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MAAEPFTIRGPGGVQIVADRLGDPRARAVVFLHGGGQTRRSWGKAAAAVAARGWQAVTVDLRGHGESDWS GDGDYRVVSFAADVQAVLGTLPPKPVLVGASLGGFTSMLLAGELSPGIASAVVLVDIVPNMDQSGANRIH AFMADRVDSGFASLDEVADAIAEYNPHRPRPTDLEGLTTNLRRRGDRWYWHWDPQFISGTAAFPPFEVTD PDRMHAAVEAILRDGVPILMIRGQMSDLVSQERADEFLARFPQVEFTDVRGAGHMVAGDRNDVFADAVLD FLARHLDVE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0677 | - | - | 100% (289) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_1846 | - | 2e-70 | 49.82% (275) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_1254 | - | 7e-58 | 41.94% (279) | hydrolase, alpha/beta fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 1e-124 | 80.77% (260) | peroxidase BpoA |
| M. gilvum PYR-GCK | Mflv_4507 | - | 1e-126 | 74.91% (283) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 1e-124 | 80.77% (260) | peroxidase BpoA |
| M. leprae Br4923 | MLBr_02603 | - | 1e-06 | 35.29% (102) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_2045 | - | 2e-55 | 43.87% (269) | putative hydrolase (alpha/beta fold) |
| M. marinum M | MMAR_4960 | bpoA | 1e-142 | 84.27% (286) | peroxidase BpoA |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 2e-60 | 43.55% (287) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 1e-53 | 42.11% (266) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 8e-58 | 39.31% (290) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_1862 | - | 1e-133 | 79.86% (283) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4507|M.gilvum_PYR-GCK ------MTETLGAPEPFLTDGHGGIVIAADRRGE-----PTARAVVFLHG
Mvan_1862|M.vanbaalenii_PYR-1 MRVSTYHPEMTSAPEQFLTDGHGGVRIVADRLGD-----PRARAVVFLHG
Mb3502c|M.bovis_AF2122/97 --------------------------------------------MVFLHG
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------MVFLHG
MAV_0677|M.avium_104 -----------MAAEPFTIRGPGGVQIVADRLGD-----PRARAVVFLHG
MMAR_4960|M.marinum_M ---------MATAPERFSVQGPDGVRIVADRCGD-----PRGRAVVFLHG
MSMEG_5209|M.smegmatis_MC2_155 --MSTAQT----ESQTVAFRGVDDLTLVGDEWNKGAERAADRPTVLLLHG
MUL_0147|M.ulcerans_Agy99 --MSAMSN----NPRTVEFSGTEGITLVADEWNR-DTAASGRPTILMLHG
TH_2112|M.thermoresistible__bu --LNSTHS----KPQTVRFRGAQGLTLVADQWNR-GSGPKDRPTILLLHG
MAB_2045|M.abscessus_ATCC_1997 --MSAKRTGDSSAPVVERVPTADGLALAVDLYHC----DAPRAVVLLLHG
MLBr_02603|M.leprae_Br4923 ---------MTITRTERNFYGVGGVRIVYDVWMP---DTRPRAVIILAHG
::: **
Mflv_4507|M.gilvum_PYR-GCK GGQTRRSWDRAAAAVAQRGWQSVTVDMRGHGESDWSPDGDYRVASFAADV
Mvan_1862|M.vanbaalenii_PYR-1 GGQTRRSWGRAAAAVAHRGWQAVTVDMRGHGESDWSPDGDYRVSSFAADV
Mb3502c|M.bovis_AF2122/97 GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYRLVSFAGDI
Rv3473c|M.tuberculosis_H37Rv GGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYRLVSFAGDI
MAV_0677|M.avium_104 GGQTRRSWGKAAAAVAARGWQAVTVDLRGHGESDWSGDGDYRVVSFAADV
MMAR_4960|M.marinum_M GGQTRRSWGRVAAVVAERGWQSVTVDLRGHGESDWSPHGDYRVVSFAADI
MSMEG_5209|M.smegmatis_MC2_155 GGQNRYSWKNTGQILADQGFHVIALDARGHGDSDRSPSANYSVDAMCGDV
MUL_0147|M.ulcerans_Agy99 GCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPDADYAIETLTSDI
TH_2112|M.thermoresistible__bu GGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDRSPTADYQLDDLCADT
MAB_2045|M.abscessus_ATCC_1997 GGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDWDPDGRYDMDRLGSDL
MLBr_02603|M.leprae_Br4923 FGEHARRYDHVAHYFAAAGLATYALDLRGHGRSAGKRVLVRDLSEYNADF
: : .. . * : * **** * : .*
Mflv_4507|M.gilvum_PYR-GCK REI--LAQLPPR---PVLVGASLGGITAMLLAGELARGIASAVVLVDIVP
Mvan_1862|M.vanbaalenii_PYR-1 REI--LDRLPPR---PVLVGASLGGITSMLLAGELARGIAAAVVLVDIVP
Mb3502c|M.bovis_AF2122/97 QEV--LRNLPGQ---PALVGASLGGFAAMLLAGELSPGIASAVVLVDIVP
Rv3473c|M.tuberculosis_H37Rv QEV--LRNLPGQ---PALVGASLGGFAAMLLAGELSPGIASAVVLVDIVP
MAV_0677|M.avium_104 QAV--LGTLPPK---PVLVGASLGGFTSMLLAGELSPGIASAVVLVDIVP
MMAR_4960|M.marinum_M QEV--LRGLPPQ---PVLVGASLGGFTSMLLAGELSPGIASAVVLVDIVP
MSMEG_5209|M.smegmatis_MC2_155 LAV--LYQISRP---VALIGASMGGLTGLLAAHEAGPERVTQLVLVDVVP
MUL_0147|M.ulcerans_Agy99 RHV--LDAIGRP---VVLIGASMGGLTGILVADSAGPDRVTGLVLVDVVP
TH_2112|M.thermoresistible__bu LSV--VDQIGRP---VSLIGASMGGLTGILVADRAGADKVTELVLVDVVP
MAB_2045|M.abscessus_ATCC_1997 LAVRSYADSGRP---VAAIGASLGGLTILGTHLLAPPDLWQAVVLVDVTP
MLBr_02603|M.leprae_Br4923 DILVGIATRDHPGLKRIVAGHSMGGAIVFAYGVERP----------DNYD
: * *:** : *
Mflv_4507|M.gilvum_PYR-GCK DMDPTGAERIHAFMADKMVDGFASLDEVADMIAEYNPHRPKPTDLDGLRK
Mvan_1862|M.vanbaalenii_PYR-1 DMDPSGAERIHAFMADRMVDGFGSLDEVADMIAEFNPHRPRPADLDGLRN
Mb3502c|M.bovis_AF2122/97 NMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVA
Rv3473c|M.tuberculosis_H37Rv NMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVA
MAV_0677|M.avium_104 NMDQSGANRIHAFMADRVDSGFASLDEVADAIAEYNPHRPRPTDLEGLTT
MMAR_4960|M.marinum_M NMDPSGASRIHAFMVERVESGFGSLDEVADMIAAYNPHRPRPTDLEGLTT
MSMEG_5209|M.smegmatis_MC2_155 NFEKSGSARIRDFMASNVD-GFDTLEEAADAVAAYLPHRRRPRNPEGLKK
MUL_0147|M.ulcerans_Agy99 KYEKDGSARIRDFMFTNLH-GFATLEEAADAVATYLPHRTKPRSPEGLKK
TH_2112|M.thermoresistible__bu RVEQAGTDRIRDFMMTNVA-GFETLEEAADAVAAYLPHRRRPRSPEGLKK
MAB_2045|M.abscessus_ATCC_1997 RMEMDGARRVVAFMSAHPE-GFDSLESAADVIAAYNPHRPRPENLDGLRK
MLBr_02603|M.leprae_Br4923 LMVLSGPAVAAQDMVSPLR---AVVGKGLGLVAPGLPVHQLEVDAISRNR
*. * : . . :* * : . .
Mflv_4507|M.gilvum_PYR-GCK NLRHK-GGRWYWHWDPRFIDG----TAPHPPMEVTDTDRLHA-AVGRIVD
Mvan_1862|M.vanbaalenii_PYR-1 NLRRR-GERWYWHWDPQFIDG----SAANPPIEVTDTERLHS-AVEAILA
Mb3502c|M.bovis_AF2122/97 NLRRR-GDRWYWHWDPQFIGG----IAAFPPVEVTDVDRMNA-AVATILR
Rv3473c|M.tuberculosis_H37Rv NLRRR-GDRWYWHWDPQFIGG----IAAFPPVEVTDVDRMNA-AVATILR
MAV_0677|M.avium_104 NLRRR-GDRWYWHWDPQFISG----TAAFPPFEVTDPDRMHA-AVEAILR
MMAR_4960|M.marinum_M NLRRR-GDRWYWHWDPRFISG----TAAFPPIEVTEPHRLYA-AVDTILR
MSMEG_5209|M.smegmatis_MC2_155 NLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLEQA-------AVN
MUL_0147|M.ulcerans_Agy99 NLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFERA-------AMN
TH_2112|M.thermoresistible__bu NLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLERA-------ALR
MAB_2045|M.abscessus_ATCC_1997 VLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFEMMSAFLLDGARQ
MLBr_02603|M.leprae_Br4923 AVVAA------YKDDPLVYHG--KVPAGVGRVMLQVGETMTR----RAPV
: :: ** . .
Mflv_4507|M.gilvum_PYR-GCK DGVPVLLVRGQVSDLVSRDRAAAFLSRFP--QIDFVDVDGAGHMVAGD-R
Mvan_1862|M.vanbaalenii_PYR-1 DGVPVLLVRGQVSDLVSRERADAFVARFP--QIAFVDVEGAGHMVAGD-R
Mb3502c|M.bovis_AF2122/97 DEVPVLLVRGQVSDIVRQESADQFLSRFP--QVEFTDVRGAGHMVAGD-R
Rv3473c|M.tuberculosis_H37Rv DEVPVLLVRGQVSDIVRQESADQFLSRFP--QVEFTDVRGAGHMVAGD-R
MAV_0677|M.avium_104 DGVPILMIRGQMSDLVSQERADEFLARFP--QVEFTDVRGAGHMVAGD-R
MMAR_4960|M.marinum_M GGVPMLLIRGQMSDLVSQERAEEFLARFP--NVEFTDVRGAGHMVAGD-R
MSMEG_5209|M.smegmatis_MC2_155 LTVPILLIRGKLSDVVSPEGVAEFLEKVP--AAEFVELSDAGHTAAGD-D
MUL_0147|M.ulcerans_Agy99 LTIPILLIRGKLSDVVTSEGVQDFLDKVP--HAEFVELSNAGHTAAGD-D
TH_2112|M.thermoresistible__bu LTVPILLVRGKLSDVVSAEGVEEFLAKVP--SAEFVELSAAXXXATIP-A
MAB_2045|M.abscessus_ATCC_1997 VSAPTLLVRGLLSDIVSEETVRHFLTVVP--HAQTVDVSGAGHMIAGD-N
MLBr_02603|M.leprae_Br4923 LTTPLLVVHGSEDRLVLVDGSHRLVECVGSTDVELKVYPGLYHEVFNEPE
* *:::* . :* : :: .
Mflv_4507|M.gilvum_PYR-GCK NDLFADAVLSFLTRREVAKP-------------------------
Mvan_1862|M.vanbaalenii_PYR-1 NDLFADAVLDFLARSEIARP-------------------------
Mb3502c|M.bovis_AF2122/97 NDAFAGAVLDFLARHVGVR--------------------------
Rv3473c|M.tuberculosis_H37Rv NDAFAGAVLDFLARHVGVR--------------------------
MAV_0677|M.avium_104 NDVFADAVLDFLARHLDVE--------------------------
MMAR_4960|M.marinum_M NDIFAAAVLDFLSRHLDAG--------------------------
MSMEG_5209|M.smegmatis_MC2_155 NDAFTQVVVEFVNR-------------------------------
MUL_0147|M.ulcerans_Agy99 NDAFTEVVVDFVKRRAATG--------------------------
TH_2112|M.thermoresistible__bu RGSPRRCVTSPVCRRRPPTSRPAPSPRSAPRHGNVAGPGANAVRR
MAB_2045|M.abscessus_ATCC_1997 NDAFSTAVVEFLDRTI-----------------------------
MLBr_02603|M.leprae_Br4923 RDQVLEDVVCWILKRL-----------------------------
.. * : :