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LTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSG RGVGFGDRVMILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTEAALAPVAIGV RNIQPLLSVIVVAGGSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTG QAMTALYTSGANINSDVGFVGVPLFHIAGIGNMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFL VPAQWQAVCTEQQARPRDLRLRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSPVTCMLLGEDAI AKRGSVGRVIPTVAARVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDLVRMDS DGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGEVPIAVAAVTNDDLRIEDLG EFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | - | 100% (554) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 3e-73 | 36.34% (487) | chain-fatty-acid-CoA ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 5e-60 | 34.98% (486) | AMP-binding domain protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 0.0 | 99.64% (554) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0714 | - | 0.0 | 70.95% (537) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-39 | 27.78% (504) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 0.0 | 73.44% (512) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0409 | fadD5 | 0.0 | 82.45% (547) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_5018 | - | 0.0 | 83.02% (530) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0131 | - | 0.0 | 72.56% (532) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2878 | - | 0.0 | 73.92% (533) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_0229 | fadD14 | 1e-54 | 31.40% (500) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | 0.0 | 74.57% (523) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0166|M.tuberculosis_H37Rv --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
Mb0172|M.bovis_AF2122/97 --------------------MTAQLASHLTRALTLAQQQPYLARRQNWVN
MMAR_0409|M.marinum_M --------------------MTAELASHLPQAA-HALEQPYLARRQNWVN
MAV_5018|M.avium_104 ---------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVN
Mflv_0714|M.gilvum_PYR-GCK -MTRTTSCLIKCHTSANPSTMERKTLTDPTGLSGSATEQPNLARRRNWAN
Mvan_0131|M.vanbaalenii_PYR-1 --------MFDQISSFRNPSMEQKTLTEAIQQPGFATEQPYLARRQNWTN
MSMEG_0131|M.smegmatis_MC2_155 -----------------------------MTAEPSQIEQPYLARRQNWVN
TH_2878|M.thermoresistible__bu ------------------------------------LQQPYLARRQNWVN
MAB_4569c|M.abscessus_ATCC_199 -----------------------MTDTIDATVQSAGLAQPYRARRQNWCN
MUL_0229|M.ulcerans_Agy99 ---------------------------------MYSTMQDFPLTITAIMR
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
Rv0166|M.tuberculosis_H37Rv QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
Mb0172|M.bovis_AF2122/97 QLERHAMMQPDAPALRFVGNTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M QLERHAMMQPRATAIRYLGHTVTWADLRYRVAALAGSLSRRGVGFGDRVM
MAV_5018|M.avium_104 QLERHALMQPNATALRFLGKGLTWGELHGRVRALADALSRRGVGFGDRVM
Mflv_0714|M.gilvum_PYR-GCK QLSRHALMQPDTVALRFLGRSTTWGELDRRVTALAGALHERGVGFGDRVL
Mvan_0131|M.vanbaalenii_PYR-1 QLARHALMQPDQPALRFLGNTTTWGELDRRVSALAGALHKRGVGFGDRVL
MSMEG_0131|M.smegmatis_MC2_155 QLTRHAMMQPDKTALRFLGRTTTWRELDDRVTRLAGALNRRGVGFGDRVL
TH_2878|M.thermoresistible__bu HLARHALMQPDATALRFMGQTTTWADLHHRVNRLAGALRRRGVEFGDRVL
MAB_4569c|M.abscessus_ATCC_199 QLARHALMQPDATAIRYLGHSISWAELHQRVQALADALSRRGVGFGDRVL
MUL_0229|M.ulcerans_Agy99 HGCGVHGSRQVITATGDAYRQTTYREVGQRAAQLANALRGLGISGDQRVA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
* :: :: . **..* *: .: :
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
MAV_5018|M.avium_104 VLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVITE
Mflv_0714|M.gilvum_PYR-GCK ILMLNRTEFMESVLAVNKLGGIAVPVNFRMTPSEIAFLVSDCAAEVVITE
Mvan_0131|M.vanbaalenii_PYR-1 ILMLNRTEFIEAVLATNKLGAIAVPVNFRMTPAEIAFLVSDCEAKAIITE
MSMEG_0131|M.smegmatis_MC2_155 ILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLVSDCEAHVVVTE
TH_2878|M.thermoresistible__bu ILMLNRTEFIETMLAANRLGAIAVPVNFRMTPPEIAFLAKDCEAKVIATE
MAB_4569c|M.abscessus_ATCC_199 ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MUL_0229|M.ulcerans_Agy99 TFMWNNAEHLVTYLAVPSMGAVLHTLNIRLFAEQIAYVANEAEDQVVLVD
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: *. .: : . :*. :* .: :: : . . :
Rv0166|M.tuberculosis_H37Rv AALAPVAIGVRNIQPLLSVIVVAG-------GSSQDSVFGYEDLLNEAGD
Mb0172|M.bovis_AF2122/97 AALAPVAIGVRNIQPLLSVIVVAG-------GSSQDSVFGYEDLLNEAGD
MMAR_0409|M.marinum_M EVLAQVAVGVREIAPALSTIVVAG-------GASDPTVVGYDELISETGD
MAV_5018|M.avium_104 AVLAPVATGVRDIESLLDTVVVAG-------GSSDDAVLGYDDLIDETGA
Mflv_0714|M.gilvum_PYR-GCK SVLENVATAVRDIDPKLATVIVAG-------GTSRDNVLDYDDVLASTTA
Mvan_0131|M.vanbaalenii_PYR-1 AVLANVATAVRDIDPTLATVISAG-------GSG-DDVLDYDDVLAENAP
MSMEG_0131|M.smegmatis_MC2_155 PVLAGVATAVRDLDATLQTVIVAGG----ATEDG---VLGYDDLIAEEGE
TH_2878|M.thermoresistible__bu PVLAGVATAVRDLAPSLSSVIVAGA----ADGSDTPDVLDYEALIAEPGE
MAB_4569c|M.abscessus_ATCC_199 TVLAPVAAAVRQQAPALETVIVAG-------SASENGVLGYEEVIAEPGE
MUL_0229|M.ulcerans_Agy99 LSLTNLLAPVLPNLDTVHTVIAVGEGDTAALEESGKTVLRYDELLDGQST
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPD----EEEPPGSTDETLAELIARSSS
: . : : ::
Rv0166|M.tuberculosis_H37Rv VHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANI
Mb0172|M.bovis_AF2122/97 VHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANI
MMAR_0409|M.marinum_M PPEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANI
MAV_5018|M.avium_104 AHQPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADI
Mflv_0714|M.gilvum_PYR-GCK APPLVDIPDDSPALIMYTSGTTGRPKGAVLTHNNLAGQAMTLLFTNGADI
Mvan_0131|M.vanbaalenii_PYR-1 CP-VVDIPNDAPALIMYTSGTTGRPKGAVLTHTNLTGQVMTLLFTNGADI
MSMEG_0131|M.smegmatis_MC2_155 PPAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMMHLFTTGADL
TH_2878|M.thermoresistible__bu DPPPVDIPDDSPALIMYTSGTTGNPKGAVLTHSNLTGQAMTNLFTIGVDL
MAB_4569c|M.abscessus_ATCC_199 PHAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDL
MUL_0229|M.ulcerans_Agy99 EFDWPHIDENSAAAMCYTSGTTGHPKGVVYSHRSSFLHSMATCTANGIGL
MLBr_02546|M.leprae_Br4923 APAPKVR--KRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRA
. .: : *:**** ***. .
Rv0166|M.tuberculosis_H37Rv N-SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLE
Mb0172|M.bovis_AF2122/97 N-SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLE
MMAR_0409|M.marinum_M N-SDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLE
MAV_5018|M.avium_104 N-NDVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLA
Mflv_0714|M.gilvum_PYR-GCK N-HDIGFIGVPFFHIAGVG-SIVSGMMLGRPTVIYPLGAFDPNELLDVLE
Mvan_0131|M.vanbaalenii_PYR-1 N-HDIGFIGVPFFHIAGVG-SSVSGLLLGRPTVLYPVGAFDPNELLDVLE
MSMEG_0131|M.smegmatis_MC2_155 N-SDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFDPDGLLDVLE
TH_2878|M.thermoresistible__bu A-NDVGFIGVPLFHIAGIAGNVLSGLTLGLPTVLYPLGAFDPGGLLDVLE
MAB_4569c|M.abscessus_ATCC_199 N-SDVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLE
MUL_0229|M.ulcerans_Agy99 GSSDRVLPIVPMFHANAWG--LPYAALMAGADLVLPDRHLDARSLVHMVE
MLBr_02546|M.leprae_Br4923 H--EVTLLPAPMFHALGYL-HATLAMFLGSTLVLR--RRFKPATVLEDIE
: : .*:** . . :. . :: :.. ::. :
Rv0166|M.tuberculosis_H37Rv AEKVTGIFLVPAQWQAVCTEQQARP--RDLRLRVLSWGAAPAPDALLRQM
Mb0172|M.bovis_AF2122/97 AEKVTGIFLVPAQWQAVCTEQQARP--RDLRLRVLSWGAAPAPDALLRQM
MMAR_0409|M.marinum_M AERVSGIFLVPAQWQAVCAEQQARP--RELSLRVMSWGAAPAPDALLRQM
MAV_5018|M.avium_104 AEKVTGIFLVPAQWQAVCAEQRARP--RDLKLRVISWGAAPAPDALLREM
Mflv_0714|M.gilvum_PYR-GCK AEKVTGIFLVPAQWQAVCAAQKANP--RNLKLRFLSWGAAPASDTLLRQM
Mvan_0131|M.vanbaalenii_PYR-1 AEKVTGIFLVPAQWQAVCAAQKARP--RDLKLRFLSWGAAPASDTLLREM
MSMEG_0131|M.smegmatis_MC2_155 SEQVTGIFLVPAQWQAVCAAQRARP--RNLKLRALSWGAAPASDTLLREM
TH_2878|M.thermoresistible__bu AEKVTGIFLVPAQWQAVCAEQRARP--RDLRLRALSWGAAPASDTLLQEM
MAB_4569c|M.abscessus_ATCC_199 SEGVTGIFLVPAQWQAVCAAQQANP--RKVRLKTLSWGAAPATDVLLRTM
MUL_0229|M.ulcerans_Agy99 NLRPTRAGAVPTIWNDVMHYLEKNPGHDVSSLGLVACGGSAVPESLMRTF
MLBr_02546|M.leprae_Br4923 KHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATR
: **. . : . : ... :
Rv0166|M.tuberculosis_H37Rv SATFPETQILAAFGQTEMSPVTCMLLG------EDAIAKRGSVGRVIPTV
Mb0172|M.bovis_AF2122/97 SATFPETQILAAFGQTEMSPVTCMLLG------EDAIAKRGSVGRVIPTV
MMAR_0409|M.marinum_M SEVFPGTQIMAAFGQTEMSPVTCMLLG------EDAIRKRGSVGKVIPTV
MAV_5018|M.avium_104 SAMFPGTQILAAFGQTEMSPVTCMLLG------EDAIRKRGSVGKVIPTV
Mflv_0714|M.gilvum_PYR-GCK SETFPGAQILAAFGQTEMSPVTCMLLG------DDALRKLGSVGKVIPTV
Mvan_0131|M.vanbaalenii_PYR-1 AETFPGAQILAAFGQTEMSPVTCMLLG------DDAIRKLGSVGKVIPTV
MSMEG_0131|M.smegmatis_MC2_155 NEVFPDAQIFAAFGQTEMSPVTCMLLG------DDAIRKLGSVGRVIPTV
TH_2878|M.thermoresistible__bu TEVFPGTKIFAAFGQTEMSPVTCMLLA------EDAVRKLGSVGKVIPTV
MAB_4569c|M.abscessus_ATCC_199 SETFPDARILAAFGQTEMSPVTCMLMG------DDAIRKMGSVGRVIPTV
MUL_0229|M.ulcerans_Agy99 EEKY-GVQIRQLWGMTETSPLATMAWPPPGTPPDRHWAIRSTQGQPVCGV
MLBr_02546|M.leprae_Br4923 ALEELGPVIYNMYGSTEIAFATIAGPK-------DLQINSATVGPVVKGV
* :* ** : : .: * : *
Rv0166|M.tuberculosis_H37Rv AARVVDQNMNDVPVG--EVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFH
Mb0172|M.bovis_AF2122/97 AARVVDQNMNDVPVG--EVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFH
MMAR_0409|M.marinum_M SARVVDDEMNDVPIG--QVGEIVYRAPTLMSGYWNNPDATAEAFAGGWFH
MAV_5018|M.avium_104 AARVVDENMNDVPVG--EVGEIVYRAPTLMSGYWNNPEATAEAFAGGWFH
Mflv_0714|M.gilvum_PYR-GCK SARIVDEDMNDVPIG--QVGEIVYRAPTLMTGYWNNPTATAEAFAGGWFH
Mvan_0131|M.vanbaalenii_PYR-1 SARIVDEDMNDVPVG--QVGEIVYRAPTLMAGYWNNPKATAEAFAGGWFH
MSMEG_0131|M.smegmatis_MC2_155 SARVVDDNMNDVPVG--EVGEIVYRGPNLMVGYWNNPKATAEAFAGGWFH
TH_2878|M.thermoresistible__bu AARIVDDTMNDVPVG--EVGEIVYRAPTLMAGYWNNPQATAEAFAGGWFH
MAB_4569c|M.abscessus_ATCC_199 SARVVDDNMNDVPVG--EVGEIVYRAPTLMQGYWNNPEATADAFAGGWFH
MUL_0229|M.ulcerans_Agy99 ETRIVDDNGEALPNDGQAVGEVEVRGPWITGAYYLG--YDQSEFDSGWLR
MLBr_02546|M.leprae_Br4923 KVKILDDSGKEVPRG--QVGRIFVGNAFPFEGYTGG---GGKQIIDGLLS
.:::*: : :* . **.: . * . . : .* :
Rv0166|M.tuberculosis_H37Rv SGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAV
Mb0172|M.bovis_AF2122/97 SGDLVRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAV
MMAR_0409|M.marinum_M SGDLVRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAV
MAV_5018|M.avium_104 SGDLVRMDEDGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAV
Mflv_0714|M.gilvum_PYR-GCK SGDLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAV
Mvan_0131|M.vanbaalenii_PYR-1 SGDLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPEIVEVAV
MSMEG_0131|M.smegmatis_MC2_155 SGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLAAHPAIMEVAV
TH_2878|M.thermoresistible__bu SGDLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPAVAEVAV
MAB_4569c|M.abscessus_ATCC_199 SGDLVRQDEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAV
MUL_0229|M.ulcerans_Agy99 TGDVGRIDELGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVVEAAV
MLBr_02546|M.leprae_Br4923 SGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATA
:**: *. . : : .* .::* **** : .*:*: : * : *.:.
Rv0166|M.tuberculosis_H37Rv IGRADEKWGEVPIAVAAVTN-------DDLRIEDLGEFLTDRLARYKHPK
Mb0172|M.bovis_AF2122/97 IGRADEKWGEVPIAVAAVTN-------DDLRIEDLGEFLTDRLARYKHPK
MMAR_0409|M.marinum_M IGRADEKWGEVPIAVAAVTK-------DHLRIEDLDEYLTERLARYKHPK
MAV_5018|M.avium_104 IGRAHEKWGEVPIAVAAVAN-------DNLALEDLDEFLTERLARYKHPK
Mflv_0714|M.gilvum_PYR-GCK IGRSHRKWGEVPVAVAVLRSSLNSTGSGRLELTDLEQFLGDRLARYKHPK
Mvan_0131|M.vanbaalenii_PYR-1 IGRAHEKWGEVPVAVAVVRSSLEATPGAGIELADLEQFLTERLARYKHPK
MSMEG_0131|M.smegmatis_MC2_155 IGRPHEKWGEVPVAVVALNS----ATAESISLGELDSFLTERLARYKHPK
TH_2878|M.thermoresistible__bu VGRPHEKWGEVPVAVVALN------PDAELTMAELEEFLADRLARYKHPK
MAB_4569c|M.abscessus_ATCC_199 IGRPHEKWGEVPVAVAAIHG-------AALTLAELDGFLTARLARYKHPK
MUL_0229|M.ulcerans_Agy99 VGVPDERWQERPLAVVVRRE------GATVSAAELRKFLADRVVRWWLPE
MLBr_02546|M.leprae_Br4923 IGVDDKEWGARLRAFVVKKQ------DATIDEDAIKAYVRDHLARYKVPR
:* ...* *... : : :: ::.*: *.
Rv0166|M.tuberculosis_H37Rv ALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Mb0172|M.bovis_AF2122/97 ALEIVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M ALEIVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104 ALEIVDALPRNPAGKVLKTELRIRYGGG----------------------
Mflv_0714|M.gilvum_PYR-GCK AIEIVEALPRNPAGKVLKTELRVRFGSEESVDAGESATAATSSAAAPKD-
Mvan_0131|M.vanbaalenii_PYR-1 ALEIVDALPRNPAGKVLKTELRIRYSAASFADAGESSTPPTISTAPQRN-
MSMEG_0131|M.smegmatis_MC2_155 ALEVVDALPRNPSGKVLKTELRERFGRATSLDGGESNSATTVSAG-----
TH_2878|M.thermoresistible__bu VLEIVDALPRNPAGKVLKTELRARFAAGPSAEKEQSSSGATTSAGSS---
MAB_4569c|M.abscessus_ATCC_199 DLVIVDALPRNPSGKVLKTELRQRFGIAD---------------------
MUL_0229|M.ulcerans_Agy99 RWAFADQVPRTSVGKYDKKTIRAGYAESVYQVTDVHN-------------
MLBr_02546|M.leprae_Br4923 EVIFLEELPRNPTGKVLKRELRDFEVH-----------------------
. : :**.. ** * :*