGYEEVIAEPG-E
MUL_0650|M.ulcerans_Agy99           DPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPK
MLBr_02661|M.leprae_Br4923          DS-LALEGVSDQRAATMRYWPIAVSYGSVTGASEGSLLVHLDDTAALHPV
                                    :    :   :             :  *          .            

Mflv_0714|M.gilvum_PYR-GCK          APPLVDIPDDSPALIMYTSGTTGRPKGAVLTHNNLAGQAMTLLFTNGADI
Mvan_0131|M.vanbaalenii_PYR-1       CP-VVDIPNDAPALIMYTSGTTGRPKGAVLTHTNLTGQVMTLLFTNGADI
MSMEG_0131|M.smegmatis_MC2_155      PPAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMMHLFTTGADL
TH_2878|M.thermoresistible__bu      DPPPVDIPDDSPALIMYTSGTTGNPKGAVLTHSNLTGQAMTNLFTIGVDL
Mb0172|M.bovis_AF2122/97            VHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANI
Rv0166|M.tuberculosis_H37Rv         VHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANI
MMAR_0409|M.marinum_M               PPEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANI
MAV_5018|M.avium_104                AHQPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADI
MAB_4569c|M.abscessus_ATCC_199      PHAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDL
MUL_0650|M.ulcerans_Agy99           PLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNIT--AMTSIQLAEWEW
MLBr_02661|M.leprae_Br4923          TSTPDGLRHDD-AMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLGP
                                         .:  :  . : :*.**** ** .  *  *::  .   :       

Mflv_0714|M.gilvum_PYR-GCK          NHDIGFIGVPFFHIAGVG-SIVSGMMLGRPTVIYPLGAFDPNELLDVLEA
Mvan_0131|M.vanbaalenii_PYR-1       NHDIGFIGVPFFHIAGVG-SSVSGLLLGRPTVLYPVGAFDPNELLDVLEA
MSMEG_0131|M.smegmatis_MC2_155      NSDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFDPDGLLDVLES
TH_2878|M.thermoresistible__bu      ANDVGFIGVPLFHIAGIAGNVLSGLTLGLPTVLYPLGAFDPGGLLDVLEA
Mb0172|M.bovis_AF2122/97            NSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEA
Rv0166|M.tuberculosis_H37Rv         NSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEA
MMAR_0409|M.marinum_M               NSDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEA
MAV_5018|M.avium_104                NNDVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAA
MAB_4569c|M.abscessus_ATCC_199      NSDVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLES
MUL_0650|M.ulcerans_Agy99           PEHPRFLMCTPLSHAGAAFFTPTLVKGGE---MIVLAKFDPGEVLRVIEE
MLBr_02661|M.leprae_Br4923          -QDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDA
                                      .  .:  .     *      : :  *    :   . *..  .   :  

Mflv_0714|M.gilvum_PYR-GCK          EKVTGIFLVPAQWQAVCAAQKANPRNLK---LRFLSWGAAPASDTLLRQM
Mvan_0131|M.vanbaalenii_PYR-1       EKVTGIFLVPAQWQAVCAAQKARPRDLK---LRFLSWGAAPASDTLLREM
MSMEG_0131|M.smegmatis_MC2_155      EQVTGIFLVPAQWQAVCAAQRARPRNLK---LRALSWGAAPASDTLLREM
TH_2878|M.thermoresistible__bu      EKVTGIFLVPAQWQAVCAEQRARPRDLR---LRALSWGAAPASDTLLQEM
Mb0172|M.bovis_AF2122/97            EKVTGIFLVPAQWQAVCTEQQARPRDLR---LRVLSWGAAPAPDALLRQM
Rv0166|M.tuberculosis_H37Rv         EKVTGIFLVPAQWQAVCTEQQARPRDLR---LRVLSWGAAPAPDALLRQM
MMAR_0409|M.marinum_M               ERVSGIFLVPAQWQAVCAEQQARPRELS---LRVMSWGAAPAPDALLRQM
MAV_5018|M.avium_104                EKVTGIFLVPAQWQAVCAEQRARPRDLK---LRVISWGAAPAPDALLREM
MAB_4569c|M.abscessus_ATCC_199      EGVTGIFLVPAQWQAVCAAQQANPRKVR---LKTLSWGAAPATDVLLRTM
MUL_0650|M.ulcerans_Agy99           QRITATMLVPSMLYALMDHPDPHTRDLSS--LETVYYGASAINPVRLAEA
MLBr_02661|M.leprae_Br4923          VAATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETAQAL
                                       :    .*:    :     ...       *. :   ::.         

Mflv_0714|M.gilvum_PYR-GCK          SETFPGAQILAA-----FGQTEMSPVTCMLLGDDALRKLGSVGKVIPTVS
Mvan_0131|M.vanbaalenii_PYR-1       AETFPGAQILAA-----FGQTEMSPVTCMLLGDDAIRKLGSVGKVIPTVS
MSMEG_0131|M.smegmatis_MC2_155      NEVFPDAQIFAA-----FGQTEMSPVTCMLLGDDAIRKLGSVGRVIPTVS
TH_2878|M.thermoresistible__bu      TEVFPGTKIFAA-----FGQTEMSPVTCMLLAEDAVRKLGSVGKVIPTVA
Mb0172|M.bovis_AF2122/97            SATFPETQILAA-----FGQTEMSPVTCMLLGEDAIAKRGSVGRVIPTVA
Rv0166|M.tuberculosis_H37Rv         SATFPETQILAA-----FGQTEMSPVTCMLLGEDAIAKRGSVGRVIPTVA
MMAR_0409|M.marinum_M               SEVFPGTQIMAA-----FGQTEMSPVTCMLLGEDAIRKRGSVGKVIPTVS
MAV_5018|M.avium_104                SAMFPGTQILAA-----FGQTEMSPVTCMLLGEDAIRKRGSVGKVIPTVA
MAB_4569c|M.abscessus_ATCC_199      SETFPDARILAA-----FGQTEMSPVTCMLMGDDAIRKMGSVGRVIPTVS
MUL_0650|M.ulcerans_Agy99           IDRFGPIFAQYY-----GQSEAPMVITYLPKADHDEKRLTSCGRPTLFAR
MLBr_02661|M.leprae_Br4923          REEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTG-VQ
                                       *               .     :. :  .:.        *:    . 

Mflv_0714|M.gilvum_PYR-GCK          ARIVDEDMNDVPIGQVGEIVYRAPTLMTGYWNNPTATAEAFAGGWFHSGD
Mvan_0131|M.vanbaalenii_PYR-1       ARIVDEDMNDVPVGQVGEIVYRAPTLMAGYWNNPKATAEAFAGGWFHSGD
MSMEG_0131|M.smegmatis_MC2_155      ARVVDDNMNDVPVGEVGEIVYRGPNLMVGYWNNPKATAEAFAGGWFHSGD
TH_2878|M.thermoresistible__bu      ARIVDDTMNDVPVGEVGEIVYRAPTLMAGYWNNPQATAEAFAGGWFHSGD
Mb0172|M.bovis_AF2122/97            ARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGD
Rv0166|M.tuberculosis_H37Rv         ARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGD
MMAR_0409|M.marinum_M               ARVVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGGWFHSGD
MAV_5018|M.avium_104                ARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGWFHSGD
MAB_4569c|M.abscessus_ATCC_199      ARVVDDNMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGGWFHSGD
MUL_0650|M.ulcerans_Agy99           VALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGD
MLBr_02661|M.leprae_Br4923          IRIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTHGWLRTGD
                                      ::..  : :* .  **:   .. :   * ..*  **  *  **:::**

Mflv_0714|M.gilvum_PYR-GCK          LVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGR
Mvan_0131|M.vanbaalenii_PYR-1       LVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPEIVEVAVIGR
MSMEG_0131|M.smegmatis_MC2_155      LVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLAAHPAIMEVAVIGR
TH_2878|M.thermoresistible__bu      LVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPAVAEVAVVGR
Mb0172|M.bovis_AF2122/97            LVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGR
Rv0166|M.tuberculosis_H37Rv         LVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGR
MMAR_0409|M.marinum_M               LVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGR
MAV_5018|M.avium_104                LVRMDEDGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGR
MAB_4569c|M.abscessus_ATCC_199      LVRQDEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGR
MUL_0650|M.ulcerans_Agy99           MAREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGA
MLBr_02661|M.leprae_Br4923          LGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGD
                                    :   .  *   : .* *::*  .* ::   .:*..:* *  : :*.*.* 

Mflv_0714|M.gilvum_PYR-GCK          SHRKWGEVPVAVAVLRSSLN-STGSGRLELTDLEQFLGDRLARYKHPKAI
Mvan_0131|M.vanbaalenii_PYR-1       AHEKWGEVPVAVAVVRSSLE-ATPGAGIELADLEQFLTERLARYKHPKAL
MSMEG_0131|M.smegmatis_MC2_155      PHEKWGEVPVAVVALNS-----ATAESISLGELDSFLTERLARYKHPKAL
TH_2878|M.thermoresistible__bu      PHEKWGEVPVAVVALN-------PDAELTMAELEEFLADRLARYKHPKVL
Mb0172|M.bovis_AF2122/97            ADEKWGEVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKAL
Rv0166|M.tuberculosis_H37Rv         ADEKWGEVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKAL
MMAR_0409|M.marinum_M               ADEKWGEVPIAVAAVTK--------DHLRIEDLDEYLTERLARYKHPKAL
MAV_5018|M.avium_104                AHEKWGEVPIAVAAVAN--------DNLALEDLDEFLTERLARYKHPKAL
MAB_4569c|M.abscessus_ATCC_199      PHEKWGEVPVAVAAIHG--------AALTLAELDGFLTARLARYKHPKDL
MUL_0650|M.ulcerans_Agy99           PDEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQV
MLBr_02661|M.leprae_Br4923          PDKVYGETVTAVIVPRE-------VIAPTPSELAVFCRDRLAAFEVPTRF
                                    ... :**.  ** .                 ::      * .  : *. .

Mflv_0714|M.gilvum_PYR-GCK          EIVEALPRNPAGKVLKTELRVRFGSEESVDAGESATAATSSAAAPKD-
Mvan_0131|M.vanbaalenii_PYR-1       EIVDALPRNPAGKVLKTELRIRYSAASFADAGESSTPPTISTAPQRN-
MSMEG_0131|M.smegmatis_MC2_155      EVVDALPRNPSGKVLKTELRERFGRATSLDGGESNSATTVSAG-----
TH_2878|M.thermoresistible__bu      EIVDALPRNPAGKVLKTELRARFAAGPSAEKEQSSSGATTSAGSS---
Mb0172|M.bovis_AF2122/97            EIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv         EIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M               EIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104                EIVDALPRNPAGKVLKTELRIRYGGG----------------------
MAB_4569c|M.abscessus_ATCC_199      VIVDALPRNPSGKVLKTELRQRFGIAD---------------------
MUL_0650|M.ulcerans_Agy99           VVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG----------------
MLBr_02661|M.leprae_Br4923          QEASALPHTAKGSLDRRAVAEQFAHRG---------------------
                                      ..:** .  *.  :  :  ::