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M. thermoresistible (build 8) TH_2112 (-)

annotation: hydrolase, alpha/beta fold family protein
coordinates: 4149713 - 4150663
length: 317

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2112--100% (317)hydrolase, alpha/beta fold family protein
M. thermoresistible (build 8)TH_0490bpoA1e-2642.94% (163) POSSIBLE PEROXIDASE BPOA (NON-HAEM PEROXIDASE)
M. thermoresistible (build 8)TH_1312-8e-1932.48% (234) POSSIBLE HYDROLASE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1154cbpoB1e-10066.42% (268) peroxidase BpoB
M. gilvum PYR-GCKMflv_2096-1e-10267.54% (268) alpha/beta hydrolase fold
M. tuberculosis H37RvRv1123cbpoB1e-10066.42% (268) peroxidase BpoB
M. leprae Br4923MLBr_02297-7e-0735.80% (81) putative hydrolase
M. abscessus ATCC 19977MAB_2045-3e-5345.62% (274) putative hydrolase (alpha/beta fold)
M. marinum MMMAR_4337bpoB1e-10568.66% (268) peroxidase BpoB
M. avium 104MAV_1254-1e-10269.77% (258) hydrolase, alpha/beta fold family protein
M. smegmatis MC2 155MSMEG_5209-1e-10669.14% (269) hydrolase, alpha/beta fold family protein
M. ulcerans Agy99MUL_0147bpoB1e-10367.54% (268) peroxidase BpoB
M. vanbaalenii PYR-1Mvan_4609-1e-10165.58% (276) alpha/beta hydrolase fold

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2096|M.gilvum_PYR-GCK          --------------MSIEHREPKTVTFRGADGLALVADEWNNPAQTEA--
Mvan_4609|M.vanbaalenii_PYR-1       --------------MSTVSSEPTTVTFRGAEDLALVADEWNNPAEAASSG
MSMEG_5209|M.smegmatis_MC2_155      --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAA--
Mb1154c|M.bovis_AF2122/97           MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
Rv1123c|M.tuberculosis_H37Rv        MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAAD--
MMAR_4337|M.marinum_M               --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MUL_0147|M.ulcerans_Agy99           --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTAASG--
MAV_1254|M.avium_104                ------------------------MEFAGVDGITLVADEWNRGSDGAG--
TH_2112|M.thermoresistible__bu      --------------LNSTHSKPQTVRFRGAQGLTLVADQWNRGSGPKD--
MAB_2045|M.abscessus_ATCC_1997      ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHCDAP-----
MLBr_02297|M.leprae_Br4923          MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATA--
                                                              .  .  :.      .  .      

Mflv_2096|M.gilvum_PYR-GCK          --FDRSRPSVLMMHGGGQNRFSWKKTGQILGEQGLHVVALDSRGHGDSDR
Mvan_4609|M.vanbaalenii_PYR-1       RDFDASRPSVLMLHGGGQNRFSWKKTGQTLASQGLHVVALDSRGHGDSDR
MSMEG_5209|M.smegmatis_MC2_155      -----DRPTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDR
Mb1154c|M.bovis_AF2122/97           ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
Rv1123c|M.tuberculosis_H37Rv        ------RPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDR
MMAR_4337|M.marinum_M               ------RPTILMLHGGGQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MUL_0147|M.ulcerans_Agy99           ------RPTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDR
MAV_1254|M.avium_104                ------RPSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDR
TH_2112|M.thermoresistible__bu      ------RPTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDR
MAB_2045|M.abscessus_ATCC_1997      ------RAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDW
MLBr_02297|M.leprae_Br4923          ------RPLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDK
                                          *. ::::**  .   :*    : * .    : * * ** *.** 

Mflv_2096|M.gilvum_PYR-GCK          SPDARYTVEALCEDTLRV--LEQIGRPTVLIGASMGGLTGILAARRAGPE
Mvan_4609|M.vanbaalenii_PYR-1       SPDANYTVEALCADTLAV--LRQIGRPTVLIGASMGGLTGILASRQAGPE
MSMEG_5209|M.smegmatis_MC2_155      SPSANYSVDAMCGDVLAV--LYQISRPVALIGASMGGLTGLLAAHEAGPE
Mb1154c|M.bovis_AF2122/97           APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
Rv1123c|M.tuberculosis_H37Rv        APGADYAVETPTTDVLHV--VEAIGRRVVVVEASMGGLTGILVAERAGPQ
MMAR_4337|M.marinum_M               APDADYAIETLTSDILHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MUL_0147|M.ulcerans_Agy99           APDADYAIETLTSDIRHV--LDAIGRPVVLIGASMGGLTGILVADSAGPD
MAV_1254|M.avium_104                SPQADYQIETLTADVLRV--LDAIGRPVTIIGASMGGLTGILAAHRAGPA
TH_2112|M.thermoresistible__bu      SPTADYQLDDLCADTLSV--VDQIGRPVSLIGASMGGLTGILVADRAGAD
MAB_2045|M.abscessus_ATCC_1997      DPDGRYDMDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPPD
MLBr_02297|M.leprae_Br4923          PPRG-YDGWTLAGDTAGL--IRALGHSSATLVGHAEGGLACWATALLHPR
                                     * . *       *   :      .:    : .   *     .     . 

Mflv_2096|M.gilvum_PYR-GCK          VVTRLVLVDVVPRYEKGGSARIRDFMFSHVHGFDSLEQAADAVAEYLPHR
Mvan_4609|M.vanbaalenii_PYR-1       LVTRLILVDVVPRYEKDGSARIREFMFSHVHGFESLEQAAEAVAAYLPHR
MSMEG_5209|M.smegmatis_MC2_155      RVTQLVLVDVVPNFEKSGSARIRDFMASNVDGFDTLEEAADAVAAYLPHR
Mb1154c|M.bovis_AF2122/97           TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
Rv1123c|M.tuberculosis_H37Rv        TVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHR
MMAR_4337|M.marinum_M               RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MUL_0147|M.ulcerans_Agy99           RVTGLVLVDVVPKYEKDGSARIRDFMFTNLHGFATLEEAADAVATYLPHR
MAV_1254|M.avium_104                KVTRLVLVDVVPRFEKDGSARIRDFMISGLDGFDSLEQAADAVAAYLPYR
TH_2112|M.thermoresistible__bu      KVTELVLVDVVPRVEQAGTDRIRDFMMTNVAGFETLEEAADAVAAYLPHR
MAB_2045|M.abscessus_ATCC_1997      LWQAVVLVDVTPRMEMDGARRVVAFMSAHPEGFDSLESAADVIAAYNPHR
MLBr_02297|M.leprae_Br4923          LVRAIALINSP-----HPAALRRSMLTHRNQGYALLPTLLRYQLPIWPER
                                        : *::               ::     *:  *           * *

Mflv_2096|M.gilvum_PYR-GCK          AKPRS-PEGLKKNLRRR-NGRWYWHWDPAFLT----KPSEDPFARVEQLE
Mvan_4609|M.vanbaalenii_PYR-1       TKPRS-PEGLKKNLRHR-HGRWYWHWDPAFLT----KPNEDPFVRVEQLE
MSMEG_5209|M.smegmatis_MC2_155      RRPRN-PEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLE
Mb1154c|M.bovis_AF2122/97           DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
Rv1123c|M.tuberculosis_H37Rv        DKPRS-PEGLKRNLRLR-DGRWHWHWDPAMMT----APGHDPQLRTENFE
MMAR_4337|M.marinum_M               TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MUL_0147|M.ulcerans_Agy99           TKPRS-PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFE
MAV_1254|M.avium_104                SKPRS-PEGLKKNLRLR-DGRWYWHWDPAFMT----KPGDDPELRTESFE
TH_2112|M.thermoresistible__bu      RRPRS-PEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLE
MAB_2045|M.abscessus_ATCC_1997      PRPEN-LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFE
MLBr_02297|M.leprae_Br4923          LLTRNNAAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALE
                                      ...    :.: :  *  .:*    * *.                  :*

Mflv_2096|M.gilvum_PYR-GCK          QA-------------------ATELTVPILLIRGKLSDVVSEEAVQDFLA
Mvan_4609|M.vanbaalenii_PYR-1       QA-------------------AIELTIPILLIRGKLSDVVSEEAVQDFLT
MSMEG_5209|M.smegmatis_MC2_155      QA-------------------AVNLTVPILLIRGKLSDVVSPEGVAEFLE
Mb1154c|M.bovis_AF2122/97           RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
Rv1123c|M.tuberculosis_H37Rv        RA-------------------AMGLTIPVLLIRGKLSDVVSSDGARDFLA
MMAR_4337|M.marinum_M               RA-------------------AMNLTIPILLIRGKLSDVVSSEGVQDFLD
MUL_0147|M.ulcerans_Agy99           RA-------------------AMNLTIPILLIRGKLSDVVTSEGVQDFLD
MAV_1254|M.avium_104                QA-------------------AKNLSIPVLLIRGKLSDVVSPEGVRHFLA
TH_2112|M.thermoresistible__bu      RA-------------------ALRLTVPILLVRGKLSDVVSAEGVEEFLA
MAB_2045|M.abscessus_ATCC_1997      MMSAFL------------LDGARQVSAPTLLVRGLLSDIVSEETVRHFLT
MLBr_02297|M.leprae_Br4923          YQRWAVRSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRR
                                                         :  .: * * :**  .  :  : .     

Mflv_2096|M.gilvum_PYR-GCK          KVPGAEFAELSGAGHTAAGDDNDAFSEVVTRFVLR---------------
Mvan_4609|M.vanbaalenii_PYR-1       KVPNAEFVELPGAGHTAAGDDNDAFSEVVAQFVLR---------------
MSMEG_5209|M.smegmatis_MC2_155      KVPAAEFVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------
Mb1154c|M.bovis_AF2122/97           KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
Rv1123c|M.tuberculosis_H37Rv        KVPNAEFVELSNAGRTAAGDDNDAFTDVVVDFVRRLS-------------
MMAR_4337|M.marinum_M               KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MUL_0147|M.ulcerans_Agy99           KVPHAEFVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------
MAV_1254|M.avium_104                TVPRAEFVELSNAGHTAAGDDNDAFSDAVVAFVKRR--------------
TH_2112|M.thermoresistible__bu      KVPSAEFVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSA
MAB_2045|M.abscessus_ATCC_1997      VVPHAQTVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------
MLBr_02297|M.leprae_Br4923          YAPHGRYVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------
                                     .* .. ..:. *               :.  : :               

Mflv_2096|M.gilvum_PYR-GCK          ----------------
Mvan_4609|M.vanbaalenii_PYR-1       ----------------
MSMEG_5209|M.smegmatis_MC2_155      ----------------
Mb1154c|M.bovis_AF2122/97           ----------------
Rv1123c|M.tuberculosis_H37Rv        ----------------
MMAR_4337|M.marinum_M               ----------------
MUL_0147|M.ulcerans_Agy99           ----------------
MAV_1254|M.avium_104                ----------------
TH_2112|M.thermoresistible__bu      PRHGNVAGPGANAVRR
MAB_2045|M.abscessus_ATCC_1997      ----------------
MLBr_02297|M.leprae_Br4923          ----------------