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MRQLPSGRWQASYLHNGVVFKALATFPTKSSAGHWLQAEEDLIDLDRRRPGEWTPPAERAARRQAEKLTL RTYAKTWLDNKTKLARRTRDNYQGHLDNHVLPALGDLGLADITPEHVRTWFAGLGNEHETRNAQAYAVLN GVFNTAVADDLIDRNPCRIRGAAQVKHARRSVVLLDATQLTALAEKMPDDARLGVLLAGWCGLRKGEVFA LRRGDVAADGSSVRIERSVTYREGRFEVGPTKTRESRRVVSVPPHVRPAVLEHLQRHVADGDDALVFVEP STGSFAGEKRFRTAWESARAAIGQPDMHFHDLRHAAGVMAAQTGATVRELMDRLGHTSPNMSMRYQHTAE GRAAALADKLSALASTNP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1484 | - | - | 100% (368) | integrase |
| M. avium 104 | MAV_2217 | - | 6e-24 | 29.46% (336) | traSA:integrase fusion protein |
| M. avium 104 | MAV_2266 | - | 5e-18 | 25.00% (372) | phage-related integrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2918c | xerC | 3e-08 | 25.43% (291) | site-specific tyrosine recombinase XerC |
| M. gilvum PYR-GCK | Mflv_3899 | - | 2e-55 | 37.07% (348) | phage integrase family protein |
| M. tuberculosis H37Rv | Rv2659c | - | 1e-63 | 40.32% (372) | phiRv2 prophage integrase |
| M. leprae Br4923 | MLBr_01600 | xerC | 2e-07 | 32.65% (98) | site-specific tyrosine recombinase XerC |
| M. abscessus ATCC 19977 | MAB_1816c | - | 2e-12 | 27.71% (249) | Phage integrase |
| M. marinum M | MMAR_4848 | - | 7e-19 | 24.30% (321) | prophage integrase |
| M. smegmatis MC2 155 | MSMEG_5754 | - | 1e-09 | 26.16% (237) | gp41 protein |
| M. thermoresistible (build 8) | TH_0846 | xerC | 3e-06 | 26.37% (273) | PROBABLE INTEGRASE/RECOMBINASE XERC |
| M. ulcerans Agy99 | MUL_0529 | - | 1e-16 | 24.44% (315) | prophage integrase |
| M. vanbaalenii PYR-1 | Mvan_4364 | - | 7e-67 | 40.98% (366) | phage integrase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2918c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01600|M.leprae_Br4923 --------------------------------------------------
TH_0846|M.thermoresistible__bu --------------------------------------------------
Mflv_3899|M.gilvum_PYR-GCK MARGTGRKDRAPGTFGSVD--KLATG-YRARYFGPDGRRH----KAPVLF
Rv2659c|M.tuberculosis_H37Rv MTQ-TGKRQRR--KFGRIR--QFNSGRWQASYTGPDGRVY----IAPKTF
Mvan_4364|M.vanbaalenii_PYR-1 ---MAGKKGHR--GWGWIR--QLPSKRYQASYIGPDLIRH----KASTTF
MAV_1484|M.avium_104 -----------------MR--QLPSGRWQASYLH-NGVVF----KALATF
MMAR_4848|M.marinum_M ---MAGSVPRG--IRKRTN--SAGQARYQVRYLVRDPNSPSGWVETSSTF
MUL_0529|M.ulcerans_Agy99 ---MAGNTPRG--IRKRLN--AAGEPRYQVRYLIRDPDAPSGWVETSATF
MAB_1816c|M.abscessus_ATCC_199 ---MAGRPPLRIGQHGKISRQYVGGGVWVARCRYRDSDGVTRIVERRGPV
MSMEG_5754|M.smegmatis_MC2_155 ---MLQRMARIPDYVKVIDLDSGRRYEVRPEVTGADGKRRQKRERFKTLK
Mb2918c|M.bovis_AF2122/97 -----MQAILDEFDEYLALQ---------------------CGRSVHT--
MLBr_01600|M.leprae_Br4923 ------MAILDEFDEHLALR---------------------CGRSEHT--
TH_0846|M.thermoresistible__bu ---MSVDTVLDEFADYLALQ---------------------RGRSPHT--
Mflv_3899|M.gilvum_PYR-GCK LTKTDARAWLAQRHSEIVAQ-----QWTPPN----AVEVPKTTFTEYADQ
Rv2659c|M.tuberculosis_H37Rv NAKIDAEAWLTDRRREIDRQ-----LWSPASG---QEDRPGAPFGEYAEG
Mvan_4364|M.vanbaalenii_PYR-1 GARIDAEGWLSQERRSIELD-----TWTPPAQRAAEVKAKAVTLGEYSTK
MAV_1484|M.avium_104 PTKSSAGHWLQAEEDLIDLDRRRPGEWTPPAERAARRQAEKLTLRTYAKT
MMAR_4848|M.marinum_M ATMREARAFKADRDGEAAIG--------------ARRFDPRLGRASLSAI
MUL_0529|M.ulcerans_Agy99 PTLREAKAFKSERDNEAALG--------------ARRFDPRLGRTPLSRI
MAB_1816c|M.abscessus_ATCC_199 DDFDKHGKLAEDALIEALSD------------RRLPADTDTIGYDTLVMA
MSMEG_5754|M.smegmatis_MC2_155 EAVDHYTAIAGDRGRGVHVAP---SELTVEDAVDSWLLGQRIRPKTMSAY
Mb2918c|M.bovis_AF2122/97 --------------RRAYLGDLRSLFAFLADR--GSSLDALTLSVLRSWL
MLBr_01600|M.leprae_Br4923 --------------RRAYLGDLRSLLTHLEGR--GSRLDQLSLPVLRSWL
TH_0846|M.thermoresistible__bu --------------CRAYLGDLRSLFDFVEQRSPGSGLGGLSLPVLRAWL
Mflv_3899|M.gilvum_PYR-GCK WLLTRQ-VAGRPLKDRTREHYQALLDDHITATFGALPLASITADDVRQWY
Rv2659c|M.tuberculosis_H37Rv WLKQ------RGIKDRTRAHYRKLLDNHILATFADTDLRDITPAAVRRWY
Mvan_4364|M.vanbaalenii_PYR-1 WIED------RNVKPRTRSSYRDILRLHIEPRLGSMAMKNLTGEVVRSWY
MAV_1484|M.avium_104 WLDN-----KTKLARRTRDNYQGHLDNHVLPALGDLGLADITPEHVRTWF
MMAR_4848|M.marinum_M WTQYSA-SKQPAVSPKTWSGYAQHWELRISPRFGHVPVDEISRKDVQQFI
MUL_0529|M.ulcerans_Agy99 WTQFSD-SKKPAVSPKTWSGYNQHWELRIKPRFGHVPVDEITRADVRAFV
MAB_1816c|M.abscessus_ATCC_199 LVDQHIGRLSDDGRSPATVATYKFASDKLRNFLGGVRVSEAHAARMDAAL
MSMEG_5754|M.smegmatis_MC2_155 ITSLRPIVDHLGKRTVQSITKDDLEQVVQALRAGTSKMGTWNAPTKLTKA
:
Mb2918c|M.bovis_AF2122/97 AATAGAGAARTTLARRTSAVKAFTAWAVRRGLLAGDPAARLQVPKARRTL
MLBr_01600|M.leprae_Br4923 ATAAGAGAARTTLARRISAVKAFTAWAKWRGQLAADPAARLQVPRAYRTL
TH_0846|M.thermoresistible__bu AAQAADGSARTTLARRTSAVKTFTAWAVRQGLLSTDPALRLQVPKARRTL
Mflv_3899|M.gilvum_PYR-GCK ARTLTDKPTMRSHA--YGLLRTILATAVSDGKISVNPCSIRGAGTAKRVH
Rv2659c|M.tuberculosis_H37Rv ATTAVGTPTMRAHS--YSLLRAIMQTALADDLIDSNPCRISGASTARRVH
Mvan_4364|M.vanbaalenii_PYR-1 AGLGTDYPRRNSHA--YGLLHAVCATAVSDGLLQSNPCNIRRAMNPPRRR
MAV_1484|M.avium_104 AGLGNEHETRNAQA--YAVLNGVFNTAVADDLIDRNPCRIRGAAQVKHAR
MMAR_4848|M.marinum_M GGLTVG-PWAKLAT--LRLLRSILDMAREDGRIHINPAQGVSSGRIPARE
MUL_0529|M.ulcerans_Agy99 DGLTVG-PWAKVST--LRLLRSILDVAHQDGRIHRNPALGVSAGRIPERE
MAB_1816c|M.abscessus_ATCC_199 RSMRTAHGTTMARQ-AKTILQGGLQLAVMANVIPANPVRDVQSLRSKTRP
MSMEG_5754|M.smegmatis_MC2_155 AKKVRSPWAASSINPMLARTRSIFEDLVNQGVVVRNVAALVKPLATDTEK
. . : :
Mb2918c|M.bovis_AF2122/97 P-AVLRQDQALRAMAAAESGAEQGD------PLALRDRLIVELLYATGIR
MLBr_01600|M.leprae_Br4923 P-AVLRQDQALQIMAAAKSGAEQGD------PLALRDRLIVEMLYATGIR
TH_0846|M.thermoresistible__bu P-AVLRRDQALAAMAAADSGAQQKD------PIALRDRLIVEMLYATGIR
Mflv_3899|M.gilvum_PYR-GCK K-VRPATVGEIGTIADAM-PAQWSL------MVLLAAWLAMRFGELTELR
Rv2659c|M.tuberculosis_H37Rv K-IRPATLDELETITKAM-PDPYQA------FVLMAAWLAMRYGELTELR
Mvan_4364|M.vanbaalenii_PYR-1 D-PVILAVADIAALAEAIQPRRLRC------LVLLAAWCGVRWGEVSELR
MAV_1484|M.avium_104 RSVVLLDATQLTALAEKM-PDDARL------GVLLAGWCGLRKGEVFALR
MMAR_4848|M.marinum_M R-HRYLSATEVAALAHAC--GDQGD------IVTILAFTGLRWSELVGLR
MUL_0529|M.ulcerans_Agy99 R-HRYLTAQEVRMLATAC--GDQGD------VVTILAYTGLRWSEPVGLR
MAB_1816c|M.abscessus_ATCC_199 KGATALSADQLRTLLAEIRASEYCAGNDLADPLIILMATGLRRSELLALR
MSMEG_5754|M.smegmatis_MC2_155 T-MNTLNAEQVTQLLAVTDSHCYGI-------AWRLAVLGLRRGEILALR
: : :. :*
Mb2918c|M.bovis_AF2122/97 VSELCGLDVDDIDTGHRLVRVLG------KGNKQRTVPFGQPAADALHAW
MLBr_01600|M.leprae_Br4923 VSELCGLDIDDVDTRHRLVRVLG------KGNKQRTAPFGVPAADALRGW
TH_0846|M.thermoresistible__bu VSELCGLDIDDVDTDRHLARVLG------KGGRQRTVPFGEPARGALTDW
Mflv_3899|M.gilvum_PYR-GCK RKDID-LADEVVRVRRAVVRTDDG--FKVTTPKSDAGIRDIAIPPHLIPP
Rv2659c|M.tuberculosis_H37Rv RKDID-LHGEVARVRRAVVRVGEG--FKVTTPKSDAGVRDISIPPHLIPA
Mvan_4364|M.vanbaalenii_PYR-1 RKDLS-DGCEVLSVSRAVTRRDGV--YRVDTPKSGKG-RAVVIPPHIRED
MAV_1484|M.avium_104 RGDVA-ADGSSVRIERSVTYREGR--FEVGPTKTRESRRVVSVPPHVRPA
MMAR_4848|M.marinum_M VGDID-LKARRLYVRQAAPDVEGR--IIVGPPKTRAAVRTVPLPRIVIDA
MUL_0529|M.ulcerans_Agy99 VKDID-LTARRLYVRRAAPEVEGH--IVIGPPKTRAGIRTVPLPQVVVDI
MAB_1816c|M.abscessus_ATCC_199 WSDFD-ANAGTLTVTGKLVRATGAGLQRIDEAKTAAGMRTVALPSFAVTA
MSMEG_5754|M.smegmatis_MC2_155 WDAVD-FDAGTLAISAARLATAGG--ATTGAPKTKTSVRTLPMPEDLTAA
. :
Mb2918c|M.bovis_AF2122/97 LVDGRRALVTAESGHALLLGAR-------GRRLDVRQARTAVHQTVAAVD
MLBr_01600|M.leprae_Br4923 LDDGRPALVTVESGPALLLGSR-------GRRLDVRQARTVVHQTVAVVA
TH_0846|M.thermoresistible__bu LTDGRPALATAESGPALLLGVR-------GRRLDPRQARTVVHQTVAAVA
Mflv_3899|M.gilvum_PYR-GCK IEAHLSQHVGAKADALLFPAVG------GGHLAPATLYR-RFYT-ARERA
Rv2659c|M.tuberculosis_H37Rv IEDHLHKHVNPGRESLLFPSVND----PNRHLAPSALYR-MFYK-ARKAA
Mvan_4364|M.vanbaalenii_PYR-1 VINHLAENVESGPESLLFPAAR------GGHMNDRVFSR-EYFSDALKAI
MAV_1484|M.avium_104 VLEHLQRHVADGDDALVFVEPS------TGSFAGEKRFR-TAWESARAAI
MMAR_4848|M.marinum_M LKPRIENRS---TKEQAITSPN------GGFLRSNNWRRHTHWNKALKKT
MUL_0529|M.ulcerans_Agy99 FKGRITGQA---PDQPAVTSTN------GAMLRSNNWRRHTHWNKALKST
MAB_1816c|M.abscessus_ATCC_199 LR-HRQGRDYVGQQLMIFPSTA-------GTWRDPNNFG-KQWRAVRDDL
MSMEG_5754|M.smegmatis_MC2_155 LRRVRKRQKEYRLKLGSKWTDSGYVVVDEFGVAPYPDTLTAAWRKTLANA
. .
Mb2918c|M.bovis_AF2122/97 GAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQ-LYTHVAVA
MLBr_01600|M.leprae_Br4923 GAPDMGPHGLRHSAATHLLEGGADLRVVQELLGHSSLATTQ-LYTHVAVS
TH_0846|M.thermoresistible__bu GAPDIGPHGLRHSAATHLLEGGADLRIVQELLGHTSLATTQ-LYTHVTVE
Mflv_3899|M.gilvum_PYR-GCK NRKDLRWHDLRHSGAVLAAATGATLAELMARLGHSTPQAAL-RYQHAAQG
Rv2659c|M.tuberculosis_H37Rv GRPDLRVHDLRHSGAVLAASTGATLAELMQRLGHSTAGAAL-RYQHAAKG
Mvan_4364|M.vanbaalenii_PYR-1 GRQGVRVHDLRHFAGTQTAQV-ANLAESMARLGHSTVKASL-IYQGLVTG
MAV_1484|M.avium_104 GQPDMHFHDLRHAAGVMAAQTGATVRELMDRLGHTSPNMSM-RYQHTAEG
MMAR_4848|M.marinum_M GLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYSD
MUL_0529|M.ulcerans_Agy99 DLAPLTIHDLRHTYASLARKSGADLRYVQKTMGHSTPTVTANIYSDLYAD
MAB_1816c|M.abscessus_ATCC_199 GVPGVTTHSFRKTMATLIDDNGLSARVGADQLGHAKVSMTQDRYMARG-K
MSMEG_5754|M.smegmatis_MC2_155 GLPHVRLHDARHSCATLMHLSGVPTVVIAAWLGHQDPGFTLRTYAHSNHD
. : *. *: . :** : *
Mb2918c|M.bovis_AF2122/97 RLRAVHERAHPRA----------------------
MLBr_01600|M.leprae_Br4923 RLRVVHDQAHPRA----------------------
TH_0846|M.thermoresistible__bu RLRAVHDQAHPRA----------------------
Mflv_3899|M.gilvum_PYR-GCK RDRQIAALLSKIAENGGA-----------------
Rv2659c|M.tuberculosis_H37Rv RDREIAALLSKLAENQEM-----------------
Mvan_4364|M.vanbaalenii_PYR-1 RDAAIADALSQLAVGES------------------
MAV_1484|M.avium_104 RAAALADKLSALASTNP------------------
MMAR_4848|M.marinum_M ELDHVATNLDRLNDVAKDQAN-GQEPDTPKHP---
MUL_0529|M.ulcerans_Agy99 ELDQVATNLDQLHATEIQTPTTGQEPDEPNQPSSA
MAB_1816c|M.abscessus_ATCC_199 VHHEVADLLDATISDE-------------------
MSMEG_5754|M.smegmatis_MC2_155 ALADAAAMLGSITTGKKKEAK--------------