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MDTSCEPGEAGRFWEERYRGAERVWSGRVNPRLAELAADLPAGRALDLGCGEGADALWLAQRGWTVLAVD ISATALRRAAEAAASRKLLARIDFQRHDLNESFPEGMFDLISAQYFHSPVHLDRDAVLRRAATRVKPGGV LLIVDHGAAPPWAQHDGHHFPGVEEVLGSLRLDPDGWTRLRAEAAGREMTGPNGEVGTLMDNIMMLRRTE QAYAAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2216 | cheR | - | 100% (216) | CheR methyltransferase SAM binding domain-containing protein |
| M. avium 104 | MAV_0982 | - | 5e-13 | 38.75% (160) | methyltransferase type 12 |
| M. avium 104 | MAV_2957 | - | 1e-12 | 34.55% (191) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0575c | - | 2e-10 | 35.33% (150) | benzoquinone methyltransferase |
| M. gilvum PYR-GCK | Mflv_2895 | - | 2e-60 | 55.84% (197) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0560c | - | 2e-10 | 35.33% (150) | benzoquinone methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3178 | - | 4e-30 | 36.54% (208) | hypothetical protein MAB_3178 |
| M. marinum M | MMAR_2640 | - | 1e-13 | 39.13% (138) | methyltransferase |
| M. smegmatis MC2 155 | MSMEG_4303 | - | 9e-63 | 58.00% (200) | methyltransferase |
| M. thermoresistible (build 8) | TH_0144 | - | 2e-61 | 62.03% (187) | methyltransferase |
| M. ulcerans Agy99 | MUL_3115 | - | 2e-14 | 38.41% (138) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3615 | - | 2e-60 | 56.44% (202) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 MENKPWDSIIVGGGAAGLSAALVLGRARRRVLLVDAGEQSNLPAHGIGGL
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------------------
Rv0560c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 LGSDGRAPADLYAAGHAELAAYPSVQVRRGEVIAGRRGFALDLADGGHEH
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------------------
Rv0560c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ARTVLLAAGMDYLPPNIPGLGELWGRSVFHCPFCHGWEVRDAPLAVIARG
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------------------
Rv0560c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 ERAVHSALLLRAWSDDIVVLTNGPDGLDDAQTEKLGAAGIPVNDASIARL
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------------------
Rv0560c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 VAHDGELVAVEFTDGTRLSRRGALVATTLHQRSPLAAQLGAIGAPTPLAG
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M --------------------------------------------------
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------------------
Rv0560c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2216|M.avium_104 --------------------------------------------------
TH_0144|M.thermoresistible__bu --------------------------------------------------
Mflv_2895|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3615|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4303|M.smegmatis_MC2_155 DAVVVDTFGRTTVPGLFAAGDLTGNLPQVATAVAAGSQTAAAIVQHLLAE
MAB_3178|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2640|M.marinum_M -------------------------MSRTAERADRLSIRYPVCSPTAQVR
MUL_3115|M.ulcerans_Agy99 --------------------------------------------------
Mb0575c|M.bovis_AF2122/97 --------------------------------------MSTVLTYIRAVD
Rv0560c|M.tuberculosis_H37Rv --------------------------------------MSTVLTYIRAVD
MAV_2216|M.avium_104 ------MDTSCEPGEAGRFWEERYRGA--ERVWSGRVNPRLAELAADLP-
TH_0144|M.thermoresistible__bu -------------------------------MWSGRVNARLAEVAGELP-
Mflv_2895|M.gilvum_PYR-GCK -----------MT-DVKQHWEERYSQR--DRIWSGHVNRWLAEVAAPLK-
Mvan_3615|M.vanbaalenii_PYR-1 -----------MTSEVKQHWEERYAER--DRIWSGRVNRWLAEVAASEK-
MSMEG_4303|M.smegmatis_MC2_155 DIGLPTPPWPTEGLSPAEYWERHYGER--EQIWSGRVNPQLEKVASDLP-
MAB_3178|M.abscessus_ATCC_1997 ------MHDHNNPPSDEKSWDEFYQSH--DALWSGNANPQLVAEISSLP-
MMAR_2640|M.marinum_M RSCRGRRMVARVAESDRRRWDRRYASLGPAAVSAARPPALLQAHLKLVPT
MUL_3115|M.ulcerans_Agy99 --------MARVAESDRRRWDRRYASLGPAAVSAVRPPALLQAHLKLVPA
Mb0575c|M.bovis_AF2122/97 IYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQPELAALIVQGKF
Rv0560c|M.tuberculosis_H37Rv IYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQPELAALIVQGKF
. *
MAV_2216|M.avium_104 AGRALDLGCGEGADALWLAQRGWTVLAVDISATALRRAAEAAASR--KLL
TH_0144|M.thermoresistible__bu PGRALDVGCGEGADAMWLAERGWQVTAVDISQTALDRAAAEAASR--GLT
Mflv_2895|M.gilvum_PYR-GCK PGRALDLGCGEGGDTLWLAEHGWEVVGVDISDTALRRAAEEADKR--GLA
Mvan_3615|M.vanbaalenii_PYR-1 PGHALDLGCGEGGDTVWLAEHGWQVLGVDISDTALGRAAAEAATR--GLT
MSMEG_4303|M.smegmatis_MC2_155 AGHALDLGCGEGGDAVWLAERGWRVTAVDISHTALSRAAAEAGRR--GVA
MAB_3178|M.abscessus_ATCC_1997 PRTALDAGCGEGGDAIWLAQHGWQVTGMDFAHTALRRAADNAVKVDPELA
MMAR_2640|M.marinum_M AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
MUL_3115|M.ulcerans_Agy99 AGRALDLGCGQGLGAVWLARRGLDVLGLDISPVAIAQARDLAERS--GVS
Mb0575c|M.bovis_AF2122/97 RGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELARHEAAKR--GLA
Rv0560c|M.tuberculosis_H37Rv RGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELARHEAAKR--GLA
.** ***:. :: **.:* . .:*:: .*: * * :
MAV_2216|M.avium_104 ARIDFQRHDLNESF-PEGM-FDLISAQYFHSPVHLDRDAVLRRAATRVKP
TH_0144|M.thermoresistible__bu --IDFQRHELPATF-PDGQ-FELVSAHFLHSEVELDRVRILRRAAEAVVP
Mflv_2895|M.gilvum_PYR-GCK DRVQLRQTDLSASF-PDGV-FDLVSAQFLQSMVHLDRERIFAAAARAVAP
Mvan_3615|M.vanbaalenii_PYR-1 DRVRFVQMNLSEAF-PEGV-FDLVSAQFLQSMVHLDRERIFAAAARAVAP
MSMEG_4303|M.smegmatis_MC2_155 DRITFERHDLSESF-PDGE-FDLVSAQFLHSTVRLERPRILSTAARAIRP
MAB_3178|M.abscessus_ATCC_1997 NRISWTQADLTAWQ-PNRQ-FDLVTSHFMHLPTNL-REPVFAALAAAVAP
MMAR_2640|M.marinum_M ARCCFDVVDLDDGL-PDGPPVDVIVCHNFR------DRRLDAAIIDRLAP
MUL_3115|M.ulcerans_Agy99 ARCRFDVVDLDDGL-PDGPPVDLIVCHNFR------DRRLDAAIIERLAP
Mb0575c|M.bovis_AF2122/97 N-ASFEVADASSFTGYDGRFDTIVDSTLFHSMPVESREGYLQSIVRAAAP
Rv0560c|M.tuberculosis_H37Rv N-ASFEVADASSFTGYDGRFDTIVDSTLFHSMPVESREGYLQSIVRAAAP
: : :: . :: *
MAV_2216|M.avium_104 GGVLLIVDHGAAPPWAQHDGHH--FPGVEEVLGSLRLDPDGWTRLRAEAA
TH_0144|M.thermoresistible__bu GGLLLIVDHGAPPPWAPDHVHEFEFPSAQEVVESLQLPEGQWELLRAEPV
Mflv_2895|M.gilvum_PYR-GCK GGVLIVVDHAAAPPWAPPEVHEHRFSTVDEVLATIDLGEGSWERLRADVV
Mvan_3615|M.vanbaalenii_PYR-1 GGVLVIVDHGAAPSWAPEHIREHVFPGVEEVLATVDLGDGQWRRVRADRV
MSMEG_4303|M.smegmatis_MC2_155 GGHLVIVDHGKMPPNATRVPHDHPFPSAEEVLAGLDLPASEWERVRVEAV
MAB_3178|M.abscessus_ATCC_1997 GGTLLIVGHHPSDMQAAIGRPDLPDWYFTAEDIADTLNPKEWTIIVAESR
MMAR_2640|M.marinum_M GGLVALVALSEVG----------------AAAGTYRAAPGELSAAFAELD
MUL_3115|M.ulcerans_Agy99 GGLVALVALSEVG----------------AAAGTYRAAPGELSTAFAELD
Mb0575c|M.bovis_AF2122/97 GASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFP
Rv0560c|M.tuberculosis_H37Rv GASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFP
*. :: .
MAV_2216|M.avium_104 GREMTGPNGEVGTLMDNIMMLRRTEQAYAAS-
TH_0144|M.thermoresistible__bu KRDAVGPDGQQGTLIDNVIMLRRR--------
Mflv_2895|M.gilvum_PYR-GCK ERDAIGPDGEAGVLRDNLIVVRRCA-------
Mvan_3615|M.vanbaalenii_PYR-1 ERDATGPDGQQAVLIDNLIVLRRL--------
MSMEG_4303|M.smegmatis_MC2_155 HREATGPDGQPMPMVDNVMVLRRTS-------
MAB_3178|M.abscessus_ATCC_1997 SRKFTR-DDEEFDIADTVLRAERKPTTESA--
MMAR_2640|M.marinum_M PIAAGEGDGRAWLLARA---------------
MUL_3115|M.ulcerans_Agy99 PIAAGEGDGRAWLLARA---------------
Mb0575c|M.bovis_AF2122/97 AGFAGMPALLDIREEPNGLQSIGGWLLSAHLG
Rv0560c|M.tuberculosis_H37Rv AGFAGMPALLDIREEPNGLQSIGGWLLSAHLG