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ASKQTLFRIFYRIGFTPWDGHPLAQSLRDLVEGTGDAAALPAGKALEIGCGTGDCAIYLAQHGWNVTAVD FVAKPLERARAKAGAAGAAVDFVQADVTRLGQAGIGTGFELIVDNGCLHNMSDADRDAYVREVTGVAAPQ ARLLIVAFVPGGRFGVRGVEDAEMQRRFTADWTLLAAGPERELDGAEKTPARYYLFQRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0982 | - | - | 100% (200) | methyltransferase type 12 |
| M. avium 104 | MAV_2216 | cheR | 4e-13 | 38.75% (160) | CheR methyltransferase SAM binding domain-containing protein |
| M. avium 104 | MAV_3570 | - | 7e-13 | 31.82% (176) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1412c | - | 2e-15 | 33.99% (153) | putative transferase |
| M. gilvum PYR-GCK | Mflv_4471 | - | 2e-12 | 33.05% (118) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1377c | - | 2e-15 | 33.99% (153) | putative transferase |
| M. leprae Br4923 | MLBr_00551 | - | 4e-05 | 24.60% (126) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0867c | - | 2e-20 | 34.20% (193) | putative transferase |
| M. marinum M | MMAR_2193 | - | 3e-15 | 32.74% (168) | NodS-like (sam)-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_3041 | - | 2e-16 | 42.48% (113) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_3761 | - | 1e-65 | 61.39% (202) | PUTATIVE methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_3309 | - | 1e-12 | 34.81% (135) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 5e-16 | 31.18% (170) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0982|M.avium_104 ----MASKQTLFRIFYRIG----------FTPWDGHPLAQSLRDLVEG-T
TH_3761|M.thermoresistible__bu ----MSSRRLLFRTLYRLG----------MTPWDGHPLAASLRGLVEGGV
MAB_0867c|M.abscessus_ATCC_199 MGAPTQN---IFEDLYRDS--LHEGGPIV--PWDSKDAKPRIKELALL--
MUL_3309|M.ulcerans_Agy99 MTAPDPTDPTRFEEMYRDQRVAHGLPAAT--PWDIGGPQPVVEQLVAL--
Mb1412c|M.bovis_AF2122/97 MPG------IDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTG--
Rv1377c|M.tuberculosis_H37Rv MPG------IDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTG--
MMAR_2193|M.marinum_M ---------MDFDALYRGESPRPGVAPMTTPPWDTKAPKENVIAWQAG--
MSMEG_3041|M.smegmatis_MC2_155 MTGPTGSE-FDFDALYRGESPAEGVPPITSVPWDTKAPKENVVAWEQA--
Mflv_4471|M.gilvum_PYR-GCK MDMDQTPTLSRFDDFYKDED--------KTPPWVIGEPQPAVVDIERA--
Mvan_1888|M.vanbaalenii_PYR-1 --MDLTPRLSRFDEFYKN----------QTPPWVIGEPQQAIVELEQA--
MLBr_00551|M.leprae_Br4923 --MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPLGPILVTATG--
: . :
MAV_0982|M.avium_104 GDAAALPAGKALEIGCGTGDCAIYLAQHGWNVTAVDFVAKPLERARAKAG
TH_3761|M.thermoresistible__bu EGFEPLPPGAALDLGCGTGDSSIYLARHGWMVTGVDYIEKPLHKARAKAE
MAB_0867c|M.abscessus_ATCC_199 ----GAIRGDVLDIGCGLGDNAIYLAQQGFNVTGLDFAPSAIEQAKGRAA
MUL_3309|M.ulcerans_Agy99 ----GAVKGEVLDPGTGPGHHAIYYASKGYSATGIDGSATAIERARDNAA
Mb1412c|M.bovis_AF2122/97 ----GWVHGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRAS
Rv1377c|M.tuberculosis_H37Rv ----GWVHGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRAS
MMAR_2193|M.marinum_M ----GWVHGDVLDIGCGLGDNAIYLAAHGHPVTGLDISPTALITAARRAD
MSMEG_3041|M.smegmatis_MC2_155 ----GLVHGHVLDIGCGLGDNAIYLAQQGYRVTALDISPTALITAERRAA
Mflv_4471|M.gilvum_PYR-GCK ----GLITGRVLDVGCGTGERTILLTAAGYDVLGVDGAPSAVEQARHNAK
Mvan_1888|M.vanbaalenii_PYR-1 ----GLIGGRVLDVGCGTGEHTILLARAGYDVLGIDGAPTAVEQARRNAE
MLBr_00551|M.leprae_Br4923 ----IRPGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRSQARAT
.*: . * *. :: : * . * : : .*
MAV_0982|M.avium_104 AAGAAVDFVQADVTRLGQAG----IGTGFELIVDNGCLHNMS--DADRDA
TH_3761|M.thermoresistible__bu AQGVDVHFLQADVTRLRQDVSPDVVGAGFDLIIDNGCLHGMS--AEDRDA
MAB_0867c|M.abscessus_ATCC_199 AAGVAVDFQVADATTLDGWDA------RFDTVIDSGVYHCF--DAEGHTE
MUL_3309|M.ulcerans_Agy99 KAGVSVNFQVADATRLEGLDN------RFDTVVDCAFYHTFGTAPELQRS
Mb1412c|M.bovis_AF2122/97 DAGVDVKFAVGDATKLTGYTG------AFDTVIDCGMFHCL--DDDGKRS
Rv1377c|M.tuberculosis_H37Rv DAGVDVKFAVGDATKLTGYTG------AFDTVIDCGMFHCL--DDDGKRS
MMAR_2193|M.marinum_M DAGVHVTFAVADATKLDGYTD------AFDTVIDSGMFHCL--DDEGKRS
MSMEG_3041|M.smegmatis_MC2_155 DAGVDVTFAVADATRLDGYDD------VFDTVVDSGMFHCL--SDDAKGS
Mflv_4471|M.gilvum_PYR-GCK TRVVDARFDVADALDLG-DEP------AYDTIIDSALFHIF--DDADREK
Mvan_1888|M.vanbaalenii_PYR-1 AQGVDARFELADALHLG-PDP------TYDTIVDSALFHIF--DDADRAT
MLBr_00551|M.leprae_Br4923 ELGLTLEYREADAQALPFGDG------EFDVVMSAIGVMFAP----DHRR
: .*. * :: ::. :
MAV_0982|M.avium_104 YVREVTGVAAPQARLLIVAFVPGGRFG-----VRGVEDAEMQRRFT-ADW
TH_3761|M.thermoresistible__bu YVREVTAVAAPDARLHIVAFTPGGLFG-----VPGITPEEVEQRFS-ADW
MAB_0867c|M.abscessus_ATCC_199 YASALHRATRPGARWYIWCFAQGAVHGVPTPFQNGQRAEEIEQVLTTSGW
MUL_3309|M.ulcerans_Agy99 YVQALWRATKPGARLYMYEFGAHQVNGL-TAIRS-LPEENFREMLPLGGW
Mb1412c|M.bovis_AF2122/97 YAASVHRATRPGATLLLSCFSNAMPPDE-EWPRSTVSEQTLRDVLGGAGW
Rv1377c|M.tuberculosis_H37Rv YAASVHRATRPGATLLLSCFSNAMPPDE-EWPRSTVSEQTLRDVLGGAGW
MMAR_2193|M.marinum_M YAAAVHRATRPGATLLMSCFCDANPPNE-QQPRPAVPEQTLRDVLGGAGW
MSMEG_3041|M.smegmatis_MC2_155 YAAAVHRATRAGATLLLGAFSDANLQHD-NWQAAWVSEDTLRSSLDDGGW
Mflv_4471|M.gilvum_PYR-GCK YVRSLGRATAPGSVVHLLALSDTG-----RGFGPEVSEETIRAAFADPGW
Mvan_1888|M.vanbaalenii_PYR-1 YVRSLHAATRPGSVVHLLALSDSG-----RGFGPEVSEHTIRAAFG-AGW
MLBr_00551|M.leprae_Br4923 AASELVRVCRPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAALW
. : . . . : *
MAV_0982|M.avium_104 TLLAAGP----------ERELDG---------------------------
TH_3761|M.thermoresistible__bu TLLSSGV----------EAESAR---------------------------
MAB_0867c|M.abscessus_ATCC_199 SVLQINP----TTMSAPKAEFLNAIRGSYRGDP-AVLDR-----------
MUL_3309|M.ulcerans_Agy99 EITYLGPTTYRTTVSMETLETMAARNPEVADQVGPLVERF----------
Mb1412c|M.bovis_AF2122/97 DIESLEP----ATVR---REL-----------------------------
Rv1377c|M.tuberculosis_H37Rv DIESLEP----ATVR---REL-----------------------------
MMAR_2193|M.marinum_M EIAALDP----VTVN---RQLGGS--------------------------
MSMEG_3041|M.smegmatis_MC2_155 DITSLTT----ETIRVPGAALAGSGDE-----------------------
Mflv_4471|M.gilvum_PYR-GCK DIEALTTTYYRGVITAPHADAMGLD-------------------------
Mvan_1888|M.vanbaalenii_PYR-1 EVEALTETTYRGVVIDAHTEALNLP-------------------------
MLBr_00551|M.leprae_Br4923 GREAYIRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEAY
MAV_0982|M.avium_104 --------------------------AEKTPARYYLFQRR-----
TH_3761|M.thermoresistible__bu --------------------------GNQ-ASRYYLFAASRRRTA
MAB_0867c|M.abscessus_ATCC_199 --------------------LDQDVTDPLLHVPVYTVIAERM---
MUL_3309|M.ulcerans_Agy99 ------------------KTIQPWLTDGIAHVPFWEVHATRPD--
Mb1412c|M.bovis_AF2122/97 -------------------------DGTEVEMAFWNVRAQRRGS-
Rv1377c|M.tuberculosis_H37Rv -------------------------DGTEVEMAFWNVRAQRRGS-
MMAR_2193|M.marinum_M -------------------------DGQPIKLAFWYVRARRQN--
MSMEG_3041|M.smegmatis_MC2_155 ------------------------GGADEFDAAFFLVQAQRR---
Mflv_4471|M.gilvum_PYR-GCK -------------------------VGTVVDEPAWLARIRRL---
Mvan_1888|M.vanbaalenii_PYR-1 -------------------------AGTVVDEPAWSARIRRL---
MLBr_00551|M.leprae_Br4923 TNIGDNSVLAAELDAQLTELAQKYLTNSTMGWEYLLLTAQKH---